Ole Jannik Bjerrum
Ole Jannik Bjerrum

Professor emeritus

  • Translational Pharmacology

    Universitetsparken 2, 2100 København Ø

    Phone: +45 35 33 63 20

  1. Published
  2. Published

    Donepezil as add-on to gabapentin for post-traumatic neuropathic pain: an exploratory study

    Basnet, A., Butler, S., Honoré, P. G. H., Butler, M., Gordh, T. E., Kristensen, K. K. & Bjerrum, Ole Jannik, 2013, In : Acta Anaesthesiologica Scandinavica. 58, 1, p. 61-73 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Promising effects of donepezil when added to patients treated with gabapentin for neuropathic pain

    Basnet, A., Butler, S., Honoré, P. G. H., Butler, M., Gordh, T. E., Kristensen, K. & Bjerrum, Ole Jannik, 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  4. Published

    Medicines combinations options and regulatory hurdles

    Bjerrum, Ole Jannik, Gautam, Y., Bjerrum, E. J., Schmiegelow, M. & Boonen, Harrie C.M., 16 Jul 2013, In : European Journal of Pharmaceutical Sciences. 49, 4, p. 659-63 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A novel inhibitor of advanced glycation end- product formation inhibits mesenteric vascular hypertrophy in experimental diabetes

    Bjerrum, Ole Jannik, 1999, In : Diabetologica. 42, p. 472-479 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Population modelling and simulation of response - time profiles for charaterization of drug combination effect in a rat model of neuropathic pain

    Bjerrum, Ole Jannik, Basnet, A. & Honoré, P. G. H., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  7. Published

    Ceftriaxone, an EAAT-2 transporter inducer, shows antinociceptive effects in acute and neuropathic pain models

    Bjerrum, Ole Jannik, Abrahamsen, B. & Honoré, P. G. H., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  8. Published

    Fixed Dose Combinations. The Physician attitude to the wider use. A pilot study

    Bjerrum, Ole Jannik & Vana, V., 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  9. Published

    Electrophoretic and chromatographic differentiation of two forms of albumin in equilibrium at neutral pH. New screening technique of ligand binding to albumin

    Bjerrum, Ole Jannik, 1995, In : Electrophoresis. 16, 8, p. 1401-1407 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Growth hormone releasing hexapeptide (GHRP-6)-activates the inositol (1,4,5)-Triphosphate/diacylglycerol pathway

    Bjerrum, Ole Jannik, 1995, In : Journal of Receptors and Signal Transduction. 15, 1-4, p. 311-323 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Fixed drug combinations: are current regulatory guidelines in the EU and US adequate for effectively guiding Development?

    Bjerrum, Ole Jannik, Gautam, Y. & Schmiegelow, M., 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  12. Published

    Dose-dependent effect of ceftriaxone (A beta-lactam) on mechanical pain hypersensitivity in the CCI nerve rat model

    Bjerrum, Ole Jannik, Frederiksen, K. K., Kristensen, P., Abrahamsen, B. & Honoré, P. G. H., 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  13. Published

    Relative contribution of advanced glycation and nitric oxide synthase inhibition to amino guanidine- mediated renoprotection in diabetic rats

    Bjerrum, Ole Jannik, 1997, In : Diabetologia. 40, 10, p. 1141-1151 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Orphan disease council - A new interdiciplinary private/public partnership promoting the Development of orphan medicinal products

    Bjerrum, Ole Jannik, Hove, H. B., Dali, C., Callesen, L., Ludvig, G. & Thyregod, L., 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  15. Published

    Measurement of sedation in rats. Comparison of the locomotor activity test, open field test and the rotarod test

    Bjerrum, Ole Jannik, Nasser, A., Basnet, A., Merry, A. & Kristensen, P., Nov 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  16. Published

    The hph-1 mouse mutant deficient in tetrahydrobiopterin show reduced acute and chronic inflammatory pain

    Bjerrum, Ole Jannik, Nasser, A. & Heegaard, Anne-Marie, 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  17. Published

    Development of quantitative Pharmacology Pharmacometrics in Denmark

    Bjerrum, Ole Jannik & Honoré, P. G. H., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  18. Published

    Characterization of drug combination effects in a rat model of neuropathic pain ny population modelling and simulation of response-time profiles

    Bjerrum, Ole Jannik & Honoré, P. G. H., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  19. Published

    Centrally mediated anti-noceptive action of GABAA receptor agonists in the spared nerve injury model of neuropathic pain

    Bjerrum, Ole Jannik, 2005, In : European Journal of Pharmaceutical Sciences. 516, p. 131-138 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Population pharmacodynamic modeling and simulation as a method to characterize drug combination effects i a rat model of neuropathic pain

