Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. 2019
  2. Published

    Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors. / Dawe, G. Brent; Kadir, Md Fahim; Venskutonyte, Raminta; Perozzo, Amanda M.; Yan, Yuhao; Alexander, Ryan P. D.; Navarrete, Camilo; Santander, Eduardo A.; Arsenault, Marika; Fuentes, Christian; Aurousseau, Mark R. P.; Frydenvang, Karla; Barrera, Nelson P.; Kastrup, Jette S.; Edwardson, J. Michael; Bowie, Derek.

    In: Neuron, Vol. 102, No. 5, 05.06.2019, p. 976-+.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol. / Frydenvang, Karla; Verkade-Vreeker, Marlies C A; Dohmen, Floor; Commandeur, Jan N M; Rafiq, Maria; Mirza, Osman; Jørgensen, Flemming Steen; Geerke, Daan P.

    In: PLoS ONE, Vol. 14, No. 5, e0217292, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. / Giraudo, Alessandro; Krall, Jacob; Bavo, Francesco; Nielsen, Birgitte; Kongstad, Kenneth Thermann; Rolando, Barbara; De Blasio, Rosella; Gloriam, David E; Löffler, Rebekka; Thiesen, Louise; Harpsøe, Kasper; Frydenvang, Karla; Boschi, Donatella; Wellendorph, Petrine; Lolli, Marco L; Jensen, Anders A.; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 12, 27.06.2019, p. 5797-5809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. / Laulumaa, Saara; Hansen, Kathrine Voigt; Masternak, Magdalena; Drapier, Thomas; Francotte, Pierre; Pirotte, Bernard; Frydenvang, Karla; Kastrup, Jette Sandholm.

    In: ACS Medicinal Chemistry Letters, Vol. 10, No. 3, 14.03.2019, p. 243-247.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. E-pub ahead of print
  7. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology. / Pallesen, Jakob Staun; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Bornholt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: A C S Chemical Neuroscience, Vol. 10, 20.03.2019, p. 1841-1853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters. / Poulie, Christian Bernard Matthijs; Alcaide Lopez, Anna; Krell-Jørgensen, Mikkel Poul; Larsen, Younes; Astier, Eloi; Bjørn-Yoshimoto, Walden; Yi, Feng; Syrenne, Jed T; Storgaard, Morten; Nielsen, Birgitte; Frydenvang, Karla Andrea; Jensen, Anders A.; Hansen, Kasper B; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 10, No. 6, 19.06.2019, p. 2989-3007.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Functionalized Helical beta-Peptoids. / Wellhofer, Isabelle; Frydenvang, Karla; Kotesova, Simona; Christiansen, Andreas M.; Laursen, Jonas Striegler; Olsen, Christian A.

    In: Journal of Organic Chemistry, Vol. 84, No. 7, 05.04.2019, p. 3762-3779.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2018
  11. Published

    (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation. / Brogi, Simone; Brindisi, Marghertia; Butini, Stefania; Kshirsagar, Giridhar; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonyte, Raminta; Han, Liwei; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 5, 08.03.2018, p. 2124-2130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. / Goffin, Eric; Drapier, Thomas; Larsen, Anja Probst; Geubelle, Pierre; Ptak, Christopher P; Laulumaa, Saara; Rovinskaja, Karoline; Gilissen, Julie; Tullio, Pascal de; Olsen, Lars; Frydenvang, Karla; Pirotte, Bernard; Hanson, Julien; Oswald, Robert E; Kastrup, Jette Sandholm; Francotte, Pierre.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 1, 01.2018, p. 251–264.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2017
  14. Published

    Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. / Hassan, Ahmed R; El-Kousy, Salah M; El-Toumy, Sayed A; Frydenvang, Karla; Tung, Truong Thanh; Olsen, Jesper; Nielsen, John; Christensen, Søren Brøgger.

    In: Journal of Natural Products, Vol. 80, 27.10.2017, p. 2830-2834.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. / Larsen, Anja Probst; Fièvre, Sabine; Frydenvang, Karla; Francotte, Pierre; Pirotte, Bernard; Kastrup, Jette Sandholm; Mulle, Christophe.

    In: Molecular Pharmacology, Vol. 91, No. 6, 06.2017, p. 576-585.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Lessons from crystal structures of kainate receptors. / Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Neuropharmacology, Vol. 112, No. Part A, 01.01.2017, p. 16-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors. / Møllerud, Stine; Pallesen, Jakob Staun; Pasini, Diletta; Marconi, Laura; Han, Liwei; Bornholt, Jan; Johansen, Tommy Nørskov; Kastrup, Jette Sandholm ; Pickering, Darryl S; Frydenvang, Karla Andrea.

