Jesper Langgaard Kristensen

Jesper Langgaard Kristensen

Professor with special responsibilities


  1. 2019
  2. E-pub ahead of print

    Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine. / Clementson, Sebastian; Jessing, Mikkel; Pedersen, Henrik; Vital, Paulo; Kristensen, Jesper L.

    In: Journal of the American Chemical Society, 28.05.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Accepted/In press

    Convenient Entry to 18 F-Labeled Amines through the Staudinger Reduction. / Stéen, E. Johanna L.; Shalgunov, Vladimir; Denk, Christoph; Mikula, Hannes; Kjær, Andreas; Kristensen, Jesper L.; Herth, Matthias M.

    In: European Journal of Organic Chemistry, 01.01.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging. / Stéen, E. Johanna L.; Jørgensen, Jesper T.; Petersen, Ida N.; Nørregaard, Kamilla; Lehel, Szabolcs; Shalgunov, Vladimir; Birke, Alexander; Edem, Patricia E.; L'Estrade, Elina T.; Hansen, Hanne D.; Villadsen, Jonas; Erlandsson, Maria; Ohlsson, Tomas; Yazdani, Abdolreza; Valliant, John F.; Kristensen, Jesper L.; Barz, Matthias; Knudsen, Gitte M.; Kjær, Andreas; Herth, Matthias M.

    In: Bioorganic and Medicinal Chemistry Letters, 01.01.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2018
  6. Published

    The importance of small polar radiometabolites in molecular neuroimaging : A PET study with [11C]Cimbi-36 labeled in two positions. / Johansen, Annette; Hansen, Hanne D; Svarer, Claus; Lehel, Szabolcs; Leth-Petersen, Sebastian; Kristensen, Jesper L; Gillings, Nic; Knudsen, Gitte M.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 4, 04.2018, p. 659-668.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. / Crestey, François; Jensen, Anders A.; Soerensen, Christian; Magnus, Charlotte Busk; Andreasen T., Jesper; Peters, Günther Herbert Johannes; Kristensen, Jesper Langgaard.

    In: Journal of Medicinal Chemistry, Vol. 61, 2018, p. 1719-1729.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2017
  9. Published

    Synthesis, radiofluorination, and preliminary evaluation of the potential 5-HT2A receptor agonists [18 F]Cimbi-92 and [18 F]Cimbi-150. / Edgar, Fraser Graeme; Hansen, Hanne D; Leth-Petersen, Sebastian; Ettrup, Anders; Kristensen, Jesper L; Knudsen, Gitte M; Herth, Matthias M.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 60, No. 12, 10.2017, p. 586-591.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    18F-Labelling of electron rich iodonium ylides : application to the radiosynthesis of potential 5-HT2A receptor PET ligands. / Petersen, I N; Villadsen, J; Hansen, H D; Madsen, J; Jensen, A A; Gillings, N; Lehel, Szabolcs; Herth, M M; Knudsen, G M; Kristensen, J L.

    In: Organic & Biomolecular Chemistry, Vol. 15, 04.2017, p. 4351-4358.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Ortho lithiation-in situ borylation of substituted morpholine benzamides. / Cederbalk, Anna; Lysén, Morten; Kehler, Jan; Kristensen, Jesper L.

    In: Tetrahedron, Vol. 73, No. 12, 23.03.2017, p. 1576–1582.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Nucleophilic 18F-Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors - Advantages and Disadvantages. / Petersen, Ida Nymann; Kristensen, Jesper Langgaard; Herth, Matthias Manfred.

    In: European Journal of Organic Chemistry, Vol. 2017, No. 3, 18.01.2017, p. 453-458.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Development of a simple proton nuclear magnetic resonance-based procedure to estimate the approximate distribution coefficient at physiological pH (logD7.4) : Evaluation and comparison to existing practices. / Stéen, E Johanna L; Nyberg, Nils; Lehel, Szabolcs; Andersen, Valdemar L; Di Pilato, Pantaleo; Knudsen, Gitte M; Kristensen, Jesper L; Herth, Matthias M.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 27, No. 2, 15.01.2017, p. 319-322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A strategic approach to [6,6]-bicyclic lactones : application towards the CD fragment of DHβE. / Jepsen, Tue Heesgaard; Glibstrup, Emil; Crestey, Francois Louis Jean; Jensen, Anders A.; Kristensen, Jesper Langgaard.

