Kristian Strømgaard

Kristian Strømgaard

Professor


  1. 2014
  2. Published

    Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin. / Maric, Hans-Michael; Kasaragod, Vikram Babu; Hausrat, Torben Johann; Kneussel, Matthias; Tretter, Verena; Strømgaard, Kristian; Schindelin, Hermann.

    In: Nature Communications, Vol. 5, 5767, 22.12.2014, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Structure–Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors. / Xiong, Xiaofeng; Poulsen, Mette H; Hussein, Rama A; Nørager, Niels G; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 9, No. 12, 12.2014, p. 2661-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    THE DEVELOPMENT AND CHARACTERIZATION OF A PEPTIDE-BASED SYNTENIN INHIBITOR - IMPLACATIONS FOR CANCER METASTASIS. / Haugaard-Kedstrom, L. M.; Albertsen, L.; Gil, F. Abalde; Ivarsson, Y.; Stromgaard, K.; Kedström, Linda Maria Haugaard.

    In: Journal of Peptide Science, Vol. 20, No. Suppl. 1, YO11, 09.2014, p. s39.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  5. Published

    Mechanistic insight into benzenethiol catalyzed amide bond formations from thioesters and primary amines. / Stuhr-Hansen, Nicolai; Bork, Nicolai; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 12, No. 30, 14.08.2014, p. 5745-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors. / Nørager, Niels G; Poulsen, Mette H; Jensen, Anna G; Jeppesen, Nanna S; Kristensen, Anders S; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 11, 12.06.2014, p. 4940-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (prozac). / Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda Grønborg; Koldsø, Heidi; Schiøtt, Birgit; Strømgaard, Kristian; Kristensen, Anders S.

    In: Molecular Pharmacology, Vol. 85, No. 5, 05.2014, p. 703-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites. / Sørensen, Lena; Strømgaard, Kristian; Kristensen, Anders S.

    In: ACS chemical biology, Vol. 9, No. 4, 18.04.2014, p. 935-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin. / Poulsen, Mette H; Lucas, Simon; Strømgaard, Kristian; Kristensen, Anders S.

    In: Neurochemical Research, Vol. 39, No. 10, 22.02.2014, p. 1906-1913.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Evaluation of PhTX-74 as Subtype-Selective Inhibitor of GluA2-Containing AMPA Receptors. / Poulsen, Mette Homann; Lucas, Simon; Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Molecular Pharmacology, Vol. 85, No. 2, 02.2014, p. 261-268.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins. / Kachel, Hamid S.; Franzyk, Henrik; Stromgaard, Kristian; Tikhonov, Denis B.; Mellor, Ian R.

    In: Biophysical Society. Annual Meeting. Abstracts, Vol. 106, No. 2, 28.01.2014, p. 338A-338A.

    Research output: Contribution to journalJournal articleResearch

  12. Published

    Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids. / Stuhr-Hansen, Nicolai; Padrah, Shahrokh; Strømgaard, Kristian.

    In: Tetrahedron Letters, Vol. 55, No. 30, 2014, p. 4149-4151.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations. / Pedersen, Søren W; Pedersen, Stine B; Anker, Louise; Hultqvist, Greta; Kristensen, Anders S; Jemth, Per; Strømgaard, Kristian.

    In: Nature Communications, Vol. 5, 3215, 2014, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain. / Pedersen, Søren W; Hultqvist, Greta; Strømgaard, Kristian; Jemth, Per.

    In: PLOS ONE, Vol. 9, No. 4, e95619, 2014, p. 1-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2013
  16. Published

    Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications. / Albertsen, Louise; Andersen, J.J.; Paulsson, J.F.; Thomsen, J.K.; Norrild, Jens Chr.; Strømgaard, K.

    In: A C S Medicinal Chemistry Letters, Vol. 4, No. 12, 12.12.2013, p. 1228-1232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Recombinant production of peptide C-terminal α-amides using an engineered intein. / Albertsen, Louise; Shaw, Allan C; Norrild, Jens Chr.; Strømgaard, Kristian.

    In: Bioconjugate Chemistry, Vol. 24, No. 11, 20.11.2013, p. 1883-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons. / Nørager, Niels Grøn; Jensen, Christel Barker; Rathje, Mette; Andersen, Jacob; Madsen, Kenneth Lindegaard; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: A C S Chemical Biology, Vol. 8, No. 9, 20.09.2013, p. 2033-2041.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations. / Eildal, Jonas N N; Hultqvist, Greta; Balle, Thomas; Stuhr-Hansen, Nicolai; Padrah, Shahrokh; Gianni, Stefano; Strømgaard, Kristian; Jemth, Per.

    In: Journal of the American Chemical Society, Vol. 135, No. 35, 04.09.2013, p. 12998-3007.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    A parallel semisynthetic approach for structure-activity relationship studies of peptide YY. / Albertsen, Louise; Østergaard, Søren; Paulsson, Johan F; Norrild, Jens Chr.; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 8, No. 9, 09.2013, p. 1505-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Preparation of peptide thioesters through fmoc-based solid-phase peptide synthesis by using amino thioesters. / Stuhr-Hansen, N.; Wilbek, T.S.; Strømgaard, K.

