Kristian Strømgaard
Professor
Medicinal Chemistry Research
Jagtvej 162, 2100 København Ø, 30, Building: 240
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A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain. / Thorsen, Thor S; Madsen, Kenneth L; Dyhring, Tino; Bach, Anders; Peters, Dan; Strømgaard, Kristian; Rønn, Lars Christian B; Gether, Ulrik.
In: Combinatorial Chemistry & High Throughput Screening, Vol. 14, No. 7, 01.08.2011, p. 590-600.Research output: Contribution to journal › Journal article › Research › peer-review
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A heteromeric snake toxin and the molecular details of pain perception. / Strømgaard, Kristian; Kristensen, Anders Skov.
In: Angewandte Chemie International Edition, Vol. 51, No. 17, 23.04.2012, p. 4009-4011.Research output: Contribution to journal › Journal article › Research › peer-review
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A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. / Bach, Anders*; Clausen, Bettina H; Møller, Magda; Vestergaard, Bente; Chi, Celestine N; Round, Adam; Sørensen, Pernille Louise; Nissen, Klaus Bertram; Kastrup, Jette Sandholm; Gajhede, Michael; Jemth, Per; Kristensen, Anders Skov; Lundström, Patrik; Lambertsen, Kate Lykke; Strømgaard, Kristian* (*Corresponding).
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, 28.02.2012, p. 3317-3322.Research output: Contribution to journal › Journal article › Research › peer-review
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A parallel semisynthetic approach for structure-activity relationship studies of peptide YY. / Albertsen, Louise; Østergaard, Søren; Paulsson, Johan F; Norrild, Jens Chr.; Strømgaard, Kristian.
In: ChemMedChem, Vol. 8, No. 9, 09.2013, p. 1505-13.Research output: Contribution to journal › Journal article › Research › peer-review
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A sequential binding mechanism in a PDZ domain. / Chi, Celestine N; Bach, Anders; Engström, Åke; Wang, Huiqun; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.
In: Biochemistry, Vol. 48, No. 30, 2009, p. 7089-7097.Research output: Contribution to journal › Journal article › Research › peer-review
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An expanded view of the protein folding landscape of PDZ domains. / Hultqvist, Greta; Pedersen, Søren W; Chi, Celestine N.; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.
In: Biochemical and Biophysical Research Communications, Vol. 421, No. 3, 11.05.2012, p. 550-553.Research output: Contribution to journal › Journal article › Research › peer-review
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Antidepressive lægemidler : nu i 3D. / Andersen, Jacob; Sørensen, Lena; Strømgaard, Kristian; Kristensen, Anders Skov.
In: Lægemiddelforskning, Vol. 2010, 12.2010, p. 25-27.Research output: Contribution to journal › Journal article › Communication
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Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes : Discovery of nanomolar, nonselective, and use-dependent antagonists. / Frølund, Sidsel; Bella, Angelo; Kristensen, Anders Skov; Ziegler, Hanne Lindvig; Witt, Matthias; Olsen, Christian Adam; Strømgaard, Kristian; Franzyk, Henrik; Jaroszewski, Jerzy W.
In: Journal of Medicinal Chemistry, Vol. 53, No. 20, 2010, p. 7441-7451.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding of ArgTX-636 in the NMDA receptor ion channel. / Poulsen, Mette H; Andersen, Jacob; Christensen, Rune; Hansen, Kasper Bø; Traynelis, Stephen F; Strømgaard, Kristian; Kristensen, Anders Skov.
In: Journal of Molecular Biology, Vol. 427, No. 1, 16.01.2015, p. 176-89.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter. / Andersen, Jacob; Ladefoged, Lucy Kate; Wang, Danyang; Kristensen, Trine N Bjerre; Bang-Andersen, Benny; Kristensen, Anders S; Schiøtt, Birgit; Strømgaard, Kristian.
In: A C S Chemical Neuroscience, Vol. 6, No. 11, 18.11.2015, p. 1892-900.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. / Andersen, Jacob; Ringsted, Kristoffer B; Bang-Andersen, Benny; Strømgaard, Kristian; Kristensen, Anders S.
In: Scientific Reports, Vol. 5, 15650, 2015, p. 1-12.Research output: Contribution to journal › Journal article › Research › peer-review
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Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. / Chi, Celestine Ngang; Bach, Anders; Engström, Åke; Strømgaard, Kristian; Lundström, Patrik; Ferguson, Neil; Jemth, Per.
In: Journal of Biological Chemistry, Vol. 286, No. 5, 04.02.2011, p. 3597-3606.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. / Bach, Anders*; Eildal, Jonas Nii Nortey*; Stuhr-Hansen, Nicolai; Deeskamp, Rasmus; Gottschalk, Marie; Pedersen, Søren Wittrup; Kristensen, Anders Skov; Strømgaard, Kristian (*Shared 1st authors).
