Michael Gajhede

Michael Gajhede

Professor


  1. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface. / Ahring, Philip K; Olsen, Jeppe A; Nielsen, Elsebet Ø; Peters, Dan; Pedersen, Martin H F; Rohde, Line A; Kastrup, Jette Sandholm Jensen; Shahsavar, Azadeh; Indurthi, Dinesh C; Chebib, Mary; Gajhede, Michael; Balle, Thomas.

    In: Neuropharmacology, Vol. 92, 2015, p. 135-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Towards the molecular understanding of glycogen elongation by amylosucrase. / Albenne, Cécile; Skov, Lars K.; Tran, Vinh; Gajhede, Michael; Monsan, Pierre; Remaud-Siméon, Magali; André-Leroux, Gwénaëlle.

    In: Proteins - Structure Function and Bioinformatics, Vol. 66, No. 1, 2007, p. 118-126.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. / Bach, Anders*; Clausen, Bettina H; Møller, Magda; Vestergaard, Bente; Chi, Celestine N; Round, Adam; Sørensen, Pernille Louise; Nissen, Klaus Bertram; Kastrup, Jette Sandholm; Gajhede, Michael; Jemth, Per; Kristensen, Anders Skov; Lundström, Patrik; Lambertsen, Kate Lykke; Strømgaard, Kristian* (*Corresponding).

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, 28.02.2012, p. 3317-3322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Expression, purification and characterization of the human MTA2-RBBP7 complex. / Brasen, Christoffer; Dorosz, Jerzy; Wiuf, Anders; Boesen, Thomas; Mirza, Osman; Gajhede, Michael.

    In: Biochimica et biophysica acta, Vol. 1865, No. 5, 04.02.2017, p. 531-538.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove. / Champion, Elise; Remaud-Simeon, Magali; Skov, Lars Kobberøe; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman Asghar.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 65, No. 12, 2009, p. 1309-1314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue : synthesis, molecular pharmacology, and biostructural characterization. / Clausen, Rasmus Prætorius; Naur, Peter; Kristensen, Anders Skov; Greenwood, Jeremy R; Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn; Nielsen, Anne Sophie T; Geneser, Ulla; Ringgaard, Lone M; Nielsen, Birgitte; Pickering, Darryl S; Brehm, Lotte; Gajhede, Michael; Krogsgaard-Larsen, Povl; Kastrup, Jette Sandholm.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 15, 2009, p. 4911-4922.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8. / Dorosz, Jerzy; Olsen, Lars; Seger, Signe Teuber; Steinhauer, Cornelia; Bouras, Giorgos; Helgstrand, Charlotte; Wiuf, Anders; Gajhede, Michael.

    In: ChemBioChem, Vol. 18, No. 14, 18.07.2017, p. 1369-1375.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Chemical and thermal unfolding of calreticulin. / Duus, K.; Larsen, N.; Tran, T. A. T.; Güven, E.; Skov, L. K.; Jespersgaard, C; Gajhede, Michael; Houen, Gunnar.

    In: Protein and Peptide Letters, Vol. 20, 2013, p. 562-568.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Structure of the first PDZ domain of human PSD-93. / Fiorentini, Monica; Nielsen, Ann Kallehauge; Kristensen, Ole; Kastrup, Jette Sandholm; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 65, No. 12, 2009, p. 1254-1257.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. / Fiorentini, Monica; Bach, Anders; Strømgaard, Kristian; Kastrup, Jette S; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 69, No. Pt 4, 04.2013, p. 587-94.

    Research output: Contribution to journalJournal articleResearch

  13. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    At være eller ikke være en antagonist. / Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2009, p. 43-45.

    Research output: Contribution to journalJournal articleCommunication

  15. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. / Hald, Helle; Ahring, Philip Kiær; Timmermann, Daniel Brunicardi; Liljefors, Tommy; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Journal of Molecular Biology, Vol. 391, No. 5, 2009, p. 906-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5 : Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. / Hald, Helle; Naur, Peter; Pickering, Darryl Scott; Sprogøe, Desiree; Madsen, Ulf; Timmermann, Daniel B.; Ahring, Philip K.; Liljefors, Tommy; Schousboe, Arne; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Journal of Biological Chemistry, Vol. 282, No. 35, 2007, p. 25726-25736.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium. / Hansen, Kasper Bø; Naur, Peter; Kurtkaya, Natalie L; Kristensen, Anders Skov; Gajhede, Michael; Kastrup, Jette Sandholm; Traynelis, Stephen F.

    In: Journal of Neuroscience, Vol. 29, No. 4, 2009, p. 907-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. / Harpsøe, Kasper; Hald, Helle; Timmermann, Daniel B; Jensen, Marianne L; Dyhring, Tino; Nielsen, Elsebet Ø; Peters, Dan; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 4, 25.01.2013, p. 2559-2570.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1. / Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik; Würtzen, Peter A; Gajhede, Michael; Larsen, Jørgen N; Lund, Kaare; Spangfort, Michael D.

    In: Journal of Biological Chemistry, Vol. 286, No. 20, 20.05.2011, p. 17569-17578.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Gennembrud i forståelsen af insulinfibrillering. / Jensen, Minna Grønning; Vestergaard, Bente; Frøkjær, Sven; Gajhede, Michael; Flink, James M.; Van De Weert, Marco; Kastrup, Jette Sandholm Jensen; Svergun, Dmitri I.

    In: Lægemiddelforskning, 2007, p. 10-11.

    Research output: Contribution to journalJournal articleCommunication

  21. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.

    In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution. / Jørgensen, Anders Dysted; Nøhr, Jane; Kastrup, Jette Sandholm; Gajhede, Michael; Sigurskjold, Bent Walther; Sauer, Jørgen; Svergun, Dmitri I.; Svensson, Birte; Vestergaard, Bente.

    In: Journal of Biological Chemistry, Vol. 283, No. 21, 2008, p. 14772-14780.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites. / Kaae, Birgitte Høiriis; Harpsøe, Kasper; Kastrup, Jette Sandholm Jensen; Sanz, Alberto Contreras; Pickering, Darryl Scott; Metzler, Bjørn; Clausen, Rasmus Prætorius; Gajhede, Michael; Sauerberg, Per; Liljefors, Tommy; Madsen, Ulf.

    In: Chemistry & Biology, Vol. 14, No. 11, 2007, p. 1294-303.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 1304192