Michael Gajhede

Michael Gajhede

Professor


  1. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. / Bach, Anders*; Clausen, Bettina H; Møller, Magda; Vestergaard, Bente; Chi, Celestine N; Round, Adam; Sørensen, Pernille Louise; Nissen, Klaus Bertram; Kastrup, Jette Sandholm; Gajhede, Michael; Jemth, Per; Kristensen, Anders Skov; Lundström, Patrik; Lambertsen, Kate Lykke; Strømgaard, Kristian* (*Corresponding).

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 9, 28.02.2012, p. 3317-3322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. / Shahsavar, Azadeh; Ahring, Philip K; Olsen, Jeppe A; Krintel, Christian; Kastrup, Jette S; Balle, Thomas; Gajhede, Michael.

    In: Molecular Pharmacology, Vol. 88, No. 4, 10.2015, p. 697-707.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    At være eller ikke være en antagonist. / Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, 2009, p. 43-45.

    Research output: Contribution to journalJournal articleCommunication

  4. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. / Venskutonyte, Raminta; Frydenvang, Karla; Gajhede, Michael; Bunch, Lennart; Pickering, Darryl S; Kastrup, Jette Sandholm.

    In: Journal of Structural Biology, Vol. 176, No. 3, 12.2011, p. 307-314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Chemical and thermal unfolding of calreticulin. / Duus, K.; Larsen, N.; Tran, T. A. T.; Güven, E.; Skov, L. K.; Jespersgaard, C; Gajhede, Michael; Houen, Gunnar.

    In: Protein and Peptide Letters, Vol. 20, 2013, p. 562-568.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters. / Assaf, Z.; Larsen, Anja Probst; Venskutonyte, Raminta; Han, Liwei; Abrahamsen, Bjarke; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm; Jensen, Anders A.; Pickering, Darryl S; Frydenvang, Karla ; Gefflaut, T; Bunch, Lennart.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 4, 2013, p. 1614-1628.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism. / Shahsavar, Azadeh; Kastrup, Jette S; Nielsen, Elsebet Ø.; Kristensen, Jesper L; Gajhede, Michael; Balle, Thomas.

    In: P L o S One, Vol. 7, No. 8, 2012, p. e40757.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published
    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit). Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Poulsen, Jens-Christian Navarro (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  9. Published
    Crystal Structure of NCAM2 Ig1-2. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  10. Published
    Crystal Structure of NCAM2 Ig2-3. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  11. Published
    Crystal Structure of NCAM2 Ig34. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2008.

    Research output: Non-textual formDatasetResearch

  12. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. / Kvist, Trine; Steffensen, Thomas Bielefeldt; Greenwood, Jeremy R; Mehrzad Tabrizi, Fatemeh; Hansen, Kasper Bø; Gajhede, Michael; Pickering, Darryl S; Traynelis, Stephen F; Kastrup, Jette Sandholm; Bräuner-Osborne, Hans.

    In: The Journal of Biological Chemistry, Vol. 288, 2013, p. 33124-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
    Crystal structure of NCAM2 IgIV-Fn3I. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009.

    Research output: Non-textual formDatasetResearch

  14. Published
    Crystal structure of NCAM2 IgIV-Fn3II. Kulahin, Nikolaj (Other); Rasmussen, Kim Krighaar (Other); Kristensen, Ole (Other); Kastrup, Jette Sandholm Jensen (Other); Berezin, Vladimir (Other); Bock, Elisabeth Marianne (Other); Walmod, Peter Schledermann (Other); Gajhede, Michael (Other). 2009. 17. November.

    Research output: Non-textual formDatasetResearch

  15. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping. / Rasmussen, Kim Krighaar; Kulahin, Nikolaj; Kristensen, Ole; Poulsen, Jens-Christian N; Sigurskjold, Bent W; Kastrup, Jette S; Berezin, Vladimir; Bock, Elisabeth; Walmod, Peter S; Gajhede, Michael.

