Miriam Kolko

Miriam Kolko

Professor with special responsibilities, Clinical Associate Professor


  1. Published

    Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A₂, group VIA and secretory phospholipase A₂, group IB

    Zhan, C., Wang, J. & Kolko, Miriam, Oct 2012, In : Current Eye Research. 37, 10, p. 930-940 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Cyclooxygenase-2 immunoreactivity in collagenous colitis

    Wildt, S., Rumessen, J. J., Csillag, C., Normark, M., Poulsen, K. A., Kolko, Miriam, Wildt, S., Rumessen, J. J., Csillag, C., Normark, M., Poulsen, K. A. & Kolko, M., 1 Jul 2009, In : Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 7, p. 500-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Phospholipases A2 in ocular homeostasis and diseases

    Wang, J., Kolko, M. & Kolko, Miriam, Jun 2010, In : Biochimie. 92, 6, p. 611-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours

    Wang, J., Wu, Y., Heegaard, Steffen & Kolko, Miriam, Nov 2011, In : Acta Ophthamologica (Online). p. 681-685 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The role of inflammation in the pathogenesis of glaucoma

    Vohra, R., Tsai, J. C. & Kolko, Miriam, 19 Jun 2013, In : Survey of Ophthalmology. 58, 4, p. 311-20 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Potential metabolic markers in glaucoma and their regulation in response to hypoxia

    Vohra, Rupali, Dalgaard, L. M., Vibaek, J., Langbøl, Mia Aggergaard, Bergersen, Linda Hildegard, Olsen, N. V., Hassel, B., Chaudhry, F. A. & Kolko, Miriam, 28 Jan 2019, In : Acta Ophthalmologica. 97, 6, p. 567-576

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Disturbed mitochondrial function restricts glutamate uptake in the human Müller glia cell line, MIO-M1

    Vohra, Rupali, Gurubaran, I. S., Henriksen, U., Bergersen, Linda Hildegard, Rasmussen, Lene Juel, Desler, C., Jensen, Dorte Skytt & Kolko, Miriam, 2017, In : Mitochondrion. 36, p. 52-59

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Potential link between sporadic cerebral amyloid angiopathy and vision loss: a case report

    Vohra, Rupali, Hjortshøj, T. D., Nordling, M. M., Sørensen, Torben Lykke, Jensen, P. K. & Kolko, Miriam, 2018, In : Acta Ophthalmologica. 96, 6, p. e753-e755

    Research output: Contribution to journalComment/debateResearch

  9. Published

    Muller cell survival and function is maintained by the presence of lactate

    Vohra, Rupali, Skytt, D. M., Aldana Garcia, Blanca Irene, Freude, Kristine, Waagepetersen, Helle S., Bergersen, Linda Hildegard & Kolko, Miriam, Jul 2018, p. 1480. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  10. Published

    Lactate: More Than Merely a Metabolic Waste Product in the Inner Retina

    Vohra, Rupali & Kolko, Miriam, 2020, In : Molecular Neurobiology. 57, p. 2021–2037

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published

    Neuroprotection of the inner retina: Muller cells and lactate

    Vohra, Rupali & Kolko, Miriam, Oct 2018, In : Neural Regeneration Research. 13, 10, p. 1741-1742 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  12. Published

    Lactate-Mediated Protection of Retinal Ganglion Cells

    Vohra, Rupali, Aldana Garcia, Blanca Irene, Bulli, G., Jensen, Dorte Skytt, Waagepetersen, Helle S., Bergersen, Linda Hildegard & Kolko, Miriam, 19 Apr 2019, In : Journal of Molecular Biology. 431, 9, p. 1878-1888 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation

    Vohra, Rupali, Aldana Garcia, Blanca Irene, Waagepetersen, Helle S., Bergersen, Linda Hildegard & Kolko, Miriam, 1 Mar 2019, In : Investigative Ophthalmology & Visual Science. 60, 4, p. 999-1008 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Essential Roles of Lactate in Müller Cell Survival and Function

    Vohra, Rupali, Aldana Garcia, Blanca Irene, Jensen, Dorte Skytt, Freude, Kristine, Waagepetersen, Helle S., Bergersen, Linda Hildegard & Kolko, Miriam, 2018, In : Molecular Neurobiology. 55, 12, p. 9108-9121 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Lactate transport and receptor actions: Potential roles in inner retinal function and disease

    Vohra, Rupali, Vosborg, F., Henriksen, U., Gurubaran, I. S., Hasan-Olive, M., Holm, E., Skytt, D., Gjedde, Albert, Storm-Mathisen, J., Kolko, Miriam & Bergersen, L. H., 2015, In : Acta Ophthalmologica. 93, S255, ABS15‐0601.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  16. Published

