Karla Andrea Frydenvang

Karla Andrea Frydenvang

Associate Professor

Introductory remarks on publicationslist

See Homepage for complete list of publications (incl. all publications from before 2007)
  1. 1994
  2. Published

    GABAB antagonists : resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen. / Frydenvang, Karla Andrea; Hansen, J J; Krogsgaard-Larsen, P; Mitrovic, A; Tran, H; Drew, C A; Johnston, G A.

    In: Chirality, Vol. 6, No. 7, 1994, p. 583-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands. / Johansen, T N; Frydenvang, Karla Andrea; Ebert, B; Krogsgaard-Larsen, P; Madsen, U.

    In: Journal of Medicinal Chemistry, Vol. 37, No. 20, 1994, p. 3252-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. 1995
  5. Published

    GABA-B Antagonists: Enantiopharmacology of 5-Amino-4-hydroxy-2-methylvaleric Acid and X-Ray Structure of the Eutomer. / Frydenvang, Karla Andrea; Kristiansen, Uffe; Frølund, Bente; Herdeis, C; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 7, 1995, p. 526–533.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 1996
  7. Published

    Conformational analysis of acetylcholine and related choline esters. / Frydenvang, Karla Andrea; Jensen, B.

    In: Acta Crystallographica. Section B: Structural Science, Vol. 52 ( Pt 1), 1996, p. 184-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    N-methyl-D-aspartic acid receptor agonists : resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. / Madsen, U; Frydenvang, Karla Andrea; Ebert, B; Johansen, T N; Brehm, L; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 39, No. 1, 1996, p. 183-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Stereospecific GABA-B receptor antagonism. / Frydenvang, Karla Andrea; Frølund, Bente; Kristiansen, Uffe; Krogsgaard-Larsen, Povl.

    GABA, receptors, transporters and metabolism. ed. / C Tanaka; N.G. Bowery. Basel : Birkhäuser Verlag, 1996.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  10. 1997
  11. Published

    Antiprotozoal compounds from Asparagus africanus. / Oketch-Rabah, H A; Dossaji, S F; Christensen, S B; Frydenvang, K; Lemmich, E; Cornett, C; Olsen, C E; Chen, M; Kharazmi, A; Theander, T.

    In: Journal of Natural Products, Vol. 60, No. 10, 1997, p. 1017-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published
  13. Published

    GABA-A and GABA-B receptor Agonists, Partial Agonists and Modulators. design and Therapeutic Prospects. / Frølund, Bente; Krogsgaard-Larsen, Povl; Kristiansen, Uffe; Frydenvang, Karla Andrea; Ebert, Bjarke .

    In: European Journal of Pharmaceutical Sciences, Vol. 4, 1997, p. 355–384.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 1998
  15. Published

    Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx. / Oketch-Rabah, H A; Brøgger Christensen, S; Frydenvang, K; Dossaji, S F; Theander, T G; Cornett, C; Watkins, W M; Kharazmi, A; Lemmich, E.

    In: Planta Medica, Vol. 64, No. 6, 1998, p. 559-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    UV-Guided isolation of alantrypinone, a novel Penicillium alkaloid. / Larsen, T O; Frydenvang, Karla Andrea; Frisvad, Jens Christian; Christophersen, C.

    In: Journal of Natural Products, Vol. 61, No. 9, 1998, p. 1154-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 1999
  18. Published

    Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and Analogues. / Falch, Erik; Frølund, Bente; Perregaard; Sanchez, Connie; Søkilde, Birgitte; Buur, Anders; Hansen, Anette; Frydenvang, Karla Andrea; Brehm, Lotte; Bolvig, Tina; Larsson, Orla Miller; Schousboe, Arne; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 42, 1999, p. 5402–5414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline. / Pedersen, H; Bräuner-Osborne, H; Ball, R G; Frydenvang, Karla Andrea; Meier, E; Bøgesø, K P; Krogsgaard-Larsen, P.

