Michael Gajhede

Michael Gajhede

Professor


  1. Published

    A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase. / Henriksen, Annette; Aghajari, Nushin; Jensen, Kaj Frank; Gajhede, Michael.

    In: Biochemistry, Vol. 35, No. 12, 1996, p. 3803-3809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. / Vestergaard, Bente; Jensen, Minna Grønning; Roessle, Manfred; Kastrup, Jette Sandholm Jensen; Van De Weert, Marco; Flink, James M.; Frøkjær, Sven; Gajhede, Michael; Svergun, Dmitri I.

    In: PLoS - Biology, Vol. 5, No. 5, 2007, p. 1089-1097.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. / Bach, Anders*; Clausen, Bettina H; Møller, Magda; Vestergaard, Bente; Chi, Celestine N; Round, Adam; Sørensen, Pernille Louise; Nissen, Klaus Bertram; Kastrup, Jette Sandholm; Gajhede, Michael; Jemth, Per; Kristensen, Anders Skov; Lundström, Patrik; Lambertsen, Kate Lykke; Strømgaard, Kristian* (*Corresponding).

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, 28.02.2012, p. 3317-3322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.

    In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A unique set of SH3-SH3 interactions controls IB1 homodimerization. / Kristensen, Ole; Guenat, Sylvie; Dar, Imran; Allaman-Pillet, Nathalie; Abderrahmani, Amar; Ferdaoussi, Mourad; Roduit, Raphaël; Maurer, Fabienne; Beckmann, Jacques S; Kastrup, Jette S; Gajhede, Michael; Bonny, Christophe.

    In: E M B O Journal, Vol. 25, No. 4, 2006, p. 785-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. / Shahsavar, Azadeh; Ahring, Philip K; Olsen, Jeppe A; Krintel, Christian; Kastrup, Jette S; Balle, Thomas; Gajhede, Michael.

    In: Molecular Pharmacology, Vol. 88, No. 4, 10.2015, p. 697-707.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Amylosucrase, a glucan-synthesizing enzyme from the alpha-amylase family. / Skov, L K; Mirza, Osman Asghar; Henriksen, A; De Montalk, G P; Remaud-Simeon, M; Sarçabal, P; Willemot, R M; Monsan, P; Gajhede, M.

    In: Journal of Biological Chemistry, Vol. 276, No. 27, 06.07.2001, p. 25273-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification. / Ostergaard, L; Teilum, K; Mirza, O; Mattsson, O; Petersen, M; Welinder, K G; Mundy, J; Gajhede, M; Henriksen, A.

    In: Plant Molecular Biology, Vol. 44, No. 2, 2000, p. 231-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Arabidopsis thaliana peroxidase N : structure of a novel neutral peroxidase. / Mirza, Osman Asghar; Henriksen, A; Ostergaard, L; Welinder, K G; Gajhede, M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 56, No. Pt 3, 03.2000, p. 372-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    At være eller ikke være en antagonist. / Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2009, p. 43-45.

    Research output: Contribution to journalJournal articleCommunication

  11. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Chaperone binding at the ribosomal exit tunnel. / Kristensen, Ole; Gajhede, Michael.

    In: Structure, Vol. 11, No. 12, 2003, p. 1547-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Chemical and thermal unfolding of calreticulin. / Duus, K.; Larsen, N.; Tran, T. A. T.; Güven, E.; Skov, L. K.; Jespersgaard, C; Gajhede, Michael; Houen, Gunnar.

    In: Protein and Peptide Letters, Vol. 20, 2013, p. 562-568.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Cobalt(III) Cage Complexes Linked to 4-Pyridyl: Models for Protein Modification. / Gajhede, Michael; Hammershøi, Anders; Skov, Lars Kobberøe.

    In: Dalton Transactions (Print Edition), Vol. 45, No. 5, 1991, p. 474-481.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Conformational stability of calreticulin. / Jørgensen, Charlotte S; Trandum, Christa; Larsen, Nanna Brink; Ryder, L Rebekka; Gajhede, Michael; Skov, Lars; Højrup, Peter; Barkholt, Vibeke; Houen, Gunnar.

    In: Protein and Peptide Letters, Vol. 12, No. 7, 2005, p. 687-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism. / Shahsavar, Azadeh; Kastrup, Jette S; Nielsen, Elsebet Ø.; Kristensen, Jesper L; Gajhede, Michael; Balle, Thomas.