    Interaction between VEGF and Calcium-Independent Phospholipase A(2) in Proliferation and Migration of Retinal Pigment Epithelium

    Toft-Kehler, A. K., Andersen, E. C., Andreasen, J. R., Vohra, Rupali, Nielsen, N. M. J., Poulsen, K. A., Kolko, Miriam & Toft-Kehler, A. K., 1 Jun 2012, In : Current Eye Research. 37, 6, p. 500-507 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation

    Toft-Kehler, A. K., Gurubaran, I. S., Madsen, Claus Desler, Rasmussen, Lene Juel, Jensen, Dorte Skytt & Kolko, Miriam, May 2016, In : Investigative Ophthalmology & Visual Science. 57, 6, p. 2721-2728

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Oxidative Stress in Retinal Muller Cells contributes to Dysfunction of Retinal Glutamate Uptake and Altered Protein Expression

    Toft-Kehler, A. K., Jensen, Dorte Skytt & Kolko, Miriam, Jun 2015, In : Investigative Ophthalmology & Visual Science. 56, 7, 3672.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  19. Published

    Mitochondrial function in Müller cells - Does it matter?

    Toft-Kehler, A. K., Jensen, Dorte Skytt, Svare, A., Lefevere, E., Van Hove, I., Moons, L., Waagepetersen, Helle S. & Kolko, Miriam, 2017, In : Mitochondrion. 36, p. 43-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina

    Toft-Kehler, A. K., Jensen, Dorte Skytt & Kolko, Miriam, Jun 2018, In : Molecular Neurobiology. 55, 6, p. 5353–5361

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment

    Tiedemann, D., Mouhammad, Zaynab Ahmad, Utheim, T. P., Dartt, D. A., Heegaard, Steffen, Petrovski, G. & Kolko, Miriam, 1 Apr 2019, In : Journal of Glaucoma. 28, 4, p. 325-333 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Potential metabolic markers in glaucoma and their regulation in response to hypoxia

    Tiedemann, D., Vohra, Rupali, Dalgaard, L. M., Jensen, J. V., Bergersen, Linda Hildegard, Olsen, N. V., Hassel, B., Chaudhry, F. A. & Kolko, Miriam, 2018, In : Acta Ophthalmologica. 96, 261/S1, p. 125-126 F012 .

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  23. Published

    Visual field defects after temporal lobe resection for epilepsy

    Steensberg, A. T., Olsen, A. S., Litman, M., Jespersen, B., Kolko, Miriam & Pinborg, Lars Hageman, Jan 2018, In : Seizure. 54, p. 1-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Glia-Neuron Interactions in the Retina Can Be Studied in Cocultures of Muller Cells and Retinal Ganglion Cells

    Jensen, Dorte Skytt, Toft-Kehler, A. K., Braendstrup, C. T., Cejvanovic, S., Gurubaran, I. S., Bergersen, Linda Hildegard & Kolko, Miriam, 2016, In : Journal of Biomedicine and Biotechnology. 2016, 11 p., 1087647.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Glutamate signalling and secretory phospholipase A2 modulate the release of arachidonic acid from neuronal membranes

    Rodriguez De Turco, E. B., Jackson, F. R., DeCoster, M. A., Kolko, M., Bazan, N. G. & Kolko, Miriam, 1 Jun 2002, In : Journal of Neuroscience Research. 68, 5, p. 558-67 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Detection of visual field defects by opticians - with Damato Multifixation Campimetry Online

    Olsen, A. S., la Cour, M., Damato, B. & Kolko, Miriam, 2019, In : Acta Ophthalmologica. 97, 6, p. 577-582 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Glaucoma detection with damato multifixation campimetry online

    Olsen, A. S., Alberti, M., Serup, L., la Cour, Morten, Damato, B. & Kolko, Miriam, May 2016, In : Eye. 30, 5, p. 731-739

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study

    Olsen, A. S., Steensberg, A. T., la Cour, M., Kjær, Troels Wesenberg, Damato, B., Pinborg, Lars Hageman & Kolko, Miriam, 2017, In : Ophthalmic Research. 58, 2, p. 85-93 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Evaluation of Damato Multifixation Campimetry Online, an online visual field test, in detection of glaucomatous defects

    Olsen, A. S., Alberti, M., la Cour, Morten, Serup, L., Damato, B. E. & Kolko, Miriam, Jun 2015, In : Investigative Ophthalmology & Visual Science. 56, 7, p. 1050 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  30. Accepted/In press

    Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study

    The VISIONARY Study Group, T. V. S. G., 1 Jan 2020, (Accepted/In press) In : Advances in Therapy.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Cannabis og glaukom

