Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor with special responsibilities


  1. Published

    Inhibitors of histone demethylases

    Lohse, Brian, Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, Karl, Helin, Kristian, Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In : Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  2. E-pub ahead of print

    Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists

    Marcher-Rørsted, E., Halberstadt, A. L., Klein, A. K., Chatha, M., Jademyr, S., Jensen, Anders A. & Kristensen, Jesper Langgaard, 26 Mar 2020, In : ACS Chemical Neuroscience.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888

    Hansen, H. D., Andersen, V. L., Lehel, S., Magnussen, J. H., Dyssegaard, A., Stroth, N., Kristensen, Jesper Langgaard, Knudsen, G. M. & Herth, Matthias Manfred, 1 May 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 9, p. 1901-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization

    Berquist, M. D., Leth-Petersen, S., Kristensen, Jesper Langgaard & Fantegrossi, W. E., 2020, In : Psychopharmacology. 237, p. 431–442

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Long-Acting Diclofenac Ester Prodrugs for Joint Injection: Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension

    Mertz, Nina, Larsen, Susan Weng, Kristensen, Jesper Langgaard, Østergaard, Jesper & Larsen, C., 27 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 10, p. 3079–3087 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Medicindepot dannes efter injektion i leddet

    Larsen, Susan Weng, Thing, M. A., Østergaard, Jesper, Kristensen, Jesper Langgaard, Hansen, M. & Larsen, C. S., 2013, In : Lægemiddelforskning. 2013, p. 38-40

    Research output: Contribution to journalJournal articleResearch

  7. Published

    Metabolic fate of hallucinogenic NBOMes

    Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, Jesper Langgaard, 2016, In : Chemical Research in Toxicology. 29, 1, p. 96–100 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands

    Clausen, Rasmus Prætorius, Christensen, C., Hansen, K. B., Greenwood, J. R., Jørgensen, L., Micale, N., Madsen, J. C., Nielsen, Birgitte, Egebjerg, J., Bräuner-Osborne, Hans, Traynelis, S. F. & Kristensen, Jesper Langgaard, 2008, In : Journal of Medicinal Chemistry. 51, 14, p. 4179-87

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Nonracemic, chiral homoenolate reagents derived from (cycloalk-1-enyl)methyl carbamates and evaluation of their configurational stabilities

    Özlügedik, M., Kristensen, Jesper Langgaard, Wibbeling, B., Fröhlich, R. & Hoppe, D., 1 Jan 2002, In : European Journal of Organic Chemistry. 3, p. 414-427 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acidA receptor ligands: synthesis, pharmacology, and structure-activity relationships

    Møller, H. A., Sander, T., Kristensen, Jesper Langgaard, Nielsen, Birgitte, Krall, J., Bergmann, M. L., Christiansen, B., Balle, T., Jensen, Anders A. & Frølund, Bente, 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3417-3421

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages

    Petersen, I. N., Kristensen, Jesper Langgaard & Herth, Matthias Manfred, 18 Jan 2017, In : European Journal of Organic Chemistry. 2017, 3, p. 453-458 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Ny bioisoster kan skabe nye lægemidler

    Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2004, In : Lægemiddelforskning. 2004, p. 16-17

    Research output: Contribution to journalJournal articleCommunication

  13. Published

    Nye NMDA-receptor-ligander til udforskning af hjernen

    Clausen, Rasmus Prætorius, Risgaard, R., Nielsen, S. D., Kristensen, Jesper Langgaard & Hansen, K. B., 2010, In : Dansk Kemi. 91, 6/7, p. 21-23

    Research output: Contribution to journalJournal articleCommunication

  14. Published

    Ortho lithiation-in situ borylation of substituted morpholine benzamides

    Cederbalk, A., Lysén, M., Kehler, J. & Kristensen, Jesper Langgaard, 23 Mar 2017, In : Tetrahedron. 73, 12, p. 1576–1582 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    PRODRUGS OF NAPROXEN AND DICLOFENAC

