Jesper Langgaard Kristensen
Jesper Langgaard Kristensen

Professor with special responsibilities


  1. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Dyssegaard, A., Knudsen, G. M. & Kristensen, Jesper Langgaard, 20 Jan 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 5, p. 1053–1056 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand

    Andersen, V. L., Hansen, H. D., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 19 Apr 2014, In : Bioorganic & Medicinal Chemistry Letters. 24, 11, p. 2408-2411 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Madsen, J., Jensen, Anders A., Gillings, N., Lehel, S., Herth, Matthias Manfred, Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, Apr 2017, In : Organic & Biomolecular Chemistry. 15, p. 4351-4358

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism

    Leth-Petersen, S., Petersen, I. N., Jensen, Anders A., Bundgaard, C., Bæk, M., Kehler, J. & Kristensen, Jesper Langgaard, 26 Aug 2016, In : A C S Chemical Neuroscience. p. 1-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A Prodrug Approach Involving In Situ Depot Formation to Achieve Localized and Sustained Action of Diclofenac After Joint Injection

    Thing, M., Agårdh, L., Larsen, Susan Weng, Rasmussen, R., Pallesen, J., Mertz, N., Kristensen, Jesper Langgaard, Hansen, M., Østergaard, Jesper & Larsen, C. S., 2014, In : Journal of Pharmaceutical Sciences. 103, 12, p. 4021–4029 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE

    Jepsen, T. H., Glibstrup, E., Crestey, F. L. J., Jensen, Anders A. & Kristensen, Jesper Langgaard, 2017, In : Beilstein Journal of Organic Chemistry. 13, p. 988-994 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes

    Herth, Matthias Manfred, Leth-Petersen, S., Lehel, S., Hansen, M., Gillings, N., Madsen, J. & Kristensen, Jesper Langgaard, 2014, In : R S C Advances. 41, p. 21347-21350 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Amination of aryl iodides using a fluorous-tagged ammonia equivalent

    Nielsen, S. D., Smith, G., Begtrup, M. & Kristensen, Jesper Langgaard, 2010, In : European Journal of Organic Chemistry. 2010, 19, p. 3704-3710

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids

    Olsen, Christian Adam, Christensen, C., Nielsen, Birgitte, Farah, M. M., Mohamed, F. M., Witt, M., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard, Franzyk, Henrik & Jaroszewski, J. W., 2006, In : Organic Letters. 8, 15, p. 3371-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36

    Gillings, N., Lehel, S., Herth, Matthias Manfred, Leth-Petersen, S., Madsen, J., Gabel-Jensen, C. & Kristensen, Jesper Langgaard, 15 May 2015, In : Journal of Labelled Compounds and Radiopharmaceuticals. 58, p. S296-S296 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  11. Published

    Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH

    Nielsen, L. M., Holm, N. B., Leth-Petersen, S., Kristensen, Jesper Langgaard, Olsen, L. & Linnet, Kristian, 2017, In : Drug Testing and Analysis. 9, 5, p. 671–679

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Computational Methods to Predict the Regioselectivity of Electrophilic Aromatic Substitution Reactions of Heteroaromatic Systems

    Kruszyk, M., Jessing, M., Kristensen, Jesper Langgaard & Jorgensen, M., 13 May 2016, In : Journal of Organic Chemistry. 81, 12, p. 5128–5134 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Concise synthesis of new bridged-nicotine analogues

    Crestey, F., Hooyberghs, G. & Kristensen, Jesper Langgaard, 4 Feb 2012, In : Tetrahedron. 68, 5, p. 1417-1421

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases

    Knuhtsen, A., Legrand, B., Van der Poorten, O., Amblard, M., Martinez, J., Ballet, S., Kristensen, Jesper Langgaard & Pedersen, D. S., 12 Aug 2016, In : Chemistry: A European Journal. 22, 39, p. 14022–14028 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction

    Stéen, E. J. L., Shalgunov, Vladimir, Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 2019, In : European Journal of Organic Chemistry. 2019, 8, p. 1722-1725

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Convenient access to F-18-labeled amines through the Staudinger reduction

    Shalgunov, Vladimir, Steen, J., Denk, C., Mikula, H., Kjær, Andreas, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S205-S206 P-050.