    Mouhammad, Zaynab Ahmad & Kolko, Miriam, 16 Jul 2018, In : Ugeskrift for Laeger. 180, p. 2-4 V11170861.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Generation of transgene-free porcine intermediate type induced pluripotent stem cells

    Li, D., Secher, Jan Bojsen-Møller, Hyttel, Poul, Ivask, M., Kolko, Miriam, Hall, Vanessa Jane & Freude, Kristine, 2018, In : Cell Cycle. 17, 23, p. 2547-2563 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Mitochondrial dysfunction underlying outer retinal diseases

    Lefevere, E., Toft-Kehler, A. K., Vohra, Rupali, Kolko, Miriam, Moons, L. & Van Hove, I., 2017, In : Mitochondrion. 36, p. 66-76

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    MicroRNA expression analysis and Multiplex ligation-dependent probe amplification in metastatic and non-metastatic uveal melanoma

    Larsen, A., Holst, L. M., Kaczkowski, B., Andersen, M. T., Manfé, V., Siersma, Volkert Dirk, Kolko, Miriam, Kiilgaard, Jens Folke, Winther, Ole, Prause, J. U., Gniadecki, R. & Heegaard, Steffen, 2014, In : Acta Ophthalmologica. 92, 6, p. 541-549

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease

    Kolko, Miriam, Vosborg, F., Henriksen, J. U. L., Hasan-Olive, M. M., Diget, E. H., Vohra, Rupali, Gurubaran, I. S., Gjedde, Albert, Mariga, S. T., Jensen, Dorte Skytt, Utheim, T. P., Storm-Mathisen, J. & Bergersen, Linda Hildegard, 1 Jun 2016, In : Neurochemical Research. 41, 6, p. 1229-1236

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The Prevalence and Incidence of Glaucoma in Denmark in a Fifteen Year Period: A Nationwide Study

    Kolko, Miriam, Horwitz, A., Thygesen, J., Jeppesen, Jørgen & Torp-Pedersen, C., 16 Jul 2015, In : P L o S One. 10, 7, p. 1-11 11 p., e0132048.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain

    Kolko, Miriam, Christoffersen, N. R., Barreiro, S. G., Miller, M. L., Pizza, A. J. & Bazan, N. G., 2006, In : Journal of Neuroscience Research. 83, 5, p. 874-882 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

    Kolko, M., Zhan, C., Andreasen, J. R., Prause, J. U., Heegaard, Steffen & Kolko, Miriam, 8 Jan 2007, In : Ugeskrift for Laeger. 169, 2, p. 115-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Secretory phospholipase A(2) induces delayed neuronal COX-2 expression compared with glutamate

    Kolko, M., Nielsen, M., Bazan, N. G., Diemer, N. H. & Kolko, Miriam, 15 Jul 2002, In : Journal of Neuroscience Research. 69, 2, p. 169-77 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors

    Kolko, M., de Turco, E. B., Diemer, N. H., Bazan, N. G. & Kolko, Miriam, 28 Oct 2002, In : NeuroReport. 13, 15, p. 1963-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture

    Kolko, M., Rodriguez de Turco, E. B., Diemer, N. H., Bazan, N. G. & Kolko, Miriam, 27 Feb 2003, In : Neuroscience Letters. 338, 2, p. 164-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Present and New Treatment Strategies in the Management of Glaucoma

    Kolko, Miriam, 2015, In : The Open Ophthalmology Journal. 9, Suppl 1: M5, p. 89-100 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Grøn stær er andet end forhøjet tryk i øjet

    Kolko, Miriam & Jensen, Dorte Skytt, Dec 2012, In : Oftalmolog. p. 18-21 4 p.

    Research output: Contribution to journalJournal articleResearch

  44. Published

    Human secretory phospholipase A(2), group IB in normal eyes and in eye diseases

    Kolko, M., Prause, J. U., Bazan, N. G., Heegaard, Steffen & Kolko, Miriam, May 2007, In : Acta Ophthalmologica. 85, 3, p. 317-23 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Opsporing og forebyggelse af blindhed hos patienter med glaukom er en samfundsøkonomisk udfordring

    Kolko, Miriam, 2017, In : Ugeskrift for Laeger. 179, 7, p. 614-617 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Expression and location of mRNAs encoding multiple forms of secretory phospholipase A2 in the rat retina

    Kolko, M., Christoffersen, N. R., Barreiro, S. G., Bazan, N. G. & Kolko, Miriam, 15 Aug 2004, In : Journal of Neuroscience Research. 77, 4, p. 517-24 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Expression and induction of secretory phospholipase A2 group IB in brain

