Jette Sandholm Jensen Kastrup
Jette Sandholm Jensen Kastrup

Professor

  • Peptides and Proteins

    Jagtvej 162

    2100 København Ø

    Phone: +45 35 33 64 86

Introductory remarks on publicationslist


Publications 1988-2013 by Jette Sandholm Kastrup

Peer-reviewed: 93

    1990-1994: 4
    1995-1999: 12
    2000-2004: 17
    2005-2009: 37
    2010-May 2013: 23

Books (editor, chapters): 7
Patents: 2
Other publications: 28
PhD thesis: 1
Structures deposited in the Protein Data Bank: 106


  1. Published

    (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation.

    Brogi, S., Brindisi, M., Butini, S., Kshirsagar, G., Maramai, S., Chemi, G., Gemma, S., Campiani, G., Novellino, E., Fiorenzani, P., Pinassi, J., Aloisi, A. M., Gynther, M., Venskutonyte, R., Han, L., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, 8 Mar 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2124-2130 7 p.

    Research output: Contribution to journalJournal article

  2. Published

    7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

    Goffin, E., Drapier, T., Larsen, A. P., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., Tullio, P. D., Olsen, L., Frydenvang, Karla Andrea, Pirotte, B., Hanson, J., Oswald, R. E., Kastrup, Jette Sandholm Jensen & Francotte, P., Jan 2018, In : Journal of Medicinal Chemistry. 61, 1, p. 251–264

    Research output: Contribution to journalJournal article

  3. Published
  4. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

    Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In : PLoS - Biology. 5, 5, p. 1089-1097

    Research output: Contribution to journalJournal article

  5. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

    Research output: Contribution to journalJournal article

  6. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

    Szymanska, E., Frydenvang, Karla Andrea, Contreras-Sanz, A., Pickering, Darryl S, Frola, E., Serafimoska, Z., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 4 Oct 2011, In : Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

    Research output: Contribution to journalJournal article

  7. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

    Christiansen, G. B., Harbak, B., Hede, S. E., Gouliaev, A. H., Olsen, L., Frydenvang, Karla Andrea, Egebjerg, J., Kastrup, Jette Sandholm Jensen & Holm, M. M., 3 Dec 2015, In : Neuroscience. 310, p. 709-22 14 p.

    Research output: Contribution to journalJournal article

  8. Published

    A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

    Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In : International Journal of Biological Macromolecules. 92, p. 779-787 9 p.

    Research output: Contribution to journalJournal article

  9. Published

    A pharmacological profile of the high-affinity GluK5 kainate receptor

    Møllerud, Stine, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, 2016, In : European Journal of Pharmacology. 788, p. 315-320 6 p.

    Research output: Contribution to journalJournal article

  10. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist

    Vogensen, S. B., Frydenvang, Karla Andrea, Greenwood, J. R., Postorino, G., Nielsen, Birgitte, Pickering, Darryl S, Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2007, In : Journal of Medicinal Chemistry. 50, 10, p. 2408-2414

    Research output: Contribution to journalJournal article

  11. Published

    A unique set of SH3-SH3 interactions controls IB1 homodimerization

    Kristensen, O., Guenat, S., Dar, I., Allaman-Pillet, N., Abderrahmani, A., Ferdaoussi, M., Roduit, R., Maurer, F., Beckmann, J. S., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Bonny, C., 2006, In : E M B O Journal. 25, 4, p. 785-97 13 p.

    Research output: Contribution to journalJournal article

  12. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

    Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In : Molecular Pharmacology. 88, 4, p. 697-707 11 p.

    Research output: Contribution to journalJournal article

  13. Published

    At være eller ikke være en antagonist

    Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In : Lægemiddelforskning. p. 43-45

    Research output: Contribution to journalJournal article

  14. Published

    Atomic resolution structure of human HBP/CAP37/Azurocidin

    Karlsen, S., Iversen, L. F., Larsen, I. K., Flodgaard, H. J. & Kastrup, Jette Sandholm Jensen, 1998, In : Acta Crystallographica. Section D: Biological Crystallography. 54, p. 598-609 12 p.

    Research output: Contribution to journalJournal article

  15. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

    Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, Darryl S, Nielsen, Birgitte, Bowie, D., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen & Bunch, Lennart, 9 Apr 2015, In : A C S Chemical Neuroscience. 6, p. 845-854 10 p.

    Research output: Contribution to journalJournal article

  16. Published
  17. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

    Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In : Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

    Research output: Contribution to journalJournal article

  18. Published

    Biostructure-based drug design

    Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 29-42

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  19. Published

    Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies

    Iversen, L. F., Brzozowski, M., Hastrup, S., Larsen, I. K., Kastrup, Jette Sandholm Jensen, Nærum, L., Nørskov-Lauridsen, L., Rasmussen, P. B., Thim, L., Wiberg, F. C. & Lundgren, K., 1997, In : Protein Sci.. 6, p. 971-982 12 p.

    Research output: Contribution to journalJournal article

  20. Published
  21. Published

    Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

    Hogner, A., Greenwood, J. R., Liljefors, T., Lunn, M., Egebjerg, J., Larsen, I. K., Gouaux, E. & Kastrup, Jette Sandholm Jensen, 16 Jan 2003, In : Journal of Medicinal Chemistry. 46, 2, p. 214-21 8 p.

    Research output: Contribution to journalJournal article

  22. Published

    Computeren viser vejen til et nyt potentielt lægemiddel

    Harpsøe, Kasper, Kaae, B. H., Balle, T., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In : Lægemiddelforskning. p. 28-30

    Research output: Contribution to journalJournal article

  23. Published

    Conformational analysis of the fungicide fenpropimorph by molecular mechanics calculations and NMR spectroscopy

    Kastrup, Jette Sandholm Jensen, Jørgensen, Flemming Steen, Klemmensen, P. D., Hacksell, U. & Petersson, I., 1992, In : Journal of Pesticide Science. 36, p. 309-318 10 p.

