Jette Sandholm Jensen Kastrup
Jette Sandholm Jensen Kastrup

Professor

  • Peptides and Proteins

    Jagtvej 162

    2100 København Ø

    Phone: +45 35 33 64 86

Introductory remarks on publicationslist


Publications 1988-2013 by Jette Sandholm Kastrup

Peer-reviewed: 93

    1990-1994: 4
    1995-1999: 12
    2000-2004: 17
    2005-2009: 37
    2010-May 2013: 23

Books (editor, chapters): 7
Patents: 2
Other publications: 28
PhD thesis: 1
Structures deposited in the Protein Data Bank: 106


  1. Published
  2. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

    Research output: Contribution to journalJournal article

  3. Published
  4. Published

    Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue

    Blicher, T., Kastrup, Jette Sandholm Jensen, Pedersen, L. Ø., Buus, Søren & Gajhede, Michael, 2006, In : Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 62, Pt 12, p. 1179-84 5 p.

    Research output: Contribution to journalJournal article

  5. Published

    High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide

    Blicher, T., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2005, In : Acta Crystallographica. Section D: Biological Crystallography. 61, Pt 8, p. 1031-40 9 p.

    Research output: Contribution to journalJournal article

  6. Published

    The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove

    Champion, E., Remaud-Simeon, M., Skov, L. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2009, In : Acta Crystallographica. Section D: Biological Crystallography. 65, 12, p. 1309-1314

    Research output: Contribution to journalJournal article

  7. Published
  8. Published

    Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides

    Ernst, H. A., Pham, A., Hald, H., Kastrup, Jette Sandholm Jensen, Rahman, M. & Mirza, Osman Asghar, 2009, In : Biochemical and Biophysical Research Communications. 389, 1, p. 112-116

    Research output: Contribution to journalJournal article

  9. Published

    Structure of the first PDZ domain of human PSD-93

    Fiorentini, M., Nielsen, A. K., Kristensen, O., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2009, In : Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 65, 12, p. 1254-1257

    Research output: Contribution to journalJournal article

  10. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In : Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journalJournal article

  11. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2

    Frandsen, A., Pickering, Darryl S, Vestergaard, Bente, Kasper, C., Nielsen, B. B., Greenwood, J. R., Campiani, G., Fattorusso, C., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In : Molecular Pharmacology. 67, 3, p. 703-13 10 p.

    Research output: Contribution to journalJournal article

  12. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

    Frydenvang, Karla Andrea, Lash, L. L., Naur, P., Postila, P. A., Pickering, Darryl S, Smith, C. M., Gajhede, Michael, Sasaki, M., Sakai, R., Pentikäinen, O. T., Swanson, G. T. & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Biological Chemistry. 284, 21, p. 14219-14229

    Research output: Contribution to journalJournal article

  13. Published

    At være eller ikke være en antagonist

    Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In : Lægemiddelforskning. p. 43-45

    Research output: Contribution to journalJournal article

  14. Published

    På jagt efter et virkningssted i hjernen

    Frydenvang, Karla Andrea, Juknaite, L. & Kastrup, Jette Sandholm Jensen, 2013, In : Lægemiddelforskning. p. 50-52 3 p.

    Research output: Contribution to journalJournal article

  15. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

    Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In : Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

    Research output: Contribution to journalJournal article

  16. Published

    Peptide nucleic acids (PNA) derived from N-(N-methylamino-ethyl)glycine. Synthesis, hybridization and structural roperties

    Haaima, G., Rasmussen, H. B., Schmidt, G., Jensen, D. K., Kastrup, Jette Sandholm Jensen, Stafshede, P. W., Nordén, B., Buchardt, O. & Nielsen, Peter E., 1999, In : New. J. Chem.. 23, p. 833-840 8 p.