    Kolko, Miriam, Christoffersen, N. R., Varoqui, H. & Bazan, N. G., Nov 2005, In : Cellular & Molecular Neurobiology. 25, 7, p. 1107-22 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Oxidative stress and mitochondrial function in Muller cells

    Kolko, Miriam, Jul 2018, p. 5998. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  49. Published

    The physical properties of generic latanoprost ophthalmic solutions are not identical

    Kolko, Miriam & Koch Jensen, P., Jun 2017, In : Acta Ophthalmologica. 95, 4, p. 370-373 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Modulation of calcium, neurotoxicity and arachidonic acid release by phospholipase a type II and glutamate in vitro

    Kolko, Miriam, De Rodriguez Turco, E. B., Decoster, M. A. & Bazan, N. G., 1 Dec 1996, In : FASEB Journal. 10, 6

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo

    Kolko, Miriam, Bruhn, T., Christensen, Thomas, Lazdunski, M., Lambeau, G., Bazan, N. G. & Diemer, N. H., 1999, In : Neuroscience Letters. 274, 3, p. 167-170 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Calcium-independent phospholipase A2 regulates retinal pigment epithelium proliferation and may be important in the pathogenesis of retinal diseases

    Kolko, Miriam, Kiilgaard, Jens Folke, Wang, J., Poulsen, K. A., Andreasen, J. R., la Cour, M., Nissen, M. H., Heegaard, Steffen, Bazan, N. G., Prause, J. U., Kolko, M., Kiilgaard, Jens Folke, Wang, J., Poulsen, K. A., Andreasen, J. R., la Cour, Morten, Nissen, M. H., Heegaard, S., Bazan, N. G. & Prause, J. U., 1 Sep 2009, In : Experimental Eye Research. 89, 3, p. 383-91 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Synergy by secretory phospholipase A2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures

    Kolko, M., DeCoster, M. A., de Turco, E. B., Bazan, N. G. & Kolko, Miriam, 20 Dec 1996, In : The Journal of Biological Chemistry. 271, 51, p. 32722-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Mitochondria and the eye diseases - Editorial

    Kolko, Miriam, Sep 2017, In : Mitochondrion. 36, p. 1-3 3 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  55. Published

    Clinical and molecular markers in retinal detachment—From hyperreflective points to stem cells and inflammation

    Josifovska, N., Lumi, X., Szatmari-Tóth, M., Kristóf, E., Russell, G., Nagymihály, R., Anisimova, N., Malyugin, B., Kolko, Miriam, Ivastinović, D. & Petrovski, G., 1 Jun 2019, In : PLoS ONE. 14, 6, 9 p., e0217548.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Danish Nationwide Data Reveal a Link between Diabetes Mellitus, Diabetic Retinopathy, and Glaucoma

    Horwitz, A., Petrovski, B. E., Torp-Pedersen, C. & Kolko, Miriam, 2016, In : Journal of Diabetes Research. 2016, 10 p., 2684674.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Incidence and prevalence of glaucoma in native and immigrant groups living in Denmark

    Horwitz, A., Klemp, Marc Patrick Brag, Torp-Pedersen, C. & Kolko, Miriam, 1 Dec 2018, In : Acta Ophthalmologica. 96, S261, p. 53 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  58. Published

    Antihypertensive Medication Postpones the Onset of Glaucoma Evidence From a Nationwide Study

    Horwitz, A., Klemp, Marc Patrick Brag, Jeppesen, Jørgen, Tsai, J. C., Torp-Pedersen, C. & Kolko, Miriam, Feb 2017, In : Hypertension. 69, 2, p. 202-210

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Accepted/In press

    Efficacy and safety evaluation of benzalkonium chloride preserved eye-drops compared with alternatively preserved and preservative-free eye-drops in the treatment of glaucoma: A systematic review and meta-analysis

    Hedengran, A., Steensberg, A. T., Virgili, G., Azuara-Blanco, A. & Kolko, Miriam, 1 Jan 2020, (Accepted/In press) In : British Journal of Ophthalmology. 315623.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Matrix metalloproteinase-2 is expressed in melanoma-associated spongiform scleropathy

    Alyahya, G. A., Kolko, M., Prause, J. U., Nielsen, B. S., Wang, J., Heegaard, Steffen & Kolko, Miriam, Jul 2008, In : Investigative Ophthalmology & Visual Science. 49, 7, p. 2806-11 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Melanopsin-mediated pupillary light reflex and sleep quality in patients with normal tension glaucoma

    Ahmadi, H., Lund-Andersen, H., Kolko, Miriam, Bach-Holm, Daniella, Alberti, M. & Ba-Ali, S., 2020, In : Acta Ophthalmologica. 98, 1, p. 65-73

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 14599192