Karla Andrea Frydenvang
Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. Published

    Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

    Conti, P., De Amici, M., Grazioso, G., Roda, G., Barberis Negra, F. F., Nielsen, Birgitte, Stensbøl, T. B., Madsen, Ulf, Bräuner-Osborne, Hans, Frydenvang, Karla Andrea, De Sarro, G., Toma, L. & De Micheli, C., 30 Dec 2004, In : Journal of Medicinal Chemistry. 47, 27, p. 6740-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

    Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In : Biophysical Journal. 110, 11, p. 2397-2406 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

    Giraudo, A., Krall, J., Bavo, F., Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, L., Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In : Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

    Frydenvang, Karla Andrea, Lash, L. L., Naur, P., Postila, P. A., Pickering, Darryl S, Smith, C. M., Gajhede, Michael, Sasaki, M., Sakai, R., Pentikäinen, O. T., Swanson, G. T. & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Biological Chemistry. 284, 21, p. 14219-14229

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Functionalized Helical beta-Peptoids

    Wellhöfer, Isabelle, Frydenvang, Karla Andrea, Kotesova, S., Christiansen, A. M., Laursen, J. S. & Olsen, Christian Adam, 5 Apr 2019, In : Journal of Organic Chemistry. 84, 7, p. 3762-3779

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects

    Krogsgaard-Larsen, Povl, Frølund, Bente & Frydenvang, Karla Andrea, 2000, In : Current Pharmaceutical Design. 6, 12, p. 1193-209 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs

    Guldbrandt, M., Johansen, Tommy Nørskov, Frydenvang, Karla Andrea, Bräuner-Osborne, Hans, Stensbøl, T. B., Nielsen, Birgitte, Karla, R., Santi, F., Krogsgaard-Larsen, Povl & Madsen, Ulf, 2002, In : Chirality. 14, 4, p. 351-63 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

    Larsen, A. P., Fièvre, S., Frydenvang, Karla Andrea, Francotte, P., Pirotte, B., Kastrup, Jette Sandholm Jensen & Mulle, C., Jun 2017, In : Molecular Pharmacology. 91, 6, p. 576-585 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Iminolactones as Tools for Inversion of the Absolute Configuration of alpha-Amino Acids and as Inhibitors of Cancer Cell Proliferation

    Jensen, C. M., Chow, H., Chen, M., Zhai, L., Frydenvang, Karla Andrea, Liu, H., Franzyk, Henrik & Christensen, Søren Brøgger, 2016, In : European Journal of Medicinal Chemistry. 114, p. 118-133 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Iminolactones from Schizophyllum commune

    Liu, X., Frydenvang, Karla Andrea, Liu, H., Zhai, L., Chen, M., Olsen, C. E. & Christensen, Søren Brøgger, 2015, In : Journal of Natural Products. 78, 5, p. 1165-1168 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Kainate induces various domain closures in AMPA and kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In : Neurochemistry International. 61, 4, p. 536-545

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In : F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Lessons from crystal structures of kainate receptors

    Møllerud, Stine, Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 1 Jan 2017, In : Neuropharmacology. 112, Part A, p. 16-28 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

    Pøhlsgaard, J., Frydenvang, Karla Andrea, Madsen, Ulf & Kastrup, Jette Sandholm Jensen, 1 Jan 2011, In : Neuropharmacology. 60, 1, p. 135-150

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

    Hassan, A. R., El-Kousy, S. M., El-Toumy, S. A., Frydenvang, Karla Andrea, Tung, T. T., Olsen, J., Nielsen, John & Christensen, Søren Brøgger, 27 Oct 2017, In : Journal of Natural Products. 80, p. 2830-2834 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines

    Crestey, F. L. J., Witt, M., Frydenvang, Karla Andrea, Stærk, Dan, Jaroszewski, J. & Franzyk, Henrik, 2008, In : Synfacts. 7, p. 769 1 p.

    Research output: Contribution to journalJournal articleResearch

  17. Published

    Microwave-assisted ring-opening of activated aziridines with resin-bound amines

    Crestey, F., Witt, M., Frydenvang, Karla Andrea, Stærk, Dan, Jaroszewski, J. W. & Franzyk, Henrik, 2008, In : Journal of Organic Chemistry. 73, 9, p. 3566-3569 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In : FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In : ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

    Pallesen, J. S., Møllerud, Stine, Frydenvang, Karla Andrea, Pickering, Darryl S, Bornholt, J., Nielsen, Birgitte, Pasini, D., Han, L., Marconi, L., Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 20 Mar 2019, In : A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

    Dawe, G. B., Kadir, M. F., Venskutonyte, R., Perozzo, A. M., Yan, Y., Alexander, R. P. D., Navarrete, C., Santander, E. A., Arsenault, M., Fuentes, C., Aurousseau, M. R. P., Frydenvang, Karla Andrea, Barrera, N. P., Kastrup, Jette Sandholm Jensen, Edwardson, J. M. & Bowie, D., 5 Jun 2019, In : Neuron. 102, 5, p. 976-+

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations

    Dallanoce, C., Magrone, P., Bazza, P., Grazioso, G., Rizzi, L., Riganti, L., Gotti, C., Clementi, F., Frydenvang, Karla Andrea & De Amici, M., 2009, In : Chemistry & Biodiversity. 6, 2, p. 244-259

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies

    Høg, S., Wellendorph, Petrine, Nielsen, Birgitte, Frydenvang, Karla Andrea, Dahl, I. F., Bräuner-Osborne, Hans, Brehm, L., Frølund, Bente & Clausen, Rasmus Prætorius, 2008, In : Journal of Medicinal Chemistry. 51, 24, p. 8088-8095

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In : Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

    Møllerud, Stine, Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Frydenvang, Karla Andrea, Aug 2017, In : Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

ID: 1305625