    Research output: Contribution to journalJournal article

  17. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

    Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Molecular Biology. 391, 5, p. 906-917

    Research output: Contribution to journalJournal article

  18. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

    Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In : Journal of Biological Chemistry. 282, 35, p. 25726-25736

    Research output: Contribution to journalJournal article

  19. Published

    Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium

    Hansen, K. B., Naur, P., Kurtkaya, N. L., Kristensen, Anders Skov, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., 2009, In : Journal of Neuroscience. 29, 4, p. 907-917

    Research output: Contribution to journalJournal article

  20. Published

    Computeren viser vejen til et nyt potentielt lægemiddel

    Harpsøe, Kasper, Kaae, B. H., Balle, T., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In : Lægemiddelforskning. p. 28-30

    Research output: Contribution to journalJournal article

  21. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

    Harpsøe, Kasper, Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Ahring, P. K., 25 Jan 2013, In : Journal of Biological Chemistry. 288, 4, p. 2559-2570 12 p.

    Research output: Contribution to journalJournal article

  22. Published

    Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core

    Hogner, A., Kastrup, Jette Sandholm Jensen, Jin, R., Liljefors, T., Mayer, M. L., Egebjerg, J., Larsen, I. K. & Gouaux, E., 6 Sep 2002, In : Journal of Molecular Biology. 322, 1, p. 93-109 17 p.

    Research output: Contribution to journalJournal article

  23. Published

    Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

    Hogner, A., Greenwood, J. R., Liljefors, T., Lunn, M., Egebjerg, J., Larsen, I. K., Gouaux, E. & Kastrup, Jette Sandholm Jensen, 16 Jan 2003, In : Journal of Medicinal Chemistry. 46, 2, p. 214-21 8 p.

    Research output: Contribution to journalJournal article

  24. Published

    Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2

    Holm, M. M., Lunn, M., Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Egebjerg, J., 23 Aug 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 12053-8 6 p.

    Research output: Contribution to journalJournal article

  25. Published

    Structure and function of the N-linked glycans of HBP/CAP37/azurocidin: crystal structure determination and biological characterization of nonglycosylated HBP

    Iversen, L. F., Kastrup, Jette Sandholm Jensen, Bjørn, S. E., Wiberg, F. C., Larsen, I. K., Flodgaard, H. J. & Rasmussen, P. B., Oct 1999, In : Protein Science. 8, 10, p. 2019-26 8 p.

    Research output: Contribution to journalJournal article

  26. Published

    Crystallization and molecular replacement solution of human heparin binding protein

    Iversen, L. F., Kastrup, Jette Sandholm Jensen, Larsen, I. K., Bjørn, S. E., Rasmussen, P. B., Wiberg, F. C. & Flodgaard, H. J., 1996, In : Acta Crystallographica. Section D: Biological Crystallography. 52, p. 1222-1223 2 p.

    Research output: Contribution to journalJournal article

  27. Published

    Structure of HBP, a multifunctional protein with a serine proteinase fold

    Iversen, L. F., Kastrup, Jette Sandholm Jensen, Bjørn, S. E., Wiberg, F. C., Flodgaard, H. J. & Larsen, I. K., 1997, In : Nature Struc. Biology. 4, p. 265-268 4 p.

    Research output: Contribution to journalJournal article

  28. Published

    Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies

    Iversen, L. F., Brzozowski, M., Hastrup, S., Larsen, I. K., Kastrup, Jette Sandholm Jensen, Nærum, L., Nørskov-Lauridsen, L., Rasmussen, P. B., Thim, L., Wiberg, F. C. & Lundgren, K., 1997, In : Protein Sci.. 6, p. 971-982 12 p.

    Research output: Contribution to journalJournal article

  29. Published

    Gennembrud i forståelsen af insulinfibrillering

    Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In : Lægemiddelforskning. p. 10-11

    Research output: Contribution to journalJournal article

  30. Published

    Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity

    Johannessen, B. R., Skov, L., Kastrup, Jette Sandholm Jensen, Kristensen, O., Bolwig, C., Larsen, J., Spangfort, M., Lund, K. & Gajhede, Michael, 2005, In : F E B S Letters. 579, 5, p. 1208-12 5 p.

