Dennis Özcelik

Dennis Özcelik

Assistant professor

RESEARCH POSITIONS

Since 2017     Assistant Professor, University of Copenhagen, Denmark

2014 - 2017   CIHR Postdoctoral fellow, University of Ottawa & National Research Council of Canada

2013 - 2014   Postdoctoral fellow, University of Toronto, Canada

 

EDUCATION

2009 - 2012   Ph.D., ETH Zürich, Switzerland

2008               Research stay, Academic Medical Center, Amsterdam, The Netherlands

2007 - 2008   Research stay, University of Michigan, USA

2004 - 2008   B.Sc. & M.Sc., University of Tübingen, Germany

 

PUBLICATIONS (* corresponding author)

 

13. *   Farzam A, Chohan K, Strmiskova M, Hewitt SJ, Park DS, Pezacki JP, Özcelik D. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biology. (in press)

12. *   Özcelik D, Pezacki JP. Small molecule inhibition of protein disulfide isomerase in neuroblastoma cells induces oxidative stress response and apoptosis pathways. ACS Chem Neurosci. 2019;10:4068-75.

11.      Bach A, Clausen BH, Kristensen LK, Andersen MG, Ellman DG, Hansen PBL, Hasseldam H, Heitz M, Özcelik D, Tuck EJ, Kopanitsa MV, Grant SGN, Lykke-Hartmann K, Johansen FF, Lambertsen KL, Strømgaard K. Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor. Neuropharmacology. 2019;150:100-11.

10.      Özcelik D, Seto A, Rakic B, Farzam A, Supek F, Pezacki JP. Gene expression profiling of endoplasmatic reticulum stress in hepatitis C virus-containing cells treated with an inhibitor of protein disulfide isomerases. ACS Omega. 2018;3:17227-35.

9.      Shaw TA, Singaravelu R, Powdrill MH, Nhan J, Ahmed N, Özcelik D, Pezacki JP. MicroRNA-124 regulates fatty acid and triglyceride homeostasis. iScience. 2018;10:149-57.

8.      Singaravelu R, O’Hara S, Jones DM, Chen R, Taylor NG, Srinivasan P, Quan C, Roy DG, Steenbergen RH, Kumar A, Lyn RK, Özcelik D, Rouleau Y, Nguyen MA, Rayner KJ, Hobman TC, Tyrrell DL, Russell RS, Pezacki JP. MicroRNAs regulate the immunometabolic response to viral infection in the liver. Nat Chem Biol. 2015;11:988-93.

7.      Striebel F, Imkamp F, Özcelik D, Weber-Ban E. Pupylation as a signal for proteasomal degradation in bacteria. Biochim Biophys Acta Mol Cell Res. 2014;1843:103-13. Review.

6.      Özcelik D, Barandun J, Sutter M, Guth E, Damberger FF, Allain FHT, Ban N, Weber-Ban E. Structures of Pup ligase PafA and depupylase Dop of the prokaryotic ubiquitin-like modification pathway. Nat Commun. 2012;3:1014.

5.      Delley CL, Striebel F, Heydenreich FM, Özcelik D, Weber-Ban E. Activity of the mycobacterial proteasomal ATPase Mpa is reversibly regulated by pupylation. J Biol Chem. 2012;287:7907-14.

4.      Imkamp F, Striebel F, Sutter M, Özcelik D, Zimmermann N, Sander P, Weber-Ban E. Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway. EMBO Rep. 2010;11:791-7.

3.      Winter J, Ilbert M, Graf PCF, Özcelik D, Jakob U. Bleach activates a redox-regulated chaperone by oxidative protein unfolding. Cell. 2008;135:691-701.

2.      Koch S, Larbi A, Derhovanessian E, Özcelik D, Naumova E, Pawelec G. Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing. 2008;5:6.

1.      Koch S, Larbi A, Özcelik D, Solana R, Gouttefangeas C, Attig S, Wikby A, Strindhall J, Franceschi C, Pawelec G. Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci. 2007;1114:23-35. Review.

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