Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor with special responsibilities


  1. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand. / Andersen, Valdemar L; Hansen, Hanne D; Herth, Matthias M; Dyssegaard, Agnete; Knudsen, Gitte M; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 5, 20.01.2015, p. 1053–1056.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand. / Andersen, Valdemar L; Hansen, Hanne D; Herth, Matthias M; Knudsen, Gitte M; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 24, No. 11, 19.04.2014, p. 2408-2411.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    18F-Labelling of electron rich iodonium ylides : application to the radiosynthesis of potential 5-HT2A receptor PET ligands. / Petersen, I N; Villadsen, J; Hansen, H D; Madsen, J; Jensen, A A; Gillings, N; Lehel, Szabolcs; Herth, M M; Knudsen, G M; Kristensen, J L.

    In: Organic & Biomolecular Chemistry, Vol. 15, 04.2017, p. 4351-4358.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism. / Leth-Petersen, Sebastian; Petersen, Ida Nymann; Jensen, Anders A; Bundgaard, Christoffer; Bæk, Mathias; Kehler, Jan; Kristensen, Jesper L.

    In: A C S Chemical Neuroscience, 26.08.2016, p. 1-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A Prodrug Approach Involving In Situ Depot Formation to Achieve Localized and Sustained Action of Diclofenac After Joint Injection. / Thing, Mette; Agårdh, Li; Larsen, Susan; Rasmussen, Rune; Pallesen, Jakob; Mertz, Nina; Kristensen, Jesper Langgaard; Hansen, Martin; Ostergaard, Jesper; Larsen, Claus Selch.

    In: Journal of Pharmaceutical Sciences, Vol. 103, No. 12, 2014, p. 4021–4029.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A strategic approach to [6,6]-bicyclic lactones : application towards the CD fragment of DHβE. / Jepsen, Tue Heesgaard; Glibstrup, Emil; Crestey, Francois Louis Jean; Jensen, Anders A.; Kristensen, Jesper Langgaard.

    In: Beilstein Journal of Organic Chemistry, Vol. 13, 2017, p. 988-994.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes. / Herth, Matthias Manfred; Leth-Petersen, Sebastian; Lehel, Szabolcs; Hansen, Martin; Gillings, Nic; Madsen, Jacob; Kristensen, Jesper Langgaard.

    In: R S C Advances, Vol. 41, 2014, p. 21347-21350.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Amination of aryl iodides using a fluorous-tagged ammonia equivalent. / Nielsen, Simon Dalsgaard; Smith, Garrick; Begtrup, Mikael; Kristensen, Jesper Langgaard.

    In: European Journal of Organic Chemistry, Vol. 2010, No. 19, 2010, p. 3704-3710.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids. / Olsen, Christian A; Christensen, Caspar; Nielsen, Birgitte; Farah, Mohamed M; Mohamed, Farah M; Witt, Matthias; Clausen, Rasmus P; Kristensen, Jesper L; Franzyk, Henrik; Jaroszewski, Jerzy W.

    In: Organic Letters, Vol. 8, No. 15, 2006, p. 3371-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36. / Gillings, Nic; Lehel, Szabolcs; Herth, Matthias; Leth-Petersen, Sebastian; Madsen, Jacob; Gabel-Jensen, Charlotte; Kristensen, Jesper L.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 58, 15.05.2015, p. S296-S296.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  11. Published

    Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH. / Nielsen, Line Marie; Holm, Niels Bjerre; Leth-Petersen, Sebastian; Kristensen, Jesper Langgaard; Olsen, Lars; Linnet, Kristian.

    In: Drug Testing and Analysis, Vol. 9, No. 5, 2017, p. 671–679.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Computational Methods to Predict the Regioselectivity of Electrophilic Aromatic Substitution Reactions of Heteroaromatic Systems. / Kruszyk, Monika; Jessing, Mikkel; Kristensen, Jesper L; Jorgensen, Morten.

    In: Journal of Organic Chemistry, Vol. 81, No. 12, 13.05.2016, p. 5128–5134.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Concise synthesis of new bridged-nicotine analogues. / Crestey, François; Hooyberghs, Geert ; Kristensen, Jesper Langgaard.

