Flemming Steen Jørgensen
Flemming Steen Jørgensen

Professor


  1. Published

    peri-Interaction, ortho-interaction, and barriers to internal rotation. A dynamic nuclear magnetic resonance and molecular mechanics investigation of 1,2-dineopentylbenzene and 1,8-dineopentylnaphthalene

    Anderson, J. E., Barkel, D. J. & Jørgensen, Flemming Steen, 1 Feb 1988, In : Journal of the Chemical Society. Perkin Transactions 2 (2001). 2, p. 199-202 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    hERG classification model based on a combination of support vector machine method and GRIND descriptors

    Li, Q., Jørgensen, Flemming Steen, Oprea, T., Brunak, Søren & Taboureau, Olivier Thierry, 2012, In : Molecular Pharmaceutics. 5, 1, p. 117-127 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    cis-disulfides protelectron spectrum of a 6,7-dithiabicyclo[3.2.1]octane

    Jørgensen, Flemming Steen & McCabe, P. H., 1983, In : Tetrahedron Letters. 24, 3, p. 319-322

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    X-ray Photoelectron Spectroscopic Study of the Enol-Enethiol Tautomerism of Thioacetylacetone and Related β-Thioxoketones

    Jørgensen, Flemming Steen, Brown, R. S., Carlsen, L. & Duus, F., 1 Jan 1982, In : Journal of the American Chemical Society. 104, 22, p. 5922-5926 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands

    Poongavanam, V., Hritz, J., Taboureau, O., Olsen, L., Jørgensen, Flemming Steen, Vermeulen, N. P. E. & Oostenbrink, C., 2009, In : Journal of Chemical Information and Modeling. 49, 1, p. 43-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Use of density functional theory in drug metabolism studies

    Rydberg, P., Jørgensen, Flemming Steen & Olsen, L., Feb 2014, In : Expert Opinion on Drug Metabolism & Toxicology. 10, 2, p. 215-27 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Update on protein structure prediction: Results of the 1995 IRBM workshop

    Hubbard, T., Tramontano, A., Barton, G., Jones, D., Sippl, M., Valencia, A., Lesk, A., Moult, J., Rost, B., Sander, C., Schneider, R., Lahm, A., Leplae, R., Buta, C., Eisenstein, M., Fjellstrom, O., Floeckner, H., Grossmann, J., Hansen, J., Citterich, M., Jørgensen, Flemming Steen, MarchlerBauer, A., Osuna, J., Park, J., Reinhardt, A., dePouplana, L., RojoDominguez, A., Saudek, V., Sinclair, J., Sturrock, S., Venclovas, C. & Vinals, C., 1996, In : Folding and Design. 1, 3, p. R55-R63

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

    Lemcke, T., Christensen, I. T. & Jørgensen, Flemming Steen, 1999, In : Bioorganic & Medicinal Chemistry. 7, 6, p. 1003-11 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Towards an identification of the pyrethroid pharmacophore. A molecular modelling study of some pyrethroid esters

    Byberg, J. R., Jørgensen, Flemming Steen & Klemmensen, P. D., 1987, In : Journal of Computer - Aided Molecular Design. 1, 3, p. 181-95 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Three-dimensional structures of human phospholipase A2 from pancreas and synovial fluid by model building

    Christensen, I. T., Jørgensen, Flemming Steen, Svensson, L. A. & Högberg, T., 1993, In : Drug Design and Discovery. 10, 2, p. 101-13 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

    Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In : Scientific Reports. 7, 12 p., 46145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro

    Munkboel, C. H., Christensen, L. R., Islin, J., Bonomo, S., Olsen, L., Jørgensen, Flemming Steen & Styrishave, Bjarne, Oct 2018, In : Biology of Reproduction. 99, 4, p. 888-897

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The Electronic Structure of β-Thioxoketones. A Photoelectron Spectroscopic Study of the Enol-Enethiol Tautomerism of Thioacetylacetone and Related Compounds

    Jørgensen, Flemming Steen, Carlsen, L. & Duus, F., 1 Jan 1981, In : Journal of the American Chemical Society. 103, 6, p. 1350-1353 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives

    Hansen, A. N., Bendiksen, C. D., Sylvest, L., Friis, T., Stærk, Dan, Jørgensen, Flemming Steen, Olsen, Christian Adam & Houen, G., 2012, In : P L o S One. 7, 9, 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Sulfur-Bridged pen-Naphthalenes: Synthesis, Conformational Analysis, and Photoelectron Spectroscopy of the Mono-, Di-, and Trisulfides of 1,8-Dimethylnaphthalene

    Guttenberger, H. G., Bestmann, H. J., Dickert, F. L., Jørgensen, Flemming Steen & Snyder, J. P., 1 Jan 1981, In : Journal of the American Chemical Society. 103, 1, p. 159-168 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Substrate-enzyme interactions and catalytic mechanism in phospholipase C: a molecular modeling study using the GRID program

    Byberg, J. R., Jørgensen, Flemming Steen, Hansen, S. & Hough, E., 1992, In : Proteins: Structure, Function, and Bioinformatics. 12, 4, p. 331-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Substrate binding and catalytic mechanism in phospholipase C from Bacillus cereus. a molecular mechanics and molecular dynamics study

    da Graça Thrige, D., Buur, J. R. & Jørgensen, Flemming Steen, 1997, In : Biopolymers. 42, 3, p. 319-36 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities

    Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In : Journal of Structural Biology. 158, 3, p. 358-369

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structure-based optimisation of non-steroidal cytochrome P450 17A1 inhibitors

    Larsen, M., Hansen, C. H., Rasmussen, T. B., Styrishave, Bjarne, Olsen, L. & Jørgensen, Flemming Steen, 28 Feb 2017, In : Chemical Communications. 53, 3118, 4 p., 3118.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes

    Terp, G. E., Christensen, I. T. & Jørgensen, Flemming Steen, 2000, In : Journal of Biomolecular Structure & Dynamics. 17, 6, p. 933-46 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structural differences of matrix metalloproteinases with potential implications for inhibitor selectivity examined by the GRID/CPCA approach

    Terp, G. E., Cruciani, G., Christensen, I. T. & Jørgensen, Flemming Steen, 2002, In : Journal of Medicinal Chemistry. 45, 13, p. 2675-84 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors

    Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  23. Published

    Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol

    Frydenvang, Karla Andrea, Verkade-Vreeker, M. C. A., Dohmen, F., Commandeur, J. N. M., rmx874, rmx874, Mirza, Osman Asghar, Jørgensen, Flemming Steen & Geerke, D. P., 2019, In : PLoS ONE. 14, 5, 15 p., e0217292.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques

    Afzelius, L., Raubacher, F., Karlén, A., Jørgensen, Flemming Steen, Andersson, T. B., Masimirembwa, C. M. & Zamora, I., 2004, In : Drug Metabolism and Disposition. 32, 11, p. 1218-29 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Solvent diversity in polymorph screening

    Allesø, M., van der Berg, Franciscus Winfried J, Cornett, Claus, Jørgensen, Flemming Steen, Halling-Sørensen, B., Lopez de Diego, H., Hovgaard, L., Aaltonen, J. & Rantanen, Jukka, 2008, In : Journal of Pharmaceutical Sciences. 97, 6, p. 2145-2159

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1302104