Michael Gajhede
Michael Gajhede

Professor


  1. 2020
  2. Published

    The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

    Ambjørner, Sophie Emilie Blomgren, Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, L., Brodin, Birger, Rump, S., Weigt, H., Brünner, Nils & Stenvang, Jan, 4 Mar 2020, In : Cells. 9, 3

    Research output: Contribution to journalJournal article

  3. 2019
  4. Published

    Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH

    Aduri, N. G., Montefiori, M., Khalil, R., Gajhede, Michael, Jørgensen, Flemming Steen & Mirza, Osman Asghar, 31 Jan 2019, In : ACS Omega. 4, 1, p. 2040-2046 7 p.

    Research output: Contribution to journalJournal article

  5. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In : Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journalJournal article

  6. 2018
  7. Published

    Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

    Jones, S. E., Olsen, L., Dorosz, J., Seger, S. T., Andersson, J. L., Kristensen, L. H. & Gajhede, Michael, 4 Sep 2018, In : ChemBioChem. 19, 17, p. 1817-1822

    Research output: Contribution to journalLetter

  8. Published

    Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

    Backe, M. B., Andersson, J. L., Bacos, K., Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, Michael, Dahlby, T., Bysani, M., Kristensen, L. H., Ling, C., Olsen, L. & Mandrup-Poulsen, Thomas, 15 Jan 2018, In : Molecular and Cellular Endocrinology. 460, p. 47-56 10 p.

    Research output: Contribution to journalJournal article

  9. Published

    Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state

    Aduri, N. G., Ernst, H. A., Prabhala, B. K., Bhatt, S., Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2018, In : Biochemical and Biophysical Research Communications. 495, 2, p. 1738-1743 6 p.

    Research output: Contribution to journalJournal article

  10. Published

    Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

    Jones, S. E., Olsen, L. & Gajhede, Michael, 2018, In : Biochemistry. 57, 5, p. 585–592

    Research output: Contribution to journalJournal article

  11. Published

    The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

    Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In : The Journal of Biological Chemistry. 293, p. 1007-1017

    Research output: Contribution to journalJournal article

  12. 2017
  13. Published

    Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8

    Dorosz, J., Olsen, L., Seger, S. T., Steinhauer, Cornelia, Bouras, G., Helgstrand, C., Wiuf, Anders Drabæk & Gajhede, Michael, 18 Jul 2017, In : ChemBioChem. 18, 14, p. 1369-1375 7 p.

    Research output: Contribution to journalJournal article

  14. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

    Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In : Scientific Reports. 7, 12 p., 46145.

    Research output: Contribution to journalJournal article

  15. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1

    Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In : Allergy. 72, 4, p. 665-670 6 p., 13111.

    Research output: Contribution to journalJournal article

  16. Published

    Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

    Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In : Research in Microbiology. 168, 5, p. 443-449

    Research output: Contribution to journalJournal article

  17. Published

    Expression, purification and characterization of the human MTA2-RBBP7 complex

    Brasen, C., Dorosz, J., Wiuf, Anders Drabæk, Boesen, T., Mirza, Osman Asghar & Gajhede, Michael, 4 Feb 2017, In : Biochimica et biophysica acta. 1865, 5, p. 531-538 8 p.

    Research output: Contribution to journalJournal article

  18. 2016
  19. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

    Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In : Molecular Pharmacology. 89, 2, p. 253-262 10 p.

    Research output: Contribution to journalJournal article

  20. 2015
  21. Published

    Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate

    Shahsavar, A., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 17 Nov 2015, In : Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.

    Research output: Contribution to journalJournal article

  22. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

    Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In : Molecular Pharmacology. 88, 4, p. 697-707 11 p.

    Research output: Contribution to journalJournal article

  23. Published

    Structure and binding properties of a cameloid nanobody raised against KDM5B

    Wiuf, Anders Drabæk, Kristensen, L. H., Kristensen, O., Dorosz, J., Jensen, J. & Gajhede, Michael, 23 Sep 2015, In : Acta crystallographica. Section F, Structural biology communications. 71, Pt 10, p. 1235-1241 7 p.

    Research output: Contribution to journalJournal article

  24. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

    Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, Jette Sandholm Jensen, Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, Michael & Balle, T., 2015, In : Neuropharmacology. 92, p. 135-45 11 p.

