Flemming Steen Jørgensen
Flemming Steen Jørgensen

Professor


  1. 1979
  2. Published

    Disulfide conformational analysis. The nature of the S-S rotation barrier1 1 Organo-Sulphur Mechanisms-9. For Part 8 see L. Carlsen and J.P. Snyder, J. Org. Chem. 43, 2216 (1978).

    Jørgensen, Flemming Steen & Snyder, J. P., 1 Jan 1979, In : Tetrahedron. 35, 11, p. 1399-1407 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 1980
  4. Published

    Crystal and Molecular Structure of Di- tert-adamantyl Disulfide. Extension of the Correlation between the Sulfur-Sulfur Dihedral Angle and the Sulfur Lone-Pair Energy Gap

    Rindorf, G., Jørgensen, Flemming Steen & Snyder, J. P., 1 Jan 1980, In : Journal of Organic Chemistry. 45, 26, p. 5343-5347 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Search for a trans-Disulfide: Structural Analysis of Di-tert-adamantyl Disulfide by Photoelectron Spectroscopy, Derivation of σI (t-Ad), and Molecular Mechanics Calculations for Related Bulky Disulfides

    Jørgensen, Flemming Steen & Snyder, J. P., 1 Jan 1980, In : Journal of Organic Chemistry. 45, 6, p. 1015-1020 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 1981
  7. Published

    Determination of ring inversion barriers for 1H,3H-naphtho[1,8-cd]-pyran and its methyl substituted derivatives by molecular mechanics calculations and dynamic nuclear magnetic resonance spectroscopy

    Anderson, J. E. & Jørgensen, Flemming Steen, 1 Jan 1981, In : Journal of the Chemical Society, Perkin Transactions 2. 4, p. 741-746 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Polyethers. Structural analysis of the 1,4,5,8-tetraoxadecalins and 2,2'-bis(1,3-dioxolane) by photoelectron spectroscopy, molecular mechanics and molecular orbital calculations

    Jørgensen, Flemming Steen, Nørskov-Lauritsen, L., Jensen, R. B. & Sshroll, G., 1 Jan 1981, In : Tetrahedron. 37, 21, p. 3671-3679 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Sulfur-Bridged pen-Naphthalenes: Synthesis, Conformational Analysis, and Photoelectron Spectroscopy of the Mono-, Di-, and Trisulfides of 1,8-Dimethylnaphthalene

    Guttenberger, H. G., Bestmann, H. J., Dickert, F. L., Jørgensen, Flemming Steen & Snyder, J. P., 1 Jan 1981, In : Journal of the American Chemical Society. 103, 1, p. 159-168 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The Electronic Structure of β-Thioxoketones. A Photoelectron Spectroscopic Study of the Enol-Enethiol Tautomerism of Thioacetylacetone and Related Compounds

    Jørgensen, Flemming Steen, Carlsen, L. & Duus, F., 1 Jan 1981, In : Journal of the American Chemical Society. 103, 6, p. 1350-1353 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 1982
  12. Published

    Anti,anti acetals : Photoelectron spectroscopy of trans-1,8-dioxadecalins

    Jørgensen, Flemming Steen & Nørskov-Lauritsen, L., 1982, In : Tetrahedron Letters. 23, 49, p. 5221 - 5224

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Correlations between Core Photoionization Energies (EB1s) and Gas-Phase Basicity. A General Method for Determining Sites of Protonation and Intramolecular Ion Reorganization Energies

    Buschek, J. M., Jørgensen, Flemming Steen & Brown, R. S., 1 Jan 1982, In : Journal of the American Chemical Society. 104, 19, p. 5019-5025 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Ring inversion of CH2-X-CH2-bridged peri-naphthalenes. A dynamic n.m.r. study

    Anderson, J. E., Jørgensen, Flemming Steen & Thomsen, T., 1 Jan 1982, In : Journal of the Chemical Society, Chemical Communications. 6, p. 333-334 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    X-ray Photoelectron Spectroscopic Study of the Enol-Enethiol Tautomerism of Thioacetylacetone and Related β-Thioxoketones

    Jørgensen, Flemming Steen, Brown, R. S., Carlsen, L. & Duus, F., 1 Jan 1982, In : Journal of the American Chemical Society. 104, 22, p. 5922-5926 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 1983
  17. Published

    On the molecular and electronic features of syn- and anti-sequinorbornene

    Jørgensen, Flemming Steen, 1983, In : Tetrahedron Letters. 24, 47, p. 5289 - 5292

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    On the presence of extremely short H...H non-bonded distances, and orbital interactions through eight s bonds or through two methylene groups in tetramethanonaphthacenes.