    In: Bioorganic & Medicinal Chemistry, Vol. 7, No. 5, 1999, p. 795-809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2000
  21. Published

    GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. / Krogsgaard-Larsen, P; Frølund, B; Frydenvang, Karla Andrea.

    In: Current Pharmaceutical Design, Vol. 6, No. 12, 2000, p. 1193-209.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist. / Vogensen, S B; Jensen, H S; Stensbøl, T B; Frydenvang, Karla Andrea; Bang-Andersen, B; Johansen, T N; Egebjerg, J; Krogsgaard-Larsen, P.

    In: Chirality, Vol. 12, No. 10, 2000, p. 705-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    UV-guided screening of benzodiazepine producing species in Penicillium. / Ostenfeld Larsen T, ; Frydenvang, Karla Andrea; Christian Frisvad J.

    In: Biochemical Systematics and Ecology, Vol. 28, No. 9, 2000, p. 881-886.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2001
  25. Published
  26. Published

    Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist. / Stensbøl, T B; Jensen, H S; Nielsen, B; Johansen, T N; Egebjerg, J; Frydenvang, Karla Andrea; Krogsgaard-Larsen, P.

    In: European Journal of Pharmacology, Vol. 411, No. 3, 2001, p. 245-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. / Madsen, U; Bräuner-Osborne, H; Frydenvang, Karla Andrea; Hvene, L; Johansen, T N; Nielsen, B; Sánchez, C; Stensbøl, T B; Bischoff, F; Krogsgaard-Larsen, P.

    In: Journal of Medicinal Chemistry, Vol. 44, No. 7, 2001, p. 1051-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol. / Bunch, L; Norrby, Per-Ola; Frydenvang, Karla Andrea; Krogsgaard-Larsen, P; Madsen, U.

    In: Organic Letters, Vol. 3, No. 3, 2001, p. 433-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2002
  30. Published

    2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid : resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors. / Johansen, Tommy N; Janin, Yves L; Nielsen, Birgitte; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Vogensen, Stine B; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Bioorganic & Medicinal Chemistry, Vol. 10, No. 7, 2002, p. 2259-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Correlation of aqueous solubility of salts of benzylamine with experimentally and theoretically derived parameters. A multivariate data analysis approach. / Parshad, Henrik; Frydenvang, Karla Andrea; Liljefors, Tommy; Larsen, Claus Selch.

    In: International Journal of Pharmaceutics, Vol. 237, No. 1-2, 2002, p. 193-207.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Glutamate receptor ligands : synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs. / Guldbrandt, Mette; Johansen, Tommy N; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Stensbøl, Tine B; Nielsen, Birgitte; Karla, Rolf; Santi, Flavio; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Chirality, Vol. 14, No. 4, 2002, p. 351-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Plant analysis by butterflies : occurrence of cyclopentenylglycines in Passifloraceae, Flacourtiaceae, and Turneraceae and discovery of the novel nonproteinogenic amino acid 2-(3'-cyclopentenyl)glycine in Rinorea. / Clausen, Vicki; Frydenvang, Karla Andrea; Koopmann, Ricarda; Jørgensen, Lise Bolt; Abbiw, Daniel K; Ekpe, Patrick; Jaroszewski, Jerzy W.

    In: Journal of Natural Products, Vol. 65, No. 4, 2002, p. 542-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2003
  35. Published

    Assessment of drug salt release from solutions, suspensions and in situ suspensions using a rotating dialysis cell. / Parshad, Henrik; Frydenvang, Karla; Liljefors, Tommy; Cornett, Claus; Larsen, Claus.

    In: European Journal of Pharmaceutical Sciences, Vol. 19, No. 4, 2003, p. 263-272.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid : a novel conformationally restricted glutamic acid analogue. / Bunch, Lennart; Liljefors, Tommy; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Bräuner-Osborne, Hans; Krogsgaard-Larsen, Povl; Madsen, Ulf.

    In: Journal of Organic Chemistry, Vol. 68, No. 4, 2003, p. 1489-95.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors. / Johansen, Tommy N; Greenwood, Jeremy R; Frydenvang, Karla Andrea; Madsen, Ulf; Krogsgaard-Larsen, Povl.