    Bjerrum, Ole Jannik & Honoré, P. G. H., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  21. Published

    Systems pharmacology from an Academic Perspective

    Bjerrum, Ole Jannik & Boonen, Harrie C.M., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  22. Published

    Combination therapy for neuropathic pain: Donepezil improves gabapentins antinoceptive effect in SNI rats

    Bjerrum, Ole Jannik & Honoré, P. G. H., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  23. Published

    Western blotting: immunoblotting

    Bjerrum, Ole Jannik & Heegaard, N. H., 2008, Encyclopedia of Life Sciences. Wiley

    Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearch

  24. Published

    Excellence in education and training advances competitiveness of the pharmaceutical industry in Europe

    Bjerrum, Ole Jannik, 2011, In : European Journal of Pharmaceutical Sciences. 44, 2, p. 174-175 2 p.

    Research output: Contribution to journalComment/debateResearch

  25. Published

    Drug-drug combinations revisited

    Bjerrum, Ole Jannik, Gautam, Y., Honoré, P. G. H. & Vana, V., 15 Jan 2014, In : European Journal of Hospital Pharmacy - Science and Practice. 21, 1, p. 8-12 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Published

    From Face-to-fase training to blended learning in the postgraduate program SafeSciMet - a case study

    Bjerrum, Ole Jannik, Vos, C., Dragovic, S., Jochimsen, M., Dirac, J., Foth, H. & Wiese, J., 2017, In : European Journal of Pharmaceutical Sciences. 96, p. III-VIII 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Pain perception and Dopa Responsive Dystonia

    Bjerrum, Ole Jannik, Nasser, A., Møller, A. T., Møller, B. & Jensen, T. S., 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  28. Published

    Dose and administration-period play a key role in the effect of ceftriaxone on neuropathic pain in CCi-operated rats

    Bjerrum, Ole Jannik, Honoré, P. G. H., Frederiksen, K. K., Kristensen, P., Abrahamsen, B. & Gegelashvili, G., 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  29. Published

    The hph-1 mouse with inherited deficiency in GTP cyclohydrolase 1 shows reduced inflammatory pain behavior

    Bjerrum, Ole Jannik & Nasser, A., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  30. Published

    Structural heterogeneity of the binding sites of HSA for phenyl-groups and medium chain fatty acids. Demonstration of equilibrium between different binding conformations

    Bjerrum, Ole Jannik & Bjerrum, Morten Jannik, 1999, In : European Journal of Biochemistry. 260, p. 470-476 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    How first time-in human studies are being performed; A survey of phase 1 dose escalation trials in healthy volunteers published between 1995-2004

    Bjerrum, Ole Jannik, 2005, In : Journal of Clinical Pharmacology. 45, p. 1123-1136 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Immunochemically identical hydrophilic and amphiphilic forms of the bovine adrenomedullary dopamine beta-hydroxylase

    Bjerrum, Ole Jannik, Helle, K. B. & Bock, E. M., 1979, In : Biochemical Journal. 181, 1, p. 231-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Why medicines Combinations? Friend or Foe?

    Bjerrum, Ole Jannik, Gautam, Y., Boonen, Harrie C.M., Schmiegelow, M. & Honoré, P. G. H., 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  34. Published

    Beta-lactam antibiotic as dose dependent analgesic treatment of neuropathic pain

    Bjerrum, Ole Jannik, Abrahamsen, B. & Honoré, P. G. H., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  35. Published

    Venlafaxine compromises the antinoceptive actions of gabapentin in rat models of neuropathic and persistent pain

    Bjerrum, Ole Jannik, 2006, In : Psychopharmacology. 187, p. 364-375 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Decrease in nocifensive behaviour in rats after treatment with the EAAT-2 transporter inducer cetriaxone

    Bjerrum, Ole Jannik, Honoré, P. G. H. & Abrahamsen, B., 2011.

    Research output: Contribution to conferencePosterResearchpeer-review

  37. Published

    Identifying Off-label Prescriptions trough Data Mining in Danish Community Pharmacy Servers: An exploratory Study on Desmopressin, Diclofenac, Fucidin, Mirtazapine and Quetiapine

    Bjerrum, Ole Jannik & Androlyte, M., 2018, In : Basic & Clinical Pharmacology & Toxicology. 123 , 2, p. 155–160 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Donepezil anvendt ved neuropatisk smerte

    Bjerrum, Ole Jannik & Bjerrum, H. J., 2013, In : Ugesskrift for læger. 175, 42, p. 2493-2494 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    A Paradigm Shift Towards Patient Involvement in Medicines Development and Regulatory Science: Workshop Proceedings and Commentary

