Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. / Bach, Anders; Stuhr-Hansen, Nicolai; Thorsen, Thor S; Bork, Nicolai; Moreira, Irina S; Frydenvang, Karla; Padrah, Shahrokh; Christensen, S Brøgger; Madsen, Kenneth L; Weinstein, Harel; Gether, Ulrik; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 8, No. 19, 2010, p. 4281-4288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol. / Bunch, L; Norrby, Per-Ola; Frydenvang, Karla Andrea; Krogsgaard-Larsen, P; Madsen, U.

    In: Organic Letters, Vol. 3, No. 3, 2001, p. 433-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid : a novel conformationally restricted glutamic acid analogue. / Bunch, Lennart; Liljefors, Tommy; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Journal of Organic Chemistry, Vol. 68, No. 4, 2003, p. 1489-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. / Christensen, Mette Knak; Erichsen, Kamille Dumong; Trojel-Hansen, Christina; Tjørnelund, Jette; Nielsen, Søren Jensby; Frydenvang, Karla Andrea; Johansen, Tommy Nørskov; Nielsen, Birgitte; Sehested, Maxwell; Jensen, Peter Buhl; Ikaunieks, Martins; Zaichenko, Andrei; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 14.10.2010, p. 7140-7145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Plant analysis by butterflies : occurrence of cyclopentenylglycines in Passifloraceae, Flacourtiaceae, and Turneraceae and discovery of the novel nonproteinogenic amino acid 2-(3'-cyclopentenyl)glycine in Rinorea. / Clausen, Vicki; Frydenvang, Karla Andrea; Koopmann, Ricarda; Jørgensen, Lise Bolt; Abbiw, Daniel K; Ekpe, Patrick; Jaroszewski, Jerzy W.

    In: Journal of Natural Products, Vol. 65, No. 4, 2002, p. 542-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists. / Conti, Paola; De Amici, Marco; Grazioso, Giovanni; Roda, Gabriella; Barberis Negra, Federico F; Nielsen, Birgitte; Stensbøl, Tine B; Madsen, Ulf; Bräuner-Osborne, Hans; Frydenvang, Karla Andrea; De Sarro, Giovambattista; Toma, Lucio; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 47, No. 27, 30.12.2004, p. 6740-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid. / Conti, Paolo; Caligiuri, Antonio; Pinto, Andrea; Roda, Gabriella; Tamborini, Lucia; Nielsen, Birgitte; Madsen, Ulf; Frydenvang, Karla Andrea; Colombo, Alessio; De Micheli, Carlo.

    In: European Journal of Medicinal Chemistry, Vol. 42, No. 8, 2007, p. 1059-1068.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Microwave-assisted ring-opening of activated aziridines with resin-bound amines. / Crestey, Francois; Witt, Matthias; Frydenvang, Karla Andrea; Stærk, Dan; Jaroszewski, Jerzy W.; Franzyk, Henrik.

    In: Journal of Organic Chemistry, Vol. 73, No. 9, 2008, p. 3566-3569.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines. / Crestey, Francois Louis Jean; Witt, Matthias; Frydenvang, Karla Andrea; Stærk, Dan; Jaroszewski, Jerzy; Franzyk, Henrik.

    In: Synfacts, Vol. 7, 2008, p. 769.

    Research output: Contribution to journalJournal articleResearch

  10. Published

    New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus : synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations. / Dallanoce, Clelia; Magrone, Pietro; Bazza, Paola; Grazioso, Giovanni; Rizzi, Luca; Riganti, Loredana; Gotti, Cecilia; Clementi, Francesco; Frydenvang, Karla Andrea; De Amici, Marco.

    In: Chemistry & Biodiversity, Vol. 6, No. 2, 2009, p. 244-259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Psychrophilin A and Cycloaspeptide D, novel cyclic peptides from the psychrotolerant fungus Penicillium ribeum. / Dalsgaard, Petur Weihe; Larsen, Thomas Ostenfeld; Frydenvang, Karla Andrea; Christophersen, Carsten.

    In: Journal of Natural Products, Vol. 67, No. 5, 2004, p. 878-881.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1 : 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). / Erichsen, Mette Norman; Huynh, Tri Hien Viet; Abrahamsen, Bjarke; Bastlund, Jesper Frank; Bundgaard, Christoffer; Monrad, Olja; Bekker-Jensen, Anders; Nielsen, Christina Wøhlk; Frydenvang, Karla Andrea; Jensen, Anders Asbjørn; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 2010, p. 7180–7191.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues. / Falch, Erik; Frølund, Bente; Perregaard; Sanchez, Connie; Søkilde, Birgitte; Buur, Anders; Hansen, Anette; Frydenvang, Karla Andrea; Brehm, Lotte; Bolvig, Tina; Larsson, Orla Miller; Schousboe, Arne; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 42, 1999, p. 5402–5414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Stereospecific GABA-B receptor antagonism. / Frydenvang, Karla Andrea; Frølund, Bente; Kristiansen, Uffe; Krogsgaard-Larsen, Povl.

