Kristian Strømgaard
Kristian Strømgaard

Professor


  1. Published

    In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, Jesper & Pickering, Darryl S, 20 Jan 2017, In : European Journal of Neuroscience. 45, 2, p. 238-248 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain

    Thorsen, Thor Seneca, Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In : Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A heteromeric snake toxin and the molecular details of pain perception

    Strømgaard, Kristian & Kristensen, Anders Skov, 23 Apr 2012, In : Angewandte Chemie International Edition. 51, 17, p. 4009-4011

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A parallel semisynthetic approach for structure-activity relationship studies of peptide YY

    Albertsen, L., Østergaard, S., Paulsson, J. F., Norrild, J. C. & Strømgaard, Kristian, Sep 2013, In : ChemMedChem. 8, 9, p. 1505-13

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A sequential binding mechanism in a PDZ domain

    Chi, C. N., Bach, Anders, Engström, Å., Wang, H., Strømgaard, Kristian, Gianni, S. & Jemth, P., 2009, In : Biochemistry. 48, 30, p. 7089-7097

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    A versatile method for solid phase synthesis of polyamines: neuroactive polyamine toxins as example

    Strømgaard, Kristian, Andersen, K., Ruhland, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 2001, In : Synthesis. 6, p. 877-884 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins

    Strømgaard, Kristian & Mellor, I., Sep 2004, In : Medicinal Research Reviews. 24, 5, p. 589-620 32 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    An expanded view of the protein folding landscape of PDZ domains

    Hultqvist, G., Pedersen, S. W., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., 11 May 2012, In : Biochemical and Biophysical Research Communications. 421, 3, p. 550-553 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Antidepressive lægemidler: nu i 3D

    Andersen, J., Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, Dec 2010, In : Lægemiddelforskning. 2010, p. 25-27

    Research output: Contribution to journalJournal articleCommunication

  11. Published

    Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists

    Frølund, S., Bella, A., Kristensen, Anders Skov, Ziegler, H. L., Witt, M., Olsen, C. A., Strømgaard, Kristian, Franzyk, Henrik & Jaroszewski, J. W., 2010, In : Journal of Medicinal Chemistry. 53, 20, p. 7441-7451

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Binding of ArgTX-636 in the NMDA receptor ion channel

    Poulsen, M. H., Andersen, J., Christensen, R., Hansen, K. B., Traynelis, S. F., Strømgaard, Kristian & Kristensen, Anders Skov, 16 Jan 2015, In : Journal of Molecular Biology. 427, 1, p. 176-89 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter

    Andersen, J., Ladefoged, L. K., Wang, Danyang, Kristensen, T. N. B., Bang-Andersen, B., Kristensen, Anders Skov, Schiøtt, B. & Strømgaard, Kristian, 18 Nov 2015, In : A C S Chemical Neuroscience. 6, 11, p. 1892-900 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

    Andersen, J., Ringsted, K. B., Bang-Andersen, B., Strømgaard, Kristian & Kristensen, Anders Skov, 2015, In : Scientific Reports. 5, p. 1-12 12 p., 15650.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97

    Chi, C. N., Bach, Anders, Engström, Å., Strømgaard, Kristian, Lundström, P., Ferguson, N. & Jemth, P., 4 Feb 2011, In : Journal of Biological Chemistry. 286, 5, p. 3597-3606

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

    Bach, Anders, Eildal, J. N. N., Stuhr-Hansen, N., Deeskamp, R., Gottschalk, M., Pedersen, S. W., Kristensen, Anders Skov & Strømgaard, Kristian, 10 Mar 2011, In : Journal of Medicinal Chemistry. 54, 5, p. 1333-1346

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites

    Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, 18 Apr 2014, In : ACS chemical biology. 9, 4, p. 935-44 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Chemical biology

    Strømgaard, Kristian, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 59-74

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  19. Published

    Chemistry and biology of terpene trilactones from Ginkgo biloba

    Strømgaard, Kristian & Nakanishi, K., 19 Mar 2004, In : Angewandte Chemie International Edition. 43, 13, p. 1640-1658 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors

    Brier, T. J., Mellor, I. R., Tikhonov, D. B., Neagoe, I., Shao, Z., Brierley, M. J., Strømgaard, Kristian, Jaroszewski, J. W., Krogsgaard-Larsen, Povl & Usherwood, P. N. R., Oct 2003, In : Molecular Pharmacology. 64, 4, p. 954-964 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers

    Norager, N. G., Poulsen, Mette Homann & Strømgaard, Kristian, 13 Sep 2018, In : Journal of Medicinal Chemistry. 61, 17, p. 8048-8053

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example

    Chi, C. N., Bach, Anders, Gottschalk, M., Kristensen, Anders Skov, Strømgaard, Kristian & Jemth, P., 2010, In : Journal of Biological Chemistry. 285, 36, p. 28252-28260

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

    Maric, H., Kasaragod, V. B., Kedström, L. M. H., Hausrat, T. J., Kneussel, M., Schindelin, H. & Strømgaard, Kristian, 7 Jan 2015, In : Angewandte Chemie (International ed. in English). 54, 2, p. 490-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction

    Bach, Anders, Chi, C. N., Pang, G. F., Olsen, L., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2009, In : Angewandte Chemie - International Edition. 48, 51, p. 9685-9689

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist

    Andersen, T. F., Vogensen, S. B., Jensen, L. S., Knapp, K. M. & Strømgaard, Kristian, 1 Sep 2005, In : Bioorganic & Medicinal Chemistry. 13, 17, p. 5104-5112 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications

    Albertsen, L., Andersen, J. J., Paulsson, J. F., Thomsen, J. K., Norrild, J. C. & Strømgaard, Kristian, 12 Dec 2013, In : A C S Medicinal Chemistry Letters. 4, 12, p. 1228-1232 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor

    Bach, Anders, Pedersen, T. B. & Strømgaard, Kristian, 2016, In : MedChemComm. 7, 3, p. 531-536 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor

    Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, Anders & Strømgaard, Kristian, 2015, In : Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors

    Jensen, L. S., Bølcho, U., Egebjerg, J. & Strømgaard, Kristian, Apr 2006, In : ChemMedChem. 1, 4, p. 419-428 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

    Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In : Drugs. 79, 11, p. 1187-1197 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction

    Gottschalk, M., Bach, Anders, Hansen, J. L., Krogsgaard-Larsen, Povl, Kristensen, Anders Skov & Strømgaard, Kristian, 2009, In : Neurochemical Research. 34, 10, p. 1729-1737

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons

    Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In : A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats: PSD-95 inhibition in experimental TBI

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Gynther, M., Bjerre, A., Gram, M. G., Marschner, L., Strømgaard, Kristian, Mogensen, Jesper & Pickering, Darryl S, 2017, In : Neurochemical Research. 42, 12, p. 3401-3413 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

    Andreasen T., Jesper, Nasser, A., Caballero Puntiverio, Maitane, Sahlholt, M., Bach, Anders, Gynther, M., Strømgaard, Kristian & Pickering, Darryl S, 5 Jun 2016, In : European Journal of Pharmacology. 780, p. 166-73 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats

    Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, Jesper & Pickering, Darryl S, Oct 2017, In : Pharmacology, Biochemistry and Behavior. 161, p. 62-67 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors

    Frølund, S. U., Ziegler, H. L., Franzyk, Henrik, Strømgaard, Kristian, Kristensen, Anders Skov & Jaroszewski, J. W., 2008.

    Research output: Contribution to conferencePosterResearch

  37. Published

    Energetic pathway sampling in a protein interaction domain

    Hultqvist, G., Haq, S. R., Punekar, A. S., Chi, C. N., Engström, A., Bach, Anders, Strømgaard, Kristian, Selmer, M., Gianni, S. & Jemth, P., 25 Jun 2013, In : Structure. 21, 7, p. 1193-1202

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors

    Poulsen, Mette Homann, Lucas, S., Strømgaard, Kristian & Kristensen, Anders Skov, Feb 2014, In : Molecular Pharmacology. 85, 2, p. 261-268 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics

    Bach, Anders & Strømgaard, Kristian, 8 Feb 2011, In : Synthesis. 2011, 5, p. 807-815

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Expressed protein ligation of ionotropic glutamate receptors

    Jensen, M. S., Kristensen, Anders Skov & Strømgaard, Kristian, 2007, In : Biopolymers. 88, 4, p. 602

    Research output: Contribution to journalConference abstract in journalResearch

  41. Published

    Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

    Stuhr-Hansen, N., Padrah, S. & Strømgaard, Kristian, 2014, In : Tetrahedron Letters. 55, 30, p. 4149-4151 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Fatty acid derivatives of dimeric inhibitors of PSD-95

    Strømgaard, Kristian, Bach, Anders & Nissen, K. B., 4 Jun 2015, IPC No. A61K38/17 , Patent No. WO2015/078477A1, Priority date 1 Dec 2013, Priority No. DK/2013/70735

    Research output: Patent

  43. Published

    From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies

    Eildal, J. N. N., Andersen, J., Kristensen, Anders Skov, Jørgensen, A. M., Bang-Andersen, B., Jørgensen, M. & Strømgaard, Kristian, 2008, In : Journal of Medicinal Chemistry. 51, 10, p. 3045-3048

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors

    Lucas, S., Poulsen, Mette Homann, Nørager, N. G., Barslund, A. F., Bach, T. B., Kristensen, Anders Skov & Strømgaard, Kristian, 26 Nov 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 10297-10301 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

    Rannversson, H., Andersen, J., Hall, L. S., Bang-Andersen, B., Park, M., Huber, T., Sakmar, T. P. & Strømgaard, Kristian, 19 Apr 2016, In : Nature Communications. 7, p. 1-9 9 p., 11261.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission

    Maric, H. M., Hausrat, T. J., Neubert, F., Dalby, N. O., Doose, S., Sauer, M., Kneussel, M. & Strømgaard, Kristian, 2017, In : Nature Chemical Biology. 13, p. 153-160 11 p., 2246.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Giftstoffer fra hvepse og edderkopper i forskning og lægemiddeludvikling

    Strømgaard, Kristian, 2008, In : Carlsbergfondet. Aarsskrift. p. 42-47

    Research output: Contribution to journalJournal articleCommunication

  48. Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation

    Strømgaard, Kristian, Saito, D. R., Shindou, H., Ishii, S., Shimizu, T. & Nakanishi, K., 29 Aug 2002, In : Journal of Medicinal Chemistry. 45, 18, p. 4038-4046 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Ginkgolides: selective acetylations, translactonization, and biological evaluation

    Jaracz, S., Strømgaard, Kristian & Nakanishi, K., 28 Jun 2002, In : Journal of Organic Chemistry. 67, 13, p. 4623-4626 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Ginkgolides and glycine receptors: a structure-activity relationship study

    Jaracz, S., Nakanishi, K., Jensen, Anders A. & Strømgaard, Kristian, 2004, In : Chemistry: A European Journal. 10, 6, p. 1507-18 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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