    Research output: Contribution to journalConference abstract in journalResearch

  17. Published

    Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

    Petersen, I. N., Villadsen, J., Hansen, H. D., Jensen, Anders A., Lehel, S., Gillings, N., Herth, Matthias Manfred, Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In : Bioorganic & Medicinal Chemistry. 24, p. 5353-5356 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Convergent synthesis of 3-arylated 1-hydroxypyrazoles via 3-metalated pyrazole-1-oxides

    Eskildsen, J., Kristensen, Jesper Langgaard, Vedsø, P., Begtrup, M. & Kristensen, Jesper Langgaard, 14 Dec 2001, In : Journal of Organic Chemistry. 66, 25, p. 8654-8656 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Convergent synthesis of 6-substituted phenanthridines via anionic ring closure

    Lysén, M., Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 1 Jan 2002, In : Organic Letters. 4, 2, p. 257-259 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Correlating the Metabolic Stability of Psychedelic 5-HT2A Agonists with Anecdotal Reports of Human Oral Bioavailability

    Leth-Petersen, S., Bundgaard, C., Hansen, M., Carnerup, M. A., Kehler, J. & Kristensen, Jesper Langgaard, 12 Feb 2014, In : Neurochemical Research. 39, 10, p. 2018-2023 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, A., Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In : P L o S One. 7, 8, p. e40757

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. E-pub ahead of print

    Dark Classics in Chemical Neuroscience: NBOMes

    Poulie, Christian Bernard Matthijs, Jensen, Anders A., Halberstadt, A. & Kristensen, Jesper Langgaard, 28 Oct 2019, In : ACS Chemical Neuroscience.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Deprotection of 2-nitrobenzenesulfonamides using fluorous and solid phase reagents

    rtc312, rtc312, Clausen, Rasmus Prætorius, Begtrup, M. & Kristensen, Jesper Langgaard, 18 Oct 2004, In : Tetrahedron Letters. 45, 43, p. 7991-7993

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design, synthesis and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

    Crestey, F., Jensen, Anders A., Borch, M., Andreasen T., Jesper, Andersen, J., Balle, T. & Kristensen, Jesper Langgaard, 2013, In : Journal of Medicinal Chemistry. 56, 23, p. 9673-9682

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published
  26. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist

    Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner-Osborne, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, In : Journal of Pharmacology and Experimental Therapeutics. 361, 3, p. 441-453

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor

    Herth, Matthias Manfred, Hansen, H., Andersen, V. L., Volk, B., Ettrup, A., Antoni, F., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., May 2013, p. S82-S82.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  28. Published

    Development of New PET Radiotracers for In Vivo 5-HT7 Brain Imaging

    Herth, Matthias Manfred, Hansen, H., Lehel, S., Ettrup, A., Paine, J., Madsen, J., Gillings, N., Kristensen, Jesper Langgaard & Knudsen, G., 2011, In : Journal of Labelled Compounds and Radiopharmaceuticals. 54, p. S277-S277

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

    Herth, Matthias Manfred, Andersen, V. L., Lehel, S., Madsen, J., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In : Chemical Communications. 49, p. 3805-3807 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4): Evaluation and comparison to existing practices

    Stéen, E. J. L., Nyberg, N., Lehel, S., Andersen, V. L., Di Pilato, P., Knudsen, Gitte Moos, Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 15 Jan 2017, In : Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 319-322 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. E-pub ahead of print

    Diclofenac prodrugs for intra-articular depot injectables: In vitro hydrolysis and species variation

    Storgaard, I. H., Kristensen, Jesper Langgaard, Larsen, C., Mertz, Nina, Østergaard, Jesper & Larsen, Susan Weng, 9 Jan 2020, In : Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

    Leurs, Ulrike, Lohse, Brian, Ming, S. A., Cole, P. A., Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Rand, Kasper Dyrberg, 17 Oct 2014, In : Analytical Chemistry. 86, 23, p. 11734-11741 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

    Crestey, F., Jensen, Anders A., Soerensen, C., Magnus, C. B., Andreasen T., Jesper, Peters, G. H. J. & Kristensen, Jesper Langgaard, 2018, In : Journal of Medicinal Chemistry. 61, p. 1719-1729

