Kristian Strømgaard

Kristian Strømgaard

Professor


  1. 2019
  2. Published

    Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities. / Petersen, Jonas; Strømgaard, Kristian; Frølund, Bente; Clemmensen, Christoffer.

    In: Drugs, Vol. 79, https://doi.org/10.1007/s40265-019-01153-6, 26.06.2019, p. 1187-1197.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity. / Malfacini, Davide; Patt, Julian; Annala, Suvi; Harpsøe, Kasper; Eryilmaz, Funda; Reher, Raphael; Crüsemann, Max; Hanke, Wiebke; Zhang, Hang; Tietze, Daniel; Gloriam, David E; Bräuner-Osborne, Hans; Strømgaard, Kristian; König, Gabriele M; Inoue, Asuka; Gomeza, Jesus; Kostenis, Evi.

    In: The Journal of Biological Chemistry, Vol. 294, No. 15, 12.04.2019, p. 5747-5758.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. E-pub ahead of print

    Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor. / Bach, Anders; Clausen, Bettina H; Kristensen, Lotte K; Andersen, Maria G; Ellman, Ditte Gry; Hansen, Pernille B L; Hasseldam, Henrik; Heitz, Marc; Özcelik, Dennis; Tuck, Ellie J; Kopanitsa, Maksym V; Grant, Seth G N; Lykke-Hartmann, Karin; Johansen, Flemming F; Lambertsen, Kate L; Strømgaard, Kristian.

    In: Neuropharmacology, Vol. 150, 02.03.2019, p. 100-111.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Structure–Activity Relationship Studies of the Natural Product G q/11 Protein Inhibitor YM-254890. / Xiong, Xiao Feng; Zhang, Hang; Boesgaard, Michael W.; Underwood, Christina R.; Bräuner-Osborne, Hans; Strømgaard, Kristian.

    In: ChemMedChem, 01.01.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2018
  7. Published

    Probing Backbone Hydrogen Bonds in Proteins by Amide-to-Ester Mutations. / Sereikaitė, Vita; Jensen, Thomas M.T.; Bartling, Christian R.O.; Jemth, Per; Pless, Stephan A.; Strømgaard, Kristian.

    In: ChemBioChem, Vol. 19, No. 20, 18.10.2018, p. 2136-2145.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Controlling Ca2+ Permeable alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Photochromic Ion Channel Blockers. / Norager, Niels G.; Poulsen, Mette H.; Stromgaard, Kristian.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 17, 13.09.2018, p. 8048-8053.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. / Zhang, Hang; Nielsen, Alexander L.; Boesgaard, Michael W.; Harpsøe, Kasper; Daly, Norelle L.; Xiong, Xiao-feng; Underwood, Christina R.; Haugaard-kedström, Linda M.; Bräuner-osborne, Hans; Gloriam, David E.; Strømgaard, Kristian.

    In: European Journal of Medicinal Chemistry, Vol. 156, 05.08.2018, p. 847-860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Peptide Modulation of Acid-Sensing Ion Channels. / Borg, Christian B.; Haugaard-Kedstrom, Linda M.; Lynagh, Timothy; Stromgaard, Kristian; Pless, Stephan A.

    2018. 130A-130A.

    Research output: Contribution to conferencePosterResearch

  11. Published

    Probing the Mint2 Protein-Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease. / Jensen, Thomas M. T.; Albertsen, Louise; Bartling, Christian R. O.; Haugaard-kedström, Linda M.; Strømgaard, Kristian.

    In: ChemBioChem, Vol. 19, No. 11, 2018, p. 1119-1122.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Protein Engineering Reveals Mechanisms of Functional Amyloid Formation in Pseudomonas aeruginosa Biofilms. / Bleem, Alissa; Christiansen, Gunna; Madsen, Daniel J.; Maric, Hans; Strømgaard, Kristian; Bryers, James D.; Daggett, Valerie; Meyer, Rikke L.; Otzen, Daniel E.

    In: Journal of Molecular Biology, Vol. 430, No. 20, 2018, p. 3751-3763.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2017
  14. Published

    Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers. / Rannversson, Hafsteinn; Andersen, Jacob; Bang-Andersen, Benny; Strømgaard, Kristian.

    In: ACS chemical biology, Vol. 12, No. 10, 20.10.2017, p. 2558-2562.

    Research output: Contribution to journalLetterResearchpeer-review

  15. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats. / Sommer, Jens Bak; Bach, Anders; Malá, Hana ; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Pharmacology, Biochemistry and Behavior, Vol. 161, 10.2017, p. 62-67.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions. / Pedersen, Søren W; Albertsen, Louise; Moran, Griffin E; Levesque, Brié; Pedersen, Stine B; Bartels, Lina; Wapenaar, Hannah; Ye, Fei; Zhang, Mingjie; Bowen, Mark E; Strømgaard, Kristian.

