Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol. / Frydenvang, Karla; Verkade-Vreeker, Marlies C A; Dohmen, Floor; Commandeur, Jan N M; Rafiq, Maria; Mirza, Osman; Jørgensen, Flemming Steen; Geerke, Daan P.

    In: PLoS ONE, Vol. 14, No. 5, e0217292, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors. / Johansen, Tommy N; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 15, No. 2, 2003, p. 167-79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Stereospecific GABA-B receptor antagonism. / Frydenvang, Karla Andrea; Frølund, Bente; Kristiansen, Uffe; Krogsgaard-Larsen, Povl.

    GABA, receptors, transporters and metabolism. ed. / C Tanaka; N.G. Bowery. Basel : Birkhäuser Verlag, 1996.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  5. Published

    Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist. / Stensbøl, T B; Jensen, H S; Nielsen, B; Johansen, T N; Egebjerg, J; Frydenvang, Karla Andrea; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 411, No. 3, 2001, p. 245-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Some transformations of tacrolimus, an immunosuppressive drug. / Skytte, Dorthe Mondrup; Jaroszewski, Jerzy W.; Johansen, Kenneth; Hansen, Steen Honore'; Hansen, Liselotte; G. Nielsen, Peter; Frydenvang, Karla Andrea.

    In: European Journal of Pharmaceutical Sciences, Vol. 48, No. 3, 2013, p. 514-522.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Solid forms of amlodipine besylate : Physiochemical, structural, and thermodynamic characterization. / Koradia, Vishal Shamji; Lopez de Diego, Heidi; Frydenvang, Karla Andrea; Ringkjøbing-Elema, Michiel; Müllertz, Anette; Bond, Andrew D; Rantanen, Jukka.

    In: Crystal Growth & Design, Vol. 10, No. 12, 28.10.2010, p. 5279-5290.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida. / Rubal, Juan J; Guerra, Francisco M; Moreno-Dorado, F Javier; Jorge, Zacarías D; Massanet, Guillermo M; Søhoel, Helmer; Smitt, Ulla W; Frydenvang, Karla Andrea; Christensen, S Brøgger; Nielsen, Charlotte; Eriksson, Margit.

    In: Journal of Natural Products, Vol. 69, No. 11, 2006, p. 1566-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. / Venskutonyte, Raminta; Butini, Stefania; Coccone, Salvatore Sanna; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Ergeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 13, 14.07.2011, p. 4793-4805.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues. / Falch, Erik; Frølund, Bente; Perregaard; Sanchez, Connie; Søkilde, Birgitte; Buur, Anders; Hansen, Anette; Frydenvang, Karla Andrea; Brehm, Lotte; Bolvig, Tina; Larsson, Orla Miller; Schousboe, Arne; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 42, 1999, p. 5402–5414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist. / Vogensen, S B; Jensen, H S; Stensbøl, T B; Frydenvang, Karla Andrea; Bang-Andersen, B; Johansen, T N; Egebjerg, J; Krogsgaard-Larsen, P.

    In: Chirality, Vol. 12, No. 10, 2000, p. 705-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published
  13. Published

    Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid : a novel conformationally restricted glutamic acid analogue. / Bunch, Lennart; Liljefors, Tommy; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Journal of Organic Chemistry, Vol. 68, No. 4, 2003, p. 1489-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    På jagt efter et virkningssted i hjernen. / Frydenvang, Karla Andrea; Juknaite, Lina; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2013, p. 50-52.

    Research output: Contribution to journalJournal articleCommunication

  15. Published

    Psychrophilin A and Cycloaspeptide D, novel cyclic peptides from the psychrotolerant fungus Penicillium ribeum. / Dalsgaard, Petur Weihe; Larsen, Thomas Ostenfeld; Frydenvang, Karla Andrea; Christophersen, Carsten.

    In: Journal of Natural Products, Vol. 67, No. 5, 2004, p. 878-881.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. / Francotte, Pierre; Nørholm, Ann-Beth; Deva, Taru; Olsen, Lars; Frydenvang, Karla; Goffin, Eric; Fraikin, Pierre; de Tullio, Pascal; Challal, Sylvie; Thomas, Jean-Yves; Iop, Fabrice; Louis, Caroline; Botez-Pop, Iuliana; Lestage, Pierre; Danober, Laurence; Kastrup, Jette Sandholm Jensen; Pirotte, Bernard.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 22, 26.11.2014, p. 9539-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Plant analysis by butterflies : occurrence of cyclopentenylglycines in Passifloraceae, Flacourtiaceae, and Turneraceae and discovery of the novel nonproteinogenic amino acid 2-(3'-cyclopentenyl)glycine in Rinorea. / Clausen, Vicki; Frydenvang, Karla Andrea; Koopmann, Ricarda; Jørgensen, Lise Bolt; Abbiw, Daniel K; Ekpe, Patrick; Jaroszewski, Jerzy W.

    In: Journal of Natural Products, Vol. 65, No. 4, 2002, p. 542-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors. / Møllerud, Stine; Pallesen, Jakob Staun; Pasini, Diletta; Marconi, Laura; Han, Liwei; Bornholt, Jan; Johansen, Tommy Nørskov; Kastrup, Jette Sandholm ; Pickering, Darryl S; Frydenvang, Karla Andrea.

    In: Journal of Neurochemistry, Vol. 142, No. S1, MTU07-13, 08.2017, p. 124.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  19. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.

    In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands : design, synthesis, and binding studies. / Høg, Signe; Wellendorph, Petrine; Nielsen, Birgitte; Frydenvang, Karla; Dahl, Ivar F; Bräuner-Osborne, Hans; Brehm, Lotte; Frølund, Bente; Clausen, Rasmus P.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 24, 2008, p. 8088-8095.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus : synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations. / Dallanoce, Clelia; Magrone, Pietro; Bazza, Paola; Grazioso, Giovanni; Rizzi, Luca; Riganti, Loredana; Gotti, Cecilia; Clementi, Francesco; Frydenvang, Karla Andrea; De Amici, Marco.

    In: Chemistry & Biodiversity, Vol. 6, No. 2, 2009, p. 244-259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors. / Dawe, G. Brent; Kadir, Md Fahim; Venskutonyte, Raminta; Perozzo, Amanda M.; Yan, Yuhao; Alexander, Ryan P. D.; Navarrete, Camilo; Santander, Eduardo A.; Arsenault, Marika; Fuentes, Christian; Aurousseau, Mark R. P.; Frydenvang, Karla; Barrera, Nelson P.; Kastrup, Jette S.; Edwardson, J. Michael; Bowie, Derek.

    In: Neuron, Vol. 102, No. 5, 05.06.2019, p. 976-+.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology. / Pallesen, Jakob Staun; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Bornholt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: A C S Chemical Neuroscience, Vol. 10, 20.03.2019, p. 1841-1853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    N-methyl-D-aspartic acid receptor agonists : resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. / Madsen, U; Frydenvang, Karla Andrea; Ebert, B; Johansen, T N; Brehm, L; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 39, No. 1, 1996, p. 183-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1305625