Patrick Ryan Gentry

Patrick Ryan Gentry

Postdoc


  1. 2014
  2. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379) : a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). / Morris, Lindsey C; Nance, Kellie D; Gentry, Patrick R; Days, Emily L; Weaver, C David; Niswender, Colleen M; Thompson, Analisa D; Jones, Carrie K; Locuson, Chuck W; Morrison, Ryan D; Daniels, J Scott; Niswender, Kevin D; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 23, 11.12.2014, p. 10192-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Drugs for allosteric sites on receptors. / Wenthur, Cody J; Gentry, Patrick R; Mathews, Thomas P; Lindsley, Craig W.

    In: Annual Review of Pharmacology and Toxicology, Vol. 54, 2014, p. 165-84.

    Research output: Contribution to journalReviewResearchpeer-review

  4. 2013
  5. Discovery of ML326 : The first sub-micromolar, selective M5 PAM. / Gentry, Patrick R; Bridges, Thomas M; Lamsal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 10, 15.05.2013, p. 2996-3000.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 22, 27.11.2013, p. 9351-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137 : continued optimization of an MLPCN probe molecule. / Melancon, Bruce J; Poslusney, Michael S; Gentry, Patrick R; Tarr, James C; Sheffler, Douglas J; Mattmann, Margrith E; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 2, 15.01.2013, p. 412-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137 : the continued optimization of an MLPCN probe molecule. / Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 6, 15.03.2013, p. 1860-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2012
  10. MGluR4 allosteric potentiators and their preparation, compositions, and methods of treating neurological dysfunction. / Conn, P Jeffrey (Inventor); Lindsley, Craig W (Inventor); Hopkins, Corey R (Inventor); Weaver, David (Inventor); Niswender, Colleen M (Inventor); Engers, Darren W (Inventor); Gentry, Patrick Ryan (Inventor); Cheung, Yiu-Yin (Inventor); Salovich, James (Inventor); Gogliotti, Rocco D (Inventor).

    Patent No.: US20120245153A1. Sep 04, 2010.

    Research output: PatentResearch

  11. 2010
  12. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I : Development of the first highly selective M(5) PAM. / Bridges, Thomas M; Kennedy, J Phillip; Cho, Hyekyung P; Breininger, Micah L; Gentry, Patrick R; Hopkins, Corey R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 2, 15.01.2010, p. 558-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II : development of a potent and highly selective M1 PAM. / Bridges, Thomas M; Phillip Kennedy, J; Noetzel, Meredith J; Breininger, Micah L; Gentry, Patrick R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 6, 15.03.2010, p. 1972-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). / Engers, Darren W; Gentry, Patrick R; Williams, Richard; Bolinger, Julie D; Weaver, C David; Menon, Usha N; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 17, 01.09.2010, p. 5175-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 172786299