    In: ACS chemical biology, Vol. 12, No. 9, 15.09.2017, p. 2313-2323.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein. / Zhang, Hang; Xiong, Xiao-feng; Boesgaard, Michael W; Underwood, Christina R; Bräuner-Osborne, Hans; Strømgaard, Kristian.

    In: ChemMedChem, Vol. 12, No. 11, 07.06.2017, p. 830-834.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. / Roszko, Kelly L; Bi, Ruiye; Gorvin, Caroline M; Bräuner-Osborne, Hans; Xiong, Xiao-Feng; Inoue, Asuka; Thakker, Rajesh V; Strømgaard, Kristian; Gardella, Thomas; Mannstadt, Michael.

    In: JCI Insight, Vol. 2, No. 3, e91079, 09.02.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Stoichiometry of Toxin Binding to Acid-Sensing Ion Channels. / Borg, Christian B.; Lynagh, Timothy; Haugaard-Kedstrom, Linda M.; Stromgaard, Kristian; Pless, Stephan A.

    In: Biophysical Society. Annual Meeting. Abstracts, Vol. 112, No. 3, 03.02.2017, p. 420A-420A.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  20. Published

    In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: European Journal of Neuroscience, Vol. 45, No. 2, 20.01.2017, p. 238-248.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Effects of dimeric PSD-95 inhibition on excitotoxic cell death and outcome after controlled cortical impact in rats : PSD-95 inhibition in experimental TBI. / Sommer, Jens Bak; Bach, Anders; Rytter, Hana Malá; Gynther, Mikko; Bjerre, Ann-Sofie; Gram, Marie Gajhede; Marschner, Linda; Strømgaard, Kristian; Mogensen, Jesper; Pickering, Darryl S.

    In: Neurochemical Research, Vol. 42, No. 12, 2017, p. 3401-3413.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission. / Maric, Hans Michael; Hausrat, Torben Johann; Neubert, Franziska; Dalby, Nils Ole; Doose, Sören; Sauer, Markus; Kneussel, Matthias; Strømgaard, Kristian.

    In: Nature Chemical Biology, Vol. 13, 2246, 2017, p. 153-160.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression. / Kucharz, Krzysztof; Søndergaard Rasmussen, Ida; Bach, Anders; Strømgaard, Kristian; Lauritzen, Martin.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 37, No. 5, 2017, p. 1820-1828.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Targeting PSD-95 as a Novel Approach in the Treatment of Stroke. / Haugaard-Kedstrom, Linda M.; Fernandes, Eduardo F. A.; Stromgaard, Kristian.

    Neuroprotective Therapy for Stroke and Ischemic Disease . Springer, 2017. p. 157-184 (Springer Series in Translational Stroke Research).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  25. 2016
  26. Published

    Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands. / Andersen, Jacob; Ladefoged, Lucy Kate; Kristensen, Trine N Bjerre; Munro, Lachlan; Grouleff, Julie; Stuhr-Hansen, Nicolai; Kristensen, Anders S; Schiøtt, Birgit; Strømgaard, Kristian.

    In: A C S Chemical Neuroscience, Vol. 7, No. 10, 19.10.2016, p. 1406-1417.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Importance of a Conserved Lys/Arg Residue for Ligand/PDZ Domain Interactions as Examined by Protein Semisynthesis. / Pedersen, Søren W; Moran, Griffin E; Sereikaité, Vita; Kedström, Linda Maria Haugaard; Strømgaard, Kristian.

    In: ChemBioChem, Vol. 17, No. 20, 17.10.2016, p. 1936-1944.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. / Cheng, Jin; Sahani, Sadhna; Hausrat, Torben Johann; Yang, Jenq-Wei; Ji, Haichao; Schmarowski, Nikolai; Endle, Heiko; Liu, Xinfeng; Li, Yunbo; Böttche, Rahel; Radyushkin, Konstantin; Maric, Hans M; Hoerder-Suabedissen, Anna; Molnár, Zoltán; Prouvot, Pierre-Hugues; Trimbuch, Thorsten; Ninnemann, Olaf; Huai, Jisen; Fan, Wei; Visentin, Barbara; Sabbadini, Roger; Strømgaard, Kristian; Stroh, Albrecht; Luhmann, Heiko J; Kneussel, Matthias; Nitsch, Robert; Vogt, Johannes.

    In: Neuron, Vol. 92, No. 1, 05.10.2016, p. 126-142.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Effects of the dimeric PSD-95 inhibitor UCCB01-144 in mouse models of pain, cognition and motor function. / Andreasen, Jesper T; Nasser, Arafat; Caballero-Puntiverio, Maitane; Sahlholt, Maj; Bach, Anders; Gynther, Mikko; Strømgaard, Kristian; Pickering, Darryl S.

    In: European Journal of Pharmacology, Vol. 780, 05.06.2016, p. 166-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1302559