Kristian Strømgaard

Kristian Strømgaard

Professor


  1. Published

    Design and synthesis of peptide YY analogues with c-terminal backbone amide-to-ester modifications

    Albertsen, L., Andersen, J. J., Paulsson, J. F., Thomsen, J. K., Norrild, J. C. & Strømgaard, Kristian, 12 Dec 2013, In : A C S Medicinal Chemistry Letters. 4, 12, p. 1228-1232 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A parallel semisynthetic approach for structure-activity relationship studies of peptide YY

    Albertsen, L., Østergaard, S., Paulsson, J. F., Norrild, J. C. & Strømgaard, Kristian, Sep 2013, In : ChemMedChem. 8, 9, p. 1505-13

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Recombinant production of peptide C-terminal α-amides using an engineered intein

    Albertsen, L., Shaw, A. C., Norrild, J. C. & Strømgaard, Kristian, 20 Nov 2013, In : Bioconjugate Chemistry. 24, 11, p. 1883-94 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter

    Andersen, J., Olsen, L., Hansen, K. B., Taboureau, O., Jørgensen, Flemming Steen, Jørgensen, A. M., Bang-Andersen, B., Egebjerg, J., Strømgaard, Kristian & Kristensen, Anders Skov, 2010, In : Journal of Biological Chemistry. 285, 3, p. 2051-2063

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands

    Andersen, J., Ladefoged, L. K., Kristensen, T. N. B., Munro, L., Grouleff, J., Stuhr-Hansen, N., Kristensen, Anders Skov, Schiøtt, B. & Strømgaard, Kristian, 19 Oct 2016, In : A C S Chemical Neuroscience. 7, 10, p. 1406-1417 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter

    Andersen, J., Ladefoged, L. K., Wang, Danyang, Kristensen, T. N. B., Bang-Andersen, B., Kristensen, Anders Skov, Schiøtt, B. & Strømgaard, Kristian, 18 Nov 2015, In : A C S Chemical Neuroscience. 6, 11, p. 1892-900 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (prozac)

    Andersen, J., Stuhr-Hansen, N., Dorvil, Linda Grønborg, Koldsø, H., Schiøtt, B., Strømgaard, Kristian & Kristensen, Anders Skov, May 2014, In : Molecular Pharmacology. 85, 5, p. 703-14 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Antidepressive lægemidler: nu i 3D

    Andersen, J., Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, Dec 2010, In : Lægemiddelforskning. 2010, p. 25-27

    Research output: Contribution to journalJournal articleCommunication

  9. Published

    Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

    Andersen, J., Ringsted, K. B., Bang-Andersen, B., Strømgaard, Kristian & Kristensen, Anders Skov, 2015, In : Scientific Reports. 5, p. 1-12 12 p., 15650.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters

    Andersen, J., Stuhr-Hansen, N., Dorvil, Linda Grønborg, Toubro, S., Hansen, S. M. R., Eildal, J. N. N., Bond, A. D., Bøgesø, K. P., Bang-Andersen, B., Kristensen, Anders Skov & Strømgaard, Kristian, 19 Jul 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 29, p. 12137-12142

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Structure and absolute configuration of ginkgolide B characterized by IR- and VCD spectroscopy

    Andersen, N. H., Christensen, Niels Johan, Lassen, P. R., Freedman, T. B. N., Nafie, L. A., Strømgaard, Kristian & Hemmingsen, Lars Bo Stegeager, 2010, In : Chirality. 22, 2, p. 217-223 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function

    Andreasen T., Jesper, Nasser, A., Caballero-Puntiverio, M., Sahlholt, M., Bach, Anders, Gynther, M., Strømgaard, Kristian & Pickering, Darryl S, 5 Jun 2016, In : European Journal of Pharmacology. 780, p. 166-73 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801

    Andreasen T., Jesper, Bach, Anders, Gynther, M., Nasser, A., Mogensen, Jesper, Strømgaard, Kristian & Pickering, Darryl S, Apr 2013, In : Neuropharmacology. 67, p. 193-200 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization: The effect of linker length on stability and activity at nicotinic acetylcholine receptors

    Armishaw, C. J., Jensen, Anders A., Balle, L. D., Scott, K. C. M., Sørensen, L. & Strømgaard, Kristian, 2011, In : Antioxidants & Redox Signaling. 14, 1, p. 65-76

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

    Bach, Anders, Stuhr-Hansen, N., Thorsen, Thor Seneca, Bork, N., Moreira, I. S., Frydenvang, Karla Andrea, Padrah, S., Christensen, Søren Brøgger, Madsen, Kenneth Lindegaard, Weinstein, H., Gether, Ulrik & Strømgaard, Kristian, 2010, In : Organic & Biomolecular Chemistry. 8, 19, p. 4281-4288 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor

