Michael Gajhede

Michael Gajhede

Professor


  1. Published

    Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2. / Frandsen, Anne; Pickering, Darryl S.; Vestergaard, Bente; Kasper, Christina; Nielsen, Bettina Bryde; Greenwood, Jeremy R; Campiani, Giuseppe; Fattorusso, Caterina; Gajhede, Michael; Schousboe, Arne; Kastrup, Jette Sandholm.

    In: Molecular Pharmacology, Vol. 67, No. 3, 2005, p. 703-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. / Olsen, Jeppe A.; Kastrup, Jette Sandholm Jensen; Peters, Dan; Gajhede, Michael; Balle, Thomas; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 50, 13.12.2013, p. 35997.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Towards the molecular understanding of glycogen elongation by amylosucrase. / Albenne, Cécile; Skov, Lars K.; Tran, Vinh; Gajhede, Michael; Monsan, Pierre; Remaud-Siméon, Magali; André-Leroux, Gwénaëlle.

    In: Proteins - Structure Function and Bioinformatics, Vol. 66, No. 1, 2007, p. 118-126.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. / Krintel, Christian; Frydenvang, Karla; Olsen, Lars; Kristensen, Maria T; de Barrios, Oriol; Naur, Peter; Francotte, Pierre; Pirotte, Bernard; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Biochemical Journal, Vol. 441, No. 1, 01.01.2012, p. 173-178.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1. / Meno, Kåre H; Kastrup, Jette S; Kuo, I-Chun; Chua, Kaw Yan; Gajhede, Michael.

    In: Allergy, Vol. 72, No. 4, 13111, 01.04.2017, p. 665-670.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit. / Paës, Gabriel; Skov, Lars K; O'Donohue, Michael J; Rémond, Caroline; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman.

    In: Biochemistry, Vol. 47, No. 28, 2008, p. 7441-7451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology. / Skov, Lars K; Pizzut-Serin, Sandra; Remaud-Simeon, Magali; Ernst, Heidi A; Gajhede, Michael; Mirza, Osman Asghar.

    In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. 69, No. Pt 9, 09.2013, p. 973-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. / Kasper, Christina; Pickering, Darryl S; Mirza, Osman; Olsen, Lars; Kristensen, Anders S; Greenwood, Jeremy R; Liljefors, Tommy; Schousboe, Arne; Wätjen, Frank; Gajhede, Michael; Sigurskjold, Bent W; Kastrup, Jette S.

    In: Journal of Molecular Biology, Vol. 357, No. 4, 2006, p. 1184-201.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells. / Prabhala, Bala K; Aduri, Nanda G; Sharma, Neha; Shaheen, Aqsa; Sharma, Arpan; Iqbal, Mazhar; Hansen, Paul R; Brasen, Christoffer; Gajhede, Michael; Rahman, Moazur; Mirza, Osman.

    In: The Journal of Biological Chemistry, Vol. 293, 2018, p. 1007-1017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The metal binding site of the major house dust mite allergen Der p 1. / Meno, Kåre; Thorsted, Peter B; Ipsen, Henrik; Kristensen, Ole; Larsen, Jørgen; Spangfort, Michael D; Gajhede, Michael; Lund, Kaare.

    In: Journal of Allergy and Clinical Immunology, Vol. 118, No. 4, 2006, p. 971.

    Research output: Contribution to journalComment/debateResearchpeer-review

  11. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region. / Tapken, Daniel; Steffensen, Thomas Bielefeldt; Leth, Rasmus; Kristensen, Lise Baadsgaard; Gerbola, Alexander; Gajhede, Michael; Jørgensen, Flemming Steen; Olsen, Lars; Kastrup, Jette Sandholm.

    In: Scientific Reports, Vol. 7, 46145, 07.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue : synthesis, molecular pharmacology, and biostructural characterization. / Clausen, Rasmus Prætorius; Naur, Peter; Kristensen, Anders Skov; Greenwood, Jeremy R; Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn; Nielsen, Anne Sophie T; Geneser, Ulla; Ringgaard, Lone M; Nielsen, Birgitte; Pickering, Darryl S; Brehm, Lotte; Gajhede, Michael; Krogsgaard-Larsen, Povl; Kastrup, Jette Sandholm.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 15, 2009, p. 4911-4922.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen. / Meno, Kåre; Thorsted, Peter B; Ipsen, Henrik; Kristensen, Ole; Larsen, Jørgen; Spangfort, Michael D; Gajhede, Michael; Lund, Kaare.