    Research output: Contribution to journalJournal article

  31. Published

    Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization

    Juknaite, L., Sugamata, Y., Tokiwa, K., Ishikawa, Y., Takamizawa, S., Eng, A., Sakai, R., Pickering, Darryl S, Frydenvang, Karla Andrea, Swanson, G. T., Kastrup, Jette Sandholm Jensen & Oikawa, M., 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2283-2293

    Research output: Contribution to journalJournal article

  32. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In : Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journalJournal article

  33. Published

    Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

    Jørgensen, A. D., Nøhr, J., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sigurskjold, B. W., Sauer, J., Svergun, D. I., Svensson, B. & Vestergaard, Bente, 2008, In : Journal of Biological Chemistry. 283, 21, p. 14772-14780

    Research output: Contribution to journalJournal article

  34. Published

    Biostructure-based drug design

    Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 29-42

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  35. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

    Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In : American Chemical Society. Abstracts of Papers (at the National Meeting). 234

    Research output: Contribution to journalConference abstract in journal

  36. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In : Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journalJournal article

  37. Published

    Atomic resolution structure of human HBP/CAP37/Azurocidin

    Karlsen, S., Iversen, L. F., Larsen, I. K., Flodgaard, H. J. & Kastrup, Jette Sandholm Jensen, 1998, In : Acta Crystallographica. Section D: Biological Crystallography. 54, p. 598-609 12 p.

    Research output: Contribution to journalJournal article

  38. Published

    Structural basis of cell-cell adhesion by NCAM

    Kasper, C., Rasmussen, H., Kastrup, Jette Sandholm Jensen, Ikemizu, S., Jones, E. Y., Berezin, V., Bock, E. & Larsen, I. K., 2000, In : Nature Structural and Molecular Biology. 7, 5, p. 389-393 5 p.

    Research output: Contribution to journalJournal article

  39. Published

    GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists

    Kasper, C., Lunn, M., Liljefors, T., Gouaux, E., Egebjerg, J. & Kastrup, Jette Sandholm Jensen, 6 Nov 2002, In : F E B S Letters. 531, 2, p. 173-8 6 p.

    Research output: Contribution to journalJournal article

  40. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209

    Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In : Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.

    Research output: Contribution to journalJournal article

  41. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In : FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journalJournal article

  42. Published

    Crystallization and preliminary X-ray analysis of a PNA-DNA complex

    Kastrup, Jette Sandholm Jensen, Pilgaard, M. & Nielsen, Peter E., 17 Apr 1995, In : FEBS letters. 363, 1-2, p. 115-7 3 p.

    Research output: Contribution to journalJournal article

  43. Published

    Structure of the C-type lectin carbohydrate recognition domain of human Tetranectin

    Kastrup, Jette Sandholm Jensen, Nielsen, B. B., Rasmussen, H. B., Las Holtet, T., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., 1998, In : Acta Crystallographica. Section D: Biological Crystallography. 54, p. 757-766 10 p.

    Research output: Contribution to journalJournal article

  44. Published

    Human plasminogen binding protein tetranectin: crystallization and preliminary X-ray analysis of the C-type lectin CRD and the full-length protein

    Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Nielsen, B. B., Larsen, I. K., Las Holtet, T., Graversen, J. H., Etzerodt, M. & Thøgersen, H. C., 1997, In : Acta Crystallographica. Section D: Biological Crystallography. 53, p. 108-111 4 p.

    Research output: Contribution to journalJournal article

  45. Published

    X-ray structure of the 154-amino-acid form of recombinant human basic fibroblast growth factor. Comparison with the truncated 146-amino-acid Form

    Kastrup, Jette Sandholm Jensen, Eriksson, E. S., Dalbøge, H. & Flodgaard, H., 1997, In : Acta Crystallographica. Section D: Biological Crystallography. 53, p. 160-168 9 p.

    Research output: Contribution to journalJournal article

  46. Published

    Crystallization and preliminary X-ray analysis of a PNA-DNA complex

    Kastrup, Jette Sandholm Jensen, Pilgaard, M., Jørgensen, Flemming Steen, Nielsen, Peter E. & Rasmussen, H. B., 1995, In : FEBS Letters. 363, p. 115-117 3 p.

    Research output: Contribution to journalJournal article

  47. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In : Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journalJournal article

  48. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Dorvil, Linda Grønborg, Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In : Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journalJournal article

  49. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In : F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journalJournal article

  50. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, Paul, Kastrup, Jette Sandholm Jensen, Helin, Kristian, Olsen, L. & Gajhede, Michael, Jun 2012, In : F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journalJournal article

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