Jette Sandholm Jensen Kastrup

Jette Sandholm Jensen Kastrup

Professor

CV: Jette Sandholm Kastrup                                              

Work address:    Department of Drug Design and Pharmacology

                           Biostructural Research

                           Faculty of Health and Medical Sciences

                           University of Copenhagen

                           Universitetsparken 2, DK-2100 CPH Ø, Denmark

                           Phone: +45 3533 6486; E-mail: jsk@sund.ku.dk

 Academic Degrees

1986: M.Sc. (pharm.), The Royal Danish School of Pharmacy (RDSP)

1988: PhD, RDSP & Cheminova Agro A/S

Considered professorable 2002 (”well qualified, broad crystallographic expertise, experience in leading a successful research group, research activities on a broad spectrum of biologically important problems”). After application of professorship within protein crystallography at the Danish University of Pharmaceutical Sciences

Employments

1981-1982: 11 Months work experience at Tårnby Apotek

1982-1986: Periodic substitute at Tårnby Apotek

1986-1988: Industrial PhD student (Erhvervsforsker). RDSP & Cheminova Agro

1988: Teaching assistant. Dept. of Organic Chemistry, RDSP (3 months)

1989-1992: Post doc. Dept. of Medicinal Chemistry, RDSP

1993-1994: Senior scientist. Dept. of Medicinal Chemistry, RDSP

1995-2008: Associate professor. Dept. of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences (DUPS)

2008-present: Professor (MSO) in structure-based drug design. Dept. of Drug Design and Pharmacology, The Faculty of Health and Medical Sciences, University of Copenhagen

Stays as visiting research fellow

1989-1991: Novo Nordisk A/S, dr. Hans Flodgaard. Protein purification (in total 2 months)

1990: University of Oregon, USA, Professor Brian W. Matthews. Proteinmcrystallography (1 month)

1991: University of Oregon, USA, Professor Brian W. Matthews. Protein crystallography (2 weeks)

1991: Uppsala University, Sweden, Dr. Elisabeth S. Eriksson. Protein crystallography (1 week)

1992: DAKO A/S, Dr. Inge Clemmensen. Protein purification (3 months)

Maternity leaves

1991: 6 months (January-June)

1997-1998: 7 months (November 1997 – May 1998)

Research prizes

45.000 kr. from ”Valborg and Edith Larsens Foundation" 2005

20.000 kr from the Faculty of Pharmaceuitcal Sciences, University of Copenhagen 2007    

Major Administrative Responsibilities

1999-2002: Member of Board, the Dansync Center for synchrotron radiation

2002-2008: Member of departmental board, Dept. of Medicinal Chemistry, DUPS

2004-2008: Deputy Head of Dept. of Medicinal Chemistry. DUPS and the Faculty of Pharmaceutical Sciences, University of Copenhagen

2004-2006: Member of Academic Council, DUPS

2004-2006: Member of committee for defining central and prioritized research areas, DUPS

2004-2006: Member of committee for evaluation of VIP assessment committees, DUPS

2005-2007: Member of scientific committee, Dept. of Medicinal Chemistry, DUPS

2007-2011: Member of Academic Council, Faculty of Pharmaceutical Sciences, University of Copenhagen

2007: Appointed director of Drug Research Academy, an industry-oriented research education programme at the Faculty of Pharmaceutical Sciences, University of Copenhagen (August-October)

2007: Member of committee for preparation of strategy plan 2007-2010, Faculty of Pharmaceutical Sciences, University of Copenhagen

2007-2008: Participant in project on competence development, The Ministry of Science, Technology and Innovation (3 days)

2007-2012: Director of Drug Research Academy

2008-present: Head of GluTarget, project within the Programme of Excellence at the University of Copenhagen (2008-2013). 24.5 mio. kr. Project title: Ionotropic glutamate receptors as targets for structure-based drug research: A multidisciplinary programme in structural biology, chemical biology, medicinal chemistry, molecular pharmacology and ex vivo/in vivo pharmacology

2010-2012: Member of board, SHARE's Cross Faculty PhD Initiative, University of Copenhagen

2010-2012: Coordinator of mobility PhD grant on project “Ion channel receptors in brain diseases”

2012: Member of Academic Council, Faculty of Health and Medical Sciences, University of Copenhagen

2012-present: Member of Research and Innovation Committee, Dept. of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen

Organizer of symposia

Co-organizer of Alfred Benzon Symposium no. 39, 1995: Structure and Function of 7TM Receptors

Co-Organizer of 9. CoLuAa-meeting, Royal Danish School of Pharmacy, 16-17 Nov. 2000 (between protein crystallographers at Lund, Copenhagen and Aarhus Universities and Novo Nordisk A/S, Carlsberg Laboratorium and Royal Danish School of Pharmacy)

