Kristian Strømgaard

Kristian Strømgaard

Professor


  1. Published

    In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: European Journal of Neuroscience, Vol. 45, No. 2, 20.01.2017, p. 238-248.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain. / Thorsen, Thor S; Madsen, Kenneth L; Dyhring, Tino; Bach, Anders; Peters, Dan; Strømgaard, Kristian; Rønn, Lars Christian B; Gether, Ulrik.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 14, No. 7, 01.08.2011, p. 590-600.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A heteromeric snake toxin and the molecular details of pain perception. / Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Angewandte Chemie International Edition, Vol. 51, No. 17, 23.04.2012, p. 4009-4011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. / Bach, Anders*; Clausen, Bettina H; Møller, Magda; Vestergaard, Bente; Chi, Celestine N; Round, Adam; Sørensen, Pernille Louise; Nissen, Klaus Bertram; Kastrup, Jette Sandholm; Gajhede, Michael; Jemth, Per; Kristensen, Anders Skov; Lundström, Patrik; Lambertsen, Kate Lykke; Strømgaard, Kristian* (*Corresponding).

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, 28.02.2012, p. 3317-3322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A parallel semisynthetic approach for structure-activity relationship studies of peptide YY. / Albertsen, Louise; Østergaard, Søren; Paulsson, Johan F; Norrild, Jens Chr.; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 8, No. 9, 09.2013, p. 1505-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A sequential binding mechanism in a PDZ domain. / Chi, Celestine N; Bach, Anders; Engström, Åke; Wang, Huiqun; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.

    In: Biochemistry, Vol. 48, No. 30, 2009, p. 7089-7097.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A versatile method for solid phase synthesis of polyamines : neuroactive polyamine toxins as example. / Strømgaard, Kristian; Andersen, K; Ruhland, T; Krogsgaard-Larsen, Povl; Jaroszewski, Jerzy W.

    In: Synthesis, No. 6, 2001, p. 877-884.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    AMPA receptor ligands : synthetic and pharmacological studies of polyamines and polyamine toxins. / Strømgaard, Kristian; Mellor, Ian.

    In: Medicinal Research Reviews, Vol. 24, No. 5, 09.2004, p. 589-620.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    An expanded view of the protein folding landscape of PDZ domains. / Hultqvist, Greta; Pedersen, Søren W; Chi, Celestine N.; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.

    In: Biochemical and Biophysical Research Communications, Vol. 421, No. 3, 11.05.2012, p. 550-553.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Antidepressive lægemidler : nu i 3D. / Andersen, Jacob; Sørensen, Lena; Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Lægemiddelforskning, Vol. 2010, 12.2010, p. 25-27.

    Research output: Contribution to journalJournal articleCommunication

  11. Published

    Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes : Discovery of nanomolar, nonselective, and use-dependent antagonists. / Frølund, Sidsel; Bella, Angelo; Kristensen, Anders Skov; Ziegler, Hanne Lindvig; Witt, Matthias; Olsen, Christian Adam; Strømgaard, Kristian; Franzyk, Henrik; Jaroszewski, Jerzy W.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 20, 2010, p. 7441-7451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Binding of ArgTX-636 in the NMDA receptor ion channel. / Poulsen, Mette H; Andersen, Jacob; Christensen, Rune; Hansen, Kasper Bø; Traynelis, Stephen F; Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Journal of Molecular Biology, Vol. 427, No. 1, 16.01.2015, p. 176-89.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter. / Andersen, Jacob; Ladefoged, Lucy Kate; Wang, Danyang; Kristensen, Trine N Bjerre; Bang-Andersen, Benny; Kristensen, Anders S; Schiøtt, Birgit; Strømgaard, Kristian.

    In: A C S Chemical Neuroscience, Vol. 6, No. 11, 18.11.2015, p. 1892-900.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. / Andersen, Jacob; Ringsted, Kristoffer B; Bang-Andersen, Benny; Strømgaard, Kristian; Kristensen, Anders S.

    In: Scientific Reports, Vol. 5, 15650, 2015, p. 1-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. / Chi, Celestine Ngang; Bach, Anders; Engström, Åke; Strømgaard, Kristian; Lundström, Patrik; Ferguson, Neil; Jemth, Per.

    In: Journal of Biological Chemistry, Vol. 286, No. 5, 04.02.2011, p. 3597-3606.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. / Bach, Anders*; Eildal, Jonas Nii Nortey*; Stuhr-Hansen, Nicolai; Deeskamp, Rasmus; Gottschalk, Marie; Pedersen, Søren Wittrup; Kristensen, Anders Skov; Strømgaard, Kristian (*Shared 1st authors).

