Employees – University of Copenhagen

Lennart Bunch

Lennart Bunch

Associate Professor


  1. 2019
  2. Accepted/In press

    Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters. / Poulie, Christian Bernard Matthijs; Alcaide Lopez, Anna; Krell-Jørgensen, Mikkel Poul; Larsen, Younes; Astier, Eloi; Bjørn-Yoshimoto, Walden; Yi, Feng; Syrenne, Jed T; Storgaard, Morten; Nielsen, Birgitte; Frydenvang, Karla Andrea; Jensen, Anders A.; Hansen, Kasper B; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, 2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The Screening and Design of Allosteric Kinase Inhibitors. / Wu, Peng; Dinér, Peter; Bunch, Lennart.

    Kinase Drug Discovery: Modern Approaches. 1. ed. Royal Society of Chemistry, 2019. p. 34-60.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  4. 2018
  5. Published

    Functionalization of Oxazolo[4,5-b]pyrazines by Deprotometallation. / Bisballe, Niels; Hedidi, Madani; Demmer, Charles S.; Chevallier, Floris; Roisnel, Thierry; Dorcet, Vincent; Halauko, Yury S.; Ivashkevich, Oleg A.; Matulis, Vadim E.; Bentabed-Ababsa, Ghenia; Bunch, Lennart; Mongin, Florence.

    In: European Journal of Organic Chemistry, No. 29, 07.08.2018, p. 3904-3913.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors. / Fu, Haigen; Zhang, J.; Tepper, P.G.; Bunch, Lennart; Jensen, Anders A.; Poelarends, G.J.

    In: Journal of Medicinal Chemistry, Vol. 61, No. 17, 2018, p. 7741-7753 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. / Olander, Emma Rie; Madjroh, Nawid; Bunch, Lennart; Söderhielm, Pella Cecilia; Jensen, Anders A.

    In: Biochemical Pharmacology, Vol. 150, 2018, p. 305-319.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2017
  9. Published

    Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist. / Gynther, Mikko; Proietti Silvestri, Ilaria; Hansen, Jacob C; Hansen, Kasper B; Malm, Tarja; Ishchenko, Yevheniia; Larsen, Younes; Han, Liwei; Kayser, Silke; Auriola, Seppo; Petsalo, Aleksanteri; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 23, 14.12.2017, p. 9885-9904.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors. / Demmer, Charles Sylvain; Rombach, David; Liu, Na; Nielsen, Birgitte; Pickering, Darryl S; Bunch, Lennart.

    In: A C S Chemical Neuroscience, Vol. 8, No. 11, 01.12.2017, p. 2477-2495.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Tetrabutylammonium Fluoride (TBAF) as a Mild and Versatile Reagent for Cleaving Boroxazolidones to their Corresponding Free α-Amino Acids. / Poulie, Christian Bernard Matthijs; Bunch, Lennart.

    In: European Journal of Organic Chemistry, Vol. 11, 03.2017, p. 1475-1478.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid. / Krogsgaard-Larsen, Niels; Delgar, Claudia; Koch, Karina; Brown, Patricia M G E; Møller, Charlotte; Han, Liwei; Huynh, Tri Hien Viet; Hansen, Stinne Wessel; Nielsen, Birgitte; Bowie, Derek; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen; Frydenvang, Karla Andrea; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 60, No. 1, 2017, p. 441-457.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2016
  14. Published

    Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences. / Hansen, Jacob Christian; Bjørn-Yoshimoto, Walden Emil; Bisballe, Niels; Nielsen, Birgitte; Jensen, Anders A.; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 59, 2016, p. 8771-8786.

    Research output: Contribution to journalJournal articleResearchpeer-review

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