    In: Beilstein Journal of Organic Chemistry, Vol. 13, 2017, p. 988-994.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Characterization of the hepatic cytochrome P450 enzymes involved in the metabolism of 25I-NBOMe and 25I-NBOH. / Nielsen, Line Marie; Holm, Niels Bjerre; Leth-Petersen, Sebastian; Kristensen, Jesper Langgaard; Olsen, Lars; Linnet, Kristian.

    In: Drug Testing and Analysis, Vol. 9, No. 5, 2017, p. 671–679.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist. / Jensen, Anders A; McCorvy, John D; Petersen, Sebastian Leth; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper L.

    In: Journal of Pharmacology and Experimental Therapeutics, Vol. 361, No. 3, 2017, p. 441-453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Textbook of Drug Design and Discovery : In vivo imaging in drug discovery. / Kristensen, Jesper Langgaard; Herth, Matthias Manfred.

    Textbook of Drug Design and Discovery. Fifth edition. ed. CRC Press, 2017.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  18. 2016
  19. Published

    5-HT2A/5-HT2C receptor pharmacology and intrinsic clearance of N-benzylphenethylamines modified at the primary site of metabolism. / Leth-Petersen, Sebastian; Petersen, Ida Nymann; Jensen, Anders A; Bundgaard, Christoffer; Bæk, Mathias; Kehler, Jan; Kristensen, Jesper L.

    In: A C S Chemical Neuroscience, 26.08.2016, p. 1-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases. / Knuhtsen, Astrid; Legrand, Baptiste; Van der Poorten, Olivier; Amblard, Muriel; Martinez, Jean; Ballet, Steven; Kristensen, Jesper L; Pedersen, Daniel Sejer.

    In: Chemistry: A European Journal, Vol. 22, No. 39, 12.08.2016, p. 14022–14028.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Long-Acting Diclofenac Ester Prodrugs for Joint Injection : Kinetics, Mechanism of Degradation, and In Vitro Release From Prodrug Suspension. / Mertz, Nina; Larsen, Susan Weng; Kristensen, Jesper; Østergaard, Jesper; Larsen, Claus.

    In: Journal of Pharmaceutical Sciences, Vol. 105, No. 10, 27.07.2016, p. 3079–3087.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Synthesis and characterisation of substrate-based peptides as inhibitors of histone demethylase KDM4C. / Nielsen, Simon D; Leurs, Ulrike; Bergner, Magnus; Barris, Silvia Amor; Devkota, Kanchan; Meyer, Kamilla; Iaria, Daniella; McCaughan, Jack; Lohse, Brian; Kristensen, Jesper L; Clausen, Rasmus Prætorius.

    In: Protein and Peptide Letters, Vol. 23, No. 9, 13.06.2016, p. 772 - 776.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Computational Methods to Predict the Regioselectivity of Electrophilic Aromatic Substitution Reactions of Heteroaromatic Systems. / Kruszyk, Monika; Jessing, Mikkel; Kristensen, Jesper L; Jorgensen, Morten.

    In: Journal of Organic Chemistry, Vol. 81, No. 12, 13.05.2016, p. 5128–5134.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
  25. Published

    Synthesis and evaluation of 18F-labeled 5-HT2A receptor agonists as PET ligands. / Herth, Matthias M; Petersen, Ida Nymann; Hansen, Hanne Demant; Hansen, Martin; Ettrup, Anders; Jensen, Anders A; Lehel, Szabolcs; Dyssegaard, Agnete; Gillings, Nic; Knudsen, Gitte M; Kristensen, Jesper L.

    In: Nuclear Medicine and Biology, Vol. 43, No. 8, 19.04.2016, p. 455-462.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published

    Convergent [18]F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands. / Petersen, Ida Nymann; Villadsen, Jonas; Hansen, Hanne Demant; Jensen, Anders A; Lehel, Szabolcs; Gillings, Nic; Herth, Matthias M; Knudsen, Gitte M; Kristensen, Jesper L.

    In: Bioorganic & Medicinal Chemistry, Vol. 24, 2016, p. 5353-5356.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Metabolic fate of hallucinogenic NBOMes. / Leth-Petersen, Sebastian; Gabel-Jensen, Charlotte; Gillings, Nic; Lehel, Szabolzs; Hansen, Hanne D; Knudsen, Gitte M; Kristensen, Jesper L.

