Employees – University of Copenhagen

Patrick Ryan Gentry

Patrick Ryan Gentry

Postdoc


  1. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. / Brady, Ashley E; Jones, Carrie K; Bridges, Thomas M; Kennedy, J Phillip; Thompson, Analisa D; Heiman, Justin U; Breininger, Micah L; Gentry, Patrick R; Yin, Huiyong; Jadhav, Satyawan B; Shirey, Jana K; Conn, P Jeffrey; Lindsley, Craig W.

    In: The Journal of Pharmacology and Experimental Therapeutics, Vol. 327, No. 3, 12.2008, p. 941-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I : Development of the first highly selective M(5) PAM. / Bridges, Thomas M; Kennedy, J Phillip; Cho, Hyekyung P; Breininger, Micah L; Gentry, Patrick R; Hopkins, Corey R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 2, 15.01.2010, p. 558-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II : development of a potent and highly selective M1 PAM. / Bridges, Thomas M; Phillip Kennedy, J; Noetzel, Meredith J; Breininger, Micah L; Gentry, Patrick R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 6, 15.03.2010, p. 1972-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure : 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Noetzel, Meredith J; Cho, Hyekyung P; Lamsal, Atin; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 18, 25.09.2014, p. 7804-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold. / Bender, Aaron M; Cho, Hyekyung P; Nance, Kellie D; Lingenfelter, Kaelyn S; Luscombe, Vincent B; Gentry, Patrick R; Voigtritter, Karl; Berizzi, Alice E; Sexton, Patrick M; Langmead, Christopher J; Christopoulos, Arthur; Locuson, Charles W; Bridges, Thomas M; Chang, Sichen; O'Neill, Jordan C; Zhan, Xiaoyan; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W.

    In: ACS Chemical Neuroscience, Vol. 9, No. 7, 18.07.2018, p. 1572-1581.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379) : a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). / Morris, Lindsey C; Nance, Kellie D; Gentry, Patrick R; Days, Emily L; Weaver, C David; Niswender, Colleen M; Thompson, Analisa D; Jones, Carrie K; Locuson, Chuck W; Morrison, Ryan D; Daniels, J Scott; Niswender, Kevin D; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 23, 11.12.2014, p. 10192-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. / Gogliotti, Rocco D; Engers, Darren W; Garcia-Barrantes, Pedro M; Panarese, Joseph D; Gentry, Patrick R; Blobaum, Anna L; Morrison, Ryan D; Daniels, J Scott; Thompson, Analisa D; Jones, Carrie K; Conn, P Jeffrey; Niswender, Colleen M; Lindsley, Craig W; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 12, 15.06.2016, p. 2915-2919.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Discovery of ML326 : The first sub-micromolar, selective M5 PAM. / Gentry, Patrick R; Bridges, Thomas M; Lamsal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 10, 15.05.2013, p. 2996-3000.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 22, 27.11.2013, p. 9351-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. / Bridges, Thomas M; Marlo, Joy E; Niswender, Colleen M; Jones, Carrie K; Jadhav, Satyawan B; Gentry, Patrick R; Plumley, Hyekyung C; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 11, 11.06.2009, p. 3445-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

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