Michael Gajhede
Professor
Biostructural Research
30, Building: 315
2100 København Ø
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Towards the molecular understanding of glycogen elongation by amylosucrase. / Albenne, Cécile; Skov, Lars K.; Tran, Vinh; Gajhede, Michael; Monsan, Pierre; Remaud-Siméon, Magali; André-Leroux, Gwénaëlle.
In: Proteins - Structure Function and Bioinformatics, Vol. 66, No. 1, 2007, p. 118-126.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.
In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.Research output: Contribution to journal › Journal article › Research › peer-review
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A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. / Bach, Anders*; Clausen, Bettina H; Møller, Magda; Vestergaard, Bente; Chi, Celestine N; Round, Adam; Sørensen, Pernille Louise; Nissen, Klaus Bertram; Kastrup, Jette Sandholm; Gajhede, Michael; Jemth, Per; Kristensen, Anders Skov; Lundström, Patrik; Lambertsen, Kate Lykke; Strømgaard, Kristian* (*Corresponding).
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, 28.02.2012, p. 3317-3322.Research output: Contribution to journal › Journal article › Research › peer-review
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Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.
In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue. / Blicher, Thomas; Kastrup, Jette Sandholm; Pedersen, Lars Østergaard; Buus, Søren; Gajhede, Michael.
In: Acta Crystallographica Section F-Structural Biology and Crystallization Communications, Vol. 62, No. Pt 12, 2006, p. 1179-84.Research output: Contribution to journal › Journal article › Research › peer-review
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The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove. / Champion, Elise; Remaud-Simeon, Magali; Skov, Lars Kobberøe; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman Asghar.
In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 65, No. 12, 2009, p. 1309-1314.Research output: Contribution to journal › Journal article › Research › peer-review
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The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue : synthesis, molecular pharmacology, and biostructural characterization. / Clausen, Rasmus Prætorius; Naur, Peter; Kristensen, Anders Skov; Greenwood, Jeremy R; Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn; Nielsen, Anne Sophie T; Geneser, Ulla; Ringgaard, Lone M; Nielsen, Birgitte; Pickering, Darryl S; Brehm, Lotte; Gajhede, Michael; Krogsgaard-Larsen, Povl; Kastrup, Jette Sandholm.
In: Journal of Medicinal Chemistry, Vol. 52, No. 15, 2009, p. 4911-4922.Research output: Contribution to journal › Journal article › Research › peer-review
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Chemical and thermal unfolding of calreticulin. / Duus, K.; Larsen, N.; Tran, T. A. T.; Güven, E.; Skov, L. K.; Jespersgaard, C; Gajhede, Michael; Houen, Gunnar.
In: Protein and Peptide Letters, Vol. 20, 2013, p. 562-568.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the first PDZ domain of human PSD-93. / Fiorentini, Monica; Nielsen, Ann Kallehauge; Kristensen, Ole; Kastrup, Jette Sandholm; Gajhede, Michael.
In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 65, No. 12, 2009, p. 1254-1257.Research output: Contribution to journal › Journal article › Research › peer-review
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Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. / Fiorentini, Monica; Bach, Anders; Strømgaard, Kristian; Kastrup, Jette S; Gajhede, Michael.
In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 69, No. Pt 4, 04.2013, p. 587-94.Research output: Contribution to journal › Journal article › Research
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Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.
In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.Research output: Contribution to journal › Journal article › Research › peer-review
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At være eller ikke være en antagonist. / Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.
In: Lægemiddelforskning, 2009, p. 43-45.Research output: Contribution to journal › Journal article › Communication
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Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. / Hald, Helle; Ahring, Philip Kiær; Timmermann, Daniel Brunicardi; Liljefors, Tommy; Gajhede, Michael; Kastrup, Jette Sandholm.
In: Journal of Molecular Biology, Vol. 391, No. 5, 2009, p. 906-917.Research output: Contribution to journal › Journal article › Research › peer-review
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Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5 : Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. / Hald, Helle; Naur, Peter; Pickering, Darryl Scott; Sprogøe, Desiree; Madsen, Ulf; Timmermann, Daniel B.; Ahring, Philip K.; Liljefors, Tommy; Schousboe, Arne; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.
In: Journal of Biological Chemistry, Vol. 282, No. 35, 2007, p. 25726-25736.Research output: Contribution to journal › Journal article › Research › peer-review
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Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium. / Hansen, Kasper Bø; Naur, Peter; Kurtkaya, Natalie L; Kristensen, Anders Skov; Gajhede, Michael; Kastrup, Jette Sandholm; Traynelis, Stephen F.
