Employees – University of Copenhagen

David E. Gloriam

David E. Gloriam

Professor


  1. 2019
  2. E-pub ahead of print

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at -Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. / Giraudo, Alessandro; Krall, Jacob; Bavo, Francesco; Nielsen, Birgitte; Kongstad, Kenneth Thermann; Rolando, Barbara; De Blasio, Rosella; Gloriam, David E; Löffler, Rebekka; Thiesen, Louise; Harpsøe, Kasper; Frydenvang, Karla; Boschi, Donatella; Wellendorph, Petrine; Lolli, Marco L; Jensen, Anders; Frølund, Bente.

    In: Journal of Medicinal Chemistry, 22.05.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity. / Malfacini, Davide; Patt, Julian; Annala, Suvi; Harpsøe, Kasper; Eryilmaz, Funda; Reher, Raphael; Crüsemann, Max; Hanke, Wiebke; Zhang, Hang; Tietze, Daniel; Gloriam, David E; Bräuner-Osborne, Hans; Strømgaard, Kristian; König, Gabriele M; Inoue, Asuka; Gomeza, Jesus; Kostenis, Evi.

    In: The Journal of Biological Chemistry, Vol. 294, No. 15, 12.04.2019, p. 5747-5758.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites. / Krall, Jacob; Bavo, Francesco; Falk-Petersen, Christina B; Jensen, Claus Hatt; Nielsen, Julie Olsson; Tian, Yongsong; Anglani, Valeria; Kongstad, Kenneth Thermann; Piilgaard, Louise; Nielsen, Birgitte; Gloriam, David E; Kehler, Jan; Jensen, Anders; Harpsøe, Kasper; Wellendorph, Petrine; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 5, 14.03.2019, p. 2798-2813.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist. / Nøhr, Anne Cathrine; Shehata, Mohamed A; Palmer, Daniel; Pokhrel, Rina; Vallianou, Maria; Foster, Simon R; Gentry, Patrick R; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Scientific Reports, Vol. 9, No. 1, 07.03.2019, p. 3802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Bigger is better in virtual drug screens. / Gloriam, David E.

    In: Nature, Vol. 566, No. 7743, 14.02.2019, p. 193-194.

    Research output: Contribution to journalLetterResearchpeer-review

  7. 2018
  8. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. / Zhang, Hang; Nielsen, Alexander L.; Boesgaard, Michael W.; Harpsøe, Kasper; Daly, Norelle L.; Xiong, Xiao-feng; Underwood, Christina R.; Haugaard-kedström, Linda M.; Bräuner-osborne, Hans; Gloriam, David E.; Strømgaard, Kristian.

    In: European Journal of Medicinal Chemistry, Vol. 156, 05.08.2018, p. 847-860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    A Structural Framework for GPCR Chemogenomics : What’s In a Residue Number? / Vass, Márton; Kooistra, Albert J.; Verhoeven, Stefan; Gloriam, David; de Esch, Iwan J.P.; de Graaf, Chris.

    Methods in Molecular Biology. Humana Press, 2018. p. 73-113.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  10. Published

    Pharmacogenomics of GPCR Drug Targets. / Hauser, Alexander Sebastian; Chavali, Sreenivas; Masuho, Ikuo; Jahn, Leonie; Martemyanov, Kirill; Gloriam, David E.; Babu, Madan.

    In: Cell, Vol. 172, 01.2018, p. 41–54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Structural Mapping of Adenosine Receptor Mutations : Ligand Binding and Signaling Mechanisms. / Jespers, Willem; Schiedel, Anke C; Heitman, Laura H; Cooke, Robert M; Kleene, Lisa; van Westen, Gerard J P; Gloriam, David E; Müller, Christa E; Sotelo, Eddy; Gutiérrez-de-Terán, Hugo.

    In: Trends in Pharmacological Sciences, Vol. 39, No. 1, 01.2018, p. 75-89.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. / Peng, Yao; McCorvy, John D.; Harpsøe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F.; Huang, Xi-ping; Wu, Yiran; Shen, Ling; Bjørn-Yoshimoto, Walden E.; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A.; Hanson, Michael A.; Zhao, Suwen; Gloriam, David E.; Roth, Bryan L.; Stevens, Raymond C.; Liu, Zhi-jie.

    In: Cell, Vol. 172, No. 4, P719-730.E14, 2018, p. 719-730.

    Research output: Contribution to journalJournal articleResearchpeer-review

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