Michael Gajhede

Michael Gajhede

Professor


  1. Published

    Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution. / van der Veen, Bart A; Skov, Lars K; Potocki-Véronèse, Gabrielle; Gajhede, Michael; Monsan, Pierre; Remaud-Simeon, Magali.

    In: F E B S Journal, Vol. 273, No. 4, 2006, p. 673-81.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Structure and binding properties of a cameloid nanobody raised against KDM5B. / Wiuf, Anders; Kristensen, Line Hyltoft; Kristensen, Ole; Dorosz, Jerzy; Jensen, Jonas; Gajhede, Michael.

    In: Acta crystallographica. Section F, Structural biology communications, Vol. 71, No. Pt 10, 23.09.2015, p. 1235-1241.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus. / Wang, Xiaole; Hald, Helle; Ernst, Heidi Asschenfeldt; Egebjerg, Jan; Christensen, Kenneth V; Gajhede, Michael; Kastrup, Jette Sandholm; Mirza, Osman Asghar.

    In: Protein Expression and Purification, Vol. 71, No. 2, 2010, p. 179-183.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The SAXS Solution Structure of RF1 Differs from Its Crystal Structure and Is Similar to Its Ribosome Bound Cryo-EM Structure. / Vestergaard, Bente; Sanyal, Suparna; Roessle, Manfred; Mora, Liliana; Buckingham, Richard; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Svergun, Dmitri I; Ehrenberg, Måns.

    In: Molecular Cell, Vol. 20, 2005, p. 929-938.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. / Vestergaard, Bente; Jensen, Minna Grønning; Roessle, Manfred; Kastrup, Jette Sandholm Jensen; Van De Weert, Marco; Flink, James M.; Frøkjær, Sven; Gajhede, Michael; Svergun, Dmitri I.

    In: PLoS - Biology, Vol. 5, No. 5, 2007, p. 1089-1097.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Kainate induces various domain closures in AMPA and kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Hald, Helle; Rabassa, Anna Ceravalls de; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm.

    In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 536-545.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists. / Ussing, Christine A.; Hansen, Camilla Petrycer; Petersen, Jette Gellert; Jensen, Anders A.; Rohde, Line A.H. ; Ahring, Philip K.; Nielsen, Elisabeth Ø. ; Kastrup, Jette Sandholm; Gajhede, Michael; Frølund, Bente; Balle, Thomas.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 940-951.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region. / Tapken, Daniel; Steffensen, Thomas Bielefeldt; Leth, Rasmus; Kristensen, Lise Baadsgaard; Gerbola, Alexander; Gajhede, Michael; Jørgensen, Flemming Steen; Olsen, Lars; Kastrup, Jette Sandholm.

    In: Scientific Reports, Vol. 7, 46145, 07.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Cyclic lipoundecapeptide amphisin from Pseudomonas sp. strain DSS73. / Sørensen, Dan; Nielsen, Tommy H.; Christophersen, Carsten; Sørensen, Jan; Gajhede, Michael.

    In: Acta Crystallographica Section C, No. Vol. C57, 2001, p. 1123-1124.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis. / Sprogøe, Desiree; van den Broek, Lambertus A M; Mirza, Osman; Kastrup, Jette Sandholm Jensen; Voragen, Alphons G J; Gajhede, Michael; Skov, Lars.

    In: Biochemistry, Vol. 43, No. 5, 10.02.2004, p. 1156-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. / Spangfort, Michael D; Mirza, Osman; Ipsen, Henrik; Van Neerven, R J Joost; Gajhede, Michael; Larsen, Jørgen.

    In: Journal of Immunology, Vol. 171, No. 6, 2003, p. 3084-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Crystallization and preliminary X-ray analysis of birch-pollen allergen Bet v 1 in complex with a murine monoclonal IgG Fab' fragment. / Spangfort, M D; Mirza, Osman Asghar; Gajhede, M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 55, No. Pt 12, 12.1999, p. 2035-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose. / Skov, Lars K.; Mirza, Osman; Sprogøe, Desiree; van der Veen, Bart; Remaud-Simeon, Magali; Albenne, Cecile; Monsan, Pierre; Gajhede, Michael.

    In: Biocatalysis and Biotransformation, Vol. 24, No. 1-2, 01.01.2006, p. 99-105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structure of recombinant Ves v 2 at 2.0 Angstrom resolution : structural analysis of an allergenic hyaluronidase from wasp venom. / Skov, Lars K; Seppälä, Ulla; Coen, Jeremy J F; Crickmore, Neil; King, Te P; Monsalve, Rafael; Kastrup, Jette S; Spangfort, Michael D; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 62, No. Pt 6, 2006, p. 595-604.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology. / Skov, Lars K; Pizzut-Serin, Sandra; Remaud-Simeon, Magali; Ernst, Heidi A; Gajhede, Michael; Mirza, Osman Asghar.

