Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor with special responsibilities


  1. 2020
  2. E-pub ahead of print

    The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

    Jensen, Anders A., Halberstadt, A. L., Marcher, Emil, Odland, Anna Ulstein, Chatha, M., Speth, N., Liebscher, G., Hansen, M., Bräuner-Osborne, Hans, Palner, M., Andreasen T., Jesper & Kristensen, Jesper Langgaard, 13 Apr 2020, In : Biochemical Pharmacology. p. 113979

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists

    Marcher-Rørsted, E., Halberstadt, A. L., Klein, A. K., Chatha, M., Jademyr, S., Jensen, Anders A. & Kristensen, Jesper Langgaard, 26 Mar 2020, In : ACS Chemical Neuroscience.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Development of a Divergent Route to Erythrina Alkaloids

    Clementson, S., Jessing, M., Vital, P. J. & Kristensen, Jesper Langgaard, 3 Mar 2020, In : Synlett. 31, 4, p. 327-333 7 p., st-2019-a0679-a.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    In vivo effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in rodents: Drug discrimination and thermoregulation

    Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 1 Mar 2020, In : Drug and Alcohol Dependence. 208, 107850.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. E-pub ahead of print

    Diclofenac prodrugs for intra-articular depot injectables: In vitro hydrolysis and species variation

    Storgaard, I. H., Kristensen, Jesper Langgaard, Larsen, C., Mertz, Nina, Østergaard, Jesper & Larsen, Susan Weng, 9 Jan 2020, In : Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization

    Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 2020, In : Psychopharmacology. 237, p. 431–442

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

    Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Johann, K., Norregaard, K., Sohr, B., Svatunek, D., Birke, A., Shalgunov, Vladimir, Edem, P. E., Rossin, R., Seidl, C., Schmid, F., Robillard, M. S., Kristensen, Jesper Langgaard, Mikula, H., Barz, M., Kjær, Andreas & Herth, Matthias Manfred, 2020, In : ACS NANO. 14, 1, p. 568-584

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2019
  10. E-pub ahead of print

    The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation

    Odland, Anna Ulstein, Jessen, L., Kristensen, Jesper Langgaard, Fitzpatrick, C. M. & Andreasen T., Jesper, 3 Nov 2019, In : Neuropharmacology. 107838.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Radiolabeling and in vivo evaluation of [11C]AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor

    L’Estrade, E. T., Petersen, I. N., Xiong, M., Hogendorf, A. S., Hogendorf, A., Kristensen, Jesper Langgaard, Kjær, Andreas, Bojarski, A. J., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 1 Nov 2019, In : Journal of Radioanalytical and Nuclear Chemistry. 322, 2, p. 847-851 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. E-pub ahead of print

    Dark Classics in Chemical Neuroscience: NBOMes

    Poulie, Christian Bernard Matthijs, Jensen, Anders A., Halberstadt, A. & Kristensen, Jesper Langgaard, 28 Oct 2019, In : ACS Chemical Neuroscience.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Convenient access to F-18-labeled amines through the Staudinger reduction

    Shalgunov, Vladimir, Steen, J., Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S205-S206 P-050.

    Research output: Contribution to journalConference abstract in journalResearch

  14. Published

    Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

    Clementson, S., Jessing, M., Pedersen, H., Vital, P. & Kristensen, Jesper Langgaard, May 2019, In : Journal of the American Chemical Society. 141, 22, p. 8783-8786

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Pretargeted PET imaging using a dual click F-18-labeling strategy: [Meeting Abstract]

    Steen, J., Denk, C., Jørgensen, Jesper Tranekjær, Norregard, K., Rossin, R., Wilkovitsch, M., Svatunek, D., Edem, P., Kuntner, C., Wanek, T., Robillard, M., Kristensen, Jesper Langgaard, Kjær, Andreas, Mikula, H. & Herth, Matthias Manfred, May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S22-S23 O-08.

    Research output: Contribution to journalConference abstract in journalResearch

  16. Published

    Trans-cyclooctene-functionalized PeptoBrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging: [Meeting Abstract]

    Steen, J., Norregard, K., Johann, K., Jørgensen, Jesper Tranekjær, Svatunek, D., Birke, A., Edem, P., Rossin, R., Seidl, C., Schmid, F., Robillard, M., Mikula, H., Kristensen, Jesper Langgaard, Barz, M., Kjær, Andreas & Herth, Matthias Manfred, May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S109-S110

    Research output: Contribution to journalConference abstract in journalResearch

  17. Published

    Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging

    Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Petersen, I. N., Nørregaard, K., Lehel, S., Shalgunov, Vladimir, Birke, A., Edem, P. E., L'Estrade, E. T., Hansen, H. D., Villadsen, J., Erlandsson, M., Ohlsson, T., Yazdani, A., Valliant, J. F., Kristensen, Jesper Langgaard, Barz, M., Knudsen, Gitte Moos, Kjær, Andreas & Herth, Matthias Manfred, 1 Jan 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 8, p. 986-990

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction

    Stéen, E. J. L., Shalgunov, Vladimir, Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2019, In : European Journal of Organic Chemistry. 2019, 8, p. 1722-1725

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions

    Johansen, A., Holm, Søren, Dall, B., Keller, S., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Hansen, H. D., 2019, In : EJNMMI Research. 9, p. 1-10 10 p., 71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2018
  21. Published

    Towards the Dual Click F-18-labeling of Antibodies

    Steen, J., Denk, C., Norregaard, K., Jorgensen, J., Rossin, R., Svatunek, D., Edem, P., Robillard, M., Kjær, Andreas, Kristensen, Jesper Langgaard, Mikula, H. & Herth, Matthias Manfred, 1 May 2018.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  22. Published