    Jørgensen, Flemming Steen & Paddon-Row, M. N., 1983, In : Tetrahedron Letters. 24, 48, p. 5415 - 5418

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    cis-disulfides protelectron spectrum of a 6,7-dithiabicyclo[3.2.1]octane

    Jørgensen, Flemming Steen & McCabe, P. H., 1983, In : Tetrahedron Letters. 24, 3, p. 319-322

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    1,2‐Oxathiolane – A Photoelectron Spectroscopic Study

    Jørgensen, Flemming Steen & Carlsen, L., 1 Jan 1983, In : Chemische Berichte. 116, 6, p. 2374-2377 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Photoelectron spectra of some decahydrotrimethanoanthracenes: Observation of large π orbital interactions through six bonds and an apparent violation of the trans rule

    Jørgensen, Flemming Steen, Paddon-Row, M. N. & Patney, H. K., 1 Jan 1983, In : Journal of the Chemical Society, Chemical Communications. 10, p. 573-575 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Crystal structure of merosinigrin, an (ap,ap)-monothioacetal; structural properties of the thioglycosidic linkage

    Nørskov-Lauritsen, L., Jørgensen, Flemming Steen & Jaroszewski, J. W., 11 Nov 1983, In : Carbohydrate Research. 123, 1, p. 1-11 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 1984
  24. Published

    3-mercaptopropanal

    Carlsen, L., Jørgensen, Flemming Steen, Egsgaard, H. & Nicolaisen, F. M., 1 Jan 1984, In : Journal of the Chemical Society, Perkin Transactions 2. 4, p. 609-613 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. 1985
  26. Published

    Cyclynes. Part 5. Pericyclynes: "exploded cycloalkanes" with unusual orbital interactions and conformational properties. MM2 and STO-3G calculations, x-ray crystal structures, photoelectron spectra, and electron transmission spectra

    Houk, K. N., Scott, L. T., Rondan, N. G., Spellmeyer, D. C., Reinhardt, G., Hyun, J. L., DeCicco, G. J., Weiss, R., Chen, M. H. M., Bass, L. S., Clardy, J., Jørgensen, Flemming Steen, Eaton, T. A., Sarkozi, V., Petit, C. M., Ng, L. & Jordan, K. D., 1985, In : Journal of the American Chemical Society. 107, 23, p. 6556-6562 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Crystal and Molecular Structure of anti-Sesquinorbornene

    Gaihede, M., Jørgensen, Flemming Steen, Kopecky, K. R., Watson, W. H. & Kashyap, R. P., 1 Jan 1985, In : Journal of Organic Chemistry. 50, 22, p. 4395-4397 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Cyclic Acetals. Structural Analysis of 1,3‐Dioxepine and Related Compounds

    Jørgensen, Flemming Steen, Gajhede, Michael & Frei, B., 1 Jan 1985, In : Helvetica Chimica Acta. 68, 8, p. 2148-2157 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 1987
  30. Published

    Crystal structures and photoelectron spectra of some trimethanoanthracenes, tetramethanonaphthacenes, and pentamethanopentacenes. Experimental evidence for laticyclic hyperconjugation

    Paddon-Row, M. N., Englehardt, L. M., Skelton, B. W., White, A. H., Jørgensen, Flemming Steen & Patney, H. K., 1987, In : J. Chem. Soc., Perkin Trans. 2. p. 1835-1850 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Setting the anomeric effect against steric effects in simple acyclic acetals. Non-anomeric non-classical conformations. An n.m.r. and molecular mechanics investigation

    Anderson, J. E., Heki, K., Hirota, M. & Jørgensen, Flemming Steen, 1987, In : Chemical communications (Cambridge, England). 1987, p. 554-555 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Towards an identification of the pyrethroid pharmacophore. A molecular modelling study of some pyrethroid esters

