Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. 2019
  2. Published
  3. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. / Giraudo, Alessandro; Krall, Jacob; Bavo, Francesco; Nielsen, Birgitte; Kongstad, Kenneth Thermann; Rolando, Barbara; De Blasio, Rosella; Gloriam, David E; Löffler, Rebekka; Thiesen, Louise; Harpsøe, Kasper; Frydenvang, Karla; Boschi, Donatella; Wellendorph, Petrine; Lolli, Marco L; Jensen, Anders A.; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 12, 27.06.2019, p. 5797-5809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters. / Poulie, Christian Bernard Matthijs; Alcaide Lopez, Anna; Krell-Jørgensen, Mikkel Poul; Larsen, Younes; Astier, Eloi; Bjørn-Yoshimoto, Walden; Yi, Feng; Syrenne, Jed T; Storgaard, Morten; Nielsen, Birgitte; Frydenvang, Karla Andrea; Jensen, Anders A.; Hansen, Kasper B; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 10, No. 6, 19.06.2019, p. 2989-3007.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors. / Dawe, G. Brent; Kadir, Md Fahim; Venskutonyte, Raminta; Perozzo, Amanda M.; Yan, Yuhao; Alexander, Ryan P. D.; Navarrete, Camilo; Santander, Eduardo A.; Arsenault, Marika; Fuentes, Christian; Aurousseau, Mark R. P.; Frydenvang, Karla; Barrera, Nelson P.; Kastrup, Jette S.; Edwardson, J. Michael; Bowie, Derek.

    In: Neuron, Vol. 102, No. 5, 05.06.2019, p. 976-+.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Functionalized Helical beta-Peptoids. / Wellhofer, Isabelle; Frydenvang, Karla; Kotesova, Simona; Christiansen, Andreas M.; Laursen, Jonas Striegler; Olsen, Christian A.

    In: Journal of Organic Chemistry, Vol. 84, No. 7, 05.04.2019, p. 3762-3779.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology. / Pallesen, Jakob Staun; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Bornholt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: A C S Chemical Neuroscience, Vol. 10, 20.03.2019, p. 1841-1853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. / Laulumaa, Saara; Hansen, Kathrine Voigt; Masternak, Magdalena; Drapier, Thomas; Francotte, Pierre; Pirotte, Bernard; Frydenvang, Karla; Kastrup, Jette Sandholm.

    In: ACS Medicinal Chemistry Letters, Vol. 10, No. 3, 14.03.2019, p. 243-247.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structural analysis of Cytochrome P450 BM3 mutant M11 in complex with dithiothreitol. / Frydenvang, Karla; Verkade-Vreeker, Marlies C A; Dohmen, Floor; Commandeur, Jan N M; Rafiq, Maria; Mirza, Osman; Jørgensen, Flemming Steen; Geerke, Daan P.

    In: PLoS ONE, Vol. 14, No. 5, e0217292, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2018
  11. Published

    (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation. / Brogi, Simone; Brindisi, Marghertia; Butini, Stefania; Kshirsagar, Giridhar; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonyte, Raminta; Han, Liwei; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 5, 08.03.2018, p. 2124-2130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. / Goffin, Eric; Drapier, Thomas; Larsen, Anja Probst; Geubelle, Pierre; Ptak, Christopher P; Laulumaa, Saara; Rovinskaja, Karoline; Gilissen, Julie; Tullio, Pascal de; Olsen, Lars; Frydenvang, Karla; Pirotte, Bernard; Hanson, Julien; Oswald, Robert E; Kastrup, Jette Sandholm; Francotte, Pierre.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 1, 01.2018, p. 251–264.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2017
  14. Published

    Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula. / Hassan, Ahmed R; El-Kousy, Salah M; El-Toumy, Sayed A; Frydenvang, Karla; Tung, Truong Thanh; Olsen, Jesper; Nielsen, John; Christensen, Søren Brøgger.

    In: Journal of Natural Products, Vol. 80, 27.10.2017, p. 2830-2834.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors. / Møllerud, Stine; Pallesen, Jakob Staun; Pasini, Diletta; Marconi, Laura; Han, Liwei; Bornholt, Jan; Johansen, Tommy Nørskov; Kastrup, Jette Sandholm ; Pickering, Darryl S; Frydenvang, Karla Andrea.

