Michael Gajhede

Michael Gajhede

Professor


  1. Published

    Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution. / Jørgensen, Anders Dysted; Nøhr, Jane; Kastrup, Jette Sandholm; Gajhede, Michael; Sigurskjold, Bent Walther; Sauer, Jørgen; Svergun, Dmitri I.; Svensson, Birte; Vestergaard, Bente.

    In: Journal of Biological Chemistry, Vol. 283, No. 21, 2008, p. 14772-14780.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Conformational stability of calreticulin. / Jørgensen, Charlotte S; Trandum, Christa; Larsen, Nanna Brink; Ryder, L Rebekka; Gajhede, Michael; Skov, Lars; Højrup, Peter; Barkholt, Vibeke; Houen, Gunnar.

    In: Protein and Peptide Letters, Vol. 12, No. 7, 2005, p. 687-93.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Cyclic Acetals. Structural Analysis of 1,3‐Dioxepine and Related Compounds. / Jørgensen, Flemming S.; Gajhede, Michael; Frei, Bruno.

    In: Helvetica Chimica Acta, Vol. 68, No. 8, 01.01.1985, p. 2148-2157.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites. / Kaae, Birgitte Høiriis; Harpsøe, Kasper; Kastrup, Jette Sandholm Jensen; Sanz, Alberto Contreras; Pickering, Darryl Scott; Metzler, Bjørn; Clausen, Rasmus Prætorius; Gajhede, Michael; Sauerberg, Per; Liljefors, Tommy; Madsen, Ulf.

    In: Chemistry & Biology, Vol. 14, No. 11, 2007, p. 1294-303.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. / Kasper, Christina; Pickering, Darryl S; Mirza, Osman; Olsen, Lars; Kristensen, Anders S; Greenwood, Jeremy R; Liljefors, Tommy; Schousboe, Arne; Wätjen, Frank; Gajhede, Michael; Sigurskjold, Bent W; Kastrup, Jette S.

    In: Journal of Molecular Biology, Vol. 357, No. 4, 2006, p. 1184-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. / Krintel, Christian; Frydenvang, Karla; Olsen, Lars; Kristensen, Maria T; de Barrios, Oriol; Naur, Peter; Francotte, Pierre; Pirotte, Bernard; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Biochemical Journal, Vol. 441, No. 1, 01.01.2012, p. 173-178.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. / Kristensen, Anders S; Hansen, Kasper B; Naur, Peter; Olsen, Lars; Kurtkaya, Natalie L; Dravid, Shashank M; Kvist, Trine; Yi, Feng; Pøhlsgaard, Jacob; Clausen, Rasmus P; Gajhede, Michael; Kastrup, Jette S; Traynelis, Stephen F.

    In: Molecular Pharmacology, Vol. 89, No. 2, 02.2016, p. 253-262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A : Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. / Kristensen, Jan B L; Nielsen, Anders L; Jørgensen, Lars; Kristensen, Line Hyltoft; Helgstrand, Charlotte; Juknaite, Lina; Kristensen, Jesper Langgaard; Kastrup, Jette Sandholm; Clausen, Rasmus Prætorius; Olsen, Lars; Gajhede, Michael.

    In: F E B S Letters, Vol. 585, No. 12, 23.06.2011, p. 1951-1956.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. / Kristensen, Line Hyltoft; Nielsen, Anders Laerke; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Kastrup, Jette Sandholm; Helin, Kristian; Olsen, Lars; Gajhede, Michael.

    In: F E B S Journal, Vol. 279, No. 11, 06.2012, p. 1905-1914.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Chaperone binding at the ribosomal exit tunnel. / Kristensen, Ole; Gajhede, Michael.

    In: Structure, Vol. 11, No. 12, 2003, p. 1547-56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Crystallization of a stringent response factor from Aquifex aeolicus. / Kristensen, Ole; Laurberg, Martin; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 58, No. Pt 7, 2002, p. 1198-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp. / Kristensen, Ole; Ross, Birthe; Gajhede, Michael.

    In: Journal of Molecular Biology, Vol. 375, No. 5, 2008, p. 1469-1476.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A unique set of SH3-SH3 interactions controls IB1 homodimerization. / Kristensen, Ole; Guenat, Sylvie; Dar, Imran; Allaman-Pillet, Nathalie; Abderrahmani, Amar; Ferdaoussi, Mourad; Roduit, Raphaël; Maurer, Fabienne; Beckmann, Jacques S; Kastrup, Jette S; Gajhede, Michael; Bonny, Christophe.