    In: European Journal of Organic Chemistry, Vol. 2013, No. 24, 01.08.2013, p. 5290-5294.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Energetic pathway sampling in a protein interaction domain. / Hultqvist, Greta; Haq, S. Raza; Punekar, Avinash S.; Chi, Celestine N.; Engström, Ake; Bach, Anders; Strømgaard, Kristian; Selmer, Maria; Gianni, Stefano; Jemth, Per.

    In: Structure, Vol. 21, No. 7, 25.06.2013, p. 1193-1202.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Synthetic and mechanistic insight into nosylation of glycine residues. / Stuhr-Hansen, Nicolai; Sølling, Theis Ivan; Strømgaard, Kristian.

    In: Organic & Biomolecular Chemistry, Vol. 11, No. 14, 14.04.2013, p. 2288-2293.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. / Fiorentini, Monica; Bach, Anders; Strømgaard, Kristian; Kastrup, Jette S; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 69, No. Pt 4, 04.2013, p. 587-94.

    Research output: Contribution to journalJournal articleResearch

  25. Published
  26. Published

    Structure-activity relationship studies of argiotoxins : selective and potent inhibitors of ionotropic glutamate receptors. / Poulsen, Mette H; Lucas, Simon; Bach, Tinna B; Barslund, Anne F; Wenzler, Claudius; Jensen, Christel B; Kristensen, Anders S; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 14.02.2013, p. 1171-1181.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95 : quantitative characterization of interactions. / Møller, Thor C; Wirth, Volker F; Roberts, Nina Ingerslev; Bender, Julia; Bach, Anders; Jacky, Birgitte P S; Strømgaard, Kristian; Deussing, Jan M; Schwartz, Thue W; Martinez, Karen L.

    In: PLOS ONE, Vol. 8, No. 5, e63352, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Synthesis of peptides using tert-butyloxycarbonyl (Boc) as the α-amino protection group. / Pedersen, Søren W; Armishaw, Christopher J; Strømgaard, Kristian.

    Peptide synthesis and applications. Vol. 1047 Humana Press, 2013. p. 65-80 (Methods in Molecular Biology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  29. 2012
  30. Published

    General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors. / Lucas, Simon; Poulsen, Mette H; Nørager, Niels G; Barslund, Anne F; Bach, Tinna B; Kristensen, Anders S; Strømgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 55, No. 22, 26.11.2012, p. 10297-10301.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    An expanded view of the protein folding landscape of PDZ domains. / Hultqvist, Greta; Pedersen, Søren W; Chi, Celestine N.; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.

    In: Biochemical and Biophysical Research Communications, Vol. 421, No. 3, 11.05.2012, p. 550-553.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    A heteromeric snake toxin and the molecular details of pain perception. / Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Angewandte Chemie International Edition, Vol. 51, No. 17, 23.04.2012, p. 4009-4011.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. / Bach, Anders*; Clausen, Bettina H; Møller, Magda; Vestergaard, Bente; Chi, Celestine N; Round, Adam; Sørensen, Pernille Louise; Nissen, Klaus Bertram; Kastrup, Jette Sandholm; Gajhede, Michael; Jemth, Per; Kristensen, Anders Skov; Lundström, Patrik; Lambertsen, Kate Lykke; Strømgaard, Kristian* (*Corresponding).

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, 28.02.2012, p. 3317-3322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. / Haq, S Raza; Chi, Celestine N; Bach, Anders; Dogan, Jakob; Engström, Åke; Hultqvist, Greta; Karlsson, O. Andreas; Lundström, Patrik; Montemiglio, Linda Celeste; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.

    In: Journal of the American Chemical Society, Vol. 134, No. 1, 01.2012, p. 599-605.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Submitted
  36. Published

    Interaction of antidepressants with the serotonin and norepinephrine transporters : mutational studies of the S1 substrate binding pocket. / Sørensen, Lena; Andersen, Jacob; Thomsen, Mette; Hansen, Stinna M.R.; Zhao, Xiaobei; Sandelin, Albin Gustav; Strømgaard, Kristian; Kristensen, Anders S.

    In: The Journal of Biological Chemistry, Vol. 287, No. 52, 2012, p. 43694-43707.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Interaction of antidepressants with the serotonin and norepinephrine transporters : mutational studies of the S1 substrate binding pocket. / Sørensen, Lena; Andersen, Jacob; Thomsen, Mette; Hansen, Stinna M.R.; Zhao, Xiaobei; Sandelin, Albin Gustav; Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Journal of Biological Chemistry, Vol. 287, 2012, p. 43694-43707.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Ligand binding by PDZ domains. / Chi, Celestine N.; Bach, Anders; Strømgaard, Kristian; Gianni, Stefano; Jemth, Per.

    In: BioFactors, Vol. 38, No. 5, 2012, p. 338-348 (Review).

