Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. 2011
  2. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors. / Dallanoce, Clelia; Magrone, Pietro; Matera, Carlo; Frigerio, Fabio; Grazioso, Giovanni; De Amici, Marco; Fucile, Sergio; Piccari, Vanessa; Frydenvang, Karla Andrea; Pucci, Luca; Gotti, Cecilia; Clementi, Francesco; De Micheli, Carlo.

    In: ChemMedChem, Vol. 6, No. 5, 02.05.2011, p. 889-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. / Pøhlsgaard, Jacob; Frydenvang, Karla Andrea; Madsen, Ulf; Kastrup, Jette Sandholm.

    In: Neuropharmacology, Vol. 60, No. 1, 01.01.2011, p. 135-150.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. / Venskutonyte, Raminta; Butini, Stefania; Coccone, Salvatore Sanna; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Ergeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 13, 14.07.2011, p. 4793-4805.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2010
  8. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. / Bach, Anders; Stuhr-Hansen, Nicolai; Thorsen, Thor S; Bork, Nicolai; Moreira, Irina S; Frydenvang, Karla; Padrah, Shahrokh; Christensen, S Brøgger; Madsen, Kenneth L; Weinstein, Harel; Gether, Ulrik; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 8, No. 19, 2010, p. 4281-4288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. / Christensen, Mette Knak; Erichsen, Kamille Dumong; Trojel-Hansen, Christina; Tjørnelund, Jette; Nielsen, Søren Jensby; Frydenvang, Karla Andrea; Johansen, Tommy Nørskov; Nielsen, Birgitte; Sehested, Maxwell; Jensen, Peter Buhl; Ikaunieks, Martins; Zaichenko, Andrei; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 14.10.2010, p. 7140-7145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1 : 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). / Erichsen, Mette Norman; Huynh, Tri Hien Viet; Abrahamsen, Bjarke; Bastlund, Jesper Frank; Bundgaard, Christoffer; Monrad, Olja; Bekker-Jensen, Anders; Nielsen, Christina Wøhlk; Frydenvang, Karla Andrea; Jensen, Anders Asbjørn; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 2010, p. 7180–7191.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. / Frydenvang, Karla Andrea; Pickering, Darryl S; Greenwood, Jeremy R; Krogsgaard-Larsen, Niels; Brehm, Lotte; Nielsen, Birgitte; Vogensen, Stine Byskov; Hald, Helle; Kastrup, Jette Sandholm; Krogsgaard-Larsen, Povl; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 23, 10.11.2010, p. 8354-8361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Solid forms of amlodipine besylate : Physiochemical, structural, and thermodynamic characterization. / Koradia, Vishal Shamji; Lopez de Diego, Heidi; Frydenvang, Karla Andrea; Ringkjøbing-Elema, Michiel; Müllertz, Anette; Bond, Andrew D; Rantanen, Jukka.

    In: Crystal Growth & Design, Vol. 10, No. 12, 28.10.2010, p. 5279-5290.

    Research output: Contribution to journalJournal articleResearchpeer-review

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