Flemming Steen Jørgensen

Flemming Steen Jørgensen

Professor


  1. Published

    peri-Interaction, ortho-interaction, and barriers to internal rotation. A dynamic nuclear magnetic resonance and molecular mechanics investigation of 1,2-dineopentylbenzene and 1,8-dineopentylnaphthalene. / Anderson, J Edgar; Barkel, David JD; Jørgensen, Flemming Steen.

    In: Journal of the Chemical Society. Perkin Transactions 2 (2001), No. 2, 01.02.1988, p. 199-202.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    hERG classification model based on a combination of support vector machine method and GRIND descriptors. / Li, Qiyuan; Jørgensen, Flemming Steen; Oprea, Tudor; Brunak, Søren; Taboureau, Olivier.

    In: Molecular Pharmaceutics, Vol. 5, No. 1, 2012, p. 117-127.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    cis-disulfides protelectron spectrum of a 6,7-dithiabicyclo[3.2.1]octane. / Jørgensen, Flemming Steen; McCabe, Peter H.

    In: Tetrahedron Letters, Vol. 24, No. 3, 1983, p. 319-322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    X-ray Photoelectron Spectroscopic Study of the Enol-Enethiol Tautomerism of Thioacetylacetone and Related β-Thioxoketones. / Jørgensen, Flemming S.; Brown, R. S.; Carlsen, Lars; Duus, Fritz.

    In: Journal of the American Chemical Society, Vol. 104, No. 22, 01.01.1982, p. 5922-5926.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands. / Poongavanam, Vasanthanathan; Hritz, Jozef; Taboureau, Olivier; Olsen, Lars; Jørgensen, Flemming Steen; Vermeulen, Nico P E; Oostenbrink, Chris.

    In: Journal of Chemical Information and Modeling, Vol. 49, No. 1, 2009, p. 43-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Use of density functional theory in drug metabolism studies. / Rydberg, Patrik; Jørgensen, Flemming Steen; Olsen, Lars.

    In: Expert Opinion on Drug Metabolism & Toxicology, Vol. 10, No. 2, 02.2014, p. 215-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Update on protein structure prediction : Results of the 1995 IRBM workshop. / Hubbard, T; Tramontano, A; Barton, G; Jones, D; Sippl, M; Valencia, A; Lesk, A; Moult, J; Rost, B; Sander, C; Schneider, R; Lahm, A; Leplae, R; Buta, C; Eisenstein, M; Fjellstrom, O; Floeckner, H; Grossmann, JG; Hansen, J; Citterich, MH; Jørgensen, Flemming Steen; MarchlerBauer, A; Osuna, J; Park, J; Reinhardt, A; dePouplana, LR; RojoDominguez, A; Saudek, V; Sinclair, J; Sturrock, S; Venclovas, C; Vinals, C.

    In: Folding and Design, Vol. 1, No. 3, 1996, p. R55-R63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Towards an understanding of drug resistance in malaria : three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building. / Lemcke, T; Christensen, I T; Jørgensen, Flemming Steen.

    In: Bioorganic & Medicinal Chemistry, Vol. 7, No. 6, 1999, p. 1003-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Towards an identification of the pyrethroid pharmacophore. A molecular modelling study of some pyrethroid esters. / Byberg, J R; Jørgensen, Flemming Steen; Klemmensen, P D.

    In: Journal of Computer - Aided Molecular Design, Vol. 1, No. 3, 1987, p. 181-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Three-dimensional structures of human phospholipase A2 from pancreas and synovial fluid by model building. / Christensen, I T; Jørgensen, Flemming Steen; Svensson, L A; Högberg, T.

    In: Drug Design and Discovery, Vol. 10, No. 2, 1993, p. 101-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region. / Tapken, Daniel; Steffensen, Thomas Bielefeldt; Leth, Rasmus; Kristensen, Lise Baadsgaard; Gerbola, Alexander; Gajhede, Michael; Jørgensen, Flemming Steen; Olsen, Lars; Kastrup, Jette Sandholm.

    In: Scientific Reports, Vol. 7, 46145, 07.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro. / Munkboel, Cecilie Hurup; Christensen, Lise Rudbaek; Islin, Julie; Bonomo, Silvia; Olsen, Lars; Jorgensen, Flemming Steen; Styrishave, Bjarne.