    In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. 69, No. Pt 9, 09.2013, p. 973-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Oligosaccharide and sucrose complexes of amylosucrase. Structural implications for the polymerase activity. / Skov, Lars K; Mirza, Osman Asghar; Sprogøe, Desiree; Dar, Imran; Remaud-Simeon, Magali; Albenne, Cecile; Monsan, Pierre; Gajhede, Michael.

    In: Journal of Biological Chemistry, Vol. 277, No. 49, 06.12.2002, p. 47741-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Amylosucrase, a glucan-synthesizing enzyme from the alpha-amylase family. / Skov, L K; Mirza, Osman Asghar; Henriksen, A; De Montalk, G P; Remaud-Simeon, M; Sarçabal, P; Willemot, R M; Monsan, P; Gajhede, M.

    In: Journal of Biological Chemistry, Vol. 276, No. 27, 06.07.2001, p. 25273-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Crystallization and preliminary X-ray studies of recombinant amylosucrase from Neisseria polysaccharea. / Skov, L K; Mirza, Osman Asghar; Henriksen, A; Potocki de Montalk, G; Remaud-Simeon, M; Sarcabal, P; Willemot, R M; Monsan, P; Gajhede, M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 56, No. Pt 2, 02.2000, p. 203-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen. / Shahsavar, Azadeh; Nielsen, Elsebeth Ø.; Kristensen, Jesper Langgaard; Gajhede, Michael; Balle, Thomas; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, Vol. 2012, 2012, p. 48-50.

    Research output: Contribution to journalJournal articleCommunication

  23. Published

    Structural Studies of Nicotinic Acetylcholine Receptors : Using Acetylcholine Binding Protein as a Structural Surrogate. / Shahsavar, Azadeh; Gajhede, Michael; Kastrup, Jette S; Balle, Thomas.

    In: Basic & Clinical Pharmacology & Toxicology Online, Vol. 118, No. 6, 17.11.2015, p. 399–407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism. / Shahsavar, Azadeh; Kastrup, Jette S; Nielsen, Elsebet Ø.; Kristensen, Jesper L; Gajhede, Michael; Balle, Thomas.

    In: P L o S One, Vol. 7, No. 8, 2012, p. e40757.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. / Shahsavar, Azadeh; Ahring, Philip K; Olsen, Jeppe A; Krintel, Christian; Kastrup, Jette S; Balle, Thomas; Gajhede, Michael.

    In: Molecular Pharmacology, Vol. 88, No. 4, 10.2015, p. 697-707.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype. / Røder, Gustav; Blicher, Thomas; Justesen, Sune; Johannesen, Birthe; Kristensen, Ole; Kastrup, Jette; Buus, Søren; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 62, No. Pt 11, 2006, p. 1300-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. / Røder, Gustav; Kristensen, Ole; Kastrup, Jette S; Buus, Søren; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 64, No. Pt 6, 2008, p. 459-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    High resolution crystal structures of the p120 RasGAP SH3 domain. / Ross, Birthe; Kristensen, Ole; Favre, Dimitri; Walicki, Joël; Kastrup, Jette Sandholm Jensen; Widmann, Christian; Gajhede, Michael.

    In: Biochemical and Biophysical Research Communications, Vol. 353, No. 2, 2007, p. 463-468.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Få kræftcellen til at begå selvmord : en strukturel vinkel på kræft. / Ross, Birthe; Borchorst, Morten; Gajhede, Michael; Kristensen, Ole.

    In: Lægemiddelforskning, 2007, p. 22-23.

    Research output: Contribution to journalJournal articleCommunication

  30. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors : Unique role of halogen bonding revealed. / Rohde, Line Aagot Hede; Ahring, Philip Kiær; Jensen, Marianne Lerbech; Nielsen, Elsebet Østergaard; Peters, Dan; Helgstrand, Charlotte; Krintel, Christian; Harpsøe, Kasper; Gajhede, Michael; Kastrup, Jette Sandholm; Balle, Thomas.

    In: The Journal of Biological Chemistry, Vol. 287, No. 6, 03.02.2012, p. 4248-4259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping. / Rasmussen, Kim Krighaar; Kulahin, Nikolaj; Kristensen, Ole; Poulsen, Jens-Christian N; Sigurskjold, Bent W; Kastrup, Jette S; Berezin, Vladimir; Bock, Elisabeth; Walmod, Peter S; Gajhede, Michael.

    In: Journal of Molecular Biology, Vol. 382, No. 5, 2008, p. 1113-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. / Prabhala, Bala K; Aduri, Nanda G; Iqbal, Mazhar; Rahman, Moazur; Gajhede, Michael; Hansen, Paul R; Mirza, Osman.

    In: Research in Microbiology, Vol. 168, No. 5, 16.02.2017, p. 443-449.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells. / Prabhala, Bala K; Aduri, Nanda G; Sharma, Neha; Shaheen, Aqsa; Sharma, Arpan; Iqbal, Mazhar; Hansen, Paul R; Brasen, Christoffer; Gajhede, Michael; Rahman, Moazur; Mirza, Osman.