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2011
  40. Published

    Small molecules from spiders used as chemical probes. / Olsen, Christian Adam; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Angewandte Chemie International Edition, Vol. 50, No. 48, 25.11.2011, p. 11296-11311.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation. / Kristensen, Anders S; Andersen, Jacob; Jørgensen, Trine N; Sørensen, Lena; Eriksen, Jacob; Løland, Claus Juul; Strømgaard, Kristian; Gether, Ulrik.

    In: Pharmacological Reviews, Vol. 63, No. 3, 01.09.2011, p. 585-640.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain. / Thorsen, Thor S; Madsen, Kenneth L; Dyhring, Tino; Bach, Anders; Peters, Dan; Strømgaard, Kristian; Rønn, Lars Christian B; Gether, Ulrik.

    In: Combinatorial Chemistry & High Throughput Screening, Vol. 14, No. 7, 01.08.2011, p. 590-600.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters. / Andersen, Jacob; Stuhr-Hansen, Nicolai; Zachariassen, Linda; Toubro, Søren; Hansen, Stinna Maria R; Eildal, Jonas Nii Nortey; Bond, Andrew D; Bøgesø, Klaus P; Bang-Andersen, Benny; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 29, 19.07.2011, p. 12137-12142.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. / Bach, Anders*; Eildal, Jonas Nii Nortey*; Stuhr-Hansen, Nicolai; Deeskamp, Rasmus; Gottschalk, Marie; Pedersen, Søren Wittrup; Kristensen, Anders Skov; Strømgaard, Kristian (*Shared 1st authors).

    In: Journal of Medicinal Chemistry, Vol. 54, No. 5, 10.03.2011, p. 1333-1346.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics. / Bach, Anders; Strømgaard, Kristian.

    In: Synthesis, Vol. 2011, No. 5, 08.02.2011, p. 807-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97. / Chi, Celestine Ngang; Bach, Anders; Engström, Åke; Strømgaard, Kristian; Lundström, Patrik; Ferguson, Neil; Jemth, Per.

    In: Journal of Biological Chemistry, Vol. 286, No. 5, 04.02.2011, p. 3597-3606.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization : The effect of linker length on stability and activity at nicotinic acetylcholine receptors. / Armishaw, Christopher J; Jensen, Anders A; Balle, Lena D; Scott, Krystle C M; Sørensen, Lena; Strømgaard, Kristian.

    In: Antioxidants & Redox Signaling, Vol. 14, No. 1, 2011, p. 65-76.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata. / Barslund, Anne Fuglsang; Poulsen, Mette Homann; Bach, Tinna Brøbech; Lucas, Simon; Kristensen, Anders Skov; Strømgaard, Kristian.

    In: Journal of Natural Products, Vol. 74, No. 3, 2011, p. 483-486.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2010
  50. Published

    Antidepressive lægemidler : nu i 3D. / Andersen, Jacob; Sørensen, Lena; Strømgaard, Kristian; Kristensen, Anders Skov.

    In: Lægemiddelforskning, Vol. 2010, 12.2010, p. 25-27.

    Research output: Contribution to journalJournal articleCommunication

  51. Published

    Modified peptides as potent inhibitors of the PSD-95/NMDA receptor interaction. / Bach, Anders (Inventor); Strømgaard, Kristian (Inventor).

    Patent No.: WO2010/004003 (Granted: EP2320927B1; US9241967B2).

    Research output: PatentResearch

  52. Published

    Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes : Discovery of nanomolar, nonselective, and use-dependent antagonists. / Frølund, Sidsel; Bella, Angelo; Kristensen, Anders Skov; Ziegler, Hanne Lindvig; Witt, Matthias; Olsen, Christian Adam; Strømgaard, Kristian; Franzyk, Henrik; Jaroszewski, Jerzy W.

    In: Journal of Medicinal Chemistry, Vol. 53, No. 20, 2010, p. 7441-7451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Chemical biology. / Strømgaard, Kristian.

    Textbook of drug design and discovery. ed. / Povl Krogsgaard-Larsen; Kristian Strømgaard; Ulf Madsen. 4. ed. Boca Raton : CRC Press, 2010. p. 59-74.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  54. Published

    Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. / Chi, Celestine N; Bach, Anders; Gottschalk, Marie; Kristensen, Anders Skov; Strømgaard, Kristian; Jemth, Per.

    In: Journal of Biological Chemistry, Vol. 285, No. 36, 2010, p. 28252-28260.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. / Thorsen, Thor S; Madsen, Kenneth L; Rebola, Nelson; Rathje, Mette; Anggono, Victor; Bach, Anders; Moreira, Irina S; Stuhr-Hansen, Nicolai; Dyhring, Tino; Peters, Dan; Beuming, Thijs; Huganir, Richard; Weinstein, Harel; Mulle, Christophe; Strømgaard, Kristian; Rønn, Lars Christian B; Gether, Ulrik.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 107, No. 1, 2010, p. 413-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

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