    In: Chirality, Vol. 15, No. 2, 2003, p. 167-79.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. 2004
  39. Published

    2-(2,3-Dihydro-1H-indol-3-yl)ethanol : synthesis, separation of enantiomers, and assignment of absolute stereochemistry by X-ray structure analysis. / Frydenvang, Karla Andrea; Sommer, Michael Bech; Heckmann, Dieter; Nielsen, Ole; Bang-Andersen, Benny.

    In: Chirality, Vol. 16, No. 2, 2004, p. 126-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Aqueous solubility study of salts of benzylamine derivatives and p-substituted benzoic acid derivatives using X-ray crystallographic analysis. / Parshad, Henrik; Frydenvang, Karla Andrea; Liljefors, Tommy; Sorensen, Henning Osholm; Larsen, Claus.

    In: International Journal of Pharmaceutics, Vol. 269, No. 1, 2004, p. 157-68.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Carbamoylcholine homologs : synthesis and pharmacology at nicotinic acetylcholine receptors. / Jensen, Anders A.; Mikkelsen, Ivan Bisgaard; Frølund, Bente; Frydenvang, Karla; Brehm, Lotte; Jaroszewski, Jerzy W; Bräuner-Osborne, Hans; Falch, Erik; Krogsgaard-Larsen, Povl.

    In: European Journal of Pharmacology, Vol. 497, No. 2, 2004, p. 125-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Psychrophilin A and Cycloaspeptide D, novel cyclic peptides from the psychrotolerant fungus Penicillium ribeum. / Dalsgaard, Petur Weihe; Larsen, Thomas Ostenfeld; Frydenvang, Karla Andrea; Christophersen, Carsten.

    In: Journal of Natural Products, Vol. 67, No. 5, 2004, p. 878-881.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists. / Conti, Paola; De Amici, Marco; Grazioso, Giovanni; Roda, Gabriella; Barberis Negra, Federico F; Nielsen, Birgitte; Stensbøl, Tine B; Madsen, Ulf; Bräuner-Osborne, Hans; Frydenvang, Karla Andrea; De Sarro, Giovambattista; Toma, Lucio; De Micheli, Carlo.

    In: Journal of Medicinal Chemistry, Vol. 47, No. 27, 30.12.2004, p. 6740-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. 2005
  45. Published

    Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications. / Overy, David P.; Larsen, Thomas O.; Dalsgaard, Petur Weihe; Frydenvang, Karla Andrea; Phipps, Richard; Munro, Murray H. G.; Christophersen, Carsten.

    In: Mycological Research, No. 109, 2005, p. 1243-1249.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Assessment of the combined approach of N-alkylation and salt formation to enhance aqueous solubility of tertiary amines using bupivacaine as a model drug. / Nielsen, Anders Bach; Frydenvang, Karla Andrea; Liljefors, Tommy; Buur, Anders; Larsen, Claus.

    In: European Journal of Pharmaceutical Sciences, Vol. 24, No. 1, 2005, p. 85-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2006
  48. Published

    Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida. / Rubal, Juan J; Guerra, Francisco M; Moreno-Dorado, F Javier; Jorge, Zacarías D; Massanet, Guillermo M; Søhoel, Helmer; Smitt, Ulla W; Frydenvang, Karla Andrea; Christensen, S Brøgger; Nielsen, Charlotte; Eriksson, Margit.

    In: Journal of Natural Products, Vol. 69, No. 11, 2006, p. 1566-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2007
  50. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid. / Conti, Paolo; Caligiuri, Antonio; Pinto, Andrea; Roda, Gabriella; Tamborini, Lucia; Nielsen, Birgitte; Madsen, Ulf; Frydenvang, Karla Andrea; Colombo, Alessio; De Micheli, Carlo.