    In: Journal of Molecular Biology, Vol. 382, No. 5, 2008, p. 1113-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Dimerization effect of sucrose octasulfate on rat FGF1. / Kulahin, Nikolaj; Kiselyov, Vladislav; Kochoyan, Artur; Kristensen, Ole; Kastrup, Jette Sandholm Jensen; Berezin, Vladimir; Bock, Elisabeth Marianne; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 64, No. Pt6, 2008, p. 448-452.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. / Hald, Helle; Ahring, Philip Kiær; Timmermann, Daniel Brunicardi; Liljefors, Tommy; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Journal of Molecular Biology, Vol. 391, No. 5, 2009, p. 906-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface. / Ahring, Philip K; Olsen, Jeppe A; Nielsen, Elsebet Ø; Peters, Dan; Pedersen, Martin H F; Rohde, Line A; Kastrup, Jette Sandholm Jensen; Shahsavar, Azadeh; Indurthi, Dinesh C; Chebib, Mary; Gajhede, Michael; Balle, Thomas.

    In: Neuropharmacology, Vol. 92, 2015, p. 135-45.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A : Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases. / Kristensen, Jan B L; Nielsen, Anders L; Jørgensen, Lars; Kristensen, Line Hyltoft; Helgstrand, Charlotte; Juknaite, Lina; Kristensen, Jesper Langgaard; Kastrup, Jette Sandholm; Clausen, Rasmus Prætorius; Olsen, Lars; Gajhede, Michael.

    In: F E B S Letters, Vol. 585, No. 12, 23.06.2011, p. 1951-1956.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1. / Holm, Jens; Ferreras, Mercedes; Ipsen, Henrik; Würtzen, Peter A; Gajhede, Michael; Larsen, Jørgen N; Lund, Kaare; Spangfort, Michael D.

    In: Journal of Biological Chemistry, Vol. 286, No. 20, 20.05.2011, p. 17569-17578.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Expression, purification and characterization of the human MTA2-RBBP7 complex. / Brasen, Christoffer; Dorosz, Jerzy; Wiuf, Anders; Boesen, Thomas; Mirza, Osman; Gajhede, Michael.

    In: Biochimica et biophysica acta, Vol. 1865, No. 5, 04.02.2017, p. 531-538.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. / Frydenvang, Karla Andrea; Lash, L Leanne; Naur, Peter; Postila, Pekka A; Pickering, Darryl S; Smith, Caleb M; Gajhede, Michael; Sasaki, Makoto; Sakai, Ryuichi; Pentikäinen, Olli T; Swanson, Geoffrey T; Kastrup, Jette Sandholm.

    In: Journal of Biological Chemistry, Vol. 284, No. 21, 2009, p. 14219-14229.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Identification of catechols as histone-lysine demethylase inhibitors. / Nielsen, Anders L; Kristensen, Line H; Stephansen, Karen B; Kristensen, Jan B L; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Helin, Kristian; Gajhede, Michael; Olsen, Lars.

    In: F E B S Letters, Vol. 586, No. 8, 2012, p. 1190-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Inhibitors of histone demethylases. / Lohse, Brian; Kristensen, Jesper L; Kristensen, Line H; Agger, Karl; Helin, Kristian; Gajhede, Michael; Clausen, Rasmus P.

    In: Bioorganic & Medicinal Chemistry, Vol. 19, No. 12, 01.02.2011, p. 3625-3636.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy. / Fiorentini, Monica; Bach, Anders; Strømgaard, Kristian; Kastrup, Jette S; Gajhede, Michael.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 69, No. Pt 4, 04.2013, p. 587-94.

    Research output: Contribution to journalJournal articleResearch

  26. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors : Unique role of halogen bonding revealed. / Rohde, Line Aagot Hede; Ahring, Philip Kiær; Jensen, Marianne Lerbech; Nielsen, Elsebet Østergaard; Peters, Dan; Helgstrand, Charlotte; Krintel, Christian; Harpsøe, Kasper; Gajhede, Michael; Kastrup, Jette Sandholm; Balle, Thomas.