    In: Chemical Research in Toxicology, Vol. 29, No. 1, 2016, p. 96–100.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2015
  30. Published

    An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [C-11]Cimbi-36. / Gillings, Nic; Lehel, Szabolcs; Herth, Matthias; Leth-Petersen, Sebastian; Madsen, Jacob; Gabel-Jensen, Charlotte; Kristensen, Jesper L.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 58, 15.05.2015, p. S296-S296.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  31. Published

    Labeling and preliminary in vivo evaluation of the 5-HT7 receptor selective agonist [(11)C]E-55888. / Hansen, Hanne D; Andersen, Valdemar L; Lehel, Szabolcs; Magnussen, Janus H; Dyssegaard, Agnete; Stroth, Nikolas; Kristensen, Jesper Langgaard; Knudsen, Gitte M; Herth, Matthias M.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 9, 01.05.2015, p. 1901-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Evaluation of 3-Ethyl-3-(phenylpiperazinylbutyl)oxindoles as PET Ligands for the Serotonin 5-HT7 Receptor : Synthesis, Pharmacology, Radiolabeling, and in Vivo Brain Imaging in Pigs. / Herth, Matthias M; Andersen, Valdemar L; Hansen, Hanne D; Stroth, Nikolas; Volk, Balázs; Lehel, Szabolcs; Dyssegaard, Agnete; Ettrup, Anders; Svenningsson, Per; Knudsen, Gitte M; Kristensen, Jesper Langgaard.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 8, 13.04.2015, p. 3631–3636.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. / Petersen, Ida Nymann; Crestey, François; Jensen, Anders A; Indurthi, Dinesh C; Pedersen, Henrik; Andreasen, Jesper T; Balle, Thomas; Kristensen, Jesper L.

    In: A C S Medicinal Chemistry Letters, Vol. 6, No. 4, 09.04.2015, p. 472-475.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    (11)C-labeling and preliminary evaluation of pimavanserin as a 5-HT2A receptor PET-radioligand. / Andersen, Valdemar L; Hansen, Hanne D; Herth, Matthias M; Dyssegaard, Agnete; Knudsen, Gitte M; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 5, 20.01.2015, p. 1053–1056.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice. / Fantegrossi, William E; Gray, Bradley W; Bailey, Jessica M; Smith, Douglas A; Hansen, Martin; Kristensen, Jesper Langgaard.

    In: Psychopharmacology, Vol. 232, No. 6, 2015, p. 1039-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. / Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry, Vol. 23, No. 14, 2015, p. 3933-3937.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2014
  38. Published

    Dissecting the Binding Mode of Low Affinity Phage Display Peptide Ligands to Protein Targets by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry. / Leurs, Ulrike; Lohse, Brian; Ming, Shonoi A; Cole, Philip A; Clausen, Rasmus P; Kristensen, Jesper L; Rand, Kasper D.

    In: Analytical Chemistry, Vol. 86, No. 23, 17.10.2014, p. 11734-11741.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide : scalable synthesis of alkynes from aldehydes. / Jepsen, Tue Heesgaard; Kristensen, Jesper Langgaard.

    In: Journal of Organic Chemistry, Vol. 79, No. 19, 12.09.2014, p. 9423-9426.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published
  41. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C. / Leurs, Ulrike; Lohse, Brian; Rand, Kasper Dyrberg; Ming, Shonoi; Riise, Erik Skjold; Cole, Philip A.; Kristensen, Jesper Langgaard; Clausen, Rasmus Prætorius.

    In: A C S Chemical Biology, Vol. 9, No. 9, 11.07.2014, p. 2131-2138.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Serotonin 2A receptor agonist binding in the human brain with [C]Cimbi-36. / Ettrup, A.; da Cunha-Bang, S.; McMahon, Barry P.; Lehel, S.; Dyssegaard, A.; Skibsted, A.W.; Jørgensen, Louise Møller; Hansen, M.; Baandrup, A.O.; Bache, S.; Svarer, C.; Kristensen, Jesper Langgaard; Gillings, N.; Madsen, Jacob; Knudsen, G.M.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 34, 30.04.2014, p. 1188-1196.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand. / Andersen, Valdemar L; Hansen, Hanne D; Herth, Matthias M; Knudsen, Gitte M; Kristensen, Jesper Langgaard.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 24, No. 11, 19.04.2014, p. 2408-2411.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Radiosynthesis and in vivo evaluation of novel radioligands for PET imaging of cerebral 5-HT7 receptors. / Hansen, Hanne D; Herth, Matthias M; Ettrup, Anders; Andersen, Valdemar L; Lehel, Szabolcs; Dyssegaard, Agnete; Kristensen, Jesper Langgaard; Knudsen, Gitte M.

