Employees – University of Copenhagen

Patrick Ryan Gentry

Patrick Ryan Gentry

Postdoc


  1. 2019
  2. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist. / Nøhr, Anne Cathrine; Shehata, Mohamed A; Palmer, Daniel; Pokhrel, Rina; Vallianou, Maria; Foster, Simon R; Gentry, Patrick R; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Scientific Reports, Vol. 9, No. 1, 07.03.2019, p. 3802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2018
  4. Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold. / Bender, Aaron M; Cho, Hyekyung P; Nance, Kellie D; Lingenfelter, Kaelyn S; Luscombe, Vincent B; Gentry, Patrick R; Voigtritter, Karl; Berizzi, Alice E; Sexton, Patrick M; Langmead, Christopher J; Christopoulos, Arthur; Locuson, Charles W; Bridges, Thomas M; Chang, Sichen; O'Neill, Jordan C; Zhan, Xiaoyan; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W.

    In: ACS Chemical Neuroscience, Vol. 9, No. 7, 18.07.2018, p. 1572-1581.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2016
  6. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators. / Berizzi, Alice E; Gentry, Patrick R; Rueda, Patricia; Den Hoedt, Sandra; Sexton, Patrick M; Langmead, Christopher J; Christopoulos, Arthur.

    In: Molecular Pharmacology, Vol. 90, No. 4, 10.2016, p. 427-36.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy. / Gogliotti, Rocco D; Engers, Darren W; Garcia-Barrantes, Pedro M; Panarese, Joseph D; Gentry, Patrick R; Blobaum, Anna L; Morrison, Ryan D; Daniels, J Scott; Thompson, Analisa D; Jones, Carrie K; Conn, P Jeffrey; Niswender, Colleen M; Lindsley, Craig W; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 12, 15.06.2016, p. 2915-2919.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2015
  9. Novel Allosteric Modulators of G Protein-coupled Receptors. / Gentry, Patrick R; Sexton, Patrick M; Christopoulos, Arthur.

    In: The Journal of Biological Chemistry, Vol. 290, No. 32, 07.08.2015, p. 19478-88.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Further optimization of the M5 NAM MLPCN probe ML375 : tactics and challenges. / Kurata, Haruto; Gentry, Patrick R; Kokubo, Masaya; Cho, Hyekyung P; Bridges, Thomas M; Niswender, Colleen M; Byers, Frank W; Wood, Michael R; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 3, 01.02.2015, p. 690-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2014
  12. M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location. / Foster, Daniel J; Gentry, Patrick R; Lizardi-Ortiz, Jose E; Bridges, Thomas M; Wood, Michael R; Niswender, Colleen M; Sulzer, David; Lindsley, Craig W; Xiang, Zixiu; Conn, P Jeffrey.

    In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, No. 9, 26.02.2014, p. 3253-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure : 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Noetzel, Meredith J; Cho, Hyekyung P; Lamsal, Atin; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 18, 25.09.2014, p. 7804-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381) : a novel molecular probe. / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Utley, Thomas J; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M; Morrison, Ryan D; Daniels, J Scott; Wood, Michael R; Conn, P Jeffrey; Lindsley, Craig W.

    In: ChemMedChem, Vol. 9, No. 8, 08.2014, p. 1677-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379) : a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). / Morris, Lindsey C; Nance, Kellie D; Gentry, Patrick R; Days, Emily L; Weaver, C David; Niswender, Colleen M; Thompson, Analisa D; Jones, Carrie K; Locuson, Chuck W; Morrison, Ryan D; Daniels, J Scott; Niswender, Kevin D; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 57, No. 23, 11.12.2014, p. 10192-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Drugs for allosteric sites on receptors. / Wenthur, Cody J; Gentry, Patrick R; Mathews, Thomas P; Lindsley, Craig W.

    In: Annual Review of Pharmacology and Toxicology, Vol. 54, 2014, p. 165-84.