    In: Tetrahedron, Vol. 68, No. 5, 04.02.2012, p. 1417-1421.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases. / Knuhtsen, Astrid; Legrand, Baptiste; Van der Poorten, Olivier; Amblard, Muriel; Martinez, Jean; Ballet, Steven; Kristensen, Jesper L; Pedersen, Daniel Sejer.

    In: Chemistry: A European Journal, Vol. 22, No. 39, 12.08.2016, p. 14022–14028.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Accepted/In press

    Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction. / Stéen, E. Johanna L.; Shalgunov, Vladimir; Denk, Christoph; Mikula, Hannes; Kjær, Andreas; Kristensen, Jesper L.; Herth, Matthias M.

    In: European Journal of Organic Chemistry, 01.01.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Convenient access to F-18-labeled amines through the Staudinger reduction. / Shalgunov, Vladimir; Steen, Johanna; Denk, Christoph; Mikula, Hannes; Kjaer, Andreas; Kristensen, Jesper; Herth, Matthias.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, No. Supl. 1/SI, P-050, 05.2019, p. S205-S206.

    Research output: Contribution to journalConference abstract in journalResearch

  17. Published

    Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands. / Petersen, Ida Nymann; Villadsen, Jonas; Hansen, Hanne Demant; Jensen, Anders A; Lehel, Szabolcs; Gillings, Nic; Herth, Matthias M; Knudsen, Gitte M; Kristensen, Jesper L.

    In: Bioorganic & Medicinal Chemistry, Vol. 24, 2016, p. 5353-5356.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Convergent synthesis of 3-arylated 1-hydroxypyrazoles via 3-metalated pyrazole-1-oxides. / Eskildsen, Jørgen; Kristensen, Jesper Langgaard; Vedsø, P.; Begtrup, M.; Kristensen, Jesper Langgaard.

    In: Journal of Organic Chemistry, Vol. 66, No. 25, 14.12.2001, p. 8654-8656.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Convergent synthesis of 6-substituted phenanthridines via anionic ring closure. / Lysén, M.; Kristensen, Jesper Langgaard; Vedsø, P.; Begtrup, M.

    In: Organic Letters, Vol. 4, No. 2, 01.01.2002, p. 257-259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Correction : Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors (PLoS ONE). / Isberg, Vignir; Paine, James; Leth-Petersen, Sebastian; Kristensen, Jesper L.; Gloriam, David E.

    In: PLOS ONE, Vol. 9, No. 1, 17.01.2014.

    Research output: Contribution to journalComment/debateResearchpeer-review

  21. Published

    Correlating the Metabolic Stability of Psychedelic 5-HT2A Agonists with Anecdotal Reports of Human Oral Bioavailability. / Leth-Petersen, Sebastian; Bundgaard, Christoffer; Hansen, Martin; Carnerup, Martin A; Kehler, Jan; Kristensen, Jesper Langgaard.

    In: Neurochemical Research, Vol. 39, No. 10, 12.02.2014, p. 2018-2023.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism. / Shahsavar, Azadeh; Kastrup, Jette S; Nielsen, Elsebet Ø.; Kristensen, Jesper L; Gajhede, Michael; Balle, Thomas.

    In: P L o S One, Vol. 7, No. 8, 2012, p. e40757.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Deprotection of 2-nitrobenzenesulfonamides using fluorous and solid phase reagents. / Christensen, C; Clausen, Rasmus Prætorius; Begtrup, M; Kristensen, Jesper Langgaard.