    In: The Journal of Biological Chemistry, Vol. 287, No. 6, 03.02.2012, p. 4248-4259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Kainate induces various domain closures in AMPA and kainate receptors. / Venskutonyte, Raminta; Frydenvang, Karla; Hald, Helle; Rabassa, Anna Ceravalls de; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm.

    In: Neurochemistry International, Vol. 61, No. 4, 09.2012, p. 536-545.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. / Krintel, Christian; Frydenvang, Karla; Ceravalls de Rabassa, Anna; Kaern, Anne Mette; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette S.

    In: F E B S Journal, 27.03.2014, p. 2422–2430.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium. / Hansen, Kasper Bø; Naur, Peter; Kurtkaya, Natalie L; Kristensen, Anders Skov; Gajhede, Michael; Kastrup, Jette Sandholm; Traynelis, Stephen F.

    In: Journal of Neuroscience, Vol. 29, No. 4, 2009, p. 907-917.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. / Harpsøe, Kasper; Hald, Helle; Timmermann, Daniel B; Jensen, Marianne L; Dyhring, Tino; Nielsen, Elsebet Ø; Peters, Dan; Balle, Thomas; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 4, 25.01.2013, p. 2559-2570.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4 . / Kasper, Christina; Frydenvang, Karla Andrea; Naur, Peter; Gajhede, Michael; Pickering, Darryl S; Kastrup, Jette Sandholm Jensen.

    In: FEBS Letters, Vol. 582, No. 29, 2008, p. 4089-4094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors. / Olsen, Jeppe A.; Balle, Thomas; Gajhede, Michael; Ahring, Philip K.; Kastrup, Jette Sandholm Jensen.

    In: PLOS ONE, Vol. 9, No. 3, 17.03.2014, p. e91232.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain. / Venskutonyte, Raminta; Larsen, Anja Probst; Frydenvang, Karla Andrea; Gajhede, Michael; Gefflaut, Thierry; Pickering, Darryl S; Bunch, Lennart; Kastrup, Jette Sandholm Jensen.

    In: ChemMedChem, Vol. 9, No. 10, 2014, p. 2254-2259.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor. / Owczarek, Sylwia; Kiryushko, Darya; Hald Larsen, Marianne; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Sandi, Carmen; Berezin, Vladimir; Bock, Elisabeth; Soroka, Vladislav.

    In: The FASEB Journal, Vol. 24, No. 4, 2010, p. 1139-1150.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus. / Wang, Xiaole; Hald, Helle; Ernst, Heidi Asschenfeldt; Egebjerg, Jan; Christensen, Kenneth V; Gajhede, Michael; Kastrup, Jette Sandholm; Mirza, Osman Asghar.

    In: Protein Expression and Purification, Vol. 71, No. 2, 2010, p. 179-183.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. / Juknaite, Lina; Venskutonyte, Raminta; Assaf, Zeinab; Faure, Sophie; Gefflaut, Thierry; Aitken, David J.; Nielsen, Birgitte; Gajhede, Michael; Kastrup, Jette Sandholm Jensen; Bunch, Lennart; Frydenvang, Karla; Pickering, Darryl S.

    In: Journal of Structural Biology, Vol. 180, No. 1, 2012, p. 39-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. / Kristensen, Anders S; Hansen, Kasper B; Naur, Peter; Olsen, Lars; Kurtkaya, Natalie L; Dravid, Shashank M; Kvist, Trine; Yi, Feng; Pøhlsgaard, Jacob; Clausen, Rasmus P; Gajhede, Michael; Kastrup, Jette S; Traynelis, Stephen F.

    In: Molecular Pharmacology, Vol. 89, No. 2, 02.2016, p. 253-262.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. / Prabhala, Bala K; Aduri, Nanda G; Iqbal, Mazhar; Rahman, Moazur; Gajhede, Michael; Hansen, Paul R; Mirza, Osman.

