Patrick Ryan Gentry

Patrick Ryan Gentry

Postdoc


  1. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure : 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Noetzel, Meredith J; Cho, Hyekyung P; Lamsal, Atin; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 18, 25.09.2014, p. 7804-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 22, 27.11.2013, p. 9351-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381) : a novel molecular probe. / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Utley, Thomas J; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M; Morrison, Ryan D; Daniels, J Scott; Wood, Michael R; Conn, P Jeffrey; Lindsley, Craig W.

    In: ChemMedChem, Vol. 9, No. 8, 08.2014, p. 1677-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Novel Allosteric Modulators of G Protein-coupled Receptors. / Gentry, Patrick R; Sexton, Patrick M; Christopoulos, Arthur.

    In: The Journal of Biological Chemistry, Vol. 290, No. 32, 07.08.2015, p. 19478-88.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Discovery of ML326 : The first sub-micromolar, selective M5 PAM. / Gentry, Patrick R; Bridges, Thomas M; Lamsal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 10, 15.05.2013, p. 2996-3000.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. / Gogliotti, Rocco D; Engers, Darren W; Garcia-Barrantes, Pedro M; Panarese, Joseph D; Gentry, Patrick R; Blobaum, Anna L; Morrison, Ryan D; Daniels, J Scott; Thompson, Analisa D; Jones, Carrie K; Conn, P Jeffrey; Niswender, Colleen M; Lindsley, Craig W; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 12, 15.06.2016, p. 2915-2919.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. / Hao, Jijun; Ho, Joshua N; Lewis, Jana A; Karim, Kaleh A; Daniels, R Nathan; Gentry, Patrick R; Hopkins, Corey R; Lindsley, Craig W; Hong, Charles C.

    In: ACS chemical biology, Vol. 5, No. 2, 19.02.2010, p. 245-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor. / Kennedy, J Phillip; Bridges, Thomas M; Gentry, Patrick R; Brogan, John T; Kane, Alexander S; Jones, Carrie K; Brady, Ashley E; Shirey, Jana K; Conn, P Jeffrey; Lindsley, Craig W.

    In: ChemMedChem, Vol. 4, No. 10, 10.2009, p. 1600-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Further optimization of the M5 NAM MLPCN probe ML375 : tactics and challenges. / Kurata, Haruto; Gentry, Patrick R; Kokubo, Masaya; Cho, Hyekyung P; Bridges, Thomas M; Niswender, Colleen M; Byers, Frank W; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 3, 01.02.2015, p. 690-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 172786299