    In: Journal of Neurochemistry, Vol. 142, No. S1, MTU07-13, 08.2017, p. 124.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  19. Published

    Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors. / Møllerud, Stine; Pinto, Andrea; Marconi, Laura; Frydenvang, Karla Andrea; Thorsen, Thor Seneca; Laulumaa, Saara Kaisa; Venskutonyte, Raminta; Winther, Nikolaj; Cunado Moral, Ana Maria; Tamborini, Lucia; Conti, Paola; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: A C S Chemical Neuroscience, Vol. 8, No. 9, 2017, p. 2056-2064.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2016
  21. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation. / Jensen, Christina Mernøe; Chow, Hsiao-Qing; Chen, Ming; Zhai, Lin; Frydenvang, Karla Andrea; Liu, Huizhen ; Franzyk, Henrik; Christensen, Søren Brøgger.

    In: European Journal of Medicinal Chemistry, Vol. 114, 2016, p. 118-133.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. / Krintel, Christian; Francotte, Pierre; Pickering, Darryl S; Juknaite, Lina; Pøhlsgaaard, Jakob; Olsen, Lars; Frydenvang, Karla Andrea; Goffin, Eric; Pirotte, Bernard; Kastrup, Jette Sandholm Jensen.

    In: Biophysical Journal, Vol. 110, No. 11, 2016, p. 2397-2406.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate. / Kristensen, Ole; Kristensen, Lise Baadsgaard; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Structure, Vol. 24, No. 9, 2016, p. 1582-1589.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. / Larsen, Anja Probst; Francotte, Pierre; Frydenvang, Karla; Tapken, Daniel; Goffin, Eric; Fraikin, Pierre; Caignard, Daniel-Henri; Lestage, Pierre; Danober, Laurence; Pirotte, Bernard; Kastrup, Jette Sandholm.

    In: A C S Chemical Neuroscience, Vol. 7, No. 3, 16.03.2016, p. 378-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. / Szymanska, Ewa; Frydenvang, Karla Andrea; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda Grønborg; Olsen, Lars; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 1, 2016, p. 448-461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues. / Wang, Shuang-Yan; Larsen, Younes; Navarrete, Cristina V.; Jensen, Anders A.; Nielsen, Birgitte; Al-Musaed, Ali; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 5, 2016, p. 2244-2254.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2015
  28. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures. / Christiansen, G B; Harbak, Barbara; Hede, S E; Gouliaev, A H; Olsen, Lars; Frydenvang, K; Egebjerg, J; Kastrup, J S; Holm, M M.

    In: Neuroscience, Vol. 310, 03.12.2015, p. 709-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. / Demmer, Charles S; Møller, Charlotte; Brown, Patricia M G E; Han, Liwei; Pickering, Darryl S; Nielsen, Birgitte; Bowie, Derek; Frydenvang, Karla; Kastrup, Jette S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 6, 09.04.2015, p. 845-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Storgaard, Morten; Møller, Charlotte; Demmer, Charles S; Hansen, Jeanette; Han, Liwei; Monrad, Rune N; Nielsen, Birgitte; Tapken, Daniel; Pickering, Darryl S; Kastrup, Jette S; Frydenvang, Karla; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 15, 2015, p. 6131-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Iminolactones from Schizophyllum commune. / Liu, Xuemei; Frydenvang, Karla Andrea; Liu, Huizhen; Zhai, Lin; Chen, Ming; Olsen, Carl Erik; Christensen, Søren Brøgger.

    In: Journal of Natural Products, Vol. 78, No. 5, 2015, p. 1165-1168.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2014
  33. Published

    Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. / Francotte, Pierre; Nørholm, Ann-Beth; Deva, Taru; Olsen, Lars; Frydenvang, Karla; Goffin, Eric; Fraikin, Pierre; de Tullio, Pascal; Challal, Sylvie; Thomas, Jean-Yves; Iop, Fabrice; Louis, Caroline; Botez-Pop, Iuliana; Lestage, Pierre; Danober, Laurence; Kastrup, Jette Sandholm Jensen; Pirotte, Bernard.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 22, 26.11.2014, p. 9539-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Advances towards aromatic oligoamide foldamers : synthesis and X-ray structures of dimeric arylopeptoids with conformation-directing side chains. / Hjelmgaard, Thomas; Plesner, Malene; Dissing, Mette Marie; Andersen, Jeanette Marker; Frydenvang, Karla Andrea; Nielsen, John.

    In: European Journal of Organic Chemistry, Vol. 2014, No. 19, 2014, p. 3971-3975.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2013
  39. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    På jagt efter et virkningssted i hjernen. / Frydenvang, Karla Andrea; Juknaite, Lina; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2013, p. 50-52.