    In: P L o S One, Vol. 7, No. 8, 2012, p. e40757.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit). Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Poulsen, Jens-Christian Navarro (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  19. Published
    Crystal Structure of NCAM2 Ig1-2. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  20. Published
    Crystal Structure of NCAM2 Ig2-3. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  21. Published
    Crystal Structure of NCAM2 Ig34. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  22. Published

    Crystal Structures of Amylosucrase from Neisseria polysaccharea in Complex with D-Glucose and the Active Site Mutant Glu328Gln in Complex with the Natural Substrate Sucrose. / Mirza, Osman; Skov, Lars Kobberø; Remaud-Simeon, Magali; Potocki de Montalk, Gabrielle; Albenne, Cecile; Monsan, Pierre; Gajhede, Michael.

    In: Biochemistry, No. 40, 2001, p. 9032-9039.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
    Crystal structure of NCAM2 IgIV-Fn3I. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009.

    Research output: Non-textual formDatasetResearch

  25. Published
    Crystal structure of NCAM2 IgIV-Fn3II. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009. 17. November.

    Research output: Non-textual formDatasetResearch

  26. Published

    Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network. / Petersson, Britt; Nielsen, Bettina Bryde; Rasmussen, Hanne; Larsen, Ingrid Kjøller; Gajhede, Michael; Nielsen, Peter E; Kastrup, Jette Sandholm Jensen.

    In: Journal of the American Chemical Society, Vol. 127, No. 5, 09.02.2005, p. 1424-30.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis. / Sprogøe, Desiree; van den Broek, Lambertus A M; Mirza, Osman; Kastrup, Jette Sandholm Jensen; Voragen, Alphons G J; Gajhede, Michael; Skov, Lars.

    In: Biochemistry, Vol. 43, No. 5, 10.02.2004, p. 1156-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose. / Skov, Lars K.; Mirza, Osman; Sprogøe, Desiree; van der Veen, Bart; Remaud-Simeon, Magali; Albenne, Cecile; Monsan, Pierre; Gajhede, Michael.

    In: Biocatalysis and Biotransformation, Vol. 24, No. 1-2, 01.01.2006, p. 99-105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping. / Rasmussen, Kim Krighaar; Kulahin, Nikolaj; Kristensen, Ole; Poulsen, Jens-Christian N; Sigurskjold, Bent W; Kastrup, Jette S; Berezin, Vladimir; Bock, Elisabeth; Walmod, Peter S; Gajhede, Michael.

    In: Journal of Molecular Biology, Vol. 382, No. 5, 2008, p. 1113-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Crystal structure of the covalent intermediate of amylosucrase from Neisseria polysaccharea. / Jensen, Malene H; Mirza, Osman Asghar; Albenne, Cecile; Remaud-Simeon, Magali; Monsan, Pierre; Gajhede, Michael; Skov, Lars.

    In: Biochemistry, Vol. 43, No. 11, 23.03.2004, p. 3104-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. / Naur, Peter; Vestergaard, Bente; Skov, Lars; Egebjerg, Jan ; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: FEBS letters, Vol. 579, 2005, p. 1154-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose. / Mirza, Osman Asghar; Skov, L K; Remaud-Simeon, M; Potocki de Montalk, G; Albenne, C; Monsan, Pierre; Gajhede, Michael.

    In: Biochemistry, Vol. 40, No. 30, 31.07.2001, p. 9032-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype. / Røder, Gustav; Blicher, Thomas; Justesen, Sune; Johannesen, Birthe; Kristensen, Ole; Kastrup, Jette; Buus, Søren; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 62, No. Pt 11, 2006, p. 1300-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Crystallization and preliminary X-ray analysis of birch-pollen allergen Bet v 1 in complex with a murine monoclonal IgG Fab' fragment. / Spangfort, M D; Mirza, Osman Asghar; Gajhede, M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 55, No. Pt 12, 12.1999, p. 2035-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Crystallization and preliminary X-ray studies of recombinant amylosucrase from Neisseria polysaccharea. / Skov, L K; Mirza, Osman Asghar; Henriksen, A; Potocki de Montalk, G; Remaud-Simeon, M; Sarcabal, P; Willemot, R M; Monsan, P; Gajhede, M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 56, No. Pt 2, 02.2000, p. 203-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein. / Dar, Imran; Bonny, Christophe; Pedersen, Jan Torleif; Gajhede, Michael; Kristensen, Ole.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 59, No. Pt 12, 2003, p. 2300-2.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Crystallization of a stringent response factor from Aquifex aeolicus. / Kristensen, Ole; Laurberg, Martin; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 58, No. Pt 7, 2002, p. 1198-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Cyclic Acetals. Structural Analysis of 1,3‐Dioxepine and Related Compounds. / Jørgensen, Flemming S.; Gajhede, Michael; Frei, Bruno.

