Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors. / Dallanoce, Clelia; Magrone, Pietro; Matera, Carlo; Frigerio, Fabio; Grazioso, Giovanni; De Amici, Marco; Fucile, Sergio; Piccari, Vanessa; Frydenvang, Karla Andrea; Pucci, Luca; Gotti, Cecilia; Clementi, Francesco; De Micheli, Carlo.

    In: ChemMedChem, Vol. 6, No. 5, 02.05.2011, p. 889-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists. / Conti, Paola; De Amici, Marco; Grazioso, Giovanni; Roda, Gabriella; Barberis Negra, Federico F; Nielsen, Birgitte; Stensbøl, Tine B; Madsen, Ulf; Bräuner-Osborne, Hans; Frydenvang, Karla Andrea; De Sarro, Giovambattista; Toma, Lucio; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 47, No. 27, 30.12.2004, p. 6740-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. / Krintel, Christian; Francotte, Pierre; Pickering, Darryl S; Juknaite, Lina; Pøhlsgaaard, Jakob; Olsen, Lars; Frydenvang, Karla Andrea; Goffin, Eric; Pirotte, Bernard; Kastrup, Jette Sandholm Jensen.

    In: Biophysical Journal, Vol. 110, No. 11, 2016, p. 2397-2406.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published
  6. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. / Giraudo, Alessandro; Krall, Jacob; Bavo, Francesco; Nielsen, Birgitte; Kongstad, Kenneth Thermann; Rolando, Barbara; De Blasio, Rosella; Gloriam, David E; Löffler, Rebekka; Thiesen, Louise; Harpsøe, Kasper; Frydenvang, Karla; Boschi, Donatella; Wellendorph, Petrine; Lolli, Marco L; Jensen, Anders A.; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 12, 27.06.2019, p. 5797-5809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Functionalized Helical beta-Peptoids. / Wellhofer, Isabelle; Frydenvang, Karla; Kotesova, Simona; Christiansen, Andreas M.; Laursen, Jonas Striegler; Olsen, Christian A.

    In: Journal of Organic Chemistry, Vol. 84, No. 7, 05.04.2019, p. 3762-3779.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. / Krogsgaard-Larsen, P; Frølund, B; Frydenvang, Karla Andrea.

    In: Current Pharmaceutical Design, Vol. 6, No. 12, 2000, p. 1193-209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects. / Frølund, Bente; Krogsgaard-Larsen, Povl; Kristiansen, Uffe; Frydenvang, Karla Andrea; Ebert, Bjarke .

    In: European Journal of Pharmaceutical Sciences, Vol. 4, 1997, p. 355–384.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer. / Frydenvang, Karla Andrea; Kristiansen, Uffe; Frølund, Bente; Herdeis, C; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 7, 1995, p. 526–533.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    GABAB antagonists : resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen. / Frydenvang, Karla Andrea; Hansen, J J; Krogsgaard-Larsen, P; Mitrovic, A; Tran, H; Drew, C A; Johnston, G A.

    In: Chirality, Vol. 6, No. 7, 1994, p. 583-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Glutamate receptor ligands : synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs. / Guldbrandt, Mette; Johansen, Tommy N; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Nielsen, Birgitte; Karla, Rolf; Santi, Flavio; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Chirality, Vol. 14, No. 4, 2002, p. 351-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. / Larsen, Anja Probst; Fièvre, Sabine; Frydenvang, Karla; Francotte, Pierre; Pirotte, Bernard; Kastrup, Jette Sandholm; Mulle, Christophe.

    In: Molecular Pharmacology, Vol. 91, No. 6, 06.2017, p. 576-585.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation. / Jensen, Christina Mernøe; Chow, Hsiao-Qing; Chen, Ming; Zhai, Lin; Frydenvang, Karla Andrea; Liu, Huizhen ; Franzyk, Henrik; Christensen, Søren Brøgger.

    In: European Journal of Medicinal Chemistry, Vol. 114, 2016, p. 118-133.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Iminolactones from Schizophyllum commune. / Liu, Xuemei; Frydenvang, Karla Andrea; Liu, Huizhen; Zhai, Lin; Chen, Ming; Olsen, Carl Erik; Christensen, Søren Brøgger.

    In: Journal of Natural Products, Vol. 78, No. 5, 2015, p. 1165-1168.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Kainate induces various domain closures in AMPA and kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Hald, Helle; Rabassa, Anna Ceravalls de; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm.

    In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 536-545.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Lessons from crystal structures of kainate receptors. / Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Neuropharmacology, Vol. 112, No. Part A, 01.01.2017, p. 16-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. / Pøhlsgaard, Jacob; Frydenvang, Karla Andrea; Madsen, Ulf; Kastrup, Jette Sandholm.

    In: Neuropharmacology, Vol. 60, No. 1, 01.01.2011, p. 135-150.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. / Hassan, Ahmed R; El-Kousy, Salah M; El-Toumy, Sayed A; Frydenvang, Karla; Tung, Truong Thanh; Olsen, Jesper; Nielsen, John; Christensen, Søren Brøgger.

    In: Journal of Natural Products, Vol. 80, 27.10.2017, p. 2830-2834.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines. / Crestey, Francois Louis Jean; Witt, Matthias; Frydenvang, Karla Andrea; Stærk, Dan; Jaroszewski, Jerzy; Franzyk, Henrik.

    In: Synfacts, Vol. 7, 2008, p. 769.

    Research output: Contribution to journalJournal articleResearch

  23. Published

    Microwave-assisted ring-opening of activated aziridines with resin-bound amines. / Crestey, Francois; Witt, Matthias; Frydenvang, Karla Andrea; Stærk, Dan; Jaroszewski, Jerzy W.; Franzyk, Henrik.

    In: Journal of Organic Chemistry, Vol. 73, No. 9, 2008, p. 3566-3569.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1305625