In: Journal of Neuroscience, Vol. 29, No. 4, 2009, p. 907-917.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. / Harpsøe, Kasper; Hald, Helle; Timmermann, Daniel B; Jensen, Marianne L; Dyhring, Tino; Nielsen, Elsebet Ø; Peters, Dan; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Ahring, Philip K.
In: Journal of Biological Chemistry, Vol. 288, No. 4, 25.01.2013, p. 2559-2570.Research output: Contribution to journal › Journal article › Research › peer-review
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Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1. / Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik; Würtzen, Peter A; Gajhede, Michael; Larsen, Jørgen N; Lund, Kaare; Spangfort, Michael D.
In: Journal of Biological Chemistry, Vol. 286, No. 20, 20.05.2011, p. 17569-17578.Research output: Contribution to journal › Journal article › Research › peer-review
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Gennembrud i forståelsen af insulinfibrillering. / Jensen, Minna Grønning; Vestergaard, Bente; Frøkjær, Sven; Gajhede, Michael; Flink, James M.; Van De Weert, Marco; Kastrup, Jette Sandholm Jensen; Svergun, Dmitri I.
In: Lægemiddelforskning, 2007, p. 10-11.Research output: Contribution to journal › Journal article › Communication
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Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.
In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.Research output: Contribution to journal › Journal article › Research › peer-review
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Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution. / Jørgensen, Anders Dysted; Nøhr, Jane; Kastrup, Jette Sandholm; Gajhede, Michael; Sigurskjold, Bent Walther; Sauer, Jørgen; Svergun, Dmitri I.; Svensson, Birte; Vestergaard, Bente.
In: Journal of Biological Chemistry, Vol. 283, No. 21, 2008, p. 14772-14780.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites. / Kaae, Birgitte Høiriis; Harpsøe, Kasper; Kastrup, Jette Sandholm Jensen; Sanz, Alberto Contreras; Pickering, Darryl Scott; Metzler, Bjørn; Clausen, Rasmus Prætorius; Gajhede, Michael; Sauerberg, Per; Liljefors, Tommy; Madsen, Ulf.
In: Chemistry & Biology, Vol. 14, No. 11, 2007, p. 1294-303.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. / Kasper, Christina; Pickering, Darryl S; Mirza, Osman; Olsen, Lars; Kristensen, Anders S; Greenwood, Jeremy R; Liljefors, Tommy; Schousboe, Arne; Wätjen, Frank; Gajhede, Michael; Sigurskjold, Bent W; Kastrup, Jette S.
In: Journal of Molecular Biology, Vol. 357, No. 4, 2006, p. 1184-201.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.
In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.Research output: Contribution to journal › Journal article › Research › peer-review
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Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. / Krintel, Christian; Frydenvang, Karla; Olsen, Lars; Kristensen, Maria T; de Barrios, Oriol; Naur, Peter; Francotte, Pierre; Pirotte, Bernard; Gajhede, Michael; Kastrup, Jette Sandholm.
In: Biochemical Journal, Vol. 441, No. 1, 01.01.2012, p. 173-178.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.
In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.Research output: Contribution to journal › Journal article › Research › peer-review
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Enzyme kinetic studies of histone demethylases KDM4C and KDM6A : Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. / Kristensen, Jan B L; Nielsen, Anders L; Jørgensen, Lars; Kristensen, Line Hyltoft; Helgstrand, Charlotte; Juknaite, Lina; Kristensen, Jesper Langgaard; Kastrup, Jette Sandholm; Clausen, Rasmus Prætorius; Olsen, Lars; Gajhede, Michael.
In: F E B S Letters, Vol. 585, No. 12, 23.06.2011, p. 1951-1956.Research output: Contribution to journal › Journal article › Research › peer-review
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Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. / Kristensen, Line Hyltoft; Nielsen, Anders Laerke; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Kastrup, Jette Sandholm; Helin, Kristian; Olsen, Lars; Gajhede, Michael.
In: F E B S Journal, Vol. 279, No. 11, 06.2012, p. 1905-1914.Research output: Contribution to journal › Journal article › Research › peer-review
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A unique set of SH3-SH3 interactions controls IB1 homodimerization. / Kristensen, Ole; Guenat, Sylvie; Dar, Imran; Allaman-Pillet, Nathalie; Abderrahmani, Amar; Ferdaoussi, Mourad; Roduit, Raphaël; Maurer, Fabienne; Beckmann, Jacques S; Kastrup, Jette S; Gajhede, Michael; Bonny, Christophe.
