Kenneth Thermann Kongstad

Kenneth Thermann Kongstad

Assistant professor, tenure track


  1. 2020
  2. Published
  3. Published

    Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

    Malik, Abd., Ardalani, H., Anam, Syariful, McNair, Laura M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, Henrik, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In : Fitoterapia. 142, 104522.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers

    Ladebo, L., Foster, D. J. R., Abuhelwa, A. Y., Upton, R. N., Kongstad, Kenneth Thermann, Drewes, A. M., Christrup, Lona Louring & Olesen, A. E., 2020, In : Basic and Clinical Pharmacology and Toxicology. 126, 3, p. 263-276

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published
  6. 2019
  7. Published

    Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at gamma-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

    Giraudo, A., Krall, J., Bavo, F., Nielsen, Birgitte, Kongstad, Kenneth Thermann, Rolando, B., De Blasio, R., Gloriam, David E., Löffler, R., Thiesen, Louise, Harpsøe, Kasper, Frydenvang, Karla Andrea, Boschi, D., Wellendorph, Petrine, Lolli, M. L., Jensen, Anders A. & Frølund, Bente, 27 Jun 2019, In : Journal of Medicinal Chemistry. 62, 12, p. 5797-5809

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published
  9. Published
  10. Published

    19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR

    Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In : Journal of Biomolecular N M R. 73, p. 167-182

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.

    Chu, C., Li, T., Pedersen, H. A., Kongstad, Kenneth Thermann, Yan, J. & Stærk, Dan, 2019, In : Phytochemistry Letters. 31, p. 47-52

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Combined magnetic ligand fishing and high-resolution inhibition profiling for identification of α-glucosidase inhibitory ligands: A new screening approach based on complementary inhibition and affinity profiles.

    Wubshet, S. G., Liu, B., Kongstad, Kenneth Thermann, Böcker, U., Petersen, Malene Johanne, Li, T., Wang, J. & Stærk, Dan, 2019, In : Talanta. 200, p. 279-287

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors

    Mortensen, M., Krall, J., Kongstad, Kenneth Thermann, Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, Birgitte, Jensen, Anders A., Smart, T. G. & Frølund, Bente, 2019, In : ACS Chemical Neuroscience. 10, 11, p. 4669-4684

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.

    Papathanasiou, Theodoros, Springborg, A., Kongstad, Kenneth Thermann, Stærk, Dan, Møller, Kirsten, Taylor, B. K., Lund, Trine Meldgaard & Werner, M. U., 2019, In : British Journal of Anaesthesia. 123, 2, p. e204-e214

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Identification of α-glucosidase inhibitors in Machilus litseifolia by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-PDA-HRMS-SPE-NMR

    Li, T., Kongstad, Kenneth Thermann & Stærk, Dan, 2019, In : Journal of Natural Products. 82, p. 249-258

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae

    Hansen, A. M., Bonke, G., Hogendorf, W. F. J., Björkling, Fredrik, Nielsen, John, Kongstad, Kenneth Thermann, Zabicka, D., Tomczak, M., Urbas, M., Nielsen, Peter E. & Franzyk, Henrik, 2019, In : European Journal of Medicinal Chemistry. 168, p. 134-145 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Simultaneous quantification of high-dose naloxone and naloxone-3-β-D-glucuronide in human plasma by UHPLC-MS/MS

    Kongstad, Kenneth Thermann, Papathanasiou, Theodoros, Springborg, A., Lund, Trine Meldgaard, Werner, M. U. & Stærk, Dan, 2019, In : Bioanalysis. 11, 03, p. 165-173

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Unraveling the complexity of complex mixtures by combining high-resolution pharmacological, analytical and spectroscopic techniques: Antidiabetic constituents in Chinese medicinal plants

    Zhao, Yong, Kongstad, Kenneth Thermann, Liu, Y., He, C. & Stærk, Dan, 2019, In : Faraday Discussions. 218, p. 202-218

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2018
  20. Published

    4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric gamma-aminobutyric acid receptor binding site

    Alessandro, G., Krall, J., Nielsen, Birgitte, Sørensen, T. E., Kongstad, Kenneth Thermann, Barbara, R., Donatella, B., Frølund, Bente & Lolli, M. L., 5 Oct 2018, In : European Journal of Medicinal Chemistry. 158, p. 311-321 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Brazilian insulin plant as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of antidiabetic compounds in Myrcia rubella Cambess

    Lima, R. D. C. L., Kato, L., Kongstad, Kenneth Thermann & Stærk, Dan, 2018, In : Journal of Functional Foods. 45, p. 444-451

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Heterologous production of the widely used natural food colorant carminic acid in Aspergillus nidulans