    Bach, Anders, Pedersen, T. B. & Strømgaard, Kristian, 2016, In : MedChemComm. 7, 3, p. 531-536 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Expedient synthesis of 1,3-substituted benzene peptidomimetics

    Bach, Anders & Strømgaard, Kristian, 8 Feb 2011, In : Synthesis. 2011, 5, p. 807-815

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Submitted
  19. Published

    Modified peptides as potent inhibitors of the PSD-95/NMDA receptor interaction

    Bach, Anders & Strømgaard, Kristian, 14 Jan 2010, Patent No. WO2010/004003 (Granted: EP2320927B1; US9241967B2)

    Research output: Patent

  20. Published

    Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

    Bach, Anders, Eildal, J. N. N., Stuhr-Hansen, N., Deeskamp, R., Gottschalk, M., Pedersen, S. W., Kristensen, Anders Skov & Strømgaard, Kristian, 10 Mar 2011, In : Journal of Medicinal Chemistry. 54, 5, p. 1333-1346

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata

    Barslund, A. F., Poulsen, Mette Homann, Bach, T. B., Lucas, S., Kristensen, Anders Skov & Strømgaard, Kristian, 2011, In : Journal of Natural Products. 74, 3, p. 483-486

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

    Cheng, J., Sahani, S., Hausrat, T. J., Yang, J., Ji, H., Schmarowski, N., Endle, H., Liu, X., Li, Y., Böttche, R., Radyushkin, K., Maric, H. M., Hoerder-Suabedissen, A., Molnár, Z., Prouvot, P., Trimbuch, T., Ninnemann, O., Huai, J., Fan, W., Visentin, B., Sabbadini, R., Strømgaard, Kristian, Stroh, A., Luhmann, H. J., Kneussel, M., Nitsch, R. & Vogt, J., 5 Oct 2016, In : Neuron. 92, 1, p. 126-142 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example

    Chi, C. N., Bach, Anders, Gottschalk, M., Kristensen, Anders Skov, Strømgaard, Kristian & Jemth, P., 2010, In : Journal of Biological Chemistry. 285, 36, p. 28252-28260

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Ligand binding by PDZ domains

    Chi, C. N., Bach, Anders, Strømgaard, Kristian, Gianni, S. & Jemth, P., 2012, In : BioFactors. 38, 5, p. 338-348 (Review) 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97

    Chi, C. N., Bach, Anders, Engström, Å., Strømgaard, Kristian, Lundström, P., Ferguson, N. & Jemth, P., 4 Feb 2011, In : Journal of Biological Chemistry. 286, 5, p. 3597-3606

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations

    Eildal, J. N. N., Hultqvist, G., Balle, T., Stuhr-Hansen, N., Padrah, S., Gianni, S., Strømgaard, Kristian & Jemth, P., 4 Sep 2013, In : Journal of the American Chemical Society. 135, 35, p. 12998-3007 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Rigidified Clicked Dimeric Ligands for Studying the Dynamics of the PDZ1-2 Supramodule of PSD-95

    Eildal, J. N. N., Bach, Anders, Dogan, J., Ye, F., Zhang, M., Jemth, P. & Strømgaard, Kristian, 2015, In : ChemBioChem. 16, p. 64–69 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In : Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journalJournal articleResearch

  30. Published

    Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists

    Frølund, S., Bella, A., Kristensen, Anders Skov, Ziegler, H. L., Witt, M., Olsen, C. A., Strømgaard, Kristian, Franzyk, Henrik & Jaroszewski, J. W., 2010, In : Journal of Medicinal Chemistry. 53, 20, p. 7441-7451

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains

    Haq, S. R., Chi, C. N., Bach, Anders, Dogan, J., Engström, Å., Hultqvist, G., Karlsson, O. A., Lundström, P., Montemiglio, L. C., Strømgaard, Kristian, Gianni, S. & Jemth, P., Jan 2012, In : Journal of the American Chemical Society. 134, 1, p. 599-605

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    THE DEVELOPMENT AND CHARACTERIZATION OF A PEPTIDE-BASED SYNTENIN INHIBITOR - IMPLACATIONS FOR CANCER METASTASIS

    Haugaard-Kedstrom, L. M., Albertsen, L., Gil, F. A., Ivarsson, Y., Strømgaard, Kristian & Kedström, L. M. H., Sep 2014, In : Journal of Peptide Science. 20, Suppl. 1, p. s39 1 p., YO11.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  33. Published

    Energetic pathway sampling in a protein interaction domain

    Hultqvist, G., Haq, S. R., Punekar, A. S., Chi, C. N., Engström, A., Bach, Anders, Strømgaard, Kristian, Selmer, M., Gianni, S. & Jemth, P., 25 Jun 2013, In : Structure. 21, 7, p. 1193-1202

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    An expanded view of the protein folding landscape of PDZ domains

    Hultqvist, G., Pedersen, S. W., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., 11 May 2012, In : Biochemical and Biophysical Research Communications. 421, 3, p. 550-553 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Subunit-Dependent Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Philanthotoxins

    Kachel, H. S., Franzyk, Henrik, Strømgaard, Kristian, Tikhonov, D. B. & Mellor, I. R., 28 Jan 2014, In : Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 338A-338A 1 p.

