Jette Sandholm Jensen Kastrup

Jette Sandholm Jensen Kastrup

Professor

Introductory remarks on publicationslist


Publications 1988-2013 by Jette Sandholm Kastrup

Peer-reviewed: 93

    1990-1994: 4
    1995-1999: 12
    2000-2004: 17
    2005-2009: 37
    2010-May 2013: 23

Books (editor, chapters): 7
Patents: 2
Other publications: 28
PhD thesis: 1
Structures deposited in the Protein Data Bank: 106


  1. 2016
  2. Published

    A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain. / Clausen, Rasmus P; Mohr, Andreas Ø; Riise, Erik; Jensen, Anders A; Gill, Avinash; Madden, Dean R; Kastrup, Jette S; Skottrup, Peter D.

    In: International Journal of Biological Macromolecules, Vol. 92, 08.07.2016, p. 779-787.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. / Larsen, Anja Probst; Francotte, Pierre; Frydenvang, Karla; Tapken, Daniel; Goffin, Eric; Fraikin, Pierre; Caignard, Daniel-Henri; Lestage, Pierre; Danober, Laurence; Pirotte, Bernard; Kastrup, Jette Sandholm.

    In: A C S Chemical Neuroscience, Vol. 7, No. 3, 16.03.2016, p. 378-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. / Kristensen, Anders S; Hansen, Kasper B; Naur, Peter; Olsen, Lars; Kurtkaya, Natalie L; Dravid, Shashank M; Kvist, Trine; Yi, Feng; Pøhlsgaard, Jacob; Clausen, Rasmus P; Gajhede, Michael; Kastrup, Jette S; Traynelis, Stephen F.

    In: Molecular Pharmacology, Vol. 89, No. 2, 02.2016, p. 253-262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A pharmacological profile of the high-affinity GluK5 kainate receptor. / Møllerud, Stine; Kastrup, Jette Sandholm Jensen; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 788, 2016, p. 315-320.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. / Krintel, Christian; Francotte, Pierre; Pickering, Darryl S; Juknaite, Lina; Pøhlsgaaard, Jakob; Olsen, Lars; Frydenvang, Karla Andrea; Goffin, Eric; Pirotte, Bernard; Kastrup, Jette Sandholm Jensen.

    In: Biophysical Journal, Vol. 110, No. 11, 2016, p. 2397-2406.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate. / Kristensen, Ole; Kristensen, Lise Baadsgaard; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Structure, Vol. 24, No. 9, 2016, p. 1582-1589.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. / Szymanska, Ewa; Frydenvang, Karla Andrea; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda Grønborg; Olsen, Lars; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 1, 2016, p. 448-461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues. / Wang, Shuang-Yan; Larsen, Younes; Navarrete, Cristina V.; Jensen, Anders A.; Nielsen, Birgitte; Al-Musaed, Ali; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 5, 2016, p. 2244-2254.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2015
  11. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures. / Christiansen, G B; Harbak, Barbara; Hede, S E; Gouliaev, A H; Olsen, Lars; Frydenvang, K; Egebjerg, J; Kastrup, J S; Holm, M M.

    In: Neuroscience, Vol. 310, 03.12.2015, p. 709-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Structural Studies of Nicotinic Acetylcholine Receptors : Using Acetylcholine Binding Protein as a Structural Surrogate. / Shahsavar, Azadeh; Gajhede, Michael; Kastrup, Jette S; Balle, Thomas.

    In: Basic & Clinical Pharmacology & Toxicology Online, Vol. 118, No. 6, 17.11.2015, p. 399–407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. / Shahsavar, Azadeh; Ahring, Philip K; Olsen, Jeppe A; Krintel, Christian; Kastrup, Jette S; Balle, Thomas; Gajhede, Michael.

    In: Molecular Pharmacology, Vol. 88, No. 4, 10.2015, p. 697-707.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. / Demmer, Charles S; Møller, Charlotte; Brown, Patricia M G E; Han, Liwei; Pickering, Darryl S; Nielsen, Birgitte; Bowie, Derek; Frydenvang, Karla; Kastrup, Jette S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 6, 09.04.2015, p. 845-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface. / Ahring, Philip K; Olsen, Jeppe A; Nielsen, Elsebet Ø; Peters, Dan; Pedersen, Martin H F; Rohde, Line A; Kastrup, Jette Sandholm Jensen; Shahsavar, Azadeh; Indurthi, Dinesh C; Chebib, Mary; Gajhede, Michael; Balle, Thomas.

    In: Neuropharmacology, Vol. 92, 2015, p. 135-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Storgaard, Morten; Møller, Charlotte; Demmer, Charles S; Hansen, Jeanette; Han, Liwei; Monrad, Rune N; Nielsen, Birgitte; Tapken, Daniel; Pickering, Darryl S; Kastrup, Jette S; Frydenvang, Karla; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 15, 2015, p. 6131-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2014
  18. Published

    Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain : Combining Experimental and Computational Methods Unravels Differences in Driving Forces. / Nørholm, Ann-Beth; Francotte, Pierre; Goffin, Eric; Botez, Iuliana; Danober, Laurence; Lestage, Pierre; Pirotte, Bernard; Kastrup, Jette Sandholm Jensen; Olsen, Lars; Oostenbrink, Chris.

    In: Journal of Chemical Information and Modeling, Vol. 54, No. 12, 22.12.2014, p. 3404-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. / Francotte, Pierre; Nørholm, Ann-Beth; Deva, Taru; Olsen, Lars; Frydenvang, Karla; Goffin, Eric; Fraikin, Pierre; de Tullio, Pascal; Challal, Sylvie; Thomas, Jean-Yves; Iop, Fabrice; Louis, Caroline; Botez-Pop, Iuliana; Lestage, Pierre; Danober, Laurence; Kastrup, Jette Sandholm Jensen; Pirotte, Bernard.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 22, 26.11.2014, p. 9539-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors. / Olsen, Jeppe A; Ahring, Philip K; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Balle, Thomas.

    In: The Journal of Biological Chemistry, Vol. 289, No. 36, 05.09.2014, p. 24911-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors. / Olsen, Jeppe A.; Balle, Thomas; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm Jensen.

    In: PLOS ONE, Vol. 9, No. 3, 17.03.2014, p. e91232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2013
  25. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. / Olsen, Jeppe A.; Kastrup, Jette Sandholm Jensen; Peters, Dan; Gajhede, Michael; Balle, Thomas; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 50, 13.12.2013, p. 35997.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. / Nørholm, Ann-Beth; Francotte, Pierre; Olsen, Lars; Krintel, Christian; Frydenvang, Karla; Goffin, Eric; Challal, Sylvie; Danober, Laurence; Botez-Pop, Iuliana; Lestage, Pierre; Pirotte, Bernard; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 21, 14.11.2013, p. 8736-45.

    Research output: Contribution to journalJournal articleResearch

  27. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. / Fiorentini, Monica; Bach, Anders; Strømgaard, Kristian; Kastrup, Jette S; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 69, No. Pt 4, 04.2013, p. 587-94.

    Research output: Contribution to journalJournal articleResearch

  29. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. / Harpsøe, Kasper; Hald, Helle; Timmermann, Daniel B; Jensen, Marianne L; Dyhring, Tino; Nielsen, Elsebet Ø; Peters, Dan; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 4, 25.01.2013, p. 2559-2570.

    Research output: Contribution to journalJournal articleResearchpeer-review

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