Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. Published

    (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation. / Brogi, Simone; Brindisi, Marghertia; Butini, Stefania; Kshirsagar, Giridhar; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonyte, Raminta; Han, Liwei; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 5, 08.03.2018, p. 2124-2130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    2-(2,3-Dihydro-1H-indol-3-yl)ethanol : synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis. / Frydenvang, Karla Andrea; Sommer, Michael Bech; Heckmann, Dieter; Nielsen, Ole; Bang-Andersen, Benny.

    In: Chirality, Vol. 16, No. 2, 2004, p. 126-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid : resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors. / Johansen, Tommy N; Janin, Yves L; Nielsen, Birgitte; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Vogensen, Stine B; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 10, No. 7, 2002, p. 2259-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. / Goffin, Eric; Drapier, Thomas; Larsen, Anja Probst; Geubelle, Pierre; Ptak, Christopher P; Laulumaa, Saara; Rovinskaja, Karoline; Gilissen, Julie; Tullio, Pascal de; Olsen, Lars; Frydenvang, Karla; Pirotte, Bernard; Hanson, Julien; Oswald, Robert E; Kastrup, Jette Sandholm; Francotte, Pierre.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 1, 01.2018, p. 251–264.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures. / Christiansen, G B; Harbak, Barbara; Hede, S E; Gouliaev, A H; Olsen, Lars; Frydenvang, K; Egebjerg, J; Kastrup, J S; Holm, M M.

    In: Neuroscience, Vol. 310, 03.12.2015, p. 709-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Advances towards aromatic oligoamide foldamers : synthesis and X-ray structures of dimeric arylopeptoids with conformation-directing side chains. / Hjelmgaard, Thomas; Plesner, Malene; Dissing, Mette Marie; Andersen, Jeanette Marker; Frydenvang, Karla Andrea; Nielsen, John.

    In: European Journal of Organic Chemistry, Vol. 2014, No. 19, 2014, p. 3971-3975.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. Published

    Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications. / Overy, David P.; Larsen, Thomas O.; Dalsgaard, Petur Weihe; Frydenvang, Karla Andrea; Phipps, Richard; Munro, Murray H. G.; Christophersen, Carsten.

    In: Mycological Research, No. 109, 2005, p. 1243-1249.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Aqueous solubility study of salts of benzylamine derivatives and p-substituted benzoic acid derivatives using X-ray crystallographic analysis. / Parshad, Henrik; Frydenvang, Karla Andrea; Liljefors, Tommy; Sorensen, Henning Osholm; Larsen, Claus.

    In: International Journal of Pharmaceutics, Vol. 269, No. 1, 2004, p. 157-68.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Assessment of drug salt release from solutions, suspensions and in situ suspensions using a rotating dialysis cell. / Parshad, Henrik; Frydenvang, Karla; Liljefors, Tommy; Cornett, Claus; Larsen, Claus.

    In: European Journal of Pharmaceutical Sciences, Vol. 19, No. 4, 2003, p. 263-272.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug. / Nielsen, Anders Bach; Frydenvang, Karla Andrea; Liljefors, Tommy; Buur, Anders; Larsen, Claus.

    In: European Journal of Pharmaceutical Sciences, Vol. 24, No. 1, 2005, p. 85-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    At være eller ikke være en antagonist. / Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2009, p. 43-45.

    Research output: Contribution to journalJournal articleCommunication

  15. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. / Demmer, Charles S; Møller, Charlotte; Brown, Patricia M G E; Han, Liwei; Pickering, Darryl S; Nielsen, Birgitte; Bowie, Derek; Frydenvang, Karla; Kastrup, Jette S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 6, 09.04.2015, p. 845-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. / Frydenvang, Karla Andrea; Pickering, Darryl S; Greenwood, Jeremy R; Krogsgaard-Larsen, Niels; Brehm, Lotte; Nielsen, Birgitte; Vogensen, Stine Byskov; Hald, Helle; Kastrup, Jette Sandholm; Krogsgaard-Larsen, Povl; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 23, 10.11.2010, p. 8354-8361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Carbamoylcholine homologs : synthesis and pharmacology at nicotinic acetylcholine receptors. / Jensen, Anders A.; Mikkelsen, Ivan Bisgaard; Frølund, Bente; Frydenvang, Karla; Brehm, Lotte; Jaroszewski, Jerzy W; Bräuner-Osborne, Hans; Falch, Erik; Krogsgaard-Larsen, Povl.

    In: European Journal of Pharmacology, Vol. 497, No. 2, 2004, p. 125-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Correlation of aqueous solubility of salts of benzylamine with experimentally and theoretically derived parameters. A multivariate data analysis approach. / Parshad, Henrik; Frydenvang, Karla Andrea; Liljefors, Tommy; Larsen, Claus Selch.

    In: International Journal of Pharmaceutics, Vol. 237, No. 1-2, 2002, p. 193-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. / Laulumaa, Saara; Hansen, Kathrine Voigt; Masternak, Magdalena; Drapier, Thomas; Francotte, Pierre; Pirotte, Bernard; Frydenvang, Karla; Kastrup, Jette Sandholm.

    In: ACS Medicinal Chemistry Letters, Vol. 10, No. 3, 14.03.2019, p. 243-247.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters. / Poulie, Christian Bernard Matthijs; Alcaide Lopez, Anna; Krell-Jørgensen, Mikkel Poul; Larsen, Younes; Astier, Eloi; Bjørn-Yoshimoto, Walden; Yi, Feng; Syrenne, Jed T; Storgaard, Morten; Nielsen, Birgitte; Frydenvang, Karla Andrea; Jensen, Anders A.; Hansen, Kasper B; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 10, No. 6, 19.06.2019, p. 2989-3007.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors. / Dallanoce, Clelia; Magrone, Pietro; Matera, Carlo; Frigerio, Fabio; Grazioso, Giovanni; De Amici, Marco; Fucile, Sergio; Piccari, Vanessa; Frydenvang, Karla Andrea; Pucci, Luca; Gotti, Cecilia; Clementi, Francesco; De Micheli, Carlo.

    In: ChemMedChem, Vol. 6, No. 5, 02.05.2011, p. 889-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists. / Conti, Paola; De Amici, Marco; Grazioso, Giovanni; Roda, Gabriella; Barberis Negra, Federico F; Nielsen, Birgitte; Stensbøl, Tine B; Madsen, Ulf; Bräuner-Osborne, Hans; Frydenvang, Karla Andrea; De Sarro, Giovambattista; Toma, Lucio; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 47, No. 27, 30.12.2004, p. 6740-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

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