In: E M B O Journal, Vol. 25, No. 4, 2006, p. 785-97.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp. / Kristensen, Ole; Ross, Birthe; Gajhede, Michael.
In: Journal of Molecular Biology, Vol. 375, No. 5, 2008, p. 1469-1476.Research output: Contribution to journal › Journal article › Research › peer-review
- PublishedCrystal structure of NCAM2 IgIV-Fn3I. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009.
Research output: Non-textual form › Dataset › Research
- PublishedCrystal Structure of NCAM2 Ig1-2. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.
Research output: Non-textual form › Dataset › Research
- PublishedCrystal Structure of NCAM2 Ig1 (I4122 Cell Unit). Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Poulsen, Jens-Christian Navarro (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.
Research output: Non-textual form › Dataset › Research
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution. / Kulahin, Nikolaj; Kiselyov, Vladislav; Kochoyan, Artur; Kristensen, Ole; Kastrup, Jette Sandholm Jensen; Berezin, Vladimir; Bock, Elisabeth Marianne; Gajhede, Michael.
In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 63, No. Pt2, 2007, p. 65-68.Research output: Contribution to journal › Journal article › Research › peer-review
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Dimerization effect of sucrose octasulfate on rat FGF1. / Kulahin, Nikolaj; Kiselyov, Vladislav; Kochoyan, Artur; Kristensen, Ole; Kastrup, Jette Sandholm Jensen; Berezin, Vladimir; Bock, Elisabeth Marianne; Gajhede, Michael.
In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 64, No. Pt6, 2008, p. 448-452.Research output: Contribution to journal › Journal article › Research › peer-review
- PublishedCrystal structure of NCAM2 IgIV-Fn3II. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009. 17. November.
Research output: Non-textual form › Dataset › Research
- PublishedCrystal Structure of NCAM2 Ig2-3. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.
Research output: Non-textual form › Dataset › Research
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Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule. / Kulahin, Nikolaj; Kristensen, Ole; Rasmussen, Kim K; Olsen, Lars; Rydberg, Patrik; Vestergaard, Bente; Kastrup, Jette Sandholm; Berezin, Vladimir; Bock, Elisabeth; Walmod, Peter Schledermann; Gajhede, Michael.
In: Structure, Vol. 19, No. 2, 09.02.2011, p. 203-211.Research output: Contribution to journal › Journal article › Research › peer-review
- PublishedCrystal Structure of NCAM2 Ig34. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.
Research output: Non-textual form › Dataset › Research
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Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.
In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.Research output: Contribution to journal › Journal article › Research › peer-review
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Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors. / Lohse, Brian; Nielsen, Anders L; Kristensen, Jan B L; Helgstrand, Charlotte; Cloos, Paul Andreas Compare; Olsen, Lars; Gajhede, Michael; Clausen, Rasmus Prætorius; Kristensen, Jesper Langgaard.
In: Angewandte Chemie International Edition, Vol. 50, No. 39, 19.09.2011, p. 9100-9103.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibitors of histone demethylases. / Lohse, Brian; Kristensen, Jesper L; Kristensen, Line H; Agger, Karl; Helin, Kristian; Gajhede, Michael; Clausen, Rasmus P.
In: Bioorganic & Medicinal Chemistry, Vol. 19, No. 12, 01.02.2011, p. 3625-3636.Research output: Contribution to journal › Review › Research › peer-review
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The metal binding site of the major house dust mite allergen Der p 1. / Meno, Kåre; Thorsted, Peter B; Ipsen, Henrik; Kristensen, Ole; Larsen, Jørgen; Spangfort, Michael D; Gajhede, Michael; Lund, Kaare.
In: Journal of Allergy and Clinical Immunology, Vol. 118, No. 4, 2006, p. 971.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion. / Mirza, Osman; Henriksen, Lars Skov; Sprogøe, Desiree; van den Broek, Lambertus A M; Beldman, Gerrit; Kastrup, Jette S; Gajhede, Michael.
In: Journal of Biological Chemistry, Vol. 281, No. 46, 2006, p. 35576-84.Research output: Contribution to journal › Journal article › Research › peer-review
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Jagten på et signalstof til hjernens delta2-receptor. / Naur, Peter; Olsen, Lars; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.