    In: E M B O Journal, Vol. 25, No. 4, 2006, p. 785-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family. / Kristensen, Ole; Laurberg, Martin; Liljas, Anders; Kastrup, Jette Sandholm Jensen; Gajhede, Michael.

    In: Biochemistry, Vol. 43, No. 28, 2004, p. 8894-900.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
    Crystal structure of NCAM2 IgIV-Fn3I. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009.

    Research output: Non-textual formDatasetResearch

  19. Published

    Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1. / Kulahin, Nikolaj; Kasper, Christina; Kristensen, Ole; Kastrup, Jette Sandholm; Berezin, Vladimir; Bock, Elisabeth; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 61, No. Pt 9, 2005, p. 858-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published
    Crystal Structure of NCAM2 Ig1-2. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  21. Published
    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit). Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Poulsen, Jens-Christian Navarro (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  22. Published

    Structure of rat acidic fibroblast growth factor at 1.4 A resolution. / Kulahin, Nikolaj; Kiselyov, Vladislav; Kochoyan, Artur; Kristensen, Ole; Kastrup, Jette Sandholm Jensen; Berezin, Vladimir; Bock, Elisabeth Marianne; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 63, No. Pt2, 2007, p. 65-68.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Dimerization effect of sucrose octasulfate on rat FGF1. / Kulahin, Nikolaj; Kiselyov, Vladislav; Kochoyan, Artur; Kristensen, Ole; Kastrup, Jette Sandholm Jensen; Berezin, Vladimir; Bock, Elisabeth Marianne; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 64, No. Pt6, 2008, p. 448-452.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
    Crystal structure of NCAM2 IgIV-Fn3II. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009. 17. November.

    Research output: Non-textual formDatasetResearch

  25. Published

    Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1. / Kulahin, Nikolaj; Kasper, Christina; Gajhede, Michael; Berezin, Vladimir; Bock, Elisabeth; Kastrup, Jette Sandholm Jensen.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 60, No. Pt 3, 03.2004, p. 591-3.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published
    Crystal Structure of NCAM2 Ig2-3. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  27. Published

    Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule. / Kulahin, Nikolaj; Kristensen, Ole; Rasmussen, Kim K; Olsen, Lars; Rydberg, Patrik; Vestergaard, Bente; Kastrup, Jette Sandholm; Berezin, Vladimir; Bock, Elisabeth; Walmod, Peter Schledermann; Gajhede, Michael.

    In: Structure, Vol. 19, No. 2, 09.02.2011, p. 203-211.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published
    Crystal Structure of NCAM2 Ig34. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  29. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors. / Lohse, Brian; Nielsen, Anders L; Kristensen, Jan B L; Helgstrand, Charlotte; Cloos, Paul Andreas Compare; Olsen, Lars; Gajhede, Michael; Clausen, Rasmus Prætorius; Kristensen, Jesper Langgaard.

    In: Angewandte Chemie International Edition, Vol. 50, No. 39, 19.09.2011, p. 9100-9103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Inhibitors of histone demethylases. / Lohse, Brian; Kristensen, Jesper L; Kristensen, Line H; Agger, Karl; Helin, Kristian; Gajhede, Michael; Clausen, Rasmus P.

    In: Bioorganic & Medicinal Chemistry, Vol. 19, No. 12, 01.02.2011, p. 3625-3636.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    The metal binding site of the major house dust mite allergen Der p 1. / Meno, Kåre; Thorsted, Peter B; Ipsen, Henrik; Kristensen, Ole; Larsen, Jørgen; Spangfort, Michael D; Gajhede, Michael; Lund, Kaare.

    In: Journal of Allergy and Clinical Immunology, Vol. 118, No. 4, 2006, p. 971.

    Research output: Contribution to journalComment/debateResearchpeer-review

  33. Published

    The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen. / Meno, Kåre; Thorsted, Peter B; Ipsen, Henrik; Kristensen, Ole; Larsen, Jørgen; Spangfort, Michael D; Gajhede, Michael; Lund, Kaare.

    In: Journal of Immunology, Vol. 175, No. 6, 2005, p. 3835-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1. / Meno, Kåre H; Kastrup, Jette S; Kuo, I-Chun; Chua, Kaw Yan; Gajhede, Michael.

    In: Allergy, Vol. 72, No. 4, 13111, 01.04.2017, p. 665-670.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion. / Mirza, Osman; Henriksen, Lars Skov; Sprogøe, Desiree; van den Broek, Lambertus A M; Beldman, Gerrit; Kastrup, Jette S; Gajhede, Michael.