    Research output: Contribution to journalJournal article

  24. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, A., Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In : P L o S One. 7, 8, p. e40757

    Research output: Contribution to journalJournal article

  25. Published

    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Poulsen, Jens-Christian Navarro, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual formDatasetResearch

  26. Published

    Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

    Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, Karla Andrea & Kastrup, Jette Sandholm Jensen, 14 Mar 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.

    Research output: Contribution to journalJournal article

  27. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner-Osborne, Hans, 2013, In : The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journalJournal article

  28. Published

    Crystal structure of NCAM2 IgIV-Fn3I

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  29. Published

    Crystal structure of NCAM2 IgIV-Fn3II

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  30. Published

    Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network

    Petersson, B., Nielsen, B. B., Rasmussen, H., Larsen, I. K., Gajhede, Michael, Nielsen, Peter E. & Kastrup, Jette Sandholm Jensen, 9 Feb 2005, In : Journal of the American Chemical Society. 127, 5, p. 1424-30 7 p.

    Research output: Contribution to journalJournal article

  31. Published

    Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 Å resolution

    Rasmussen, H. B., Kastrup, Jette Sandholm Jensen, Nielsen, J. N., Nielsen, J. M. & Nielsen, Peter E., 1997, In : Nature Structural and Molecular Biology. 4, p. 98-101 4 p.

    Research output: Contribution to journalJournal article

  32. Published

    Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

    Sprogøe, D., van den Broek, L. A. M., Mirza, Osman Asghar, Kastrup, Jette Sandholm Jensen, Voragen, A. G. J., Gajhede, Michael & Skov, L., 10 Feb 2004, In : Biochemistry. 43, 5, p. 1156-62 7 p.

    Research output: Contribution to journalJournal article

  33. Published

    Crystal structure of tetranectin, a trimeric plasminogen binding protein with an alpha-helical coiled coil

    Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Las Holtet, T., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., 1997, In : FEBS Letters. 412, p. 388-396 9 p.

    Research output: Contribution to journalJournal article

  34. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

    Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, Jens-Christian Navarro, Sigurskjold, B. W., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 2008, In : Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.

    Research output: Contribution to journalJournal article

  35. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

    Naur, P., Vestergaard, Bente, Skov, L., Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2005, In : FEBS letters. 579, p. 1154-60

    Research output: Contribution to journalJournal article

  36. Published

    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype

    Røder, G., Blicher, T., Justesen, S., Johannesen, B., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2006, In : Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 11, p. 1300-10 10 p.

    Research output: Contribution to journalJournal article

  37. Published

    Crystallization and molecular replacement solution of human heparin binding protein

    Iversen, L. F., Kastrup, Jette Sandholm Jensen, Larsen, I. K., Bjørn, S. E., Rasmussen, P. B., Wiberg, F. C. & Flodgaard, H. J., 1996, In : Acta Crystallographica. Section D: Biological Crystallography. 52, p. 1222-1223 2 p.

    Research output: Contribution to journalJournal article

  38. Published

    Crystallization and molecular-replacement solution of a truncated form of human recombinant tetranectin

    Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., May 2000, In : Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 5, p. 637-9 3 p.

    Research output: Contribution to journalJournal article

  39. Published

    Crystallization and preliminary X-ray analysis of a PNA-DNA complex

    Kastrup, Jette Sandholm Jensen, Pilgaard, M. & Nielsen, Peter E., 17 Apr 1995, In : FEBS letters. 363, 1-2, p. 115-7 3 p.

    Research output: Contribution to journalJournal article

  40. Published

    Crystallization and preliminary X-ray analysis of a PNA-DNA complex

    Kastrup, Jette Sandholm Jensen, Pilgaard, M., Jørgensen, Flemming Steen, Nielsen, Peter E. & Rasmussen, H. B., 1995, In : FEBS Letters. 363, p. 115-117 3 p.

    Research output: Contribution to journalJournal article

  41. Published
  42. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

    Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In : American Chemical Society. Abstracts of Papers (at the National Meeting). 234

    Research output: Contribution to journalConference abstract in journal

  43. Published

    Dimerization effect of sucrose octasulfate on rat FGF1.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2008, In : Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.

    Research output: Contribution to journalJournal article

  44. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

    Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Molecular Biology. 391, 5, p. 906-917

    Research output: Contribution to journalJournal article

  45. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

    Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, Jette Sandholm Jensen, Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, Michael & Balle, T., 2015, In : Neuropharmacology. 92, p. 135-45 11 p.

    Research output: Contribution to journalJournal article

  46. Published

    Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds

    Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S., Francotte, P., Hanson, J., Pochet, L., Kastrup, Jette Sandholm Jensen & Pirotte, B., 28 Jun 2018, In : Journal of Medicinal Chemistry. 61, 12, p. 5279-5291 13 p.

    Research output: Contribution to journalJournal article

  47. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

    Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In : Biophysical Journal. 110, 11, p. 2397-2406 10 p.

    Research output: Contribution to journalJournal article

  48. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In : F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journalJournal article

  49. Published

    Establishment of an immunized murine Fab library for selection of iGluR6 binders by phage display

    Mohr, A. Ø., Skottrup, P. D., Jensen, A. A., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Riise, E. S., 28 May 2009.

    Research output: Contribution to conferencePosterResearch

  50. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In : FEBS Journal. 272, 7, p. 1639-48 9 p.

    Research output: Contribution to journalJournal article

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