In: Lægemiddelforskning, 2007, p. 32-33.Research output: Contribution to journal › Journal article › Communication
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Ionotropic glutamate-like receptor d2 binds D-serine and glycine. / Naur, Peter; Hansen, Kasper Bø; Kristensen, Anders Skov; Dravid, Shashank M.; Pickering, Darryl Scott; Olsen, Lars; Vestergaard, Bente; Egebjerg, Jan; Gajhede, Michael; Traynelis, Stephen F.; Kastrup, Jette Sandholm Jensen.
In: Proceedings of the National Academy of Science of the United States of America, Vol. 104, No. 35, 2007, p. 14116-14121.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of catechols as histone-lysine demethylase inhibitors. / Nielsen, Anders L; Kristensen, Line H; Stephansen, Karen B; Kristensen, Jan B L; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Helin, Kristian; Gajhede, Michael; Olsen, Lars.
In: F E B S Letters, Vol. 586, No. 8, 2012, p. 1190-4.Research output: Contribution to journal › Journal article › Research › peer-review
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Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. / Olsen, Jeppe A.; Kastrup, Jette Sandholm Jensen; Peters, Dan; Gajhede, Michael; Balle, Thomas; Ahring, Philip K.
In: Journal of Biological Chemistry, Vol. 288, No. 50, 13.12.2013, p. 35997.Research output: Contribution to journal › Journal article › Research › peer-review
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Hvad har varme at gøre med lægemidler? / Olsen, Lars; Kasper, Christina; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Jørgensen, Flemming Steen.
In: Lægemiddelforskning, 2006, p. 31-33.Research output: Contribution to journal › Journal article › Communication
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Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. / Owczarek, Sylwia; Kiryushko, Darya; Hald Larsen, Marianne; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Sandi, Carmen; Berezin, Vladimir; Bock, Elisabeth; Soroka, Vladislav.
In: The FASEB Journal, Vol. 24, No. 4, 2010, p. 1139-1150.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit. / Paës, Gabriel; Skov, Lars K; O'Donohue, Michael J; Rémond, Caroline; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman.
In: Biochemistry, Vol. 47, No. 28, 2008, p. 7441-7451.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping. / Rasmussen, Kim Krighaar; Kulahin, Nikolaj; Kristensen, Ole; Poulsen, Jens-Christian N; Sigurskjold, Bent W; Kastrup, Jette S; Berezin, Vladimir; Bock, Elisabeth; Walmod, Peter S; Gajhede, Michael.
In: Journal of Molecular Biology, Vol. 382, No. 5, 2008, p. 1113-20.Research output: Contribution to journal › Journal article › Research › peer-review
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Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors : Unique role of halogen bonding revealed. / Rohde, Line Aagot Hede; Ahring, Philip Kiær; Jensen, Marianne Lerbech; Nielsen, Elsebet Østergaard; Peters, Dan; Helgstrand, Charlotte; Krintel, Christian; Harpsøe, Kasper; Gajhede, Michael; Kastrup, Jette Sandholm; Balle, Thomas.
In: The Journal of Biological Chemistry, Vol. 287, No. 6, 03.02.2012, p. 4248-4259.Research output: Contribution to journal › Journal article › Research › peer-review
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High resolution crystal structures of the p120 RasGAP SH3 domain. / Ross, Birthe; Kristensen, Ole; Favre, Dimitri; Walicki, Joël; Kastrup, Jette Sandholm Jensen; Widmann, Christian; Gajhede, Michael.
In: Biochemical and Biophysical Research Communications, Vol. 353, No. 2, 2007, p. 463-468.Research output: Contribution to journal › Journal article › Research › peer-review
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Få kræftcellen til at begå selvmord : en strukturel vinkel på kræft. / Ross, Birthe; Borchorst, Morten; Gajhede, Michael; Kristensen, Ole.
In: Lægemiddelforskning, 2007, p. 22-23.Research output: Contribution to journal › Journal article › Communication
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Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype. / Røder, Gustav; Blicher, Thomas; Justesen, Sune; Johannesen, Birthe; Kristensen, Ole; Kastrup, Jette; Buus, Søren; Gajhede, Michael.
In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 62, No. Pt 11, 2006, p. 1300-10.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. / Røder, Gustav; Kristensen, Ole; Kastrup, Jette S; Buus, Søren; Gajhede, Michael.