    In: Journal of Biological Chemistry, Vol. 281, No. 46, 2006, p. 35576-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Crystal Structures of Amylosucrase from Neisseria polysaccharea in Complex with D-Glucose and the Active Site Mutant Glu328Gln in Complex with the Natural Substrate Sucrose. / Mirza, Osman; Skov, Lars Kobberø; Remaud-Simeon, Magali; Potocki de Montalk, Gabrielle; Albenne, Cecile; Monsan, Pierre; Gajhede, Michael.

    In: Biochemistry, No. 40, 2001, p. 9032-9039.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Arabidopsis thaliana peroxidase N : structure of a novel neutral peroxidase. / Mirza, Osman Asghar; Henriksen, A; Ostergaard, L; Welinder, K G; Gajhede, M.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 56, No. Pt 3, 03.2000, p. 372-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Dominant epitopes and allergic cross-reactivity : complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. / Mirza, Osman Asghar; Henriksen, A; Ipsen, H; Larsen, J N; Wissenbach, M; Spangfort, M D; Gajhede, M.

    In: Journal of Immunology, Vol. 165, No. 1, 01.07.2000, p. 331-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose. / Mirza, Osman Asghar; Skov, L K; Remaud-Simeon, M; Potocki de Montalk, G; Albenne, C; Monsan, Pierre; Gajhede, Michael.

    In: Biochemistry, Vol. 40, No. 30, 31.07.2001, p. 9032-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Jagten på et signalstof til hjernens delta2-receptor. / Naur, Peter; Olsen, Lars; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2007, p. 32-33.

    Research output: Contribution to journalJournal articleCommunication

  41. Published

    Ionotropic glutamate-like receptor d2 binds D-serine and glycine. / Naur, Peter; Hansen, Kasper Bø; Kristensen, Anders Skov; Dravid, Shashank M.; Pickering, Darryl Scott; Olsen, Lars; Vestergaard, Bente; Egebjerg, Jan; Gajhede, Michael; Traynelis, Stephen F.; Kastrup, Jette Sandholm Jensen.

    In: Proceedings of the National Academy of Science of the United States of America, Vol. 104, No. 35, 2007, p. 14116-14121.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate. / Naur, Peter; Vestergaard, Bente; Skov, Lars; Egebjerg, Jan ; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: FEBS letters, Vol. 579, 2005, p. 1154-60.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Identification of catechols as histone-lysine demethylase inhibitors. / Nielsen, Anders L; Kristensen, Line H; Stephansen, Karen B; Kristensen, Jan B L; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Helin, Kristian; Gajhede, Michael; Olsen, Lars.

    In: F E B S Letters, Vol. 586, No. 8, 2012, p. 1190-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP. / Nielsen, Bettina B; Pickering, Darryl S; Greenwood, Jeremy R; Brehm, Lotte; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette S.

    In: FEBS Journal, Vol. 272, No. 7, 2005, p. 1639-48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Differential Activity and Structure of Highly Similar Peroxidases. Spectroscopic, Crystallographic, and Enzymatic Analyses of Lignifying Arabidopsis thaliana Peroxidase A2 and Horseradish Peroxidase A2. / Nielsen, Kåre Lehmann; Indiani, Chiara; Henriksen, Anette; Feis, Alessandro; Becucci, Maurizio; Gajhede, Michael; Smulevich, Giuliette; Welinder, Karen G.

    In: Biochemistry, No. 40, 2001, p. 11013-11021.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors. / Olsen, Jeppe A; Ahring, Philip K; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Balle, Thomas.

    In: The Journal of Biological Chemistry, Vol. 289, No. 36, 05.09.2014, p. 24911-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. / Olsen, Jeppe A.; Kastrup, Jette Sandholm Jensen; Peters, Dan; Gajhede, Michael; Balle, Thomas; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 50, 13.12.2013, p. 35997.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors. / Olsen, Jeppe A.; Balle, Thomas; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm Jensen.

    In: PLOS ONE, Vol. 9, No. 3, 17.03.2014, p. e91232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Hvad har varme at gøre med lægemidler? / Olsen, Lars; Kasper, Christina; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Jørgensen, Flemming Steen.

    In: Lægemiddelforskning, 2006, p. 31-33.

    Research output: Contribution to journalJournal articleCommunication

  50. Published

    Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification. / Ostergaard, L; Teilum, K; Mirza, O; Mattsson, O; Petersen, M; Welinder, K G; Mundy, J; Gajhede, M; Henriksen, A.

    In: Plant Molecular Biology, Vol. 44, No. 2, 2000, p. 231-43.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1304192