    In: European Journal of Medicinal Chemistry, Vol. 42, No. 8, 2007, p. 1059-1068.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. 2008
  53. Published

    Microwave-Assisted Ring-Opening of Activated Aziridines with Resin-Bound Amines. / Crestey, Francois Louis Jean; Witt, Matthias; Frydenvang, Karla Andrea; Stærk, Dan; Jaroszewski, Jerzy; Franzyk, Henrik.

    In: Synfacts, Vol. 7, 2008, p. 769.

    Research output: Contribution to journalJournal articleResearch

  54. Published

    Microwave-assisted ring-opening of activated aziridines with resin-bound amines. / Crestey, Francois; Witt, Matthias; Frydenvang, Karla Andrea; Stærk, Dan; Jaroszewski, Jerzy W.; Franzyk, Henrik.

    In: Journal of Organic Chemistry, Vol. 73, No. 9, 2008, p. 3566-3569.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Novel high-affinity and selective biaromatic 4-substituted ¿-hydroxybutyric acid (GHB) analogues as GHB ligands : design, synthesis, and binding studies. / Høg, Signe; Wellendorph, Petrine; Nielsen, Birgitte; Frydenvang, Karla; Dahl, Ivar F; Bräuner-Osborne, Hans; Brehm, Lotte; Frølund, Bente; Clausen, Rasmus P.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 24, 2008, p. 8088-8095.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2009
  58. Published

    At være eller ikke være en antagonist. / Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2009, p. 43-45.

    Research output: Contribution to journalJournal articleCommunication

  59. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus : synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations. / Dallanoce, Clelia; Magrone, Pietro; Bazza, Paola; Grazioso, Giovanni; Rizzi, Luca; Riganti, Loredana; Gotti, Cecilia; Clementi, Francesco; Frydenvang, Karla Andrea; De Amici, Marco.

    In: Chemistry & Biodiversity, Vol. 6, No. 2, 2009, p. 244-259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Structural characterisation and dehydration behaviour of siramesine hydrochloride. / Zimmermann, Anne; Tian, Fang; Lopez de Diego, Heidi; Frydenvang, Karla Andrea; Rantanen, Jukka Tapio; Elema, Michiel Ringkjøbing; Hovgaard, Lars.

    In: Journal of Pharmaceutical Sciences, Vol. 98, No. 10, 2009, p. 3596-3607.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. 2010
  63. Published

    Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1 : 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). / Erichsen, Mette Norman; Huynh, Tri Hien Viet; Abrahamsen, Bjarke; Bastlund, Jesper Frank; Bundgaard, Christoffer; Monrad, Olja; Bekker-Jensen, Anders; Nielsen, Christina Wøhlk; Frydenvang, Karla Andrea; Jensen, Anders Asbjørn; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 2010, p. 7180–7191.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. / Bach, Anders; Stuhr-Hansen, Nicolai; Thorsen, Thor S; Bork, Nicolai; Moreira, Irina S; Frydenvang, Karla; Padrah, Shahrokh; Christensen, S Brøgger; Madsen, Kenneth L; Weinstein, Harel; Gether, Ulrik; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 8, No. 19, 2010, p. 4281-4288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Synthesis and characterization of an epimer of tacrolimus, an immunosuppressive drug. / Skytte, Dorthe Mondrup; Frydenvang, Karla Andrea; Hansen, Liselotte; Nielsen, Peter G; Jaroszewski, Jerzy W.

    In: Journal of Natural Products, Vol. 73, No. 4, 18.02.2010, p. 776-779.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones. / Christensen, Mette Knak; Erichsen, Kamille Dumong; Trojel-Hansen, Christina; Tjørnelund, Jette; Nielsen, Søren Jensby; Frydenvang, Karla Andrea; Johansen, Tommy Nørskov; Nielsen, Birgitte; Sehested, Maxwell; Jensen, Peter Buhl; Ikaunieks, Martins; Zaichenko, Andrei; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 19, 14.10.2010, p. 7140-7145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Solid forms of amlodipine besylate : Physiochemical, structural, and thermodynamic characterization. / Koradia, Vishal Shamji; Lopez de Diego, Heidi; Frydenvang, Karla Andrea; Ringkjøbing-Elema, Michiel; Müllertz, Anette; Bond, Andrew D; Rantanen, Jukka.