    In: Journal of Nuclear Medicine, Vol. 55, No. 4, 24.02.2014, p. 640-646.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Correlating the Metabolic Stability of Psychedelic 5-HT2A Agonists with Anecdotal Reports of Human Oral Bioavailability. / Leth-Petersen, Sebastian; Bundgaard, Christoffer; Hansen, Martin; Carnerup, Martin A; Kehler, Jan; Kristensen, Jesper Langgaard.

    In: Neurochemical Research, Vol. 39, No. 10, 12.02.2014, p. 2018-2023.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Correction : Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-HT2 receptors (PLoS ONE). / Isberg, Vignir; Paine, James; Leth-Petersen, Sebastian; Kristensen, Jesper L.; Gloriam, David E.

    In: PLOS ONE, Vol. 9, No. 1, 17.01.2014.

    Research output: Contribution to journalComment/debateResearchpeer-review

  47. Published

    Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. / Hansen, Martin; Phonekeo, Karina; Paine, James S; Leth-Petersen, Sebastian; Begtrup, Mikael; Bräuner-Osborne, Hans; Kristensen, Jesper Langgaard.

    In: A C S Chemical Neuroscience, Vol. 5, No. 3, 07.01.2014, p. 243-249.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Synthesis and SAR study of a novel series of dopamine receptor agonists. / Risgaard, R.; Jensen, M.; Jørgensen, M.; Bang-Andersen, B.; Christoffersen, C.T.; Jensen, Klaus Gervig; Kristensen, Jesper Langgaard; Püschl, A.

    In: Bioorganic and Medicinal Chemistry, Vol. 22, No. 1, 01.01.2014, p. 381-392.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Synthesis of Pyridoacridines through Anionic Cascade Ring Closure. / Petersen, I.N.; Kristensen, Jesper Langgaard.

    In: Synthesis, Vol. 46, 01.01.2014, p. 1469-1474.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    A Prodrug Approach Involving In Situ Depot Formation to Achieve Localized and Sustained Action of Diclofenac After Joint Injection. / Thing, Mette; Agårdh, Li; Larsen, Susan; Rasmussen, Rune; Pallesen, Jakob; Mertz, Nina; Kristensen, Jesper Langgaard; Hansen, Martin; Ostergaard, Jesper; Larsen, Claus Selch.

    In: Journal of Pharmaceutical Sciences, Vol. 103, No. 12, 2014, p. 4021–4029.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Accelerating preclinical PET-screening: reductive amination with [11C]methoxybenzaldehydes. / Herth, Matthias Manfred; Leth-Petersen, Sebastian; Lehel, Szabolcs; Hansen, Martin; Gillings, Nic; Madsen, Jacob; Kristensen, Jesper Langgaard.

    In: R S C Advances, Vol. 41, 2014, p. 21347-21350.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Synthesis and pharmacological evaluation of DHβE analogs as neuronal nicotinic acetylcholine receptor antagonists. / Jepsen, Tue H.; Jensen, Anders A.; Lund, Mads Henrik; Glibstrup, Emil; Kristensen, Jesper Langgaard.

    In: A C S Medicinal Chemistry Letters, Vol. 5, No. 7, 2014, p. 766-770.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. 2013
  54. Published

    Posttranslational Modifications of the Histone 3 Tail and Their Impact on the Activity of Histone Lysine Demethylases In Vitro. / Lohse, Brian; Helgstrand, Charlotte; Andersson, Jan Legaard; Leurs, Ulrike; Cloos, Paul Andreas Compare; Kristensen, Jesper Langgaard; Clausen, Rasmus Prætorius.

    In: P L o S One, Vol. 8, No. 7, 02.07.2013, p. e67653.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Identification of a new metabolite of GHB : gamma-hydroxybutyric acid glucuronide. / Petersen, Ida Nymann; Tortzen, Christian; Kristensen, Jesper Langgaard; Pedersen, Daniel Sejer; Breindahl, Torben.

    In: Journal of Analytical Toxicology, Vol. 37, No. 5, 06.2013, p. 291-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published
  57. Published

    Development of C-11-labeled oxindole derivatives for in vivo PET imaging of the 5-HT7 receptor. / Herth, Matthias Manfred; Hansen, Hanne; Andersen, Valdemar L.; Volk, Balazs; Ettrup, Anders; Antoni, Ferenc; Lehel, Szabolcs; Dyssegaard, Agnete; Kristensen, Jesper L.; Knudsen, Gitte M.

    In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 56, 05.2013, p. S82-S82.

    Research output: Contribution to journalJournal articleResearchpeer-review

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