    In: Journal of Medicinal Chemistry, Vol. 54, No. 5, 10.03.2011, p. 1333-1346.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites. / Sørensen, Lena; Strømgaard, Kristian; Kristensen, Anders S.

    In: ACS chemical biology, Vol. 9, No. 4, 18.04.2014, p. 935-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Chemical biology. / Strømgaard, Kristian.

    Textbook of drug design and discovery. ed. / Povl Krogsgaard-Larsen; Kristian Strømgaard; Ulf Madsen. 4. ed. Boca Raton : CRC Press, 2010. p. 59-74.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  19. Published

    Chemistry and biology of terpene trilactones from Ginkgo biloba. / Strømgaard, Kristian; Nakanishi, Koji.

    In: Angewandte Chemie International Edition, Vol. 43, No. 13, 19.03.2004, p. 1640-1658.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors. / Brier, Tim J; Mellor, Ian R; Tikhonov, Denis B; Neagoe, Ioana; Shao, Zuoyi; Brierley, Matt J; Strømgaard, Kristian; Jaroszewski, Jerzy W; Krogsgaard-Larsen, Povl; Usherwood, Peter N R.

    In: Molecular Pharmacology, Vol. 64, No. 4, 10.2003, p. 954-964.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers. / Norager, Niels G.; Poulsen, Mette H.; Stromgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 17, 13.09.2018, p. 8048-8053.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. / Chi, Celestine N; Bach, Anders; Gottschalk, Marie; Kristensen, Anders Skov; Strømgaard, Kristian; Jemth, Per.

    In: Journal of Biological Chemistry, Vol. 285, No. 36, 2010, p. 28252-28260.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors. / Maric, Hans-Michael; Kasaragod, Vikram Babu; Kedström, Linda Maria Haugaard; Hausrat, Torben Johann; Kneussel, Matthias; Schindelin, Hermann; Strømgaard, Kristian.

    In: Angewandte Chemie (International ed. in English), Vol. 54, No. 2, 07.01.2015, p. 490-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction. / Bach, Anders; Chi, Celestine N; Pang, Gar Fai; Olsen, Lars; Kristensen, Anders Skov; Jemth, Per; Strømgaard, Kristian.

    In: Angewandte Chemie - International Edition, Vol. 48, No. 51, 2009, p. 9685-9689.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist. / Andersen, Trine F; Vogensen, Stine B; Jensen, Lars S; Knapp, Kolja M; Strømgaard, Kristian.

    In: Bioorganic & Medicinal Chemistry, Vol. 13, No. 17, 01.09.2005, p. 5104-5112.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications. / Albertsen, Louise; Andersen, J.J.; Paulsson, J.F.; Thomsen, J.K.; Norrild, Jens Chr.; Strømgaard, K.

    In: A C S Medicinal Chemistry Letters, Vol. 4, No. 12, 12.12.2013, p. 1228-1232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor. / Bach, Anders; Pedersen, Thomas B.; Strømgaard, Kristian.

    In: MedChemComm, Vol. 7, No. 3, 2016, p. 531-536.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor. / Nissen, Klaus B; Andersen, Julie J; Haugaard-Kedström, Linda Maria; Bach, Anders; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 58, 2015, p. 1575-1580.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Design, synthesis, and pharmacological characterization of polyamine toxin derivatives : potent ligands for the pore-forming region of AMPA receptors. / Jensen, Lars S; Bølcho, Ulrik; Egebjerg, Jan; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 1, No. 4, 04.2006, p. 419-428.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities. / Petersen, Jonas; Strømgaard, Kristian; Frølund, Bente; Clemmensen, Christoffer.

    In: Drugs, Vol. 79, https://doi.org/10.1007/s40265-019-01153-6, 26.06.2019, p. 1187-1197.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Detecting protein-protein interactions in living cells : development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction. / Gottschalk, Marie; Bach, Anders; Hansen, Jakob Lerche; Krogsgaard-Larsen, Povl; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Neurochemical Research, Vol. 34, No. 10, 2009, p. 1729-1737.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons. / Nørager, Niels Grøn; Jensen, Christel Barker; Rathje, Mette; Andersen, Jacob; Madsen, Kenneth Lindegaard; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: A C S Chemical Biology, Vol. 8, No. 9, 20.09.2013, p. 2033-2041.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats : PSD-95 inhibition in experimental TBI. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Gynther, Mikko; Bjerre, Ann-Sofie; Gram, Marie Gajhede; Marschner, Linda; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Neurochemical Research, Vol. 42, No. 12, 2017, p. 3401-3413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function. / Andreasen, Jesper T; Nasser, Arafat; Caballero-Puntiverio, Maitane; Sahlholt, Maj; Bach, Anders; Gynther, Mikko; Strømgaard, Kristian; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 780, 05.06.2016, p. 166-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats. / Sommer, Jens Bak; Bach, Anders; Malá, Hana ; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Pharmacology, Biochemistry and Behavior, Vol. 161, 10.2017, p. 62-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors. / Frølund, Sidsel Ullerup; Ziegler, Hanne Lindvig; Franzyk, Henrik; Strømgaard, Kristian; Kristensen, Anders Skov; Jaroszewski, Jerzy Witold.