    Frandsen, R. J. N., Khorsand-Jamal, P., Kongstad, Kenneth Thermann, Nafisi, M., Kannangara, R. M., Stærk, Dan, Okkels, F. T., Binderup, K., Madsen, B., Møller, Birger Lindberg, Thrane, U. & Mortensen, U. H., 2018, In : Scientific Reports. 8, p. 1-10 10 p., 12853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    High-resolution PTP1B inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of PTP1B inhibitors from Miconia albicans

    Lima, R. D. C. L., Kongstad, Kenneth Thermann, Kato, L., José das Silva, M., Franzyk, Henrik & Stærk, Dan, 2018, In : Molecules. 23, 7, 13 p., 1755.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    On the biosynthetic origin of carminic acid

    Rasmussen, S. A., Kongstad, Kenneth Thermann, Khorsand-Jamal, P., Kannangara, R. M., Nafisi, M., Van Dam, A., Bennedsen, M., Madsen, B., Okkels, F. T., Gotfredsen, C. H., Stærk, Dan, Thrane, U., Mortensen, U. H., Larsen, T. O. & Frandsen, R. J. N., 2018, In : Insect Biochemistry and Molecular Biology. 96, p. 51-61 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published
  26. Published

    Recreational drug use at a major music festival: trend analysis of anonymised pooled urine

    Hoegberg, L., Christiansen, C., Søe, J. L., Telving, R., Andreasen, M. F., Stærk, Dan, Christrup, Lona Louring & Kongstad, Kenneth Thermann, 2018, In : Clinical Toxicology. 56, p. 245-255 1360496.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2017
  28. Published

    Advancing HPLC-PDA-HRMS-SPE-NMR analysis of coumarins in Coleonema album by use of orthogonal reversed-phase C18 and pentafluorophenyl separations

    Lima, R. D. C. L., Gramsbergen, S., Van Staden, J., Jäger, A. K., Kongstad, Kenneth Thermann & Stærk, Dan, 2017, In : Journal of Natural Products. 80, 4, p. 1020-1027

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Characterization of a membrane-bound C-glucosyltransferase responsible for carminic acid biosynthesis in Dactylopius coccus Costa

    Kannangara, R. M., Siukstaite, L., Borch-Jensen, J., Madsen, B., Kongstad, Kenneth Thermann, Stærk, Dan, Bennedsen, M., Okkels, F. T., Rasmussen, S. A., Larsen, T. O., Frandsen, R. J. N. & Møller, Birger Lindberg, 2017, In : Nature Communications. 8, 12 p., 1987.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Characterization of antileishmanial compounds from Lawsonia inermis leaves using semi-high resolution antileishmanial profiling combined with HPLC-HRMS-SPE-NMR

    Iqbal, K., Iqbal, J., Stærk, Dan & Kongstad, Kenneth Thermann, 2017, In : Frontiers in Pharmacology. 8, 7 p., 337.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs

    Krall, J., Jensen, C. H., Bavo, F., Falk-Petersen, Christina Birkedahl, Haugaard, A. S., Vogensen, S. B., Tian, Y., Nittegaard-Nielsen, M., Sigurdardóttir, S. B., Kehler, J., Kongstad, Kenneth Thermann, Gloriam, David E., Clausen, Rasmus Prætorius, Harpsøe, Kasper, Wellendorph, Petrine & Frølund, Bente, 2017, In : Journal of Medicinal Chemistry. 60, 21, p. 9022-9039 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Potential of Polygonum cuspidatum root as an antidiabetic food: Dual high-resolution α-glucosidase and PTP1B inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic constituents

    Zhao, Yong, Chen, M. X., Kongstad, Kenneth Thermann, Jäger, A. K. & Stærk, Dan, 2017, In : Journal of Agricultural and Food Chemistry. 65, p. 4421-4427

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Synthesis of C-glucosylated octaketide anthraquinones in Nicotiana benthamiana using a multispecies-based biosynthetic pathway

    Andersen-Ranberg, Johan, Kongstad, Kenneth Thermann, Nafisi, M., Stærk, Dan, Okkels, F. T., Mortensen, U. H., Møller, Birger Lindberg, Frandsen, R. J. N. & Kannangara, R. M., 2017, In : ChemBioChem. 18, 19, p. 1893-1897 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2016
  35. Published

    Accelerating drug lead discovery from nature by high-resolution bioactivity profiling combined with HPLC-HRMS-SPE-NMR

    Kongstad, Kenneth Thermann, Nyberg, N. T., Wubshet, S. G. & Stærk, Dan, Dec 2016, In : Planta Medica. 81, S 01

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  36. Published

    HPLC-HRMS-SPE-NMR combined with high resolution in vitro screening for natural fungicides

    Kongstad, Kenneth Thermann, Wubshet, S. G., Kjellerup, L., Winther, A. & Stærk, Dan, Dec 2016, In : Planta Medica. 82, S 01

