Kristian Strømgaard

Kristian Strømgaard

Professor


  1. 2020
  2. Published

    Mechanism and Binding Site of the ASIC1A-Big Dynorphin Interaction

    Borg, Christian Bernsen, Braun, Nina, Heusser, Stephanie Andrea, Bay, Y., Weis, D., Galleano, Iacopo, Lund, Camilla, Tian, W., Haugaard-Kedstrom, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 7 Feb 2020, p. 582A-582A.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  3. E-pub ahead of print

    Mechanism and site of action of big dynorphin on ASIC1a

    Borg, Christian Bernsen, Braun, Nina, Heusser, Stephanie Andrea, Bay, Y., Weis, D., Galleano, Iacopo, Lund, Camilla, Tian, W., Haugaard-Kedström, L. M., Bennett, Eric Paul, Lynagh, T., Strømgaard, Kristian, Andersen, J. & Pless, Stephan, 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 201919323.

    Research output: Contribution to journalJournal article

  4. Accepted/In press

    A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

    Christensen, Nikolaj Riis, De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, Gith, Jensen, Kathrine Louise, Rathje, Mette, Jensen, Dennis Bo, Erlendsson, Simon, Bartling, Christian Reinhard Otto, Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, Kaare, Arleth, Lise, Sørensen, Andreas Toft, Bach, Anders, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 30 Apr 2020, (Accepted/In press) In : EMBO Molecular Medicine. e11248.

    Research output: Contribution to journalJournal article

  5. Published

    Recent achievements in developing selective Gq inhibitors

    Zhang, H., Nielsen, Alexander Lund & Strømgaard, Kristian, 2020, In : Medicinal Research Reviews. 40, 1, p. 135-157

    Research output: Contribution to journalReview

  6. 2019
  7. Published

    Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

    Bach, Anders, Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, Henrik, Heitz, M., Özcelik, Dennis, Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-Hartmann, K., Johansen, Flemming Fryd, Lambertsen, K. L. & Strømgaard, Kristian, May 2019, In : Neuropharmacology. 150, p. 100-111 12 p.

    Research output: Contribution to journalJournal article

  8. Published

    Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

    Malfacini, D., Patt, J., Annala, S., Harpsøe, Kasper, Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian, König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 Apr 2019, In : The Journal of Biological Chemistry. 294, 15, p. 5747-5758

    Research output: Contribution to journalJournal article

  9. Published

    Plant polyphenols inhibit functional amyloid and biofilm formation in Pseudomonas strains by directing monomers to off-pathway oligomers

    Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Sønderby, T. V., Shojaosadati, S. A., Morshedi, D., Strømgaard, Kristian, Meisl, G., Sutherland, D., Pedersen, J. S. & Otzen, D. E., 2019, In : Biomolecules. 9, 11, 21 p., 659.

    Research output: Contribution to journalJournal article

  10. Published
  11. Published

    Targeting the gamma-Aminobutyric Acid Type B (GABA(B)) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABA(B) Receptor Protein-Protein Interaction

    Sereikaité, Vita, Fritzius, T., Kasaragod, V. B., Bader, N., Maric, H. M., Schindelin, H., Bettler, B. & Strømgaard, Kristian, 2019, In : Journal of Medicinal Chemistry. 62, 19, p. 8819-8830

    Research output: Contribution to journalJournal article

  12. Published

    Structure–Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890

    Xiong, X. F., Zhang, H., Boesgaard, M. W., Underwood, C. R., Bräuner-Osborne, Hans & Strømgaard, Kristian, Apr 2019, In : ChemMedChem. 14, 8, p. 865-870

    Research output: Contribution to journalJournal article

  13. 2018
  14. Published

    Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms

    Bleem, A., Christiansen, G., Madsen, D. J., Maric, H., Strømgaard, Kristian, Bryers, J. D., Daggett, V., Meyer, R. L. & Otzen, D. E., 2018, In : Journal of Molecular Biology. 430, 20, p. 3751-3763 13 p.

    Research output: Contribution to journalJournal article

  15. Published

    Peptide Modulation of Acid-Sensing Ion Channels

    Borg, Christian Bernsen, Haugaard-Kedstrom, L. M., Lynagh, T., Strømgaard, Kristian & Pless, Stephan, 2 Feb 2018, p. 130A-130A.