    The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions

    Johansen, A., Hansen, H. D., Svarer, C., Lehel, S., Leth-Petersen, S., Kristensen, Jesper Langgaard, Gillings, N. & Knudsen, Gitte Moos, Apr 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 4, p. 659-668

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

    Crestey, F., Jensen, Anders A., Soerensen, C., Magnus, C. B., Andreasen T., Jesper, Peters, G. H. J. & Kristensen, Jesper Langgaard, 2018, In : Journal of Medicinal Chemistry. 61, p. 1719-1729

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2017
  25. Published

    Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150

    Edgar, F. G., Hansen, H. D., Leth-Petersen, S., Ettrup, A., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Herth, Matthias Manfred, Oct 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, 12, p. 586-591 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Madsen, J., Jensen, Anders A., Gillings, N., Lehel, S., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, Apr 2017, In : Organic & Biomolecular Chemistry. 15, p. 4351-4358

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Ortho lithiation-in situ borylation of substituted morpholine benzamides

    Cederbalk, A., Lysén, M., Kehler, J. & Kristensen, Jesper Langgaard, 23 Mar 2017, In : Tetrahedron. 73, 12, p. 1576–1582 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages

    Petersen, I. N., Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 18 Jan 2017, In : European Journal of Organic Chemistry. 2017, 3, p. 453-458 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices

    Stéen, E. J. L., Nyberg, N., Lehel, S., Andersen, V. L., Di Pilato, P., Knudsen, Gitte Moos, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 15 Jan 2017, In : Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE

    Jepsen, T. H., Glibstrup, E., Crestey, F. L. J., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2017, In : Beilstein Journal of Organic Chemistry. 13, p. 988-994 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH

    Nielsen, L. M., Holm, N. B., Leth-Petersen, S., Kristensen, Jesper Langgaard, Olsen, L. & Linnet, Kristian, 2017, In : Drug Testing and Analysis. 9, 5, p. 671–679

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist

    Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner-Osborne, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In : Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Textbook of Drug Design and Discovery: In vivo imaging in drug discovery

    Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2017, Textbook of Drug Design and Discovery. Fifth edition ed. CRC Press

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  34. 2016
  35. Published

    5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism

    Leth-Petersen, S., Petersen, I. N., Jensen, Anders A., Bundgaard, C., Bæk, M., Kehler, J. & Kristensen, Jesper Langgaard, 26 Aug 2016, In : A C S Chemical Neuroscience. p. 1-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases

    Knuhtsen, A., Legrand, B., Van der Poorten, O., Amblard, M., Martinez, J., Ballet, S., Kristensen, Jesper Langgaard & Pedersen, D. S., 12 Aug 2016, In : Chemistry: A European Journal. 22, 39, p. 14022–14028 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension

    Mertz, Nina, Larsen, Susan Weng, Kristensen, Jesper Langgaard, Østergaard, Jesper & Larsen, C., 27 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 10, p. 3079–3087 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C

    Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, Brian, Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 13 Jun 2016, In : Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Computational Methods to Predict the Regioselectivity of Electrophilic Aromatic Substitution Reactions of Heteroaromatic Systems

    Kruszyk, M., Jessing, M., Kristensen, Jesper Langgaard & Jorgensen, M., 13 May 2016, In : Journal of Organic Chemistry. 81, 12, p. 5128–5134 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, Jensen, Henrik & Østergaard, Jesper, 6 May 2016, IPC No. A61P 29/ 00 A I, Patent No. WO2016066612, Priority date 28 Oct 2014, Priority No. DK20140070657

    Research output: Patent

  41. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In : Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    PRODRUGS OF NAPROXEN AND DICLOFENAC

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, Jensen, Henrik & Østergaard, Jesper, 17 Mar 2016, IPC No. A61K 45/ 06 A I, Patent No. US2016074523, Priority date 28 Apr 2014, Priority No. WO2014EP58530

    Research output: Patent

  43. Published

    Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In : Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Metabolic fate of hallucinogenic NBOMes

    Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In : Chemical Research in Toxicology. 29, 1, p. 96–100 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2015
  46. Published

    An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36

    Gillings, N., Lehel, S., Herth, Matthias Manfred, Leth-Petersen, S., Madsen, J., Gabel-Jensen, C. & Kristensen, Jesper Langgaard, 15 May 2015, In : Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S296-S296 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  47. Published

    Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888

    Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs

    Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In : Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors

    Petersen, I. N., Crestey, F., Jensen, Anders A., Indurthi, D. C., Pedersen, H., Andreasen T., Jesper, Balle, T. & Kristensen, Jesper Langgaard, 9 Apr 2015, In : A C S Medicinal Chemistry Letters. 6, 4, p. 472-475 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Dyssegaard, A., Knudsen, G. M. & Kristensen, Jesper Langgaard, 20 Jan 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053–1056 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

    Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, Jesper Langgaard, 2015, In : Psychopharmacology. 232, 6, p. 1039-47 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

    Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G. E., McCorvy, J. D., Bräuner-Osborne, Hans & Kristensen, Jesper Langgaard, 2015, In : Bioorganic & Medicinal Chemistry. 23, 14, p. 3933-3937 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. 2014
  54. Published

    Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

    Leurs, U., Lohse, Brian, Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In : Analytical Chemistry. 86, 23, p. 11734-11741 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes

    Jepsen, T. H. & Kristensen, Jesper Langgaard, 12 Sep 2014, In : Journal of Organic Chemistry. 79, 19, p. 9423-9426 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published
  57. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, Brian, Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In : A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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