In: Journal of Medicinal Chemistry, Vol. 54, No. 5, 10.03.2011, p. 1333-1346.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites. / Sørensen, Lena; Strømgaard, Kristian; Kristensen, Anders S.
In: ACS chemical biology, Vol. 9, No. 4, 18.04.2014, p. 935-44.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemical biology. / Strømgaard, Kristian.
Textbook of drug design and discovery. ed. / Povl Krogsgaard-Larsen; Kristian Strømgaard; Ulf Madsen. 4. ed. Boca Raton : CRC Press, 2010. p. 59-74.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Education
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Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. / Chi, Celestine N; Bach, Anders; Gottschalk, Marie; Kristensen, Anders Skov; Strømgaard, Kristian; Jemth, Per.
In: Journal of Biological Chemistry, Vol. 285, No. 36, 2010, p. 28252-28260.Research output: Contribution to journal › Journal article › Research › peer-review
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Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors. / Maric, Hans-Michael; Kasaragod, Vikram Babu; Kedström, Linda Maria Haugaard; Hausrat, Torben Johann; Kneussel, Matthias; Schindelin, Hermann; Strømgaard, Kristian.
In: Angewandte Chemie (International ed. in English), Vol. 54, No. 2, 07.01.2015, p. 490-4.Research output: Contribution to journal › Journal article › Research › peer-review
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Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction. / Bach, Anders; Chi, Celestine N; Pang, Gar Fai; Olsen, Lars; Kristensen, Anders Skov; Jemth, Per; Strømgaard, Kristian.
In: Angewandte Chemie - International Edition, Vol. 48, No. 51, 2009, p. 9685-9689.Research output: Contribution to journal › Journal article › Research › peer-review
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Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications. / Albertsen, Louise; Andersen, J.J.; Paulsson, J.F.; Thomsen, J.K.; Norrild, Jens Chr.; Strømgaard, K.
In: A C S Medicinal Chemistry Letters, Vol. 4, No. 12, 12.12.2013, p. 1228-1232.Research output: Contribution to journal › Journal article › Research › peer-review
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Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor. / Nissen, Klaus B; Andersen, Julie J; Haugaard-Kedström, Linda Maria; Bach, Anders; Strømgaard, Kristian.
In: Journal of Medicinal Chemistry, Vol. 58, 2015, p. 1575-1580.Research output: Contribution to journal › Journal article › Research › peer-review
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Design, synthesis, and pharmacological characterization of polyamine toxin derivatives : potent ligands for the pore-forming region of AMPA receptors. / Jensen, Lars S; Bølcho, Ulrik; Egebjerg, Jan; Strømgaard, Kristian.
In: ChemMedChem, Vol. 1, No. 4, 04.2006, p. 419-428.Research output: Contribution to journal › Journal article › Research › peer-review
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Detecting protein-protein interactions in living cells : development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction. / Gottschalk, Marie; Bach, Anders; Hansen, Jakob Lerche; Krogsgaard-Larsen, Povl; Kristensen, Anders Skov; Strømgaard, Kristian.
In: Neurochemical Research, Vol. 34, No. 10, 2009, p. 1729-1737.Research output: Contribution to journal › Journal article › Research › peer-review
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Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons. / Nørager, Niels Grøn; Jensen, Christel Barker; Rathje, Mette; Andersen, Jacob; Madsen, Kenneth Lindegaard; Kristensen, Anders Skov; Strømgaard, Kristian.
In: A C S Chemical Biology, Vol. 8, No. 9, 20.09.2013, p. 2033-2041.Research output: Contribution to journal › Journal article › Research › peer-review
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Electrophysiological characterization of analogues of philanthotoxin-343 on ionotropic glutamate receptors. / Frølund, Sidsel Ullerup; Ziegler, Hanne Lindvig; Franzyk, Henrik; Strømgaard, Kristian; Kristensen, Anders Skov; Jaroszewski, Jerzy Witold.
2008. Poster session presented at Fællesmøde for de danske farmakologiske selskaber 2008, Odense, Denmark.Research output: Contribution to conference › Poster › Research
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Energetic pathway sampling in a protein interaction domain. / Hultqvist, Greta; Haq, S. Raza; Punekar, Avinash S.; Chi, Celestine N.; Engström, Ake; Bach, Anders; Strømgaard, Kristian; Selmer, Maria; Gianni, Stefano; Jemth, Per.
In: Structure, Vol. 21, No. 7, 25.06.2013, p. 1193-1202.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 1302559
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PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Research output: Contribution to journal › Journal article › Research › peer-review
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