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

    Clementson, S., Jessing, M., Pedersen, H., Vital, P. & Kristensen, Jesper Langgaard, May 2019, In : Journal of the American Chemical Society. 141, 22, p. 8783-8786

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In : F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor: Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs

    Herth, Matthias Manfred, Andersen, V. L., Hansen, H. D., Stroth, N., Volk, B., Lehel, S., Dyssegaard, A., Ettrup, A., Svenningsson, P., Knudsen, G. M. & Kristensen, Jesper Langgaard, 13 Apr 2015, In : Journal of Medicinal Chemistry. 58, 8, p. 3631–3636 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for alpha1-adrenoceptors

    Kristensen, Jesper Langgaard, Pu¨schl, A., Jensen, M., Risgaard, R., Christoffersen, C. T., Bang-Andersen, B. & Balle, T., 2010, In : Journal of Medicinal Chemistry. 53, 19, p. 7021-7034

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

    Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, Jesper Langgaard, 2015, In : Psychopharmacology. 232, 6, p. 1039-47 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Heterocyclic pentafluorophenyl sulfonate esters as shelf stable alternatives to sulfonyl chlorides

    Bornholdt, J., Fjære, K. W., Felding, J. & Kristensen, Jesper Langgaard, 2009, In : Tetrahedron. 65, 45, p. 9280-9284

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Histonhaler: et nyt mål inden for kræftbehandling

    Kristensen, Jesper Langgaard, Lohse, Brian & Clausen, Rasmus Prætorius, Dec 2010, In : Lægemiddelforskning. 2010, p. 7-9

    Research output: Contribution to journalJournal articleCommunication

  41. Published

    Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions

    Johansen, A., Holm, Søren, Dall, B., Keller, S., Kristensen, Jesper Langgaard, Knudsen, Gitte Moos & Hansen, H. D., 2019, In : EJNMMI Research. 9, p. 1-10 10 p., 71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    IMIDAZOLE DERIVATIVES AS PRODRUGS OF DICLOFENAC

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, Jensen, Henrik & Østergaard, Jesper, 6 May 2016, IPC No. A61P 29/ 00 A I, Patent No. WO2016066612, Priority date 28 Oct 2014, Priority No. DK20140070657

    Research output: Patent

  43. Published

    Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide

    Petersen, I. N., Tortzen, C., Kristensen, Jesper Langgaard, Pedersen, D. S. & Breindahl, T., Jun 2013, In : Journal of Analytical Toxicology. 37, 5, p. 291-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging

    Stéen, E. J. L., Jørgensen, Jesper Tranekjær, Petersen, I. N., Nørregaard, K., Lehel, S., Shalgunov, Vladimir, Birke, A., Edem, P. E., L'Estrade, E. T., Hansen, H. D., Villadsen, J., Erlandsson, M., Ohlsson, T., Yazdani, A., Valliant, J. F., Kristensen, Jesper Langgaard, Barz, M., Knudsen, Gitte Moos, Kjær, Andreas & Herth, Matthias Manfred, 1 Jan 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 8, p. 986-990

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes

    Jepsen, T. H. & Kristensen, Jesper Langgaard, 12 Sep 2014, In : Journal of Organic Chemistry. 79, 19, p. 9423-9426 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    In vivo PET imaging of cerebral 5-HT7 receptors with novel radioligands

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Szabolcs, L., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, G. M., Aug 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, p. S126-S127

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    In vivo effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in rodents: Drug discrimination and thermoregulation

    Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 1 Mar 2020, In : Drug and Alcohol Dependence. 208, 107850.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Ind i hjernen med nye stoffer

    Clausen, Rasmus Prætorius, Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2009, In : Lægemiddelforskning. p. 34-36

    Research output: Contribution to journalJournal articleCommunication

  49. Published

    Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C)

    Leurs, Ulrike, Clausen, Rasmus Prætorius, Kristensen, Jesper Langgaard & Lohse, Brian, 15 Sep 2012, In : Bioorganic & Medicinal Chemistry Letters. 22, 18, p. 5811-3 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Inhibitors of histone demethylases

    Lohse, Brian, Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, Karl, Helin, Kristian, Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In : Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

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