    In: Research in Microbiology, Vol. 168, No. 5, 16.02.2017, p. 443-449.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution. / Jørgensen, Anders Dysted; Nøhr, Jane; Kastrup, Jette Sandholm; Gajhede, Michael; Sigurskjold, Bent Walther; Sauer, Jørgen; Svergun, Dmitri I.; Svensson, Birte; Vestergaard, Bente.

    In: Journal of Biological Chemistry, Vol. 283, No. 21, 2008, p. 14772-14780.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen. / Shahsavar, Azadeh; Nielsen, Elsebeth Ø.; Kristensen, Jesper Langgaard; Gajhede, Michael; Balle, Thomas; Kastrup, Jette Sandholm Jensen.

    In: Lægemiddelforskning, Vol. 2012, 2012, p. 48-50.

    Research output: Contribution to journalJournal articleCommunication

  41. Published

    Structural Studies of Nicotinic Acetylcholine Receptors : Using Acetylcholine Binding Protein as a Structural Surrogate. / Shahsavar, Azadeh; Gajhede, Michael; Kastrup, Jette S; Balle, Thomas.

    In: Basic & Clinical Pharmacology & Toxicology Online, Vol. 118, No. 6, 17.11.2015, p. 399–407.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. / Krintel, Christian; Harpsøe, Kasper; Zachariassen, Linda G; Peters, Dan; Frydenvang, Karla; Pickering, Darryl S; Gajhede, Michael; Kastrup, Jette S.

    In: Acta crystallographica. Section D, Biological crystallography, Vol. 69, No. Pt 9, 09.2013, p. 1645-52.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors. / Olsen, Jeppe A; Ahring, Philip K; Kastrup, Jette Sandholm Jensen; Gajhede, Michael; Balle, Thomas.

    In: The Journal of Biological Chemistry, Vol. 289, No. 36, 05.09.2014, p. 24911-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule. / Kulahin, Nikolaj; Kristensen, Ole; Rasmussen, Kim K; Olsen, Lars; Rydberg, Patrik; Vestergaard, Bente; Kastrup, Jette Sandholm; Berezin, Vladimir; Bock, Elisabeth; Walmod, Peter Schledermann; Gajhede, Michael.

    In: Structure, Vol. 19, No. 2, 09.02.2011, p. 203-211.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Structure and binding properties of a cameloid nanobody raised against KDM5B. / Wiuf, Anders; Kristensen, Line Hyltoft; Kristensen, Ole; Dorosz, Jerzy; Jensen, Jonas; Gajhede, Michael.

    In: Acta crystallographica. Section F, Structural biology communications, Vol. 71, No. Pt 10, 23.09.2015, p. 1235-1241.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501. / Røder, Gustav; Kristensen, Ole; Kastrup, Jette S; Buus, Søren; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 64, No. Pt 6, 2008, p. 459-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp. / Kristensen, Ole; Ross, Birthe; Gajhede, Michael.

    In: Journal of Molecular Biology, Vol. 375, No. 5, 2008, p. 1469-1476.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Structure of the first PDZ domain of human PSD-93. / Fiorentini, Monica; Nielsen, Ann Kallehauge; Kristensen, Ole; Kastrup, Jette Sandholm; Gajhede, Michael.

    In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications, Vol. 65, No. 12, 2009, p. 1254-1257.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8. / Dorosz, Jerzy; Olsen, Lars; Seger, Signe Teuber; Steinhauer, Cornelia; Bouras, Giorgos; Helgstrand, Charlotte; Wiuf, Anders; Gajhede, Michael.

    In: ChemBioChem, Vol. 18, No. 14, 18.07.2017, p. 1369-1375.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. / Beich-Frandsen, Mads; Pickering, Darryl S; Mirza, Osman; Johansen, Tommy N; Greenwood, Jeremy; Vestergaard, Bente; Schousboe, Arne; Gajhede, Michael; Liljefors, Tommy; Kastrup, Jette S.