    In: Journal of Immunology, Vol. 175, No. 6, 2005, p. 3835-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove. / Champion, Elise; Remaud-Simeon, Magali; Skov, Lars Kobberøe; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman Asghar.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 65, No. 12, 2009, p. 1309-1314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    The Structures of the Horseradish Peroxidase C-Ferulic Acid Complex and the Ternary Comples with Cyanide Suggest How Peroxidases Oxidize Small Phenolic Substrates. / Henriksen, Anette; Smith, Andrew T.; Gajhede, Michael.

    In: J. of Biol. Chem., No. 49, 1999, p. 35005-34011.

    Research output: Contribution to journalJournal articleResearch

  16. Published

    The SAXS Solution Structure of RF1 Differs from Its Crystal Structure and Is Similar to Its Ribosome Bound Cryo-EM Structure. / Vestergaard, Bente; Sanyal, Suparna; Roessle, Manfred; Mora, Liliana; Buckingham, Richard; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Svergun, Dmitri I; Ehrenberg, Måns.

    In: Molecular Cell, Vol. 20, 2005, p. 929-938.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors. / Lohse, Brian; Nielsen, Anders L; Kristensen, Jan B L; Helgstrand, Charlotte; Cloos, Paul Andreas Compare; Olsen, Lars; Gajhede, Michael; Clausen, Rasmus Prætorius; Kristensen, Jesper Langgaard.

    In: Angewandte Chemie International Edition, Vol. 50, No. 39, 19.09.2011, p. 9100-9103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists. / Ussing, Christine A.; Hansen, Camilla Petrycer; Petersen, Jette Gellert; Jensen, Anders A.; Rohde, Line A.H. ; Ahring, Philip K.; Nielsen, Elisabeth Ø. ; Kastrup, Jette Sandholm; Gajhede, Michael; Frølund, Bente; Balle, Thomas.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 940-951.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. / Kristensen, Line Hyltoft; Nielsen, Anders Laerke; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Kastrup, Jette Sandholm; Helin, Kristian; Olsen, Lars; Gajhede, Michael.

    In: F E B S Journal, Vol. 279, No. 11, 06.2012, p. 1905-1914.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8. / Dorosz, Jerzy; Olsen, Lars; Seger, Signe Teuber; Steinhauer, Cornelia; Bouras, Giorgos; Helgstrand, Charlotte; Wiuf, Anders; Gajhede, Michael.

    In: ChemBioChem, Vol. 18, No. 14, 18.07.2017, p. 1369-1375.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structure of the house dust mite allergen Der f 2 : implications for function and molecular basis of IgE cross-reactivity. / Johannessen, Birthe R; Skov, Lars; Kastrup, Jette S; Kristensen, Ole; Bolwig, Caroline; Larsen, Jørgen; Spangfort, Michael; Lund, Kaare; Gajhede, Michael.

    In: F E B S Letters, Vol. 579, No. 5, 2005, p. 1208-12.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structure of the first PDZ domain of human PSD-93. / Fiorentini, Monica; Nielsen, Ann Kallehauge; Kristensen, Ole; Kastrup, Jette Sandholm; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 65, No. 12, 2009, p. 1254-1257.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp. / Kristensen, Ole; Ross, Birthe; Gajhede, Michael.

    In: Journal of Molecular Biology, Vol. 375, No. 5, 2008, p. 1469-1476.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Structure of soybean seed coat peroxidase: a plant peroxidase with unusual stability and haem-apoprotein interactions. / Henriksen, A; Mirza, O; Indiani, C; Teilum, K; Smulevich, G; Welinder, K G; Gajhede, M.

    In: Protein Science, Vol. 10, No. 1, 2001, p. 108-15.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1304192