    Research output: Contribution to journalJournal articleCommunication

  41. Published

    Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159 : asymmetric synthesis, neuroactivity, and structural characterization. / Juknaite, Lina; Sugamata, Yutaro; Tokiwa, Kazuya; Ishikawa, Yuichi; Takamizawa, Satoshi; Eng, Andrew; Sakai, Ryuichi; Pickering, Darryl S; Frydenvang, Karla; Swanson, Geoffrey T; Kastrup, Jette Sandholm Jensen; Oikawa, Masato.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 6, 2013, p. 2283-2293.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. / Nørholm, Ann-Beth; Francotte, Pierre; Olsen, Lars; Krintel, Christian; Frydenvang, Karla; Goffin, Eric; Challal, Sylvie; Danober, Laurence; Botez-Pop, Iuliana; Lestage, Pierre; Pirotte, Bernard; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 21, 14.11.2013, p. 8736-45.

    Research output: Contribution to journalJournal articleResearch

  44. Published

    Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists. / Petersen, Jette Gellert; Bergmann, Rikke; Møller, Henriette A.; Jørgensen, Charlotte Grube; Nielsen, Birgitte; Kehler, Jan; Frydenvang, Karla ; Kristensen, Jesper; Balle, Thomas; Jensen, Anders A.; Kristiansen, Uffe; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 993-1006.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Some transformations of tacrolimus, an immunosuppressive drug. / Skytte, Dorthe Mondrup; Jaroszewski, Jerzy W.; Johansen, Kenneth; Hansen, Steen Honore'; Hansen, Liselotte; G. Nielsen, Peter; Frydenvang, Karla Andrea.

    In: European Journal of Pharmaceutical Sciences, Vol. 48, No. 3, 2013, p. 514-522.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2012
  47. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.

    In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. / Krintel, Christian; Frydenvang, Karla; Olsen, Lars; Kristensen, Maria T; de Barrios, Oriol; Naur, Peter; Francotte, Pierre; Pirotte, Bernard; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Biochemical Journal, Vol. 441, No. 1, 01.01.2012, p. 173-178.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Kainate induces various domain closures in AMPA and kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Hald, Helle; Rabassa, Anna Ceravalls de; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm.

    In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 536-545.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Valadés, Elena Antón; Szymanska, Ewa Monika; Johansen, Tommy N; Kastrup, Jette S; Pickering, Darryl S.

    In: ChemMedChem, Vol. 7, No. 10, 10.2012, p. 1793-1798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2011
  52. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors. / Dallanoce, Clelia; Magrone, Pietro; Matera, Carlo; Frigerio, Fabio; Grazioso, Giovanni; De Amici, Marco; Fucile, Sergio; Piccari, Vanessa; Frydenvang, Karla Andrea; Pucci, Luca; Gotti, Cecilia; Clementi, Francesco; De Micheli, Carlo.

    In: ChemMedChem, Vol. 6, No. 5, 02.05.2011, p. 889-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. / Pøhlsgaard, Jacob; Frydenvang, Karla Andrea; Madsen, Ulf; Kastrup, Jette Sandholm.

    In: Neuropharmacology, Vol. 60, No. 1, 01.01.2011, p. 135-150.

    Research output: Contribution to journalReviewResearchpeer-review

  54. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. / Venskutonyte, Raminta; Butini, Stefania; Coccone, Salvatore Sanna; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Ergeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 13, 14.07.2011, p. 4793-4805.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2010
  58. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. / Bach, Anders; Stuhr-Hansen, Nicolai; Thorsen, Thor S; Bork, Nicolai; Moreira, Irina S; Frydenvang, Karla; Padrah, Shahrokh; Christensen, S Brøgger; Madsen, Kenneth L; Weinstein, Harel; Gether, Ulrik; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 8, No. 19, 2010, p. 4281-4288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. / Christensen, Mette Knak; Erichsen, Kamille Dumong; Trojel-Hansen, Christina; Tjørnelund, Jette; Nielsen, Søren Jensby; Frydenvang, Karla Andrea; Johansen, Tommy Nørskov; Nielsen, Birgitte; Sehested, Maxwell; Jensen, Peter Buhl; Ikaunieks, Martins; Zaichenko, Andrei; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 14.10.2010, p. 7140-7145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1 : 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). / Erichsen, Mette Norman; Huynh, Tri Hien Viet; Abrahamsen, Bjarke; Bastlund, Jesper Frank; Bundgaard, Christoffer; Monrad, Olja; Bekker-Jensen, Anders; Nielsen, Christina Wøhlk; Frydenvang, Karla Andrea; Jensen, Anders Asbjørn; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 2010, p. 7180–7191.

    Research output: Contribution to journalJournal articleResearchpeer-review

Previous 1 2 Next

ID: 1305625