    In: Journal of Medicinal Chemistry, Vol. 51, No. 5, 2008, p. 1459-63.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. / Kristensen, Line Hyltoft; Nielsen, Anders Laerke; Helgstrand, Charlotte; Lees, Michael; Cloos, Paul; Kastrup, Jette Sandholm; Helin, Kristian; Olsen, Lars; Gajhede, Michael.

    In: F E B S Journal, Vol. 279, No. 11, 06.2012, p. 1905-1914.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists. / Ussing, Christine A.; Hansen, Camilla Petrycer; Petersen, Jette Gellert; Jensen, Anders A.; Rohde, Line A.H. ; Ahring, Philip K.; Nielsen, Elisabeth Ø. ; Kastrup, Jette Sandholm; Gajhede, Michael; Frølund, Bente; Balle, Thomas.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 3, 2013, p. 940-951.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors. / Lohse, Brian; Nielsen, Anders L; Kristensen, Jan B L; Helgstrand, Charlotte; Cloos, Paul Andreas Compare; Olsen, Lars; Gajhede, Michael; Clausen, Rasmus Prætorius; Kristensen, Jesper Langgaard.

    In: Angewandte Chemie International Edition, Vol. 50, No. 39, 19.09.2011, p. 9100-9103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove. / Champion, Elise; Remaud-Simeon, Magali; Skov, Lars Kobberøe; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman Asghar.

    In: Acta Crystallographica. Section D: Biological Crystallography, Vol. 65, No. 12, 2009, p. 1309-1314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue : synthesis, molecular pharmacology, and biostructural characterization. / Clausen, Rasmus Prætorius; Naur, Peter; Kristensen, Anders Skov; Greenwood, Jeremy R; Strange, Mette; Bräuner-Osborne, Hans; Jensen, Anders Asbjørn; Nielsen, Anne Sophie T; Geneser, Ulla; Ringgaard, Lone M; Nielsen, Birgitte; Pickering, Darryl S; Brehm, Lotte; Gajhede, Michael; Krogsgaard-Larsen, Povl; Kastrup, Jette Sandholm.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 15, 2009, p. 4911-4922.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region. / Tapken, Daniel; Steffensen, Thomas Bielefeldt; Leth, Rasmus; Kristensen, Lise Baadsgaard; Gerbola, Alexander; Gajhede, Michael; Jørgensen, Flemming Steen; Olsen, Lars; Kastrup, Jette Sandholm.

    In: Scientific Reports, Vol. 7, 46145, 07.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology. / Skov, Lars K; Pizzut-Serin, Sandra; Remaud-Simeon, Magali; Ernst, Heidi A; Gajhede, Michael; Mirza, Osman Asghar.

    In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online, Vol. 69, No. Pt 9, 09.2013, p. 973-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit. / Paës, Gabriel; Skov, Lars K; O'Donohue, Michael J; Rémond, Caroline; Kastrup, Jette Sandholm; Gajhede, Michael; Mirza, Osman.

    In: Biochemistry, Vol. 47, No. 28, 2008, p. 7441-7451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1. / Meno, Kåre H; Kastrup, Jette S; Kuo, I-Chun; Chua, Kaw Yan; Gajhede, Michael.

    In: Allergy, Vol. 72, No. 4, 13111, 01.04.2017, p. 665-670.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. / Krintel, Christian; Frydenvang, Karla; Olsen, Lars; Kristensen, Maria T; de Barrios, Oriol; Naur, Peter; Francotte, Pierre; Pirotte, Bernard; Gajhede, Michael; Kastrup, Jette Sandholm.

    In: Biochemical Journal, Vol. 441, No. 1, 01.01.2012, p. 173-178.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors. / Olsen, Jeppe A.; Kastrup, Jette Sandholm Jensen; Peters, Dan; Gajhede, Michael; Balle, Thomas; Ahring, Philip K.

    In: Journal of Biological Chemistry, Vol. 288, No. 50, 13.12.2013, p. 35997.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1304192