    In: Crystal Growth & Design, Vol. 10, No. 12, 28.10.2010, p. 5279-5290.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. / Frydenvang, Karla Andrea; Pickering, Darryl S; Greenwood, Jeremy R; Krogsgaard-Larsen, Niels; Brehm, Lotte; Nielsen, Birgitte; Vogensen, Stine Byskov; Hald, Helle; Kastrup, Jette Sandholm; Krogsgaard-Larsen, Povl; Clausen, Rasmus Prætorius.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 23, 10.11.2010, p. 8354-8361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Syntheses of aza-analogous iso-ergoline scaffolds using carbene mediated C-H insertion. / Krogsgaard-Larsen, Niels; Begtrup, Mikael; Frydenvang, Karla Andrea; Kehler, Jan .

    In: Tetrahedron, Vol. 66, No. 47, 20.11.2010, p. 9297-9303.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. 2011
  71. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. / Pøhlsgaard, Jacob; Frydenvang, Karla Andrea; Madsen, Ulf; Kastrup, Jette Sandholm.

    In: Neuropharmacology, Vol. 60, No. 1, 01.01.2011, p. 135-150.

    Research output: Contribution to journalReviewResearchpeer-review

  72. Published

    Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Delta2 -isoxazoline derivatives as potent and selective agonists of alpha7 nicotinic acetylcholine receptors. / Dallanoce, Clelia; Magrone, Pietro; Matera, Carlo; Frigerio, Fabio; Grazioso, Giovanni; De Amici, Marco; Fucile, Sergio; Piccari, Vanessa; Frydenvang, Karla Andrea; Pucci, Luca; Gotti, Cecilia; Clementi, Francesco; De Micheli, Carlo.

    In: ChemMedChem, Vol. 6, No. 5, 02.05.2011, p. 889-903.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. / Venskutonyte, Raminta; Butini, Stefania; Coccone, Salvatore Sanna; Gemma, Sandra; Brindisi, Margherita; Kumar, Vinod; Guarino, Ergeria; Maramai, Samuele; Valenti, Salvatore; Amir, Ahmad; Valades, Elena Anton; Frydenvang, Karla Andrea; Kastrup, Jette Sandholm Jensen; Novellino, Ettore; Campiani, Giuseppe; Pickering, Darryl S.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 13, 14.07.2011, p. 4793-4805.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure : Synthesis, resolution, pharmacology, and crystal structure. / Szymanska, Ewa; Frydenvang, Karla; Contreras-Sanz, Alberto; Pickering, Darryl S; Frola, Elena; Serafimoska, Zorica; Nielsen, Birgitte; Kastrup, Jette Sandholm; Johansen, Tommy Nørskov.

    In: Journal of Medicinal Chemistry, Vol. 54, No. 20, 04.10.2011, p. 7289-7298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. 2012
  77. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.

    In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. / Krintel, Christian; Frydenvang, Karla; Olsen, Lars; Kristensen, Maria T; de Barrios, Oriol; Naur, Peter; Francotte, Pierre; Pirotte, Bernard; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Biochemical Journal, Vol. 441, No. 1, 01.01.2012, p. 173-178.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Kainate induces various domain closures in AMPA and kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Hald, Helle; Rabassa, Anna Ceravalls de; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm.

    In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 536-545.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Valadés, Elena Antón; Szymanska, Ewa Monika; Johansen, Tommy N; Kastrup, Jette S; Pickering, Darryl S.

    In: ChemMedChem, Vol. 7, No. 10, 10.2012, p. 1793-1798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. 2013
  82. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    På jagt efter et virkningssted i hjernen. / Frydenvang, Karla Andrea; Juknaite, Lina; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2013, p. 50-52.