Organizer of symposium on Receptor Structure and Function, Royal Danish School of Pharmacy 2001

Organizer of DANSYNC annual meeting, Royal Danish School of Pharmacy, 23. May 2001

Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2002

Organizer of mini-symposium on Protein Crystallography in Structural Biology, Danish University of Pharmaceutical Sciences, 18. June 2002

Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2003

Co-organizer of the 33. Danske Krystallograf/5. DANSYNC meeting, Danish University of Pharmaceutical Sciences, May 27-28 2003

Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2004

Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2005

Organizer of symposium on Receptor Structure and Function, Danish University of Pharmaceutical Sciences 2006

Co-organizer of Academic Council strategy seminar, Danish University of Pharmaceutical Sciences 2006

Co-Organizer of the 15. CoLuAa meeting, Danish University of Pharmaceutical Sciences, Nov. 9-10 2006

Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2007

Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2008

Organizer of Symposium on iGluRs, Faculty of Pharmaceutical Sciences, University of Copenhagen, November 2008

Organizer of GluTarget General Meeting for members, May 2009

Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2009

Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2010

Organizer of GluTarget Day of Research, April 2010

Organizer of symposium with presentations by the members of the Advisory Board and GluTarget members, June 2010

Organizer of symposium on Receptor Structure and Function, Faculty of Pharmaceutical Sciences, University of Copenhagen 2011

Organizer of GluTarget symposium on ionotropic glutamate receptors, February 2012

Organizer of symposium on Receptor Structure and Function, Faculty of Health and Medical Sciences, University of Copenhagen 2012

Organizer of symposium with presentations by the members of the Advisory Board and GluTarget members, October 2012

Organizer of symposium on Receptor Structure and Function, Faculty of Health and Medical Sciences, University of Copenhagen 2013

Reviewer at several international journals and of international grant applications

Conferences and symposia

Participation in numerous conferences and meetings. Numerous poster presentations with abstracts. Examples of invited speaker within recent years at international conferences:

Gordon Conference on Excitatory synapses & brain function, Colby-Sawyer College, New London, NH, June 10-15, 2007

Physiology 2010 Conference, University Place, Manchester, UK, June 30-July 2, 2010

20th Neuropharmacology Conference - High Resolution Neuropharmacology: Structure Changes the Paradigm, San Diego, USA, November 10-12, 2010

Membrane Proteins:  Structure & Function,Lady Margaret Hall, Oxford, April 6-8, 2011

Glutamatergic Synapse ISN Satelite meeting, Crete Island, Greece, September 2-5, 2011

Present central research projects

Group leader on BR core project on ion channel receptors (ionotropic glutamate receptors and Cys-loop receptors)

Active in BR core project on Chromatin modifying enzymes

Expertise

Structural biology, protein crystallography

National and international collaborations on iGluRs

Emory University School of Medicine, Georgia, USA

Northwestern Univ. Feinberg School of Medicine, Illinois, USA     

University of Sienna, Italy

University of Jyväskylä, Finland

Oregon Health and Science University, Oregon, USA

Dartmouth Medical School, New Hampshire, USA

Yokohama City University, Japan

University of Liege, Belgium

Neurosearch A/S, Denmark

H. Lundbeck A/S, Denmark

The Faculty of Science, University of Copenhagen, Denmark

National and international collaborations on Cys-loop receptors

University of Sydney, Australia

University of Milano, Italy

Aniona, Denmark

Grants – as main applicant (excl. internal and industrial PhD stipends)

Alfred Benzon's Fond; Augustinus Foundation; Carlsberg Foundation; Danish Agency for Science Technology and Innovation; Danish Council for Independent Research, Medical Sciences; Danish Council for Independent Research, Natural Sciences; Danish Research Academy;Hede Nielsen Foundation; Lundbeck Foundation; Novo Nordisk A/S; Programme of Excellence at the University of Copenhagen

Grants – as co-applicant

Apotekerfonden of 1991; Copenhagen 2016, University of Copenhagen; Danish Agency for Science, Technology and Innovation; Danish Medical Research Council; Danish Natural Science Research Council; Ib Henriksens Fond; Lundbeck Foundation, Novo Nordisk Fond

Publications 1988-2013

Peer-reviewed: 93

            1990-1994: 4

         1995-1999: 12

         2000-2004: 17

         2005-2009: 37

         2010-May 2013: 23

Books (editor, chapters): 7

Patents: 2

Other publications: 28

PhD thesis: 1

Structures deposited in the Protein Data Bank: 106

Education

Cand. pharm., PhD

ID: 1298590