Michael Gajhede
Professor
Biostructural Research
30, Building: 315
2100 København Ø
- 2019
- Published
Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH. / Aduri, Nanda G.; Montefiori, Marco; Khalil, Ruqaiya; Gajhede, Michael; Jørgensen, Flemming Steen; Mirza, Osman.
In: ACS Omega, Vol. 4, No. 1, 31.01.2019, p. 2040-2046.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular architecture of the Jumonji C family histone demethylase KDM5B. / Dorosz, Jerzy; Kristensen, Line Hyltoft; Aduri, Nanda G; Mirza, Osman; Lousen, Rikke; Bucciarelli, Saskia; Mehta, Ved; Sellés-Baiget, Selene; Solbak, Sara Marie Øie; Bach, Anders; Mesa, Pablo; Hernandez, Pablo Alcon; Montoya, Guillermo; Nguyen, Tam T. T. N.; Rand, Kasper D.; Boesen, Thomas; Gajhede, Michael.
In: Scientific Reports, Vol. 9, 4019, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes. / Jones, Sarah E.; Olsen, Lars; Dorosz, Jerzy; Seger, Signe T.; Andersson, Jan L.; Kristensen, Line H.; Gajhede, Michael.
In: ChemBioChem, Vol. 19, No. 17, 04.09.2018, p. 1817-1822.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function. / Backe, Marie Balslev; Andersson, Jan Legaard; Bacos, Karl; Christensen, Dan Ploug; Hansen, Jakob Bondo; Dorosz, Jerzy Jòzef; Gajhede, Michael; Dahlby, Tina; Bysani, Madhusudhan; Kristensen, Line Hyltoft; Ling, Charlotte; Olsen, Lars; Mandrup-Poulsen, Thomas.
In: Molecular and Cellular Endocrinology, Vol. 460, 15.01.2018, p. 47-56.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state. / Aduri, Nanda G; Ernst, Heidi A.; Prabhala, Bala K.; Bhatt, Shweta; Boesen, Thomas; Gajhede, Michael; Mirza, Osman.
In: Biochemical and Biophysical Research Communications, Vol. 495, No. 2, 2018, p. 1738-1743.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity. / Jones, Sarah E; Olsen, Lars; Gajhede, Michael.
In: Biochemistry, Vol. 57, No. 5, 2018, p. 585–592.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells. / Prabhala, Bala K; Aduri, Nanda G; Sharma, Neha; Shaheen, Aqsa; Sharma, Arpan; Iqbal, Mazhar; Hansen, Paul R; Brasen, Christoffer; Gajhede, Michael; Rahman, Moazur; Mirza, Osman.
In: The Journal of Biological Chemistry, Vol. 293, 2018, p. 1007-1017.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8. / Dorosz, Jerzy; Olsen, Lars; Seger, Signe Teuber; Steinhauer, Cornelia; Bouras, Giorgos; Helgstrand, Charlotte; Wiuf, Anders; Gajhede, Michael.
In: ChemBioChem, Vol. 18, No. 14, 18.07.2017, p. 1369-1375.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region. / Tapken, Daniel; Steffensen, Thomas Bielefeldt; Leth, Rasmus; Kristensen, Lise Baadsgaard; Gerbola, Alexander; Gajhede, Michael; Jørgensen, Flemming Steen; Olsen, Lars; Kastrup, Jette Sandholm.
In: Scientific Reports, Vol. 7, 46145, 07.04.2017.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1. / Meno, Kåre H; Kastrup, Jette S; Kuo, I-Chun; Chua, Kaw Yan; Gajhede, Michael.
In: Allergy, Vol. 72, No. 4, 13111, 01.04.2017, p. 665-670.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. / Prabhala, Bala K; Aduri, Nanda G; Iqbal, Mazhar; Rahman, Moazur; Gajhede, Michael; Hansen, Paul R; Mirza, Osman.
In: Research in Microbiology, Vol. 168, No. 5, 16.02.2017, p. 443-449.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression, purification and characterization of the human MTA2-RBBP7 complex. / Brasen, Christoffer; Dorosz, Jerzy; Wiuf, Anders; Boesen, Thomas; Mirza, Osman; Gajhede, Michael.
In: Biochimica et biophysica acta, Vol. 1865, No. 5, 04.02.2017, p. 531-538.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. / Kristensen, Anders S; Hansen, Kasper B; Naur, Peter; Olsen, Lars; Kurtkaya, Natalie L; Dravid, Shashank M; Kvist, Trine; Yi, Feng; Pøhlsgaard, Jacob; Clausen, Rasmus P; Gajhede, Michael; Kastrup, Jette S; Traynelis, Stephen F.
In: Molecular Pharmacology, Vol. 89, No. 2, 02.2016, p. 253-262.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Structural Studies of Nicotinic Acetylcholine Receptors : Using Acetylcholine Binding Protein as a Structural Surrogate. / Shahsavar, Azadeh; Gajhede, Michael; Kastrup, Jette S; Balle, Thomas.
In: Basic & Clinical Pharmacology & Toxicology Online, Vol. 118, No. 6, 17.11.2015, p. 399–407.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. / Shahsavar, Azadeh; Ahring, Philip K; Olsen, Jeppe A; Krintel, Christian; Kastrup, Jette S; Balle, Thomas; Gajhede, Michael.
In: Molecular Pharmacology, Vol. 88, No. 4, 10.2015, p. 697-707.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and binding properties of a cameloid nanobody raised against KDM5B. / Wiuf, Anders; Kristensen, Line Hyltoft; Kristensen, Ole; Dorosz, Jerzy; Jensen, Jonas; Gajhede, Michael.
In: Acta crystallographica. Section F, Structural biology communications, Vol. 71, No. Pt 10, 23.09.2015, p. 1235-1241.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface. / Ahring, Philip K; Olsen, Jeppe A; Nielsen, Elsebet Ø; Peters, Dan; Pedersen, Martin H F; Rohde, Line A; Kastrup, Jette Sandholm Jensen; Shahsavar, Azadeh; Indurthi, Dinesh C; Chebib, Mary; Gajhede, Michael; Balle, Thomas.
In: Neuropharmacology, Vol. 92, 2015, p. 135-45.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors. / Olsen, Jeppe A; Ahring, Philip K; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Balle, Thomas.
In: The Journal of Biological Chemistry, Vol. 289, No. 36, 05.09.2014, p. 24911-21.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.
In: F E B S Journal, 27.03.2014, p. 2422–2430.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors. / Olsen, Jeppe A.; Balle, Thomas; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm Jensen.
In: PLOS ONE, Vol. 9, No. 3, 17.03.2014, p. e91232.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.
In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. / Olsen, Jeppe A.; Kastrup, Jette Sandholm Jensen; Peters, Dan; Gajhede, Michael; Balle, Thomas; Ahring, Philip K.
In: Journal of Biological Chemistry, Vol. 288, No. 50, 13.12.2013, p. 35997.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.
In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology. / Skov, Lars K; Pizzut-Serin, Sandra; Remaud-Simeon, Magali; Ernst, Heidi A; Gajhede, Michael; Mirza, Osman Asghar.
In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. 69, No. Pt 9, 09.2013, p. 973-8.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. / Fiorentini, Monica; Bach, Anders; Strømgaard, Kristian; Kastrup, Jette S; Gajhede, Michael.
In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 69, No. Pt 4, 04.2013, p. 587-94.Research output: Contribution to journal › Journal article › Research
ID: 1304192
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
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