Michael Gajhede
Michael Gajhede

Professor


  1. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

    Olsen, J. A., Kastrup, Jette Sandholm Jensen, Peters, D., Gajhede, Michael, Balle, T. & Ahring, P. K., 13 Dec 2013, In : Journal of Biological Chemistry. 288, 50, p. 35997 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Towards the molecular understanding of glycogen elongation by amylosucrase

    Albenne, C., Skov, L. K., Tran, V., Gajhede, Michael, Monsan, P., Remaud-Siméon, M. & André-Leroux, G., 2007, In : Proteins - Structure Function and Bioinformatics. 66, 1, p. 118-126

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In : Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1

    Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In : Allergy. 72, 4, p. 665-670 6 p., 13111.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit

    Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In : Biochemistry. 47, 28, p. 7441-7451

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology

    Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In : Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

    Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In : Scientific Reports. 7, 12 p., 46145.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

    Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner-Osborne, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In : Journal of Medicinal Chemistry. 52, 15, p. 4911-4922

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove

    Champion, E., Remaud-Simeon, M., Skov, L. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2009, In : Acta Crystallographica. Section D: Biological Crystallography. 65, 12, p. 1309-1314

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, Brian, Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, Paul, Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In : Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists

    Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 940-951

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, Paul, Kastrup, Jette Sandholm Jensen, Helin, Kristian, Olsen, L. & Gajhede, Michael, Jun 2012, In : F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. Published

    Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8

    Dorosz, J., Olsen, L., Seger, S. T., Steinhauer, Cornelia, Bouras, G., Helgstrand, C., Wiuf, Anders Drabæk & Gajhede, Michael, 18 Jul 2017, In : ChemBioChem. 18, 14, p. 1369-1375 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Structure of the first PDZ domain of human PSD-93

    Fiorentini, M., Nielsen, A. K., Kristensen, O., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2009, In : Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 65, 12, p. 1254-1257

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp

    Kristensen, O., Ross, B. & Gajhede, Michael, 2008, In : Journal of Molecular Biology. 375, 5, p. 1469-1476

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structure of rat acidic fibroblast growth factor at 1.4 A resolution.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2007, In : Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 63, Pt2, p. 65-68 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

    Røder, G., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2008, In : Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt 6, p. 459-62 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structure and binding properties of a cameloid nanobody raised against KDM5B

    Wiuf, Anders Drabæk, Kristensen, L. H., Kristensen, O., Dorosz, J., Jensen, J. & Gajhede, Michael, 23 Sep 2015, In : Acta crystallographica. Section F, Structural biology communications. 71, Pt 10, p. 1235-1241 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In : Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

    Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, Bente, Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 9 Feb 2011, In : Structure. 19, 2, p. 203-211

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

    Olsen, J. A., Ahring, P. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Balle, T., 5 Sep 2014, In : The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Dorvil, Linda Grønborg, Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In : Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate

    Shahsavar, A., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 17 Nov 2015, In : Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen

    Shahsavar, A., Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In : Lægemiddelforskning. 2012, p. 48-50 3 p.

    Research output: Contribution to journalJournal articleCommunication

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