    Research output: Contribution to conferencePosterResearch

  16. Published

    Probing the Mint2 Protein-Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease

    Jensen, T. M. T., Albertsen, L., Bartling, Christian Reinhard Otto, Haugaard-kedström, L. M. & Strømgaard, Kristian, 2018, In : ChemBioChem. 19, 11, p. 1119-1122 4 p.

    Research output: Contribution to journalJournal article

  17. Published

    Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

    Norager, N. G., Poulsen, Mette Homann & Strømgaard, Kristian, 13 Sep 2018, In : Journal of Medicinal Chemistry. 61, 17, p. 8048-8053

    Research output: Contribution to journalJournal article

  18. Published

    Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations

    Sereikaité, Vita, Jensen, T. M. T., Bartling, Christian Reinhard Otto, Jemth, P., Pless, Stephan & Strømgaard, Kristian, 18 Oct 2018, In : ChemBioChem. 19, 20, p. 2136-2145

    Research output: Contribution to journalReview

  19. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359

    Zhang, H., Nielsen, Alexander Lund, Boesgaard, M. W., Harpsøe, Kasper, Daly, N. L., Xiong, X., Underwood, C. R., Haugaard-kedström, L. M., Bräuner-Osborne, Hans, Gloriam, David E. & Strømgaard, Kristian, 5 Aug 2018, In : European Journal of Medicinal Chemistry. 156, p. 847-860

    Research output: Contribution to journalJournal article

  20. 2017
  21. Published

    Stoichiometry of Toxin Binding to Acid-Sensing Ion Channels

    Borg, Christian Bernsen, Lynagh, T., Haugaard-Kedstrom, L. M., Strømgaard, Kristian & Pless, Stephan, 3 Feb 2017, In : Biophysical Society. Annual Meeting. Abstracts. 112, 3, p. 420A-420A

    Research output: Contribution to journalConference abstract in journal

  22. Published

    Targeting PSD-95 as a Novel Approach in the Treatment of Stroke

    Haugaard-Kedstrom, L. M., Fernandes, E. F. A. & Strømgaard, Kristian, 2017, Neuroprotective Therapy for Stroke and Ischemic Disease . Springer, p. 157-184 28 p. (Springer Series in Translational Stroke Research).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  23. Published

    PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression

    Kucharz, Krzysztof, Søndergaard Rasmussen, I., Bach, Anders, Strømgaard, Kristian & Lauritzen, Martin, 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 5, p. 1820-1828

    Research output: Contribution to journalJournal article

  24. Published

    Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

    Maric, H. M., Hausrat, T. J., Neubert, F., Dalby, N. O., Doose, S., Sauer, M., Kneussel, M. & Strømgaard, Kristian, 2017, In : Nature Chemical Biology. 13, p. 153-160 11 p., 2246.

    Research output: Contribution to journalJournal article

  25. Published

    Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions

    Pedersen, S. W., Albertsen, L., Moran, G. E., Levesque, B., Pedersen, S. B., Bartels, L., Wapenaar, H., Ye, F., Zhang, M., Bowen, M. E. & Strømgaard, Kristian, 15 Sep 2017, In : ACS chemical biology. 12, 9, p. 2313-2323 11 p.

    Research output: Contribution to journalJournal article

  26. Published

    Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers

    Rannversson, H., Andersen, J., Bang-Andersen, B. & Strømgaard, Kristian, 20 Oct 2017, In : ACS chemical biology. 12, 10, p. 2558-2562 5 p.

    Research output: Contribution to journalLetter

  27. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors

    Roszko, K. L., Bi, R., Gorvin, C. M., Bräuner-Osborne, Hans, Xiong, X., Inoue, A., Thakker, R. V., Strømgaard, Kristian, Gardella, T. & Mannstadt, M., 9 Feb 2017, In : JCI insight. 2, 3, 15 p., e91079.

    Research output: Contribution to journalJournal article

  28. Published

    In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, Jesper & Pickering, Darryl S, 20 Jan 2017, In : European Journal of Neuroscience. 45, 2, p. 238-248 11 p.

    Research output: Contribution to journalJournal article

  29. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Gynther, M., Bjerre, A., Gram, M. G., Marschner, L., Strømgaard, Kristian, Mogensen, Jesper & Pickering, Darryl S, 2017, In : Neurochemical Research. 42, 12, p. 3401-3413 13 p.

    Research output: Contribution to journalJournal article

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ID: 1302559