Michael Gajhede
Michael Gajhede

Professor


  1. 2012
  2. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, Paul, Kastrup, Jette Sandholm Jensen, Helin, Kristian, Olsen, L. & Gajhede, Michael, Jun 2012, In : F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Identification of catechols as histone-lysine demethylase inhibitors

    Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, Paul, Helin, Kristian, Gajhede, Michael & Olsen, L., 2012, In : F E B S Letters. 586, 8, p. 1190-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In : The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, A., Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In : P L o S One. 7, 8, p. e40757

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen

    Shahsavar, A., Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In : Lægemiddelforskning. 2012, p. 48-50 3 p.

    Research output: Contribution to journalJournal articleCommunication

  7. Published

    Kainate induces various domain closures in AMPA and kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In : Neurochemistry International. 61, 4, p. 536-545

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2013
  9. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

    Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In : Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Chemical and thermal unfolding of calreticulin

    Duus, K., Larsen, N., Tran, T. A. T., Güven, E., Skov, L. K., Jespersgaard, C., Gajhede, Michael & Houen, G., 2013, In : Protein and Peptide Letters. 20, p. 562-568

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In : Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journalJournal articleResearch

  12. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

    Harpsøe, Kasper, Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Ahring, P. K., 25 Jan 2013, In : Journal of Biological Chemistry. 288, 4, p. 2559-2570 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Dorvil, Linda Grønborg, Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In : Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner-Osborne, Hans, 2013, In : The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

    Olsen, J. A., Kastrup, Jette Sandholm Jensen, Peters, D., Gajhede, Michael, Balle, T. & Ahring, P. K., 13 Dec 2013, In : Journal of Biological Chemistry. 288, 50, p. 35997 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology

    Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In : Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists

    Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 940-951

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2014
  19. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In : F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

    Olsen, J. A., Ahring, P. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Balle, T., 5 Sep 2014, In : The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

    Olsen, J. A., Balle, T., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, 17 Mar 2014, In : PLOS ONE. 9, 3, p. e91232 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In : ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2015
  24. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

    Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, Jette Sandholm Jensen, Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, Michael & Balle, T., 2015, In : Neuropharmacology. 92, p. 135-45 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

    Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In : Molecular Pharmacology. 88, 4, p. 697-707 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate

    Shahsavar, A., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 17 Nov 2015, In : Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Structure and binding properties of a cameloid nanobody raised against KDM5B

    Wiuf, Anders Drabæk, Kristensen, L. H., Kristensen, O., Dorosz, J., Jensen, J. & Gajhede, Michael, 23 Sep 2015, In : Acta crystallographica. Section F, Structural biology communications. 71, Pt 10, p. 1235-1241 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2016
  29. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

    Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In : Molecular Pharmacology. 89, 2, p. 253-262 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2017
  31. Published

    Expression, purification and characterization of the human MTA2-RBBP7 complex

    Brasen, C., Dorosz, J., Wiuf, Anders Drabæk, Boesen, T., Mirza, Osman Asghar & Gajhede, Michael, 4 Feb 2017, In : Biochimica et biophysica acta. 1865, 5, p. 531-538 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8

    Dorosz, J., Olsen, L., Seger, S. T., Steinhauer, Cornelia, Bouras, G., Helgstrand, C., Wiuf, Anders Drabæk & Gajhede, Michael, 18 Jul 2017, In : ChemBioChem. 18, 14, p. 1369-1375 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1

    Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In : Allergy. 72, 4, p. 665-670 6 p., 13111.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

    Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In : Research in Microbiology. 168, 5, p. 443-449

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

    Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In : Scientific Reports. 7, 12 p., 46145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. 2018
  37. Published

    Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state

    Aduri, N. G., Ernst, H. A., Prabhala, B. K., Bhatt, S., Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2018, In : Biochemical and Biophysical Research Communications. 495, 2, p. 1738-1743 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

    Backe, M. B., Andersson, J. L., Bacos, K., Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, Michael, Dahlby, T., Bysani, M., Kristensen, L. H., Ling, C., Olsen, L. & Mandrup-Poulsen, Thomas, 15 Jan 2018, In : Molecular and Cellular Endocrinology. 460, p. 47-56 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

    Jones, S. E., Olsen, L. & Gajhede, Michael, 2018, In : Biochemistry. 57, 5, p. 585–592

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

    Jones, S. E., Olsen, L., Dorosz, J., Seger, S. T., Andersson, J. L., Kristensen, L. H. & Gajhede, Michael, 4 Sep 2018, In : ChemBioChem. 19, 17, p. 1817-1822

    Research output: Contribution to journalLetterResearchpeer-review

  41. Published

    The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

    Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In : The Journal of Biological Chemistry. 293, p. 1007-1017

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. 2019
  43. Published

    Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH

    Aduri, N. G., Montefiori, M., Khalil, R., Gajhede, Michael, Jørgensen, Flemming Steen & Mirza, Osman Asghar, 31 Jan 2019, In : ACS Omega. 4, 1, p. 2040-2046 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In : Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journalJournal articleResearchpeer-review

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