Jette Sandholm Jensen Kastrup

Jette Sandholm Jensen Kastrup

Professor

  • Peptides and Proteins

    Jagtvej 162

    2100 København Ø

    Phone: +45 35 33 64 86

Introductory remarks on publicationslist


Publications 1988-2013 by Jette Sandholm Kastrup

Peer-reviewed: 93

    1990-1994: 4
    1995-1999: 12
    2000-2004: 17
    2005-2009: 37
    2010-May 2013: 23

Books (editor, chapters): 7
Patents: 2
Other publications: 28
PhD thesis: 1
Structures deposited in the Protein Data Bank: 106


  1. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

    Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In : PLoS - Biology. 5, 5, p. 1089-1097

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

    Szymanska, E., Frydenvang, Karla Andrea, Contreras-Sanz, A., Pickering, Darryl S, Frola, E., Serafimoska, Z., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 4 Oct 2011, In : Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

    Christiansen, G. B., Harbak, B., Hede, S. E., Gouliaev, A. H., Olsen, L., Frydenvang, Karla Andrea, Egebjerg, J., Kastrup, Jette Sandholm Jensen & Holm, M. M., 3 Dec 2015, In : Neuroscience. 310, p. 709-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

    Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In : International Journal of Biological Macromolecules. 92, p. 779-787 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A pharmacological profile of the high-affinity GluK5 kainate receptor

    Frantsen, Stine Møllerud, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, 2016, In : European Journal of Pharmacology. 788, p. 315-320 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist

    Vogensen, S. B., Frydenvang, Karla Andrea, Greenwood, J. R., Postorino, G., Nielsen, Birgitte, Pickering, Darryl S, Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2007, In : Journal of Medicinal Chemistry. 50, 10, p. 2408-2414

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    A unique set of SH3-SH3 interactions controls IB1 homodimerization

    Kristensen, O., Guenat, S., Dar, I., Allaman-Pillet, N., Abderrahmani, A., Ferdaoussi, M., Roduit, R., Maurer, F., Beckmann, J. S., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Bonny, C., 2006, In : E M B O Journal. 25, 4, p. 785-97 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

    Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In : Molecular Pharmacology. 88, 4, p. 697-707 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    At være eller ikke være en antagonist

    Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In : Lægemiddelforskning. p. 43-45

    Research output: Contribution to journalJournal articleCommunication

  11. Published

    Atomic resolution structure of human HBP/CAP37/Azurocidin

    Karlsen, S., Iversen, L. F., Larsen, I. K., Flodgaard, H. J. & Kastrup, Jette Sandholm Jensen, 1998, In : Acta Crystallographica. Section D: Biological Crystallography. 54, p. 598-609 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

    Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, Darryl S, Nielsen, Birgitte, Bowie, D., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen & Bunch, Lennart, 9 Apr 2015, In : A C S Chemical Neuroscience. 6, p. 845-854 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

    Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In : Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Biostructure-based drug design

    Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 29-42

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  16. Published

    Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies

    Iversen, L. F., Brzozowski, M., Hastrup, S., Larsen, I. K., Kastrup, Jette Sandholm Jensen, Nærum, L., Nørskov-Lauridsen, L., Rasmussen, P. B., Thim, L., Wiberg, F. C. & Lundgren, K., 1997, In : Protein Sci.. 6, p. 971-982 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

    Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In : Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

    Hogner, A., Greenwood, J. R., Liljefors, T., Lunn, M., Egebjerg, J., Larsen, I. K., Gouaux, E. & Kastrup, Jette Sandholm Jensen, 16 Jan 2003, In : Journal of Medicinal Chemistry. 46, 2, p. 214-21 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Computeren viser vejen til et nyt potentielt lægemiddel

    Harpsøe, Kasper, Kaae, B. H., Balle, T., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In : Lægemiddelforskning. p. 28-30

    Research output: Contribution to journalJournal articleCommunication

  20. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, A., Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In : P L o S One. 7, 8, p. e40757

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Poulsen, Jens-Christian Navarro, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual formDatasetResearch

  22. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner-Osborne, Hans, 2013, In : The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Crystal structure of NCAM2 IgIV-Fn3I

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  24. Published

    Crystal structure of NCAM2 IgIV-Fn3II

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  25. Published

    Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network

    Petersson, B., Nielsen, B. B., Rasmussen, H., Larsen, I. K., Gajhede, Michael, Nielsen, Peter E. & Kastrup, Jette Sandholm Jensen, 9 Feb 2005, In : Journal of the American Chemical Society. 127, 5, p. 1424-30 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 Å resolution

