Patrick Ryan Gentry
Patrick Ryan Gentry

Postdoc


  1. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Noetzel, M. J., Cho, H. P., Lamsal, A., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Lindsley, C. W. & Wood, M. R., 25 Sep 2014, In : Journal of Medicinal Chemistry. 57, 18, p. 7804-10 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Kett, N. R., Harp, J. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9351-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

    Gentry, Patrick Ryan, Kokubo, M., Bridges, T. M., Cho, H. P., Smith, E., Chase, P., Hodder, P. S., Utley, T. J., Rajapakse, A., Byers, F., Niswender, C. M., Morrison, R. D., Daniels, J. S., Wood, M. R., Conn, P. J. & Lindsley, C. W., Aug 2014, In : ChemMedChem. 9, 8, p. 1677-82 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Novel Allosteric Modulators of G Protein-coupled Receptors

    Gentry, Patrick Ryan, Sexton, P. M. & Christopoulos, A., 7 Aug 2015, In : The Journal of Biological Chemistry. 290, 32, p. 19478-88 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Discovery of ML326: The first sub-micromolar, selective M5 PAM

    Gentry, Patrick Ryan, Bridges, T. M., Lamsal, A., Vinson, P. N., Smith, E., Chase, P., Hodder, P. S., Engers, J. L., Niswender, C. M., Daniels, J. S., Conn, P. J., Wood, M. R. & Lindsley, C. W., 15 May 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, 10, p. 2996-3000 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

    Gogliotti, R. D., Engers, D. W., Garcia-Barrantes, P. M., Panarese, J. D., Gentry, Patrick Ryan, Blobaum, A. L., Morrison, R. D., Daniels, J. S., Thompson, A. D., Jones, C. K., Conn, P. J., Niswender, C. M., Lindsley, C. W. & Hopkins, C. R., 15 Jun 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 12, p. 2915-2919 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors

    Hao, J., Ho, J. N., Lewis, J. A., Karim, K. A., Daniels, R. N., Gentry, Patrick Ryan, Hopkins, C. R., Lindsley, C. W. & Hong, C. C., 19 Feb 2010, In : ACS chemical biology. 5, 2, p. 245-53 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

    Kennedy, J. P., Bridges, T. M., Gentry, Patrick Ryan, Brogan, J. T., Kane, A. S., Jones, C. K., Brady, A. E., Shirey, J. K., Conn, P. J. & Lindsley, C. W., Oct 2009, In : ChemMedChem. 4, 10, p. 1600-7 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges

    Kurata, H., Gentry, Patrick Ryan, Kokubo, M., Cho, H. P., Bridges, T. M., Niswender, C. M., Byers, F. W., Wood, M. R., Daniels, J. S., Conn, P. J. & Lindsley, C. W., 1 Feb 2015, In : Bioorganic & Medicinal Chemistry Letters. 25, 3, p. 690-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 172786299