    Borup, G., Bach, K. F., Schmiegelow, M., Wallach-Kildemoes, Helle, Bjerrum, Ole Jannik & Westergaard, N., May 2016, In : Therapeutic Innovation & Regulatory Science. 50, 3, p. 304-311 8 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  40. Published

    Pharmacy student driven detection of adverse drug reactions in the community pharmacy setting

    Christensen, S. T., Søndergaard, B., Honoré, P. H. & Bjerrum, Ole Jannik, 2011, In : Pharmacoepidemiology and Drug Safety. 20, p. 399-404 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Fast detection of adverse drug reactions of new drugs by community pharmacists

    Christensen, S. T. & Bjerrum, Ole Jannik, 2010, In : Drug Safety. 33, 10, p. 928

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  42. Published

    The EUFEPS workshop on institutional peer review "The ultimate tool to advance the pharmaceutical sciences?" A continuing story: A continuing story

    Crommelin, D. J. A. & Bjerrum, Ole Jannik, 2008, In : European Journal of Pharmaceutical Sciences. 35, 4, p. 361-364

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Effects of the excitatory amino acid transporter subtype 2(EAAT-2) inducer ceftriaxone on different pain modalities in rat

    Eljaja, L., Bjerrum, Ole Jannik, Honoré, P. G. H. & Abrahamsen, B., 2011, In : Scandinavian Journal of Pain. 2, 3, p. 132-136 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies

    Folkesson, A., Honoré, P. H., Andersen, L. M., Kristensen, P. J. & Bjerrum, Ole Jannik, 2010, In : Journal of Neural Transmission. 117, p. 1377-1385

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Co-administered gabapentin and venlafaxine in nerve injured rats: effect on mechanical hypersensitivity, motor function and pharmacokinetics

    Folkesson, A. J. M., Honoré, P. G. H. & Bjerrum, Ole Jannik, 2009, In : Scandinavian Journal of Pain. 1, 2, p. 91-97

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    The wider use of fixed-dose combinations emphasizes the need for a global approach to regulatory guideline development

    Gautam, Y., Bjerrum, Ole Jannik & Schmiegelow, M., 2015, In : Therapeutic Innovation & Regulatory Science. 49, 1, p. 197-204 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    High-affinity Glutamate Transporters in Pain: An Emerging and Therapeutic Target

    Gegelashvili, George & Bjerrum, Ole Jannik, 2015, In : Journal of Neurochemistry. 6, p. 712-30 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology

    Gegelashvili, G. & Bjerrum, Ole Jannik, 2017, Glial Amino Acid Transporters. Springer, Vol. 16. p. 225-253 29 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  49. Published

    Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain

    Hald, A., Ding, M., Egerod, Kristoffer Lihme, Hansen, Rie Bager, Konradsen, D., Jørgensen, S. G., Atalay, B., Nasser, A., Bjerrum, Ole Jannik & Heegaard, Anne-Marie, 2008, In : Pharmacology, Biochemistry and Behavior. 91, 1, p. 38-46 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Neuropathic pain models in the development of analgesic drugs

    Honoré, P. G. H., Basnet, A., Eljaja, L., Kristensen, P., Neustrup, L. M., Møllgaard, P. & Bjerrum, Ole Jannik, 2011, In : Scandinavian Journal of Pain. 2, 4, p. 172-177 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  51. Published

    Predictive validity of pharmacologic interventions in animal models of neuropathic pain

    Honoré, P. G. H., Basnet, A., Kristensen, P., Andersen, L. M., Neustrup, S., Møllgaard, P., Eljaja, L. & Bjerrum, Ole Jannik, 2011, In : Scandinavian Journal of Pain. 2, 4, p. 178-184 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Development of quantitative pharmacology-pharmacometrics in Denmark

    Honoré, P. G. H., Bjerrum, Ole Jannik, Lund, Trine Meldgaard, Angelo, H., Ingwersen, S. H., Thygesen, P., Kristensen, K. & Larsen, F., 2011.

    Research output: Contribution to conferencePosterResearch

  53. Published

    The antinociceptive efficacy of buprenorphine administered through the drinking water of rats

    Jessen, L., Bjerrum, Ole Jannik & Christensen, S., 2007, In : Laboratory Animals. Journal of the Laboratory Animal Science Association. 41, 2, p. 185-96 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Effective integration of systems biology, biomarkers, biosimulation and modelling in streamlining drug development

    Krishna, R., Schaefer, H. G. & Bjerrum, Ole Jannik, 2007, In : European Journal of Pharmaceutical Sciences. 31, 1, p. 62-67

    Research output: Contribution to journalLetterResearch

  55. Published

    Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?