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, Jensen, Henrik & Østergaard, Jesper, 17 Mar 2016, IPC No. A61K 45/ 06 A I, Patent No. US2016074523, Priority date 28 Apr 2014, Priority No. WO2014EP58530

    Research output: Patent

  16. Published

    PRODRUGS OF NON- STEROID ANTI - INFLAMMATORY AGENTS (NSAIDS)

    Larsen, C. S., Larsen, Susan Weng, Thing, M. A., Kristensen, Jesper Langgaard, Jensen, Henrik & Østergaard, Jesper, 10 May 2013, IPC No. C07D 487/ 04 A I, Patent No. WO2013064153, Priority date 31 Oct 2011, Priority No. DK20110070591

    Research output: Patent

  17. Published

    Palladium-Catalyzed Arylation and Acylation of 1-Benzyloxy-1,2,3-triazole Through a Directed Ortho Lithiation-Transmetalation Strategy.

    Felding, J., Uhlmann, P., Kristensen, Jesper Langgaard, Vedsø, P. & Begtrup, M., 1998, In : Synthesis. 8, p. 1181-1184 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones

    Trost, B. M., Schroeder, G. M. & Kristensen, Jesper Langgaard, 16 Sep 2002, In : Angewandte Chemie International Edition. 41, 18, p. 3492-3495 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Palladium-mediated conversion of para-aminoarylboronic esters into para-aminoaryl- 11C-methanes

    Andersen, V. L., Herth, Matthias Manfred, Lehel, S., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In : Tetrahedron Letters. 54, 3, p. 213-216 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro

    Lohse, Brian, Helgstrand, C., Andersson, J. L., Leurs, U., Cloos, Paul, Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 2 Jul 2013, In : P L o S One. 8, 7, p. e67653

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Preclinical Safety Assessment of the 5-HT(2A) Receptor Agonist PET Radioligand [ (11)C]Cimbi-36

    Ettrup, A., Holm, Søren, Hansen, M., Wasim, M., Santini, M. A., Palner, M., Madsen, J., Svarer, C., Kristensen, Jesper Langgaard & Knudsen, G. M., 10 Jan 2013, In : Molecular Imaging and Biology. 15, 4, p. 376-83

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Preparation of 5-acyl- and 5-aryl-substituted 1-(benzyloxy)pyrazoles via directed ortho-lithiation/transmetalation and palladium catalyzed cross- coupling

    Kristensen, Jesper Langgaard, Begtrup, M. & Vedsø, P., 1 Nov 1998, In : Synthesis. 11, p. 1604-1608 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Pretargeted PET imaging using a dual click F-18-labeling strategy: [Meeting Abstract]

    Steen, J., Denk, C., Jørgensen, Jesper Tranekjær, Norregard, K., Rossin, R., Wilkovitsch, M., Svatunek, D., Edem, P., Kuntner, C., Wanek, T., Robillard, M., Kristensen, Jesper Langgaard, Kjær, Andreas, Mikula, H. & Herth, Matthias Manfred, May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, Supl. 1/SI, p. S22-S23 O-08.

    Research output: Contribution to journalConference abstract in journalResearch

  24. Published

    Radiolabeling and in vivo evaluation of [11C]AGH-44: a potential lead structure to develop a positron emission tomography radioligand for the 5-HT7 receptor

    L’Estrade, E. T., Petersen, I. N., Xiong, M., Hogendorf, A. S., Hogendorf, A., Kristensen, Jesper Langgaard, Kjær, Andreas, Bojarski, A. J., Erlandsson, M., Ohlsson, T., Knudsen, Gitte Moos & Herth, Matthias Manfred, 1 Nov 2019, In : Journal of Radioanalytical and Nuclear Chemistry. 322, 2, p. 847-851 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Radiolabelling and PET brain imaging of the a1-adrenoceptor antagonist Lu AE43936

