Kristian Strømgaard

Kristian Strømgaard

Professor


  1. Published

    Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor. / Bach, Anders; Clausen, Bettina H; Kristensen, Lotte K; Andersen, Maria G; Ellman, Ditte Gry; Hansen, Pernille B L; Hasseldam, Henrik; Heitz, Marc; Özcelik, Dennis; Tuck, Ellie J; Kopanitsa, Maksym V; Grant, Seth G N; Lykke-Hartmann, Karin; Johansen, Flemming F; Lambertsen, Kate L; Strømgaard, Kristian.

    In: Neuropharmacology, Vol. 150, 05.2019, p. 100-111.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. / Haq, S Raza; Chi, Celestine N; Bach, Anders; Dogan, Jakob; Engström, Åke; Hultqvist, Greta; Karlsson, O. Andreas; Lundström, Patrik; Montemiglio, Linda Celeste; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.

    In: Journal of the American Chemical Society, Vol. 134, No. 1, 01.2012, p. 599-605.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions. / Pedersen, Søren W; Albertsen, Louise; Moran, Griffin E; Levesque, Brié; Pedersen, Stine B; Bartels, Lina; Wapenaar, Hannah; Ye, Fei; Zhang, Mingjie; Bowen, Mark E; Strømgaard, Kristian.

    In: ACS chemical biology, Vol. 12, No. 9, 15.09.2017, p. 2313-2323.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Site-specific incorporation of unnatural amino acids into proteins. / Strømgaard, Anne; Jensen, Anders A.; Strømgaard, Kristian.

    In: ChemBioChem, Vol. 5, No. 7, 2004, p. 909-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Skræddersyede proteiner : uden naturens begrænsninger. / Strømgaard, Kristian; Jensen, Mette Stougård; Kristensen, Anders Skov.

    In: Lægemiddelforskning, 2009, p. 10-12.

    Research output: Contribution to journalJournal articleCommunication

  6. Published

    Small molecules from spiders used as chemical probes. / Olsen, Christian Adam; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Angewandte Chemie International Edition, Vol. 50, No. 48, 25.11.2011, p. 11296-11311.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12. / Strømgaard, K; Bjørnsdottir, I; Andersen, K; Brierley, M J; Rizoli, S; Eldursi, N; Mellor, I R; Usherwood, P N; Hansen, S H; Krogsgaard-Larsen, P; Jaroszewski, J W.

    In: Chirality, Vol. 12, No. 2, 02.2000, p. 93-102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata. / Barslund, Anne Fuglsang; Poulsen, Mette Homann; Bach, Tinna Brøbech; Lucas, Simon; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Journal of Natural Products, Vol. 74, No. 3, 2011, p. 483-486.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues. / Strømgaard, K; Brier, T J; Andersen, K; Mellor, I R; Saghyan, A; Tikhonov, D; Usherwood, P N; Krogsgaard-Larsen, P; Jaroszewski, J W.

    In: Journal of Medicinal Chemistry, Vol. 43, No. 23, 16.11.2000, p. 4526-4533.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist. / Strømgaard, Kristian; Mellor, Ian R; Andersen, Kim; Neagoe, Ioana; Pluteanu, Florentina; Usherwood, Peter N R; Krogsgaard-Larsen, Povl; Jaroszewski, Jerzy W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 12, No. 8, 22.04.2002, p. 1159-1162.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Solid-phase synthesis of polyamine toxin analogues : potent and selective antagonists of Ca2+-permeable AMPA receptors. / Kromann, Hasse; Krikstolaityte, Sonata; Andersen, Anne J; Andersen, Kim; Krogsgaard-Larsen, Povl; Jaroszewski, Jerzy W; Egebjerg, Jan; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 45, No. 26, 19.12.2002, p. 5745-5754.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Stoffer fra Tempeltæet (Ginkgo biloba) som redskaber for studier af hjernens funktion. / Jensen, Anders A.; Strømgaard, Kristian.

    In: Dansk Kemi 83, Vol. 87, No. 1, 2006, p. 16-18.

    Research output: Contribution to journalJournal articleCommunication

  13. Published

    Stoichiometry of Toxin Binding to Acid-Sensing Ion Channels. / Borg, Christian B.; Lynagh, Timothy; Haugaard-Kedstrom, Linda M.; Stromgaard, Kristian; Pless, Stephan A.