    GABA, receptors, transporters and metabolism. ed. / C Tanaka; N.G. Bowery. Basel : Birkhäuser Verlag, 1996.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  15. Published

    GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer. / Frydenvang, Karla Andrea; Kristiansen, Uffe; Frølund, Bente; Herdeis, C; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 7, 1995, p. 526–533.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Conformational analysis of acetylcholine and related choline esters. / Frydenvang, Karla Andrea; Jensen, B.

    In: Acta Crystallographica. Section B: Structural Science, Vol. 52 ( Pt 1), 1996, p. 184-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    At være eller ikke være en antagonist. / Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2009, p. 43-45.

    Research output: Contribution to journalJournal articleCommunication

  18. Published

    GABAB antagonists : resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen. / Frydenvang, Karla Andrea; Hansen, J J; Krogsgaard-Larsen, P; Mitrovic, A; Tran, H; Drew, C A; Johnston, G A.

    In: Chirality, Vol. 6, No. 7, 1994, p. 583-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    2-(2,3-Dihydro-1H-indol-3-yl)ethanol : synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis. / Frydenvang, Karla Andrea; Sommer, Michael Bech; Heckmann, Dieter; Nielsen, Ole; Bang-Andersen, Benny.

    In: Chirality, Vol. 16, No. 2, 2004, p. 126-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. / Frydenvang, Karla Andrea; Pickering, Darryl S; Greenwood, Jeremy R; Krogsgaard-Larsen, Niels; Brehm, Lotte; Nielsen, Birgitte; Vogensen, Stine Byskov; Hald, Helle; Kastrup, Jette Sandholm; Krogsgaard-Larsen, Povl; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 23, 10.11.2010, p. 8354-8361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects. / Frølund, Bente; Krogsgaard-Larsen, Povl; Kristiansen, Uffe; Frydenvang, Karla Andrea; Ebert, Bjarke .

    In: European Journal of Pharmaceutical Sciences, Vol. 4, 1997, p. 355–384.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Glutamate receptor ligands : synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs. / Guldbrandt, Mette; Johansen, Tommy N; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Nielsen, Birgitte; Karla, Rolf; Santi, Flavio; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Chirality, Vol. 14, No. 4, 2002, p. 351-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands : design, synthesis, and binding studies. / Høg, Signe; Wellendorph, Petrine; Nielsen, Birgitte; Frydenvang, Karla; Dahl, Ivar F; Bräuner-Osborne, Hans; Brehm, Lotte; Frølund, Bente; Clausen, Rasmus P.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 24, 2008, p. 8088-8095.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Carbamoylcholine homologs : synthesis and pharmacology at nicotinic acetylcholine receptors. / Jensen, Anders A.; Mikkelsen, Ivan Bisgaard; Frølund, Bente; Frydenvang, Karla; Brehm, Lotte; Jaroszewski, Jerzy W; Bräuner-Osborne, Hans; Falch, Erik; Krogsgaard-Larsen, Povl.

    In: European Journal of Pharmacology, Vol. 497, No. 2, 2004, p. 125-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
  27. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands. / Johansen, T N; Frydenvang, Karla Andrea; Ebert, B; Krogsgaard-Larsen, P; Madsen, U.

    In: Journal of Medicinal Chemistry, Vol. 37, No. 20, 1994, p. 3252-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published
  29. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid : resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors. / Johansen, Tommy N; Janin, Yves L; Nielsen, Birgitte; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Vogensen, Stine B; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 10, No. 7, 2002, p. 2259-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors. / Johansen, Tommy N; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 15, No. 2, 2003, p. 167-79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Solid forms of amlodipine besylate : Physiochemical, structural, and thermodynamic characterization. / Koradia, Vishal Shamji; Lopez de Diego, Heidi; Frydenvang, Karla Andrea; Ringkjøbing-Elema, Michiel; Müllertz, Anette; Bond, Andrew D; Rantanen, Jukka.

    In: Crystal Growth & Design, Vol. 10, No. 12, 28.10.2010, p. 5279-5290.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C-H insertion. / Krogsgaard-Larsen, Niels; Begtrup, Mikael; Frydenvang, Karla Andrea; Kehler, Jan .

    In: Tetrahedron, Vol. 66, No. 47, 20.11.2010, p. 9297-9303.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. / Krogsgaard-Larsen, P; Frølund, B; Frydenvang, Karla Andrea.

    In: Current Pharmaceutical Design, Vol. 6, No. 12, 2000, p. 1193-209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid. / Larsen, T O; Frydenvang, Karla Andrea; Frisvad, Jens Christian; Christophersen, C.