    Kristensen, P. J., Heegaard, Anne-Marie, Kristensen, S. H., Jeggo, R. D., Bjerrum, Ole Jannik & Munro, G., Apr 2017, In : European Journal of Pain. 21, 4, p. 692-704 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    The β-lactam clavulanic acid mediates glutamate transport-sensitive pain relief in a rat model of neuropathic pain

    Kristensen, P. J., Gegelashvili, George, Munro, G., Heegaard, Anne-Marie & Bjerrum, Ole Jannik, Feb 2018, In : European Journal of Pain. 22, 2, p. 282-294

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, B., Oosterhuis, B., Bjerrum, Ole Jannik, Rowland, M. & Garner, C., 2010, In : European Journal of Pharmaceutical Sciences. 40, 2, p. 125-31 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen) and phenobarbital in human volunteers

    Lappin, G., Shishikura, Y., Jochemsen, R., Weaver, R. J., Gesson, C., Houston, J. B., Oosterhuis, B., Bjerrum, Ole Jannik, Grynkiewicz, G., Alder, J., Rowland, M. & Garner, C., 20 Apr 2011, In : European Journal of Pharmaceutical Sciences. 43, 3, p. 141-150 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain

    Nasser, A., Bjerrum, Ole Jannik, Heegaard, Anne-Marie, Møller, A. T., Larsen, M., Dalbøge, L. S., Dupont, E., Jensen, T. S. & Møller, L. B., 19 Feb 2013, In : Molecular Pain. 9, p. 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Intraplantar injection of tetrahydrobiopterin induces nociception in mice

    Nasser, A., Ali, S., Wilsbech, S., Bjerrum, Ole Jannik & Birk Møller, L., 2015, In : Neuroscience Letters. 584, p. 247-252 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity

    Nasser, A., Møller, A. T., Hellmund, V., Thorborg, S. S., Jespersgaard, C., Bjerrum, Ole Jannik, Dupontd, E., Nachman, G., Lykkesfeldt, Jens, Jensen, T. S. & Møller, L. B., 2018, In : Pain. 159, 6, p. 1012-1024 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Genetik kan forudsige følsomhed for smerte

    Nasser, A., Bjerrum, Ole Jannik, Heegaard, Anne-Marie & Møller, L. B., 2010, In : Lægemiddelforskning. 2010, p. 34-36

    Research output: Contribution to journalJournal articleResearch

  63. Published

    Modification of beta-2-microglobulin in sera from patients with small cell lung cancer: evidence for involvement of a serine protease.

    Nissen, Mogens Holst, Bjerrum, Ole Jannik, Plesner, T., Wilken, M. & Rørth, M., 1987, In : Clinical and Experimental Immunology. 67, 2, p. 425-32 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    A simple method for the preparation and purification of C1 complement cleaved beta 2-microglobulin from human serum.

    Nissen, Mogens Holst, Johansen, B. & Bjerrum, Ole Jannik, 1997, In : Journal of Immunological Methods. 205, 1, p. 29-33 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Body of evidence and approaches applied in the clinical development programme of fixed-dose combinations in the European Union from 2010 to 2016

    Nøhr-Nielsen, Asbjørn, De Bruin, Marie Louise (Marieke), Thomsen, M., Pipper, C. B., Lange, Theis, Bjerrum, Ole Jannik & Lund, Trine Meldgaard, 2019, In : British Journal of Clinical Pharmacology. 85, 8, p. 1829-1840 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Sortilins in neuropathic pain

    Richner, M., Bjerrum, Ole Jannik, Koninck, Y. D., Nykjaer, A. & Vaegter, C. B., 29 Dec 2012, In : Scandinavian Journal of Pain. 3, 3, p. 183-184 2 p.

    Research output: Contribution to journalConference abstract in journalResearch

  67. Published

    The spared nerve injury (SNI) model of induced mechanical allodynia in mice

    Richner, M., Bjerrum, Ole Jannik, Nykjær, A. & Vaegter, C. B., 18 Aug 2011, In : Journal of Visualized Experiments. 54, p. e3092

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain

    Rode, F., Thomsen, M., Jensen, D. G., Blackburn-Munro, G., Bjerrum, Ole Jannik & Broløs, T., 2007, In : European Journal of Pharmacology. 564, 1-3, p. 103-111

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    An analysis of the fixed-dose combinations authorized by the European Union, 2009-14: A Focus on benefit-risk and clinial development condition

    Sawicki-Wrzask, D., Thomsen, M. & Bjerrum, Ole Jannik, 2015, In : Therapeutic Innovation & Regulatory Science. 49, 4, p. 553-559 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Mechanical sensory threshold in Cavalier King Charles spaniels with syringomyelia-associated scratching and control dogs

    Thoefner, M. S., Westrup, Ulrik, Toft, N., Bjerrum, Ole Jannik & Berendt, Mette, 2019, In : Veterinary Journal. 246, p. 92-97 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1302721