In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 64, No. Pt 6, 2008, p. 459-62.Research output: Contribution to journal › Journal article › Research › peer-review
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Snegleprotein øger forståelsen af vigtige receptorer i hjernen. / Shahsavar, Azadeh; Nielsen, Elsebeth Ø.; Kristensen, Jesper Langgaard; Gajhede, Michael; Balle, Thomas; Kastrup, Jette Sandholm Jensen.
In: Lægemiddelforskning, Vol. 2012, 2012, p. 48-50.Research output: Contribution to journal › Journal article › Communication
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Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism. / Shahsavar, Azadeh; Kastrup, Jette S; Nielsen, Elsebet Ø.; Kristensen, Jesper L; Gajhede, Michael; Balle, Thomas.
In: P L o S One, Vol. 7, No. 8, 2012, p. e40757.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of recombinant Ves v 2 at 2.0 Angstrom resolution : structural analysis of an allergenic hyaluronidase from wasp venom. / Skov, Lars K; Seppälä, Ulla; Coen, Jeremy J F; Crickmore, Neil; King, Te P; Monsalve, Rafael; Kastrup, Jette S; Spangfort, Michael D; Gajhede, Michael.
In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 62, No. Pt 6, 2006, p. 595-604.Research output: Contribution to journal › Journal article › Research › peer-review
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The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology. / Skov, Lars K; Pizzut-Serin, Sandra; Remaud-Simeon, Magali; Ernst, Heidi A; Gajhede, Michael; Mirza, Osman Asghar.
In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. 69, No. Pt 9, 09.2013, p. 973-8.Research output: Contribution to journal › Journal article › Research › peer-review
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Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose. / Skov, Lars K.; Mirza, Osman; Sprogøe, Desiree; van der Veen, Bart; Remaud-Simeon, Magali; Albenne, Cecile; Monsan, Pierre; Gajhede, Michael.
In: Biocatalysis and Biotransformation, Vol. 24, No. 1-2, 01.01.2006, p. 99-105.Research output: Contribution to journal › Journal article › Research › peer-review
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Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists. / Ussing, Christine A.; Hansen, Camilla Petrycer; Petersen, Jette Gellert; Jensen, Anders A.; Rohde, Line A.H. ; Ahring, Philip K.; Nielsen, Elisabeth Ø. ; Kastrup, Jette Sandholm; Gajhede, Michael; Frølund, Bente; Balle, Thomas.
In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 940-951.Research output: Contribution to journal › Journal article › Research › peer-review
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Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.
In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.Research output: Contribution to journal › Journal article › Research › peer-review
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Kainate induces various domain closures in AMPA and kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Hald, Helle; Rabassa, Anna Ceravalls de; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm.
In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 536-545.Research output: Contribution to journal › Journal article › Research › peer-review
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A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils. / Vestergaard, Bente; Jensen, Minna Grønning; Roessle, Manfred; Kastrup, Jette Sandholm Jensen; Van De Weert, Marco; Flink, James M.; Frøkjær, Sven; Gajhede, Michael; Svergun, Dmitri I.
In: PLoS - Biology, Vol. 5, No. 5, 2007, p. 1089-1097.Research output: Contribution to journal › Journal article › Research › peer-review
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A tetrazolyl-substituted subtype-selective AMPA receptor agonist. / Vogensen, Stine Byskov; Frydenvang, Karla Andrea; Greenwood, Jeremy R.; Postorino, Giovanna; Nielsen, Birgitte; Pickering, Darryl Scott; Ebert, Bjarke; Bølcho, Ulrik; Egebjerg, Jan; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Johansen, Tommy Nørskov; Clausen, Rasmus Prætorius; Krogsgaard-Larsen, Povl.
In: Journal of Medicinal Chemistry, Vol. 50, No. 10, 2007, p. 2408-2414.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus. / Wang, Xiaole; Hald, Helle; Ernst, Heidi Asschenfeldt; Egebjerg, Jan; Christensen, Kenneth V; Gajhede, Michael; Kastrup, Jette Sandholm; Mirza, Osman Asghar.
In: Protein Expression and Purification, Vol. 71, No. 2, 2010, p. 179-183.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution. / van der Veen, Bart A; Skov, Lars K; Potocki-Véronèse, Gabrielle; Gajhede, Michael; Monsan, Pierre; Remaud-Simeon, Magali.
In: F E B S Journal, Vol. 273, No. 4, 2006, p. 673-81.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
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