    In: Journal of Natural Products, Vol. 61, No. 9, 1998, p. 1154-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. / Madsen, U; Bräuner-Osborne, H; Frydenvang, Karla Andrea; Hvene, L; Johansen, T N; Nielsen, B; Sánchez, C; Stensbøl, T B; Bischoff, F; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 7, 2001, p. 1051-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    N-methyl-D-aspartic acid receptor agonists : resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. / Madsen, U; Frydenvang, Karla Andrea; Ebert, B; Johansen, T N; Brehm, L; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 39, No. 1, 1996, p. 183-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug. / Nielsen, Anders Bach; Frydenvang, Karla Andrea; Liljefors, Tommy; Buur, Anders; Larsen, Claus.

    In: European Journal of Pharmaceutical Sciences, Vol. 24, No. 1, 2005, p. 85-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx. / Oketch-Rabah, H A; Brøgger Christensen, S; Frydenvang, K; Dossaji, S F; Theander, T G; Cornett, C; Watkins, W M; Kharazmi, A; Lemmich, E.

    In: Planta Medica, Vol. 64, No. 6, 1998, p. 559-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Antiprotozoal compounds from Asparagus africanus. / Oketch-Rabah, H A; Dossaji, S F; Christensen, S B; Frydenvang, K; Lemmich, E; Cornett, C; Olsen, C E; Chen, M; Kharazmi, A; Theander, T.

    In: Journal of Natural Products, Vol. 60, No. 10, 1997, p. 1017-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    UV-guided screening of benzodiazepine producing species in Penicillium. / Ostenfeld Larsen T, ; Frydenvang, Karla Andrea; Christian Frisvad J.

    In: Biochemical Systematics and Ecology, Vol. 28, No. 9, 2000, p. 881-886.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications. / Overy, David P.; Larsen, Thomas O.; Dalsgaard, Petur Weihe; Frydenvang, Karla Andrea; Phipps, Richard; Munro, Murray H. G.; Christophersen, Carsten.

    In: Mycological Research, No. 109, 2005, p. 1243-1249.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Aqueous solubility study of salts of benzylamine derivatives and p-substituted benzoic acid derivatives using X-ray crystallographic analysis. / Parshad, Henrik; Frydenvang, Karla Andrea; Liljefors, Tommy; Sorensen, Henning Osholm; Larsen, Claus.

    In: International Journal of Pharmaceutics, Vol. 269, No. 1, 2004, p. 157-68.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Assessment of drug salt release from solutions, suspensions and in situ suspensions using a rotating dialysis cell. / Parshad, Henrik; Frydenvang, Karla; Liljefors, Tommy; Cornett, Claus; Larsen, Claus.

    In: European Journal of Pharmaceutical Sciences, Vol. 19, No. 4, 2003, p. 263-272.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Correlation of aqueous solubility of salts of benzylamine with experimentally and theoretically derived parameters. A multivariate data analysis approach. / Parshad, Henrik; Frydenvang, Karla Andrea; Liljefors, Tommy; Larsen, Claus Selch.

    In: International Journal of Pharmaceutics, Vol. 237, No. 1-2, 2002, p. 193-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline. / Pedersen, H; Bräuner-Osborne, H; Ball, R G; Frydenvang, Karla Andrea; Meier, E; Bøgesø, K P; Krogsgaard-Larsen, P.

    In: Bioorganic & Medicinal Chemistry, Vol. 7, No. 5, 1999, p. 795-809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida. / Rubal, Juan J; Guerra, Francisco M; Moreno-Dorado, F Javier; Jorge, Zacarías D; Massanet, Guillermo M; Søhoel, Helmer; Smitt, Ulla W; Frydenvang, Karla Andrea; Christensen, S Brøgger; Nielsen, Charlotte; Eriksson, Margit.

    In: Journal of Natural Products, Vol. 69, No. 11, 2006, p. 1566-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug. / Skytte, Dorthe Mondrup; Frydenvang, Karla Andrea; Hansen, Liselotte; Nielsen, Peter G; Jaroszewski, Jerzy W.

    In: Journal of Natural Products, Vol. 73, No. 4, 18.02.2010, p. 776-779.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist. / Stensbøl, T B; Jensen, H S; Nielsen, B; Johansen, T N; Egebjerg, J; Frydenvang, Karla Andrea; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 411, No. 3, 2001, p. 245-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist. / Vogensen, S B; Jensen, H S; Stensbøl, T B; Frydenvang, Karla Andrea; Bang-Andersen, B; Johansen, T N; Egebjerg, J; Krogsgaard-Larsen, P.

    In: Chirality, Vol. 12, No. 10, 2000, p. 705-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

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