    Research output: Contribution to journalJournal articleCommunication

  84. Published

    Some transformations of tacrolimus, an immunosuppressive drug. / Skytte, Dorthe Mondrup; Jaroszewski, Jerzy W.; Johansen, Kenneth; Hansen, Steen Honore'; Hansen, Liselotte; G. Nielsen, Peter; Frydenvang, Karla Andrea.

    In: European Journal of Pharmaceutical Sciences, Vol. 48, No. 3, 2013, p. 514-522.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159 : asymmetric synthesis, neuroactivity, and structural characterization. / Juknaite, Lina; Sugamata, Yutaro; Tokiwa, Kazuya; Ishikawa, Yuichi; Takamizawa, Satoshi; Eng, Andrew; Sakai, Ryuichi; Pickering, Darryl S; Frydenvang, Karla; Swanson, Geoffrey T; Kastrup, Jette Sandholm Jensen; Oikawa, Masato.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 6, 2013, p. 2283-2293.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as ¿-aminobutyric acidA receptor agonists. / Petersen, Jette Gellert; Bergmann, Rikke; Møller, Henriette A.; Jørgensen, Charlotte Grube; Nielsen, Birgitte; Kehler, Jan; Frydenvang, Karla ; Kristensen, Jesper; Balle, Thomas; Jensen, Anders A.; Kristiansen, Uffe; Frølund, Bente.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 993-1006.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. / Nørholm, Ann-Beth; Francotte, Pierre; Olsen, Lars; Krintel, Christian; Frydenvang, Karla; Goffin, Eric; Challal, Sylvie; Danober, Laurence; Botez-Pop, Iuliana; Lestage, Pierre; Pirotte, Bernard; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 21, 14.11.2013, p. 8736-45.

    Research output: Contribution to journalJournal articleResearch

  89. 2014
  90. Published

    Advances towards aromatic oligoamide foldamers : synthesis and X-ray structures of dimeric arylopeptoids with conformation-directing side chains. / Hjelmgaard, Thomas; Plesner, Malene; Dissing, Mette Marie; Andersen, Jeanette Marker; Frydenvang, Karla Andrea; Nielsen, John.

    In: European Journal of Organic Chemistry, Vol. 2014, No. 19, 2014, p. 3971-3975.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published
  92. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. / Francotte, Pierre; Nørholm, Ann-Beth; Deva, Taru; Olsen, Lars; Frydenvang, Karla; Goffin, Eric; Fraikin, Pierre; de Tullio, Pascal; Challal, Sylvie; Thomas, Jean-Yves; Iop, Fabrice; Louis, Caroline; Botez-Pop, Iuliana; Lestage, Pierre; Danober, Laurence; Kastrup, Jette Sandholm Jensen; Pirotte, Bernard.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 22, 26.11.2014, p. 9539-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. 2015
  96. Published

    Iminolactones from Schizophyllum commune. / Liu, Xuemei; Frydenvang, Karla Andrea; Liu, Huizhen; Zhai, Lin; Chen, Ming; Olsen, Carl Erik; Christensen, Søren Brøgger.

    In: Journal of Natural Products, Vol. 78, No. 5, 2015, p. 1165-1168.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Storgaard, Morten; Møller, Charlotte; Demmer, Charles S; Hansen, Jeanette; Han, Liwei; Monrad, Rune N; Nielsen, Birgitte; Tapken, Daniel; Pickering, Darryl S; Kastrup, Jette S; Frydenvang, Karla; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 15, 2015, p. 6131-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. / Demmer, Charles S; Møller, Charlotte; Brown, Patricia M G E; Han, Liwei; Pickering, Darryl S; Nielsen, Birgitte; Bowie, Derek; Frydenvang, Karla; Kastrup, Jette S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 6, 09.04.2015, p. 845-854.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures. / Christiansen, G B; Harbak, Barbara; Hede, S E; Gouliaev, A H; Olsen, Lars; Frydenvang, K; Egebjerg, J; Kastrup, J S; Holm, M M.

    In: Neuroscience, Vol. 310, 03.12.2015, p. 709-22.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1305625