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  37. Published

    HPLC-HRMS-SPE-NMR for accelerated identification of compounds in complex plant extracts: New coumarine derivatives from Coleonema album (Thunb.) Bartl. & Wendl

    de Cássia Lemos Lima, R., Gramsbergen, S. M., Van Staden, J., Jäger, A. K., Kongstad, Kenneth Thermann & Stærk, Dan, Dec 2016, In : Planta Medica. 82, S 01

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  38. Published

    Ligand-fishing and bioactivity-correlated metabolomics for accelerated discovery of antidiabetic drug leads

    Nyberg, N. T., Wubshet, S. G., Kongstad, Kenneth Thermann & Stærk, Dan, Dec 2016, In : Planta Medica. 82, S 01

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  39. Published

    The α-glucosidase and PTP1B inhibitory effect of 45 medicinal plants extracts

    Liu, B., Kongstad, Kenneth Thermann, Jäger, A. K. & Stærk, Dan, Dec 2016, In : Planta Medica. 81, S 01, p. 1 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  40. Published

    Characterization of midazolam metabolism in locusts: The role of CYP3A4-like enzyme in the formation of 1'-OH and 4-OH midazolam

    Olsen, L. R., Gabel-Jensen, C., Wubshet, S. G., Kongstad, Kenneth Thermann, Janfelt, Christian, Badolo, L. & Hansen, S. H., 2016, In : Xenobiotica. 46, 2, p. 99–107 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Edible seaweed as future functional food: Identification of α-glucosidase inhibitors by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR

    Liu, B., Kongstad, Kenneth Thermann, Wiese, S., Jäger, A. K. & Stærk, Dan, 2016, In : Food Chemistry. 203, p. 16-22 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Expanding the landscape of diterpene structural diversity by stereochemically controlled combinatorial biosynthesis

    Andersen-Ranberg, Johan, Kongstad, Kenneth Thermann, Nielsen, M. T., Bjerg Jensen, N., Pateraki, Irini, Bach, S. S., Hamberger, B., Zerbe, P., Stærk, Dan, Bohlmann, J., Møller, Birger Lindberg & Hamberger, B. R., 2016, In : Angewandte Chemie International Edition. 55, 6, p. 2142-2146 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published
  44. Published
  45. Published

    Identification of PTP1B and α-glucosidase inhibitory serrulatanes from Eremophila spp. by combined use of dual high-resolution PTP1B and α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR

    Wubshet, S. G., Tahtah, Y., Heskes, Allison, Kongstad, Kenneth Thermann, Pateraki, Irini, Hamberger, B. R., Møller, Birger Lindberg & Stærk, Dan, 2016, In : Journal of Natural Products. 79, 4, p. 1063-1072 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. 2015
  47. Published

    High-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of bioactive constituents in crude extract of Pueraria lobata

    Liu, B., Kongstad, Kenneth Thermann, Nyberg, N. T., Sun, Q., Jager, A. K. & Stærk, Dan, Nov 2015, In : Planta Medica. 81, 16, p. 1437-1437

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  48. Published
  49. Published

    Flipped Learning in Organic Chemistry for Life Sciences – Experiences and Considerations

    Kongstad, Kenneth Thermann, 24 Aug 2015, Pedagogical Projects 2014. Vol. 7. p. 125-147 (Improving University Science Teaching and Learning; No. 1-2, Vol. 7).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  50. Published

    Fungal plasma membrane H+-ATPase inhibitory activity of o-hydroxybenzylated flavanones and chalcones from Uvaria chamae P. Beauv

    Kongstad, Kenneth Thermann, Wubshet, S. G., Kjellerup, L., winther, A. L. & Stærk, Dan, 20 Jun 2015, In : Fitoterapia. 105, p. 102-106 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Dual High-Resolution α-Glucosidase and Radical Scavenging Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of Minor and Major Constituents Directly from the Crude Extract of Pueraria lobata

    Liu, B., Kongstad, Kenneth Thermann, Qinglei, S., Nyberg, N., Jäger, A. & Stærk, Dan, 13 Feb 2015, In : Journal of Natural Products. 78, 2, p. 294–300 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR for investigation of antidiabetic principles in crude plant extracts

    Kongstad, Kenneth Thermann, Özdemir, C., Barzak, A., Wubshet, S. G. & Stærk, Dan, 5 Feb 2015, In : Journal of Agricultural and Food Chemistry. 63, 8, p. 2257-2263 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published
  54. Published
  55. Published
  56. 2014
  57. Published

    Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin

    Eghorn, L. F., Høstgaard-Jensen, K., Kongstad, Kenneth Thermann, Bay, T., Higgins, D., Frølund, Bente & Wellendorph, Petrine, 5 Oct 2014, In : European Journal of Pharmacology. 740, p. 570-577 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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