    In: Helvetica Chimica Acta, Vol. 68, No. 8, 01.01.1985, p. 2148-2157.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Cyclic lipoundecapeptide amphisin from Pseudomonas sp. strain DSS73. / Sørensen, Dan; Nielsen, Tommy H.; Christophersen, Carsten; Sørensen, Jan; Gajhede, Michael.

    In: Acta Crystallographica Section C, No. Vol. C57, 2001, p. 1123-1124.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Cyclic lipoundecapeptide tensin from Pseudomonas fluorescens strain 96.578. / Henriksen, A. S.; Anthoni, Uffe; Nielsen, Tommy H.; Sørensen, Jan; Christophersen, Sven Carsten; Gajhede, Michael.

    In: Acta Crystallographica Section C, No. C56, 2000, p. 113-115.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Differential Activity and Structure of Highly Similar Peroxidases. Spectroscopic, Crystallographic, and Enzymatic Analyses of Lignifying Arabidopsis thaliana Peroxidase A2 and Horseradish Peroxidase A2. / Nielsen, Kåre Lehmann; Indiani, Chiara; Henriksen, Anette; Feis, Alessandro; Becucci, Maurizio; Gajhede, Michael; Smulevich, Giuliette; Welinder, Karen G.

    In: Biochemistry, No. 40, 2001, p. 11013-11021.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Dimerization effect of sucrose octasulfate on rat FGF1. / Kulahin, Nikolaj; Kiselyov, Vladislav; Kochoyan, Artur; Kristensen, Ole; Kastrup, Jette Sandholm Jensen; Berezin, Vladimir; Bock, Elisabeth Marianne; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 64, No. Pt6, 2008, p. 448-452.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. / Hald, Helle; Ahring, Philip Kiær; Timmermann, Daniel Brunicardi; Liljefors, Tommy; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Journal of Molecular Biology, Vol. 391, No. 5, 2009, p. 906-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Dominant epitopes and allergic cross-reactivity : complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. / Mirza, Osman Asghar; Henriksen, A; Ipsen, H; Larsen, J N; Wissenbach, M; Spangfort, M D; Gajhede, M.

    In: Journal of Immunology, Vol. 165, No. 1, 01.07.2000, p. 331-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis. / Spangfort, Michael D; Mirza, Osman; Ipsen, Henrik; Van Neerven, R J Joost; Gajhede, Michael; Larsen, Jørgen.

    In: Journal of Immunology, Vol. 171, No. 6, 2003, p. 3084-90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface. / Ahring, Philip K; Olsen, Jeppe A; Nielsen, Elsebet Ø; Peters, Dan; Pedersen, Martin H F; Rohde, Line A; Kastrup, Jette Sandholm Jensen; Shahsavar, Azadeh; Indurthi, Dinesh C; Chebib, Mary; Gajhede, Michael; Balle, Thomas.

    In: Neuropharmacology, Vol. 92, 2015, p. 135-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A : Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. / Kristensen, Jan B L; Nielsen, Anders L; Jørgensen, Lars; Kristensen, Line Hyltoft; Helgstrand, Charlotte; Juknaite, Lina; Kristensen, Jesper Langgaard; Kastrup, Jette Sandholm; Clausen, Rasmus Prætorius; Olsen, Lars; Gajhede, Michael.

    In: F E B S Letters, Vol. 585, No. 12, 23.06.2011, p. 1951-1956.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1. / Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik; Würtzen, Peter A; Gajhede, Michael; Larsen, Jørgen N; Lund, Kaare; Spangfort, Michael D.

    In: Journal of Biological Chemistry, Vol. 286, No. 20, 20.05.2011, p. 17569-17578.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP. / Nielsen, Bettina B; Pickering, Darryl S; Greenwood, Jeremy R; Brehm, Lotte; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette S.

    In: FEBS Journal, Vol. 272, No. 7, 2005, p. 1639-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1. / Kulahin, Nikolaj; Kasper, Christina; Gajhede, Michael; Berezin, Vladimir; Bock, Elisabeth; Kastrup, Jette Sandholm Jensen.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 60, No. Pt 3, 03.2004, p. 591-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

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