    Byberg, J. R., Jørgensen, Flemming Steen & Klemmensen, P. D., 1987, In : Journal of Computer - Aided Molecular Design. 1, 3, p. 181-95 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Molecular modelling of GABA uptake inhibitors

    Jørgensen, Flemming Steen & Thøgersen, H., 1 Jan 1987, In : Nordic Journal of Psychiatry. 41, 6, p. 483-486 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 1988
  35. Published

    peri-Interaction, ortho-interaction, and barriers to internal rotation. A dynamic nuclear magnetic resonance and molecular mechanics investigation of 1,2-dineopentylbenzene and 1,8-dineopentylnaphthalene

    Anderson, J. E., Barkel, D. J. & Jørgensen, Flemming Steen, 1 Feb 1988, In : Journal of the Chemical Society. Perkin Transactions 2 (2001). 2, p. 199-202 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Conformational analysis of peri-interactions in napththalene derivatives. Ring inversion in CH2–X–CH2-bridged peri-naphthalenes

    Anderson, J. E. & Jørgensen, Flemming Steen, 1 Apr 1988, In : Journal of the Chemical Society. Perkin Transactions 2 (2001). 1988, 4, p. 469-471 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 1989
  38. Published

    3D-QSAR. Towards a quantitative three-dimensional description of muscarinic agonists.

    Lagersted, A. & Jørgensen, Flemming Steen, 1 Jan 1989, In : Progress in Clinical and Biological Research. 291, p. 333-336 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Heterocyclic muscarinic agonists: Structural and therapeutic aspects

    Krogsgaard-Larsen, Povl, Jensen, B., Falch, E. & Jørgensen, Flemming Steen, 1 Jan 1989, In : Drugs of the Future. 14, 6, p. 541-561 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 1990
  41. Published

    Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors

    Madsen, Ulf, Brehm, L., Schaumburg, K., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1990, In : Journal of Medicinal Chemistry. 33, 1, p. 374-80 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors

    Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  43. 1991
  44. Published

    Conformational and pharmacological characterization of 4-AHCP, a bicyclic homologue of the excitatory amino acid receptor agonist AMPA

    Lund, Trine Meldgaard, Madsen, Ulf, Ebert, B., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1991, In : Med. Chem. Res. 1, p. 136-141 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Excitatory amino acid receptors: multiplicity and structural requirements for activation and blockade

    Krogsgaard-Larsen, Povl, Lund, Trine Meldgaard, Jørgensen, Flemming Steen & Brehn, L., 1991, Excitatory amino acids and synaptic function. Wheal, H. & Thomson, A. (eds.). London: Academic Press, p. 1-17 17 p. (Excitatory Amino Acids and Synaptic Transmission, Academic Press, London).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  46. Published

    Primary structure and conformational analysis of peptide methionine-tyrosine, a peptide related to neuropeptide Y and peptide YY isolated from lamprey intestine

    Conlon, J. M., Bjørnholm, B., Jørgensen, Flemming Steen, Youson, J. H. & Schwartz, T. W., 1991, In : European Journal of Biochemistry. 199, 2, p. 293-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 1992
  48. Published

    AMPA receptor agonists: structural, conformational and stereochemical aspects

    Hansen, J., Jørgensen, Flemming Steen, Lund, Trine Meldgaard, Nielsen, Birgitte, Reinhardt, A., Breum, I., Brehm, L. & Krogsgaard-Larsen, Povl, 1992, Excitatory Amino Acid Receptors. Krogsgaard-Larsen, P. & Hansen, J. J. (eds.). Ellis Horwood: Chichester, 30 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  49. Published

    Conformational analysis of the fungicide fenpropimorph by molecular mechanics calculations and NMR spectroscopy

    Kastrup, Jette Sandholm Jensen, Jørgensen, Flemming Steen, Klemmensen, P. D., Hacksell, U. & Petersson, I., 1992, In : Journal of Pesticide Science. 36, p. 309-318 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Substrate-enzyme interactions and catalytic mechanism in phospholipase C: a molecular modeling study using the GRID program

    Byberg, J. R., Jørgensen, Flemming Steen, Hansen, S. & Hough, E., 1992, In : Proteins: Structure, Function, and Bioinformatics. 12, 4, p. 331-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 1993
  52. Published

