Patrick Ryan Gentry
Patrick Ryan Gentry

Postdoc


  1. 2019
  2. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist

    Nøhr, A. C., Shehata, Mohamed A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, Patrick Ryan, Gloriam, David E. & Bräuner-Osborne, Hans, 7 Mar 2019, In : Scientific Reports. 9, 1, p. 3802

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2018
  4. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

    Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, Patrick Ryan, Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2016
  6. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators

    Berizzi, A. E., Gentry, Patrick Ryan, Rueda, P., Den Hoedt, S., Sexton, P. M., Langmead, C. J. & Christopoulos, A., Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-36 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

    Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, Patrick Ryan, Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., 15 Jun 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2015
  9. Novel Allosteric Modulators of G Protein-coupled Receptors

    Gentry, Patrick Ryan, Sexton, P. M. & Christopoulos, A., 7 Aug 2015, In : The Journal of Biological Chemistry. 290, 32, p. 19478-88 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges

    Kurata, H., Gentry, Patrick Ryan, Kokubo, M., Cho, H. P., Bridges, T. M., Niswender, C. M., Byers, F. W., Wood, M. R., Daniels, J. S., Conn, P. J. & Lindsley, C. W., 1 Feb 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 3, p. 690-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2014
  12. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)

    Morris, L. C., Nance, K. D., Gentry, Patrick Ryan, Days, E. L., Weaver, C. D., Niswender, C. M., Thompson, A. D., Jones, C. K., Locuson, C. W., Morrison, R. D., Daniels, J. S., Niswender, K. D. & Lindsley, C. W., 11 Dec 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 10192-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Lindsley, C. W. & Wood, M. R., 25 Sep 2014, In : Journal of Medicinal Chemistry. 57, 18, p. 7804-10 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., Daniels, J. S., Wood, M. R., Conn, P. J. & Lindsley, C. W., Aug 2014, In : ChemMedChem. 9, 8, p. 1677-82 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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