    In: Biophysical Society. Annual Meeting. Abstracts, Vol. 112, No. 3, 03.02.2017, p. 420A-420A.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  14. Published

    Structure and absolute configuration of ginkgolide B characterized by IR- and VCD spectroscopy. / Andersen, Niels Højmark; Christensen, Niels Johan; Lassen, Peter Rygaard; Freedman, Teresa B.N.; Nafie, Laurence A.; Strømgaard, Kristian; Hemmingsen, Lars Bo Stegeager.

    In: Chirality, Vol. 22, No. 2, 2010, p. 217-223.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein. / Zhang, Hang; Xiong, Xiao-feng; Boesgaard, Michael W; Underwood, Christina R; Bräuner-Osborne, Hans; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 12, No. 11, 07.06.2017, p. 830-834.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors. / Nørager, Niels G; Poulsen, Mette H; Jensen, Anna G; Jeppesen, Nanna S; Kristensen, Anders S; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 11, 12.06.2014, p. 4940-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structure-activity relationship studies of argiotoxins : selective and potent inhibitors of ionotropic glutamate receptors. / Poulsen, Mette H; Lucas, Simon; Bach, Tinna B; Barslund, Anne F; Wenzler, Claudius; Jensen, Christel B; Kristensen, Anders S; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 14.02.2013, p. 1171-1181.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Structure-activity relationship studies of citalopram derivatives : examining substituents conferring selectivity for the allosteric site in the serotonin transporter. / Larsen, M Andreas B; Plenge, Per; Andersen, Jacob; Eildal, Jonas Nii Nortey; Kristensen, Anders S; Bøgesø, Klaus P; Gether, Ulrik; Strømgaard, Kristian; Bang-Andersen, Benny; Loland, Claus J.

    In: British Journal of Pharmacology, Vol. 173, No. 5, 03.2016, p. 925-936.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1. / Bach, Anders; Stuhr-Hansen, Nicolai; Thorsen, Thor S; Bork, Nicolai; Moreira, Irina S; Frydenvang, Karla; Padrah, Shahrokh; Christensen, S Brøgger; Madsen, Kenneth L; Weinstein, Harel; Gether, Ulrik; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 8, No. 19, 2010, p. 4281-4288.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structure–Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890. / Xiong, Xiao Feng; Zhang, Hang; Boesgaard, Michael W.; Underwood, Christina R.; Bräuner-Osborne, Hans; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 14, No. 8, 04.2019, p. 865-870.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structure–Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors. / Xiong, Xiaofeng; Poulsen, Mette H; Hussein, Rama A; Nørager, Niels G; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 9, No. 12, 12.2014, p. 2661-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. / Zhang, Hang; Nielsen, Alexander L.; Boesgaard, Michael W.; Harpsøe, Kasper; Daly, Norelle L.; Xiong, Xiao-feng; Underwood, Christina R.; Haugaard-kedström, Linda M.; Bräuner-osborne, Hans; Gloriam, David E.; Strømgaard, Kristian.

    In: European Journal of Medicinal Chemistry, Vol. 156, 05.08.2018, p. 847-860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins. / Kachel, Hamid S.; Franzyk, Henrik; Stromgaard, Kristian; Tikhonov, Denis B.; Mellor, Ian R.

    In: Biophysical Society. Annual Meeting. Abstracts, Vol. 106, No. 2, 28.01.2014, p. 338A-338A.

    Research output: Contribution to journalJournal articleResearch

  24. Published

    Synthesis and biological activity of argiotoxin 636 and analogues : selective antagonists for ionotropic glutamate receptors. / Nelson, Jared Keith; Frølund, Sidsel Ullerup; Tikhonov, Dennis B; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Angewandte Chemie - International Edition, Vol. 48, No. 17, 2009, p. 3087-3091.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Synthesis and biological activity of novel a-conotoxin analogues incorporating substituted proline derivatives. / Armishaw, Christopher; Jensen, Anders Asbjørn; Skonberg, Christian; Liljefors, Tommy; Strømgaard, Kristian.

    Peptides for youth: The proceedings of the 20th American peptide symposium. ed. / Susan Del Valle; Emanuel Escher; William D Lubell. Vol. 611 Springer, 2009. p. 179-180 (Advances in Experimental Medicine and Biology, Vol. 611).