    Risgaard, R., Ettrup, A. J., Balle, T., Dyssegaard, A., Hansen, H. D., Lehel, S., Madsen, J., Pedersen, H., Püschl, A., Badolo, L., Bang-Andersen, B., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 2013, In : Nuclear Medicine & Biology. 40, 1, p. 135-140 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

    Ettrup, A., Hansen, M., Santini, M. A., Paine, J. S., Gillings, N., Palner, M., Lehel, S., Herth, Matthias Manfred, Madsen, J., Kristensen, Jesper Langgaard, Begtrup, M. & Knudsen, Gitte Moos, 1 Apr 2011, In : European Journal of Nuclear Medicine and Molecular Imaging. 38, 4, p. 681-693

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors

    Hansen, H. D., Herth, Matthias Manfred, Ettrup, A., Andersen, V. L., Lehel, S., Dyssegaard, A., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 24 Feb 2014, In : Journal of Nuclear Medicine. 55, 4, p. 640-646

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Ring opening of pymisyl-protected aziridines with organocuprates

    Bornholdt, J., Felding, J., Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 2010, In : Chemistry: A European Journal. 16, 41, p. 12474-12480

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36

    Ettrup, A., da Cunha-Bang, S., McMahon, B. P., Lehel, S., Dyssegaard, A., Skibsted, A. W., Jørgensen, Louise Møller, Hansen, M., Baandrup, A. O., Bache, S., Svarer, C., Kristensen, Jesper Langgaard, Gillings, N., Madsen, J. & Knudsen, Gitte Moos, 30 Apr 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, p. 1188-1196 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen

    Shahsavar, A., Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In : Lægemiddelforskning. 2012, p. 48-50 3 p.

    Research output: Contribution to journalJournal articleCommunication

  31. Published

    Stereoselective synthesis of highly substituted bicyclic γ-lactones using homoaldol addition of 1-(1-cycloalkenyl)methyl carbamates

    Özlügedik, M., Kristensen, Jesper Langgaard, Reuber, J., Fröhlich, R. & Hoppe, D., 1 Oct 2004, In : Synthesis. 14, p. 2303-2316 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors

    Isberg, V., Paine, J., Leth-Petersen, S., Kristensen, Jesper Langgaard & Gloriam, David E., 2013, In : P L o S One. 8, 11, e78515.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, Brian, Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In : A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Synthesis and In Vitro Evaluation of Oxindole Derivatives as Potential Radioligands for 5-HT7 Receptor Imaging with PET

    Herth, Matthias Manfred, Volk, B., Pallagi, K., Koefoed Bech, L., A. Antoni, F., Knudsen, Gitte Moos & Kristensen, Jesper Langgaard, 31 Aug 2012, In : ACS Chemical Neuroscience. 3, 12, p. 1002-1007

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Synthesis and SAR study of a novel series of dopamine receptor agonists

    Risgaard, R., Jensen, M., Jørgensen, M., Bang-Andersen, B., Christoffersen, C. T., Jensen, K. G., Kristensen, Jesper Langgaard & Püschl, A., 1 Jan 2014, In : Bioorganic and Medicinal Chemistry. 22, 1, p. 381-392

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Synthesis and application of a new fluorous-tagged ammonia equivalent

    Nielsen, S. D., Smith, G., Begtrup, M. & Kristensen, Jesper Langgaard, 2010, In : Chemistry: A European Journal. 16, 15, p. 4557-4566

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Synthesis and binding studies of 2-arylapomorphines

    Søndergaard, K., Kristensen, Jesper Langgaard, Palner, M., Gillings, N., Knudsen, Gitte Moos, Roth, B. & Begtrup, M., 21 Nov 2005, In : Organic & Biomolecular Chemistry. 3, 22, p. 4077-4081 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists

    Petersen, J. G., Bergmann, R., Møller, H. A., Jørgensen, C. G., Nielsen, Birgitte, Kehler, J., Frydenvang, Karla Andrea, Kristensen, Jesper Langgaard, Balle, T., Jensen, Anders A., Kristiansen, Uffe & Frølund, Bente, 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 993-1006

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C

    Nielsen, S. D., Leurs, U., Bergner, M., Barris, S. A., Devkota, K., Meyer, K., Iaria, D., McCaughan, J., Lohse, Brian, Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 13 Jun 2016, In : Protein and Peptide Letters. 23, 9, p. 772 - 776 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands

    Herth, Matthias Manfred, Petersen, I. N., Hansen, H. D., Hansen, M., Ettrup, A., Jensen, Anders A., Lehel, S., Dyssegaard, A., Gillings, N., Knudsen, G. M. & Kristensen, Jesper Langgaard, 19 Apr 2016, In : Nuclear Medicine and Biology. 43, 8, p. 455-462 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

    Herth, Matthias Manfred, Hansen, H. D., Ettrup, A. J., Dyssegaard, A., Lehel, S., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, 2012, In : Bioorganic and Medicinal Chemistry. 20, 14, p. 4574-4581 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Synthesis and evaluation of [C-11]CIMBI-712 and [C-11]CIMBI-772

    Andersen, V. L., Herth, Matthias Manfred, Hansen, H. D., Kristensen, Jesper Langgaard & Knudsen, Gitte Moos, May 2013, p. S101-S101.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  43. Published

    Synthesis and pharmacological evaluation of DHβE analogs as neuronal nicotinic acetylcholine receptor antagonists

    Jepsen, T. H., Jensen, Anders A., Lund, M. H., Glibstrup, E. & Kristensen, Jesper Langgaard, 2014, In : A C S Medicinal Chemistry Letters. 5, 7, p. 766-770 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

    Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G. E., McCorvy, J. D., Bräuner-Osborne, Hans & Kristensen, Jesper Langgaard, 2015, In : Bioorganic & Medicinal Chemistry. 23, 14, p. 3933-3937 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Synthesis and stability study of a new major metabolite of gamma-hydroxybutyric acid

    Petersen, I. N., Kristensen, Jesper Langgaard, Tortzen, C., Breindahl, T. & Pedersen, D. S., 2013, In : Beilstein Journal of Organic Chemistry. 9, p. 641-646 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

    Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, Hans & Kristensen, Jesper Langgaard, 7 Jan 2014, In : A C S Chemical Neuroscience. 5, 3, p. 243-249 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Synthesis of (R)-(-)-2-fluoronorapomorphine - A precursor for the synthesis of (R)-(-)-2-fluoro-N-[C]propylnorapomorphine for evaluation as a dopamine D agonist ligand for PET investigations

    Søndergaard, K., Kristensen, Jesper Langgaard, Gillings, N. & Begtrup, M., 14 Oct 2005, In : European Journal of Organic Chemistry. 20, p. 4428-4433 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Synthesis of 4-substituted 1-(benzyloxy)pyrazoles via iodine-magnesium exchange of 1-(benzyloxy)-4-iodopyrazole

    Felding, J., Kristensen, Jesper Langgaard, Bjerregaard, T., Sander, L., Vedsø, P. & Begtrup, M., 28 May 1999, In : Journal of Organic Chemistry. 64, 11, p. 4196-4198 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Synthesis of N-alkylated amino acids using fluorous-tagged hydroxylamines

    Nielsen, S. D., Smith, G. P., Begtrup, M. & Kristensen, Jesper Langgaard, 22 Jul 2011, In : Tetrahedron. 67, 29, p. 5261-5267

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Synthesis of Ortho Substituted Arylboronic Esters by in Situ Trapping of Unstable Lithio Intermediates

    Kristensen, Jesper Langgaard, Lysén, M., Vedsø, P. & Begtrup, M., 17 May 2001, In : Organic Letters. 3, 10, p. 1435-1437 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

ID: 1305029