    In: The Journal of Biological Chemistry, Vol. 293, 2018, p. 1007-1017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network. / Petersson, Britt; Nielsen, Bettina Bryde; Rasmussen, Hanne; Larsen, Ingrid Kjøller; Gajhede, Michael; Nielsen, Peter E; Kastrup, Jette Sandholm Jensen.

    In: Journal of the American Chemical Society, Vol. 127, No. 5, 09.02.2005, p. 1424-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit. / Paës, Gabriel; Skov, Lars K; O'Donohue, Michael J; Rémond, Caroline; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman.

    In: Biochemistry, Vol. 47, No. 28, 2008, p. 7441-7451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. / Owczarek, Sylwia; Kiryushko, Darya; Hald Larsen, Marianne; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Sandi, Carmen; Berezin, Vladimir; Bock, Elisabeth; Soroka, Vladislav.

    In: The FASEB Journal, Vol. 24, No. 4, 2010, p. 1139-1150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification. / Ostergaard, L; Teilum, K; Mirza, O; Mattsson, O; Petersen, M; Welinder, K G; Mundy, J; Gajhede, M; Henriksen, A.

    In: Plant Molecular Biology, Vol. 44, No. 2, 2000, p. 231-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Hvad har varme at gøre med lægemidler? / Olsen, Lars; Kasper, Christina; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Jørgensen, Flemming Steen.

    In: Lægemiddelforskning, 2006, p. 31-33.

    Research output: Contribution to journalJournal articleCommunication

  39. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. / Olsen, Jeppe A.; Kastrup, Jette Sandholm Jensen; Peters, Dan; Gajhede, Michael; Balle, Thomas; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 50, 13.12.2013, p. 35997.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors. / Olsen, Jeppe A.; Balle, Thomas; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm Jensen.

    In: PLOS ONE, Vol. 9, No. 3, 17.03.2014, p. e91232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors. / Olsen, Jeppe A; Ahring, Philip K; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Balle, Thomas.

    In: The Journal of Biological Chemistry, Vol. 289, No. 36, 05.09.2014, p. 24911-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Differential Activity and Structure of Highly Similar Peroxidases. Spectroscopic, Crystallographic, and Enzymatic Analyses of Lignifying Arabidopsis thaliana Peroxidase A2 and Horseradish Peroxidase A2. / Nielsen, Kåre Lehmann; Indiani, Chiara; Henriksen, Anette; Feis, Alessandro; Becucci, Maurizio; Gajhede, Michael; Smulevich, Giuliette; Welinder, Karen G.

    In: Biochemistry, No. 40, 2001, p. 11013-11021.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP. / Nielsen, Bettina B; Pickering, Darryl S; Greenwood, Jeremy R; Brehm, Lotte; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette S.

    In: FEBS Journal, Vol. 272, No. 7, 2005, p. 1639-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Identification of catechols as histone-lysine demethylase inhibitors. / Nielsen, Anders L; Kristensen, Line H; Stephansen, Karen B; Kristensen, Jan B L; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Helin, Kristian; Gajhede, Michael; Olsen, Lars.

    In: F E B S Letters, Vol. 586, No. 8, 2012, p. 1190-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Jagten på et signalstof til hjernens delta2-receptor. / Naur, Peter; Olsen, Lars; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2007, p. 32-33.

    Research output: Contribution to journalJournal articleCommunication

  46. Published

    Ionotropic glutamate-like receptor d2 binds D-serine and glycine. / Naur, Peter; Hansen, Kasper Bø; Kristensen, Anders Skov; Dravid, Shashank M.; Pickering, Darryl Scott; Olsen, Lars; Vestergaard, Bente; Egebjerg, Jan; Gajhede, Michael; Traynelis, Stephen F.; Kastrup, Jette Sandholm Jensen.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 104, No. 35, 2007, p. 14116-14121.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. / Naur, Peter; Vestergaard, Bente; Skov, Lars; Egebjerg, Jan ; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: FEBS letters, Vol. 579, 2005, p. 1154-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Arabidopsis thaliana peroxidase N : structure of a novel neutral peroxidase. / Mirza, Osman Asghar; Henriksen, A; Ostergaard, L; Welinder, K G; Gajhede, M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 56, No. Pt 3, 03.2000, p. 372-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Dominant epitopes and allergic cross-reactivity : complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. / Mirza, Osman Asghar; Henriksen, A; Ipsen, H; Larsen, J N; Wissenbach, M; Spangfort, M D; Gajhede, M.

    In: Journal of Immunology, Vol. 165, No. 1, 01.07.2000, p. 331-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose. / Mirza, Osman Asghar; Skov, L K; Remaud-Simeon, M; Potocki de Montalk, G; Albenne, C; Monsan, Pierre; Gajhede, Michael.

    In: Biochemistry, Vol. 40, No. 30, 31.07.2001, p. 9032-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

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