    2008. Poster session presented at Fællesmøde for de danske farmakologiske selskaber 2008, Odense, Denmark.

    Research output: Contribution to conferencePosterResearch

  37. Published

    Energetic pathway sampling in a protein interaction domain. / Hultqvist, Greta; Haq, S. Raza; Punekar, Avinash S.; Chi, Celestine N.; Engström, Ake; Bach, Anders; Strømgaard, Kristian; Selmer, Maria; Gianni, Stefano; Jemth, Per.

    In: Structure, Vol. 21, No. 7, 25.06.2013, p. 1193-1202.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors. / Poulsen, Mette Homann; Lucas, Simon; Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Molecular Pharmacology, Vol. 85, No. 2, 02.2014, p. 261-268.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics. / Bach, Anders; Strømgaard, Kristian.

    In: Synthesis, Vol. 2011, No. 5, 08.02.2011, p. 807-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Expressed protein ligation of ionotropic glutamate receptors. / Jensen, Mette Stougård; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Biopolymers, Vol. 88, No. 4, 2007, p. 602.

    Research output: Contribution to journalConference abstract in journalResearch

  41. Published

    Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids. / Stuhr-Hansen, Nicolai; Padrah, Shahrokh; Strømgaard, Kristian.

    In: Tetrahedron Letters, Vol. 55, No. 30, 2014, p. 4149-4151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Fatty acid derivatives of dimeric inhibitors of PSD-95. / Strømgaard, Kristian (Inventor); Bach, Anders (Inventor); Nissen, Klaus Bertram (Inventor).

    IPC No.: A61K38/17 . Patent No.: WO2015/078477A1.

    Research output: PatentResearch

  43. Published

    From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram : Synthesis and structure-activity relationship studies. / Eildal, Jonas Nii Nortey; Andersen, Jacob; Kristensen, Anders Skov; Jørgensen, Anne Marie; Bang-Andersen, Benny; Jørgensen, Morten; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 10, 2008, p. 3045-3048.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors. / Lucas, Simon; Poulsen, Mette H; Nørager, Niels G; Barslund, Anne F; Bach, Tinna B; Kristensen, Anders S; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 55, No. 22, 26.11.2012, p. 10297-10301.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter. / Rannversson, Hafsteinn; Andersen, Jacob; Hall, Lena Sørensen; Bang-Andersen, Benny; Park, Minyoung; Huber, Thomas; Sakmar, Thomas P; Strømgaard, Kristian.

    In: Nature Communications, Vol. 7, 11261, 19.04.2016, p. 1-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission. / Maric, Hans Michael; Hausrat, Torben Johann; Neubert, Franziska; Dalby, Nils Ole; Doose, Sören; Sauer, Markus; Kneussel, Matthias; Strømgaard, Kristian.

    In: Nature Chemical Biology, Vol. 13, 2246, 2017, p. 153-160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Giftstoffer fra hvepse og edderkopper i forskning og lægemiddeludvikling. / Strømgaard, Kristian.

    In: Carlsbergfondet. Aarsskrift, 2008, p. 42-47.

    Research output: Contribution to journalJournal articleCommunication

  48. Ginkgolide derivatives for photolabeling studies : preparation and pharmacological evaluation. / Strømgaard, Kristian; Saito, D Roland; Shindou, Hideo; Ishii, Satoshi; Shimizu, Takao; Nakanishi, Koji.

    In: Journal of Medicinal Chemistry, Vol. 45, No. 18, 29.08.2002, p. 4038-4046.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Ginkgolides : selective acetylations, translactonization, and biological evaluation. / Jaracz, Stanislav; Strømgaard, Kristian; Nakanishi, Koji.

    In: Journal of Organic Chemistry, Vol. 67, No. 13, 28.06.2002, p. 4623-4626.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Ginkgolides and glycine receptors : a structure-activity relationship study. / Jaracz, Stanislav; Nakanishi, Koji; Jensen, Anders A.; Strømgaard, Kristian.

    In: Chemistry: A European Journal, Vol. 10, No. 6, 2004, p. 1507-18.

    Research output: Contribution to journalJournal articleResearchpeer-review

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