    In: Biology of Reproduction, Vol. 99, No. 4, 10.2018, p. 888-897.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The Electronic Structure of β-Thioxoketones. A Photoelectron Spectroscopic Study of the Enol-Enethiol Tautomerism of Thioacetylacetone and Related Compounds. / Jorgensen, Flemming S.; Carlsen, Lars; Duus, Fritz.

    In: Journal of the American Chemical Society, Vol. 103, No. 6, 01.01.1981, p. 1350-1353.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives. / Hansen, Anders N.; Bendiksen, Christine D.; Sylvest, Lene; Friis, Tina; Stærk, Dan; Jørgensen, Flemming Steen; Olsen, Christian Adam; Houen, Gunnar.

    In: P L o S One, Vol. 7, No. 9, 2012.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Sulfur-Bridged pen-Naphthalenes : Synthesis, Conformational Analysis, and Photoelectron Spectroscopy of the Mono-, Di-, and Trisulfides of 1,8-Dimethylnaphthalene. / Guttenberger, Hans G.; Bestmann, Hans J.; Dickert, Franz L.; Jorgensen, Flemming S.; Snyder, James P.

    In: Journal of the American Chemical Society, Vol. 103, No. 1, 01.01.1981, p. 159-168.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Substrate-enzyme interactions and catalytic mechanism in phospholipase C : a molecular modeling study using the GRID program. / Byberg, J R; Jørgensen, Flemming Steen; Hansen, S; Hough, E.

    In: Proteins: Structure, Function, and Bioinformatics, Vol. 12, No. 4, 1992, p. 331-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Substrate binding and catalytic mechanism in phospholipase C from Bacillus cereus. a molecular mechanics and molecular dynamics study. / da Graça Thrige, D; Buur, J R; Jørgensen, Flemming Steen.

    In: Biopolymers, Vol. 42, No. 3, 1997, p. 319-36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities. / Jensen, Minna Grønning; Olsen, Lars; Van De Weert, Marco; Flink, James M.; Frøkjær, Sven; Jørgensen, Flemming Steen.

    In: Journal of Structural Biology, Vol. 158, No. 3, 2007, p. 358-369.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors. / Larsen, Morten; Hansen, Cecilie Hurup; Rasmussen, Tobias B.; Styrishave, Bjarne; Olsen, Lars; Jørgensen, Flemming Steen.

    In: Chemical Communications, Vol. 53, No. 3118, 3118, 28.02.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes. / Terp, G E; Christensen, I T; Jørgensen, Flemming Steen.

    In: Journal of Biomolecular Structure & Dynamics, Vol. 17, No. 6, 2000, p. 933-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structural differences of matrix metalloproteinases with potential implications for inhibitor selectivity examined by the GRID/CPCA approach. / Terp, Gitte Elgaard; Cruciani, Gabriele; Christensen, Inge Thøger; Jørgensen, Flemming Steen.

    In: Journal of Medicinal Chemistry, Vol. 45, No. 13, 2002, p. 2675-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors. / Brehm, Lotte; Christensen, Inge T; Nielsen, Birgitte; Reinhardt, Annemarie ; Ebert, Bjarke; Madsen, Ulf; Jørgensen, Flemming Steen; Hansen, Jan J.; Krogsgaard-Larsen, Povl.

    Frontiers in Drug Research; Alfred Benzon Symposium 28. ed. / B. Jensen; F. S. Jørgensen; H. Kofod. Copenhagen : Munksgaard , 1990. p. 92-105.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  23. Published

    Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol. / Frydenvang, Karla; Verkade-Vreeker, Marlies C A; Dohmen, Floor; Commandeur, Jan N M; Rafiq, Maria; Mirza, Osman; Jørgensen, Flemming Steen; Geerke, Daan P.

    In: PLoS ONE, Vol. 14, No. 5, e0217292, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques. / Afzelius, Lovisa; Raubacher, Florian; Karlén, Anders; Jørgensen, Flemming Steen; Andersson, Tommy B; Masimirembwa, Collen M; Zamora, Ismael.

    In: Drug Metabolism and Disposition, Vol. 32, No. 11, 2004, p. 1218-29.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Solvent diversity in polymorph screening. / Allesø, Morten; Van Der Berg, Franciscus Winfried J; Cornett, Claus; Jørgensen, Flemming Steen; Halling-Sørensen, Bent; Lopez de Diego, Heidi; Hovgaard, Lars; Aaltonen, Jaakko; Rantanen, Jukka Tapio.

    In: Journal of Pharmaceutical Sciences, Vol. 97, No. 6, 2008, p. 2145-2159.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1302104