    Research output: Contribution to journalJournal article

  25. 2014
  26. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

    Olsen, J. A., Ahring, P. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Balle, T., 5 Sep 2014, In : The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.

    Research output: Contribution to journalJournal article

  27. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In : F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journalJournal article

  28. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

    Olsen, J. A., Balle, T., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, 17 Mar 2014, In : PLOS ONE. 9, 3, p. e91232 8 p.

    Research output: Contribution to journalJournal article

  29. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In : ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journalJournal article

  30. 2013
  31. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

    Olsen, J. A., Kastrup, Jette Sandholm Jensen, Peters, D., Gajhede, Michael, Balle, T. & Ahring, P. K., 13 Dec 2013, In : Journal of Biological Chemistry. 288, 50, p. 35997 10 p.

    Research output: Contribution to journalJournal article

  32. Published

    The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology

    Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In : Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.

    Research output: Contribution to journalJournal article

  33. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In : Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journalJournal article

  34. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

    Harpsøe, Kasper, Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Ahring, P. K., 25 Jan 2013, In : Journal of Biological Chemistry. 288, 4, p. 2559-2570 12 p.

    Research output: Contribution to journalJournal article

  35. Published

    Chemical and thermal unfolding of calreticulin

    Duus, K., Larsen, N., Tran, T. A. T., Güven, E., Skov, L. K., Jespersgaard, C., Gajhede, Michael & Houen, G., 2013, In : Protein and Peptide Letters. 20, p. 562-568

    Research output: Contribution to journalJournal article

  36. Published
  37. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner-Osborne, Hans, 2013, In : The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journalJournal article

  38. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Dorvil, Linda Grønborg, Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In : Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journalJournal article

  39. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists

    Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 940-951

    Research output: Contribution to journalJournal article

  40. 2012
  41. Published

    Kainate induces various domain closures in AMPA and kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In : Neurochemistry International. 61, 4, p. 536-545

    Research output: Contribution to journalJournal article

  42. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, Paul, Kastrup, Jette Sandholm Jensen, Helin, Kristian, Olsen, L. & Gajhede, Michael, Jun 2012, In : F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journalJournal article

  43. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

    Research output: Contribution to journalJournal article

  44. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In : The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journalJournal article

  45. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In : Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journalJournal article

  46. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, A., Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In : P L o S One. 7, 8, p. e40757

    Research output: Contribution to journalJournal article

  47. Published

    Identification of catechols as histone-lysine demethylase inhibitors

    Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, Paul, Helin, Kristian, Gajhede, Michael & Olsen, L., 2012, In : F E B S Letters. 586, 8, p. 1190-4 5 p.

    Research output: Contribution to journalJournal article

  48. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In : Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journalJournal article

  49. 2011
  50. Published
  51. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, Brian, Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, Paul, Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In : Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journalJournal article

  52. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In : F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journalJournal article

  53. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

    Holm, J., Ferreras, M., Ipsen, H., Würtzen, P. A., Gajhede, Michael, Larsen, J. N., Lund, K. & Spangfort, M. D., 20 May 2011, In : Journal of Biological Chemistry. 286, 20, p. 17569-17578

    Research output: Contribution to journalJournal article

  54. Published

    Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

    Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, Bente, Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 9 Feb 2011, In : Structure. 19, 2, p. 203-211

    Research output: Contribution to journalJournal article

  55. Published

    Inhibitors of histone demethylases

    Lohse, Brian, Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, Karl, Helin, Kristian, Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In : Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journalReview

  56. 2010
  57. Published

    Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

    Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sandi, C., Berezin, V., Bock, E. & Soroka, V., 2010, In : The FASEB Journal. 24, 4, p. 1139-1150 12 p.

    Research output: Contribution to journalJournal article

  58. Published

    Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

    Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Mirza, Osman Asghar, 2010, In : Protein Expression and Purification. 71, 2, p. 179-183

    Research output: Contribution to journalJournal article

  59. 2009
  60. Published

    Crystal structure of NCAM2 IgIV-Fn3I

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  61. Published

    Crystal structure of NCAM2 IgIV-Fn3II

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  62. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

    Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Molecular Biology. 391, 5, p. 906-917

    Research output: Contribution to journalJournal article

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