    In: Tetrahedron Letters, Vol. 45, No. 43, 18.10.2004, p. 7991-7993.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. / Crestey, François; Jensen, Anders A.; Borch, Morten; Andreasen T., Jesper; Andersen, Jacob; Balle, Thomas; Kristensen, Jesper Langgaard.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 23, 2013, p. 9673-9682.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published
  26. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. / Jensen, Anders A; McCorvy, John D; Petersen, Sebastian Leth; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper L.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 361, No. 3, 2017, p. 441-453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor. / Herth, Matthias Manfred; Hansen, Hanne; Andersen, Valdemar L.; Volk, Balazs; Ettrup, Anders; Antoni, Ferenc; Lehel, Szabolcs; Dyssegaard, Agnete; Kristensen, Jesper L.; Knudsen, Gitte M.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 56, 05.2013, p. S82-S82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging. / Herth, Matthias Manfred; Hansen, Hanne; Lehel, Szabolcs; Ettrup, Anders; Paine, James; Madsen, Jacob; Gillings, Nic; Kristensen, Jesper; Knudsen, Gitte.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 54, 2011, p. S277-S277.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation. / Herth, Matthias Manfred; Andersen, Valdemar L. ; Lehel, Szabolcs; Madsen, Jacob; Knudsen, Gitte Moos; Kristensen, Jesper Langgaard.

    In: Chemical Communications, Vol. 49, 2013, p. 3805-3807.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4) : Evaluation and comparison to existing practices. / Stéen, E Johanna L; Nyberg, Nils; Lehel, Szabolcs; Andersen, Valdemar L; Di Pilato, Pantaleo; Knudsen, Gitte M; Kristensen, Jesper L; Herth, Matthias M.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 27, No. 2, 15.01.2017, p. 319-322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry. / Leurs, Ulrike; Lohse, Brian; Ming, Shonoi A; Cole, Philip A; Clausen, Rasmus P; Kristensen, Jesper L; Rand, Kasper D.

    In: Analytical Chemistry, Vol. 86, No. 23, 17.10.2014, p. 11734-11741.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. / Crestey, François; Jensen, Anders A.; Soerensen, Christian; Magnus, Charlotte Busk; Andreasen T., Jesper; Peters, Günther Herbert Johannes; Kristensen, Jesper Langgaard.

    In: Journal of Medicinal Chemistry, Vol. 61, 2018, p. 1719-1729.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine. / Clementson, Sebastian; Jessing, Mikkel; Pedersen, Henrik; Vital, Paulo; Kristensen, Jesper L.

    In: Journal of the American Chemical Society, Vol. 141, No. 22, 05.2019, p. 8783-8786.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A : Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. / Kristensen, Jan B L; Nielsen, Anders L; Jørgensen, Lars; Kristensen, Line Hyltoft; Helgstrand, Charlotte; Juknaite, Lina; Kristensen, Jesper Langgaard; Kastrup, Jette Sandholm; Clausen, Rasmus Prætorius; Olsen, Lars; Gajhede, Michael.

    In: F E B S Letters, Vol. 585, No. 12, 23.06.2011, p. 1951-1956.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor : Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs. / Herth, Matthias M; Andersen, Valdemar L; Hansen, Hanne D; Stroth, Nikolas; Volk, Balázs; Lehel, Szabolcs; Dyssegaard, Agnete; Ettrup, Anders; Svenningsson, Per; Knudsen, Gitte M; Kristensen, Jesper Langgaard.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 8, 13.04.2015, p. 3631–3636.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Exploring the neuroleptic substituent in octoclothepin : potential ligands for positron emission tomography with subnanomolar affinity for alpha1-adrenoceptors. / Kristensen, Jesper Langgaard; Pu¨schl, Ask; Jensen, Martin; Risgaard, Rune; Christoffersen, Claus T; Bang-Andersen, Benny; Balle, Thomas.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 2010, p. 7021-7034.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice. / Fantegrossi, William E; Gray, Bradley W; Bailey, Jessica M; Smith, Douglas A; Hansen, Martin; Kristensen, Jesper Langgaard.

    In: Psychopharmacology, Vol. 232, No. 6, 2015, p. 1039-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides. / Bornholdt, Jan; Fjære, Karianne Wilhemsen; Felding, Jakob; Kristensen, Jesper Langgaard.

    In: Tetrahedron, Vol. 65, No. 45, 2009, p. 9280-9284.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Histonhaler : et nyt mål inden for kræftbehandling. / Kristensen, Jesper Langgaard; Lohse, Brian; Clausen, Rasmus Prætorius.