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  26. Published

    Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group. / Pedersen, Søren W; Armishaw, Christopher J; Strømgaard, Kristian.

    Peptide synthesis and applications. Vol. 1047 Humana Press, 2013. p. 65-80 (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  27. Published

    Synthesis of polyamines and polyamine toxins. An improved alkylation procedure. / Strømgaard, Kristian; Andersen, TF.

    In: Tetrahedron Letters, Vol. 45, 2004, p. 7929-7933.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Synthesis of symmetrical and non-symmetrical bivalent neurotransmitter ligands. / Stuhr-Hansen, Nicolai; Andersen, Jacob; Thygesen, Mikkel Boas; Strømgaard, Kristian.

    In: ChemistrySelect, Vol. 1, No. 3, 2016, p. 407-413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Synthetic and mechanistic insight into nosylation of glycine residues. / Stuhr-Hansen, Nicolai; Sølling, Theis Ivan; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 11, No. 14, 14.04.2013, p. 2288-2293.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    THE DEVELOPMENT AND CHARACTERIZATION OF A PEPTIDE-BASED SYNTENIN INHIBITOR - IMPLACATIONS FOR CANCER METASTASIS. / Haugaard-Kedstrom, L. M.; Albertsen, L.; Gil, F. Abalde; Ivarsson, Y.; Stromgaard, K.; Kedström, Linda Maria Haugaard.

    In: Journal of Peptide Science, Vol. 20, No. Suppl. 1, YO11, 09.2014, p. s39.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  31. Published

    Targeting PSD-95 as a Novel Approach in the Treatment of Stroke. / Haugaard-Kedstrom, Linda M.; Fernandes, Eduardo F. A.; Stromgaard, Kristian.

    Neuroprotective Therapy for Stroke and Ischemic Disease . Springer, 2017. p. 157-184 (Springer Series in Translational Stroke Research).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  32. Published

    Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family. / Nissen, Klaus B; Kedström, Linda Maria Haugaard; Wilbek, Theis S; Nielsen, Line S; Åberg, Emma; Kristensen, Anders S; Bach, Anders; Jemth, Per; Strømgaard, Kristian.

    In: PLOS ONE, Vol. 10, No. 2, e0117668, 2015, p. 1-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. / Ivic, Lidija; Sands, Tristan T J; Fishkin, Nathan; Nakanishi, Koji; Kriegstein, Arnold R; Strømgaard, Kristian.

    In: Journal of Biological Chemistry, Vol. 278, No. 49, 05.12.2003, p. 49279-49285.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Textbook of drug design and discovery. / Krogsgaard-Larsen, Povl; Strømgaard, Kristian; Madsen, Ulf.

    4 ed. Boca Raton : CRC Press, 2010. 460 p.

    Research output: Book/ReportBookEducation

  35. Published

    The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain. / Pedersen, Søren W; Hultqvist, Greta; Strømgaard, Kristian; Jemth, Per.

    In: PLOS ONE, Vol. 9, No. 4, e95619, 2014, p. 1-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors. / Xiong, Xiaofeng; Zhang, Hang; Underwood, Christina R.; Harpsøe, Kasper; Gardella, Thomas J.; Wöldike, Mie F.; Mannstadt, Michael; Gloriam, David E.; Bräuner-osborne, Hans; Strømgaard, Kristian.

    In: Nature Chemistry, Vol. 8, No. 11, 2016, p. 1035-1041.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published
  38. Published

    Unaturlige aminosyrer skaber ny viden om proteiner. / Rannes, Julie; Andersen, Jacob; Jensen, Anders A.; Christensen, Leif; Strømgaard, Kristian.

    In: Lægemiddelforskning, 2006, p. 28-29.

    Research output: Contribution to journalJournal articleCommunication

  39. Published

    Uncompetitive antagonism of AMPA receptors : Mechanistic insights from studies of polyamine toxin derivatives. / Andersen, Trine F; Tikhonov, Denis B; Bølcho, Ulrik; Bolshakov, Konstantin; Nelson, Jared K; Pluteanu, Florentina; Mellor, Ian R; Egebjerg, Jan; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 49, No. 18, 07.09.2006, p. 5414-5423.

    Research output: Contribution to journalJournal articleResearchpeer-review

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