    In: Journal of Neurochemistry, Vol. 142, No. S1, MTU07-13, 08.2017, p. 124.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  16. Published

    Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. / Larsen, Anja Probst; Fièvre, Sabine; Frydenvang, Karla; Francotte, Pierre; Pirotte, Bernard; Kastrup, Jette Sandholm; Mulle, Christophe.

    In: Molecular Pharmacology, Vol. 91, No. 6, 06.2017, p. 576-585.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Lessons from crystal structures of kainate receptors. / Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Neuropharmacology, Vol. 112, No. Part A, 01.01.2017, p. 16-28.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structure and affinity of two bicyclic glutamate analogues at AMPA and kainate receptors. / Møllerud, Stine; Pinto, Andrea; Marconi, Laura; Frydenvang, Karla Andrea; Thorsen, Thor Seneca; Laulumaa, Saara Kaisa; Venskutonyte, Raminta; Winther, Nikolaj; Cunado Moral, Ana Maria; Tamborini, Lucia; Conti, Paola; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: A C S Chemical Neuroscience, Vol. 8, No. 9, 2017, p. 2056-2064.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2016
  21. Published

    Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. / Larsen, Anja Probst; Francotte, Pierre; Frydenvang, Karla; Tapken, Daniel; Goffin, Eric; Fraikin, Pierre; Caignard, Daniel-Henri; Lestage, Pierre; Danober, Laurence; Pirotte, Bernard; Kastrup, Jette Sandholm.

    In: A C S Chemical Neuroscience, Vol. 7, No. 3, 16.03.2016, p. 378-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. / Krintel, Christian; Francotte, Pierre; Pickering, Darryl S; Juknaite, Lina; Pøhlsgaaard, Jakob; Olsen, Lars; Frydenvang, Karla Andrea; Goffin, Eric; Pirotte, Bernard; Kastrup, Jette Sandholm Jensen.

    In: Biophysical Journal, Vol. 110, No. 11, 2016, p. 2397-2406.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation. / Jensen, Christina Mernøe; Chow, Hsiao-Qing; Chen, Ming; Zhai, Lin; Frydenvang, Karla Andrea; Liu, Huizhen ; Franzyk, Henrik; Christensen, Søren Brøgger.

    In: European Journal of Medicinal Chemistry, Vol. 114, 2016, p. 118-133.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate. / Kristensen, Ole; Kristensen, Lise Baadsgaard; Møllerud, Stine; Frydenvang, Karla Andrea; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: Structure, Vol. 24, No. 9, 2016, p. 1582-1589.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. / Szymanska, Ewa; Frydenvang, Karla Andrea; Pickering, Darryl S; Krintel, Christian; Nielsen, Birgitte; Kooshki, Ayesheh; Zachariassen, Linda Grønborg; Olsen, Lars; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 1, 2016, p. 448-461.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Tweaking subtype-selectivity and agonist efficacy at (S)-2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptors in a small series of BnTetAMPA analogues. / Wang, Shuang-Yan; Larsen, Younes; Navarrete, Cristina V.; Jensen, Anders A.; Nielsen, Birgitte; Al-Musaed, Ali; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 59, No. 5, 2016, p. 2244-2254.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2015
  28. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures. / Christiansen, G B; Harbak, Barbara; Hede, S E; Gouliaev, A H; Olsen, Lars; Frydenvang, K; Egebjerg, J; Kastrup, J S; Holm, M M.

    In: Neuroscience, Vol. 310, 03.12.2015, p. 709-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. / Demmer, Charles S; Møller, Charlotte; Brown, Patricia M G E; Han, Liwei; Pickering, Darryl S; Nielsen, Birgitte; Bowie, Derek; Frydenvang, Karla; Kastrup, Jette S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 6, 09.04.2015, p. 845-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Iminolactones from Schizophyllum commune. / Liu, Xuemei; Frydenvang, Karla Andrea; Liu, Huizhen; Zhai, Lin; Chen, Ming; Olsen, Carl Erik; Christensen, Søren Brøgger.

    In: Journal of Natural Products, Vol. 78, No. 5, 2015, p. 1165-1168.

    Research output: Contribution to journalJournal articleResearchpeer-review

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