    Conservation of a helix-stabilizing dipole moment in the PP-fold family of regulatory peptides

    Bjørnholm, B., Jørgensen, Flemming Steen & Schwartz, Thue W., 1993, In : Biochemistry. 32, 12, p. 2954-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Three-dimensional structures of human phospholipase A2 from pancreas and synovial fluid by model building

    Christensen, I. T., Jørgensen, Flemming Steen, Svensson, L. A. & Högberg, T., 1993, In : Drug Design and Discovery. 10, 2, p. 101-13 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Conformational analysis and molecular modelling of a partial GABA(A) agonist and a glycine antagonist related to the GABA(A) agonist, THIP

    Byberg Buur, J. R., Hjeds, H., Krogsgaard-Larsen, Povl & Jørgensen, Flemming Steen, 1 Dec 1993, In : Drug Design and Discovery. 10, 3, p. 213-229 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 1994
  56. Published

    GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects

    Krogsgaard-Larsen, Povl, Frølund, Bente, Jørgensen, Flemming Steen & Schousboe, Arne, 1994, In : Journal of Medicinal Chemistry. 37, 16, p. 2489-505 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 1995
  58. Published

    Crystallization and preliminary X-ray analysis of a PNA-DNA complex

    Kastrup, Jette Sandholm Jensen, Pilgaard, M., Jørgensen, Flemming Steen, Nielsen, Peter E. & Rasmussen, H. B., 1995, In : FEBS Letters. 363, p. 115-117 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 1996
  60. Published

    Update on protein structure prediction: Results of the 1995 IRBM workshop

    Hubbard, T., Tramontano, A., Barton, G., Jones, D., Sippl, M., Valencia, A., Lesk, A., Moult, J., Rost, B., Sander, C., Schneider, R., Lahm, A., Leplae, R., Buta, C., Eisenstein, M., Fjellstrom, O., Floeckner, H., Grossmann, J., Hansen, J., Citterich, M., Jørgensen, Flemming Steen, MarchlerBauer, A., Osuna, J., Park, J., Reinhardt, A., dePouplana, L., RojoDominguez, A., Saudek, V., Sinclair, J., Sturrock, S., Venclovas, C. & Vinals, C., 1996, In : Folding and Design. 1, 3, p. R55-R63

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. 1997
  62. Published

    Conformational analysis of six- and twelve-membered ring compounds by molecular dynamics

    Christensen, I. T. & Jørgensen, Flemming Steen, 1997, In : Journal of Computer - Aided Molecular Design. 11, 4, p. 385-94 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Molecular mechanics calculations of proteins. Comparison of different energy minimization strategies

    Christensen, I. T. & Jørgensen, Flemming Steen, 1997, In : Journal of Biomolecular Structure & Dynamics. 15, 3, p. 473-88 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Substrate binding and catalytic mechanism in phospholipase C from Bacillus cereus. a molecular mechanics and molecular dynamics study

    da Graça Thrige, D., Buur, J. R. & Jørgensen, Flemming Steen, 1997, In : Biopolymers. 42, 3, p. 319-36 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. 1999
  66. Published

    Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

    Lemcke, T., Christensen, I. T. & Jørgensen, Flemming Steen, 1999, In : Bioorganic & Medicinal Chemistry. 7, 6, p. 1003-11 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. 2000
  68. Published

    Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes

    Terp, G. E., Christensen, I. T. & Jørgensen, Flemming Steen, 2000, In : Journal of Biomolecular Structure & Dynamics. 17, 6, p. 933-46 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. 2001
  70. Published

    A new concept for multidimensional selection of ligand conformations (MultiSelect) and multidimensional scoring (MultiScore) of protein-ligand binding affinities

    Terp, G. E., Johansen, B. N., Christensen, I. T. & Jørgensen, Flemming Steen, 2001, In : Journal of Medicinal Chemistry. 44, 14, p. 2333-43 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. 2002
  72. Published

    Assessing the relative importance of the biophysical properties of amino acid substitutions associated with human genetic disease

    Terp, B. N., Cooper, D. N., Christensen, I. T., Jørgensen, Flemming Steen, Bross, P. G., Gregersen, Niels Henrik & Krawczak, M., 2002, In : Human Mutation. 20, 2, p. 98-109 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1302104