    Rasmussen, H. B., Kastrup, Jette Sandholm Jensen, Nielsen, J. N., Nielsen, J. M. & Nielsen, Peter E., 1997, In : Nature Structural and Molecular Biology. 4, p. 98-101 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

    Sprogøe, D., van den Broek, L. A. M., Mirza, Osman Asghar, Kastrup, Jette Sandholm Jensen, Voragen, A. G. J., Gajhede, Michael & Skov, L., 10 Feb 2004, In : Biochemistry. 43, 5, p. 1156-62 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Crystal structure of tetranectin, a trimeric plasminogen binding protein with an alpha-helical coiled coil

    Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Las Holtet, T., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., 1997, In : FEBS Letters. 412, p. 388-396 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

    Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, Jens-Christian Navarro, Sigurskjold, B. W., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 2008, In : Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

    Naur, P., Vestergaard, Bente, Skov, L., Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2005, In : FEBS letters. 579, p. 1154-60

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype

    Røder, G., Blicher, T., Justesen, S., Johannesen, B., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2006, In : Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 11, p. 1300-10 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Crystallization and molecular-replacement solution of a truncated form of human recombinant tetranectin

    Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., May 2000, In : Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 5, p. 637-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

    Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, Birgitte, Bowie, D., Pickering, Darryl S, Kastrup, Jette Sandholm Jensen, Frydenvang, Karla Andrea & Bunch, Lennart, 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 441-457 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

    Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In : American Chemical Society. Abstracts of Papers (at the National Meeting). 234

    Research output: Contribution to journalConference abstract in journalResearch

  35. Published

    Dimerization effect of sucrose octasulfate on rat FGF1.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2008, In : Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

    Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Molecular Biology. 391, 5, p. 906-917

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

    Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, Jette Sandholm Jensen, Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, Michael & Balle, T., 2015, In : Neuropharmacology. 92, p. 135-45 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

    Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In : Biophysical Journal. 110, 11, p. 2397-2406 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In : F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Establishment of an immunized murine Fab library for selection of iGluR6 binders by phage display

    Mohr, A. Ø., Skottrup, P. D., Jensen, A. A., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Riise, E. S., 28 May 2009.

    Research output: Contribution to conferencePosterResearch

  41. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In : FEBS Journal. 272, 7, p. 1639-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1

    Kulahin, N., Kasper, C., Gajhede, Michael, Berezin, V., Bock, E. & Kastrup, Jette Sandholm Jensen, Mar 2004, In : Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 3, p. 591-3 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1

    Kulahin, N., Kasper, C., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. & Gajhede, Michael, 2005, In : Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 9, p. 858-60 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

    Frydenvang, Karla Andrea, Lash, L. L., Naur, P., Postila, P. A., Pickering, Darryl S, Smith, C. M., Gajhede, Michael, Sasaki, M., Sakai, R., Pentikäinen, O. T., Swanson, G. T. & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Biological Chemistry. 284, 21, p. 14219-14229

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Gennembrud i forståelsen af insulinfibrillering

    Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In : Lægemiddelforskning. p. 10-11

    Research output: Contribution to journalJournal articleCommunication

  46. Published

    GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists

    Kasper, C., Lunn, M., Liljefors, T., Gouaux, E., Egebjerg, J. & Kastrup, Jette Sandholm Jensen, 6 Nov 2002, In : F E B S Letters. 531, 2, p. 173-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    High resolution crystal structures of the p120 RasGAP SH3 domain

    Ross, B., Kristensen, O., Favre, D., Walicki, J., Kastrup, Jette Sandholm Jensen, Widmann, C. & Gajhede, Michael, 2007, In : Biochemical and Biophysical Research Communications. 353, 2, p. 463-468

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide

    Blicher, T., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2005, In : Acta Crystallographica. Section D: Biological Crystallography. 61, Pt 8, p. 1031-40 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Human plasminogen binding protein tetranectin: crystallization and preliminary X-ray analysis of the C-type lectin CRD and the full-length protein

    Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Nielsen, B. B., Larsen, I. K., Las Holtet, T., Graversen, J. H., Etzerodt, M. & Thøgersen, H. C., 1997, In : Acta Crystallographica. Section D: Biological Crystallography. 53, p. 108-111 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Hvad har varme at gøre med lægemidler?

    Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In : Lægemiddelforskning. p. 31-33

    Research output: Contribution to journalJournal articleCommunication

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