    Research output: Contribution to journalReviewResearchpeer-review

  17. 2013
  18. Discovery of ML326 : The first sub-micromolar, selective M5 PAM. / Gentry, Patrick R; Bridges, Thomas M; Lamsal, Atin; Vinson, Paige N; Smith, Emery; Chase, Peter; Hodder, Peter S; Engers, Julie L; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 10, 15.05.2013, p. 2996-3000.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). / Gentry, Patrick R; Kokubo, Masaya; Bridges, Thomas M; Kett, Nathan R; Harp, Joel M; Cho, Hyekyung P; Smith, Emery; Chase, Peter; Hodder, Peter S; Niswender, Colleen M; Daniels, J Scott; Conn, P Jeffrey; Wood, Michael R; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 56, No. 22, 27.11.2013, p. 9351-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137 : continued optimization of an MLPCN probe molecule. / Melancon, Bruce J; Poslusney, Michael S; Gentry, Patrick R; Tarr, James C; Sheffler, Douglas J; Mattmann, Margrith E; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 2, 15.01.2013, p. 412-6.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137 : the continued optimization of an MLPCN probe molecule. / Poslusney, Michael S; Melancon, Bruce J; Gentry, Patrick R; Sheffler, Douglas J; Bridges, Thomas M; Utley, Thomas J; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Wood, Michael R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 6, 15.03.2013, p. 1860-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2012
  23. MGluR4 allosteric potentiators and their preparation, compositions, and methods of treating neurological dysfunction. / Conn, P Jeffrey (Inventor); Lindsley, Craig W (Inventor); Hopkins, Corey R (Inventor); Weaver, David (Inventor); Niswender, Colleen M (Inventor); Engers, Darren W (Inventor); Gentry, Patrick Ryan (Inventor); Cheung, Yiu-Yin (Inventor); Salovich, James (Inventor); Gogliotti, Rocco D (Inventor).

    Patent No.: US20120245153A1. Sep 04, 2010.

    Research output: PatentResearch

  24. 2010
  25. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I : Development of the first highly selective M(5) PAM. / Bridges, Thomas M; Kennedy, J Phillip; Cho, Hyekyung P; Breininger, Micah L; Gentry, Patrick R; Hopkins, Corey R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 2, 15.01.2010, p. 558-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II : development of a potent and highly selective M1 PAM. / Bridges, Thomas M; Phillip Kennedy, J; Noetzel, Meredith J; Breininger, Micah L; Gentry, Patrick R; Conn, P Jeffrey; Lindsley, Craig W.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 6, 15.03.2010, p. 1972-5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). / Engers, Darren W; Gentry, Patrick R; Williams, Richard; Bolinger, Julie D; Weaver, C David; Menon, Usha N; Conn, P Jeffrey; Lindsley, Craig W; Niswender, Colleen M; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 17, 01.09.2010, p. 5175-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. / Hao, Jijun; Ho, Joshua N; Lewis, Jana A; Karim, Kaleh A; Daniels, R Nathan; Gentry, Patrick R; Hopkins, Corey R; Lindsley, Craig W; Hong, Charles C.

    In: ACS chemical biology, Vol. 5, No. 2, 19.02.2010, p. 245-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2009
  30. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. / Bridges, Thomas M; Marlo, Joy E; Niswender, Colleen M; Jones, Carrie K; Jadhav, Satyawan B; Gentry, Patrick R; Plumley, Hyekyung C; Weaver, C David; Conn, P Jeffrey; Lindsley, Craig W.

    In: Journal of Medicinal Chemistry, Vol. 52, No. 11, 11.06.2009, p. 3445-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor. / Kennedy, J Phillip; Bridges, Thomas M; Gentry, Patrick R; Brogan, John T; Kane, Alexander S; Jones, Carrie K; Brady, Ashley E; Shirey, Jana K; Conn, P Jeffrey; Lindsley, Craig W.

    In: ChemMedChem, Vol. 4, No. 10, 10.2009, p. 1600-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). / Williams, Richard; Johnson, Kari A; Gentry, Patrick R; Niswender, Colleen M; Weaver, Charles D; Conn, P Jeffrey; Lindsley, Craig W; Hopkins, Corey R.

    In: Bioorganic & Medicinal Chemistry Letters, Vol. 19, No. 17, 01.09.2009, p. 4967-70.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2008
  34. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. / Brady, Ashley E; Jones, Carrie K; Bridges, Thomas M; Kennedy, J Phillip; Thompson, Analisa D; Heiman, Justin U; Breininger, Micah L; Gentry, Patrick R; Yin, Huiyong; Jadhav, Satyawan B; Shirey, Jana K; Conn, P Jeffrey; Lindsley, Craig W.

    In: The Journal of Pharmacology and Experimental Therapeutics, Vol. 327, No. 3, 12.2008, p. 941-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

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