    Research output: Contribution to journalJournal articleResearch

  36. Published

    SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

    Kristensen, Anders Skov, Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, Claus Juul, Strømgaard, Kristian & Gether, Ulrik, 1 Sep 2011, In : Pharmacological Reviews. 63, 3, p. 585-640 56 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Textbook of drug design and discovery

    Krogsgaard-Larsen, Povl, Strømgaard, Kristian & Madsen, Ulf, 2010, 4 ed. Boca Raton: CRC Press. 460 p.

    Research output: Book/ReportBookEducation

  38. Published

    Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter

    Larsen, M. A. B., Plenge, P., Andersen, J., Eildal, J. N. N., Kristensen, Anders Skov, Bøgesø, K. P., Gether, Ulrik, Strømgaard, Kristian, Bang-Andersen, B. & Loland, Claus Juul, Mar 2016, In : British Journal of Pharmacology. 173, 5, p. 925-936 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors

    Lucas, S., Poulsen, Mette Homann, Nørager, N. G., Barslund, A. F., Bach, T. B., Kristensen, Anders Skov & Strømgaard, Kristian, 26 Nov 2012, In : Journal of Medicinal Chemistry. 55, 22, p. 10297-10301 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin

    Maric, H., Kasaragod, V. B., Hausrat, T. J., Kneussel, M., Tretter, V., Strømgaard, Kristian & Schindelin, H., 22 Dec 2014, In : Nature Communications. 5, p. 1-11 11 p., 5767.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors

    Maric, H., Kasaragod, V. B., Kedström, L. M. H., Hausrat, T. J., Kneussel, M., Schindelin, H. & Strømgaard, Kristian, 7 Jan 2015, In : Angewandte Chemie (International ed. in English). 54, 2, p. 490-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions

    Møller, Thor C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In : PLOS ONE. 8, 5, e63352.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Targeting Protein-Protein Interactions with Trimeric Ligands: High Affinity Inhibitors of the MAGUK Protein Family

    Nissen, K. B., Kedström, L. M. H., Wilbek, T. S., Nielsen, L. S., Åberg, E., Kristensen, Anders Skov, Bach, Anders, Jemth, P. & Strømgaard, Kristian, 2015, In : PLOS ONE. 10, 2, p. 1-17 17 p., e0117668.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Design, Synthesis, and Characterization of Fatty Acid Derivatives of a Dimeric Peptide-Based Postsynaptic Density-95 (PSD-95) Inhibitor

    Nissen, K. B., Andersen, J. J., Haugaard-Kedström, L. M., Bach, Anders & Strømgaard, Kristian, 2015, In : Journal of Medicinal Chemistry. 58, p. 1575-1580 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors

    Nørager, N. G., Poulsen, Mette Homann, Jensen, A. G., Jeppesen, N. S., Kristensen, Anders Skov & Strømgaard, Kristian, 12 Jun 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4940-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons

    Nørager, N. G., Jensen, C. B., Rathje, Mette, Andersen, J., Madsen, Kenneth Lindegaard, Kristensen, Anders Skov & Strømgaard, Kristian, 20 Sep 2013, In : A C S Chemical Biology. 8, 9, p. 2033-2041 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Small molecules from spiders used as chemical probes

    Olsen, C. A., Kristensen, Anders Skov & Strømgaard, Kristian, 25 Nov 2011, In : Angewandte Chemie International Edition. 50, 48, p. 11296-11311

    Research output: Contribution to journalReviewResearchpeer-review

  48. Published

    The role of backbone hydrogen bonds in the transition state for protein folding of a PDZ domain

    Pedersen, S. W., Hultqvist, G., Strømgaard, Kristian & Jemth, P., 2014, In : PLOS ONE. 9, 4, p. 1-7 7 p., e95619.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis

    Pedersen, S. W., Moran, G. E., Sereikaité, Vita, Kedström, L. M. H. & Strømgaard, Kristian, 17 Oct 2016, In : ChemBioChem. 17, 20, p. 1936-1944 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations

    Pedersen, S. W., Pedersen, S. B., Anker, L., Hultqvist, G., Kristensen, Anders Skov, Jemth, P. & Strømgaard, Kristian, 2014, In : Nature Communications. 5, p. 1-11 11 p., 3215.

    Research output: Contribution to journalJournal articleResearchpeer-review

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