    In: Lægemiddelforskning, Vol. 2010, 12.2010, p. 7-9.

    Research output: Contribution to journalJournal articleCommunication

  40. Published

    Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions. / Johansen, Annette; Holm, Søren; Dall, Bente; Keller, Sune; Kristensen, Jesper L; Knudsen, Gitte M; Hansen, Hanne D.

    In: EJNMMI Research, Vol. 9, 71, 2019, p. 1-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC. / Larsen, Claus Selch (Inventor); Larsen, Susan Weng (Inventor); Thing, Mette Agergaard (Inventor); Kristensen, Jesper Langgaard (Inventor); JENSEN, HENRIK (Inventor); ØSTERGAARD, JESPER (Inventor).

    IPC No.: A61P 29/ 00 A I. Patent No.: WO2016066612.

    Research output: PatentResearch

  42. Published

    Identification of a new metabolite of GHB : gamma-hydroxybutyric acid glucuronide. / Petersen, Ida Nymann; Tortzen, Christian; Kristensen, Jesper Langgaard; Pedersen, Daniel Sejer; Breindahl, Torben.

    In: Journal of Analytical Toxicology, Vol. 37, No. 5, 06.2013, p. 291-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging. / Stéen, E. Johanna L.; Jørgensen, Jesper T.; Petersen, Ida N.; Nørregaard, Kamilla; Lehel, Szabolcs; Shalgunov, Vladimir; Birke, Alexander; Edem, Patricia E.; L'Estrade, Elina T.; Hansen, Hanne D.; Villadsen, Jonas; Erlandsson, Maria; Ohlsson, Tomas; Yazdani, Abdolreza; Valliant, John F.; Kristensen, Jesper L.; Barz, Matthias; Knudsen, Gitte M.; Kjær, Andreas; Herth, Matthias M.

    In: Bioorganic and Medicinal Chemistry Letters, 01.01.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide : scalable synthesis of alkynes from aldehydes. / Jepsen, Tue Heesgaard; Kristensen, Jesper Langgaard.

    In: Journal of Organic Chemistry, Vol. 79, No. 19, 12.09.2014, p. 9423-9426.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands. / Hansen, Hanne D.; Herth, Matthias Manfred; Ettrup, Anders; Szabolcs, Lehel; Dyssegaard, Agnete; Kristensen, Jesper; Knudsen, Gitte M.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 32, 08.2012, p. S126-S127.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Ind i hjernen med nye stoffer. / Clausen, Rasmus Prætorius; Nielsen, Simon Dalsgaard; Kristensen, Jesper Langgaard; Hansen, Kasper Bø.

    In: Lægemiddelforskning, 2009, p. 34-36.

    Research output: Contribution to journalJournal articleCommunication

  47. Published

    Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C). / Leurs, Ulrike; Clausen, Rasmus P; Kristensen, Jesper L; Lohse, Brian.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 22, No. 18, 15.09.2012, p. 5811-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Inhibitors of histone demethylases. / Lohse, Brian; Kristensen, Jesper L; Kristensen, Line H; Agger, Karl; Helin, Kristian; Gajhede, Michael; Clausen, Rasmus P.

    In: Bioorganic & Medicinal Chemistry, Vol. 19, No. 12, 01.02.2011, p. 3625-3636.

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published

    Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888. / Hansen, Hanne D; Andersen, Valdemar L; Lehel, Szabolcs; Magnussen, Janus H; Dyssegaard, Agnete; Stroth, Nikolas; Kristensen, Jesper Langgaard; Knudsen, Gitte M; Herth, Matthias M.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 9, 01.05.2015, p. 1901-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Long-Acting Diclofenac Ester Prodrugs for Joint Injection : Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension. / Mertz, Nina; Larsen, Susan Weng; Kristensen, Jesper; Østergaard, Jesper; Larsen, Claus.

    In: Journal of Pharmaceutical Sciences, Vol. 105, No. 10, 27.07.2016, p. 3079–3087.

    Research output: Contribution to journalJournal articleResearchpeer-review

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